DE69332911T2 - Rekombinanter humanisierter Antikörper gegen menschlichen Immunschwächevirus - Google Patents
Rekombinanter humanisierter Antikörper gegen menschlichen ImmunschwächevirusInfo
- Publication number
- DE69332911T2 DE69332911T2 DE69332911T DE69332911T DE69332911T2 DE 69332911 T2 DE69332911 T2 DE 69332911T2 DE 69332911 T DE69332911 T DE 69332911T DE 69332911 T DE69332911 T DE 69332911T DE 69332911 T2 DE69332911 T2 DE 69332911T2
- Authority
- DE
- Germany
- Prior art keywords
- humanized antibody
- antibody against
- immunodeficiency virus
- human immunodeficiency
- against human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000725303 Human immunodeficiency virus Species 0.000 title abstract 2
- 241001529936 Murinae Species 0.000 abstract 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000017960 syncytium formation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB1993/001798 WO1995006119A1 (en) | 1993-08-24 | 1993-08-24 | Recombinant humanized anti-human immunodeficiency virus antibody |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69332911D1 DE69332911D1 (de) | 2003-05-28 |
DE69332911T2 true DE69332911T2 (de) | 2003-12-18 |
Family
ID=10729537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69332911T Expired - Fee Related DE69332911T2 (de) | 1993-08-24 | 1993-08-24 | Rekombinanter humanisierter Antikörper gegen menschlichen Immunschwächevirus |
Country Status (9)
Country | Link |
---|---|
US (1) | US5607847A (de) |
EP (1) | EP0714439B1 (de) |
JP (1) | JP3741221B2 (de) |
KR (1) | KR100304333B1 (de) |
AT (1) | ATE238420T1 (de) |
AU (1) | AU685397B2 (de) |
CA (1) | CA2170034C (de) |
DE (1) | DE69332911T2 (de) |
WO (1) | WO1995006119A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69332911T2 (de) * | 1993-08-24 | 2003-12-18 | Nissin Food Products Ltd | Rekombinanter humanisierter Antikörper gegen menschlichen Immunschwächevirus |
US5843882A (en) | 1995-04-27 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides |
US6987096B1 (en) | 1995-04-27 | 2006-01-17 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof |
US7048935B2 (en) | 1995-04-27 | 2006-05-23 | The United States Of America As Represented By The Department Of Health And Human Services | Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use |
US6428790B1 (en) | 1995-04-27 | 2002-08-06 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use |
US6780847B2 (en) | 1995-04-27 | 2004-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins |
WO1999013332A1 (fr) * | 1997-09-05 | 1999-03-18 | Matsushita Electric Industrial Co., Ltd. | Procede de polarisation de fluorescence |
FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
AU2002254382B2 (en) | 2001-03-22 | 2007-02-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Glycosylation-resistant and nonglycosylated cyanovirins |
FR2844513B1 (fr) * | 2002-09-13 | 2007-08-03 | Lab Francais Du Fractionnement | Anticorps pour adcc et induisant la production de cytokines. |
EP2025762A3 (de) | 2006-01-17 | 2009-09-30 | Health Research Inc. | Heteroduplex-Trackingassay |
AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
LT2691530T (lt) | 2011-06-10 | 2018-08-10 | Oregon Health & Science University | Cmv glikoproteinai ir rekombinantiniai vektoriai |
US20130189754A1 (en) | 2011-09-12 | 2013-07-25 | International Aids Vaccine Initiative | Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies |
US9402894B2 (en) | 2011-10-27 | 2016-08-02 | International Aids Vaccine Initiative | Viral particles derived from an enveloped virus |
EP2679596B1 (de) | 2012-06-27 | 2017-04-12 | International Aids Vaccine Initiative | HIV-1 Env-proteinvariante |
US20150065381A1 (en) | 2013-09-05 | 2015-03-05 | International Aids Vaccine Initiative | Methods of identifying novel hiv-1 immunogens |
US10058604B2 (en) | 2013-10-07 | 2018-08-28 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
US10174292B2 (en) | 2015-03-20 | 2019-01-08 | International Aids Vaccine Initiative | Soluble HIV-1 envelope glycoprotein trimers |
EP3072901A1 (de) | 2015-03-23 | 2016-09-28 | International Aids Vaccine Initiative | Lösliche hiv-1-hüllglykoproteintrimere |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5245015A (en) * | 1991-04-26 | 1993-09-14 | Tanox Biosystems, Inc. | Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro |
WO1991019797A1 (en) * | 1990-06-15 | 1991-12-26 | New York University | Heterohybridomas producing human monoclonal antibodies to hiv-1 |
AU668349B2 (en) * | 1991-04-25 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin 6 receptor |
CA2094611C (en) * | 1991-08-22 | 2000-07-25 | Tsuneya Ohno | Hiv immunotherapeutics |
WO1993008216A1 (en) * | 1991-10-15 | 1993-04-29 | New York University | Human monoclonal antibodies to the cd4-binding domain of hiv, uses thereof and synergistic neutralization of hiv |
DE69330280T2 (de) * | 1992-08-24 | 2001-12-06 | Nissin Food Products Ltd | Immuntherapeutika gegen hiv |
DE69332911T2 (de) * | 1993-08-24 | 2003-12-18 | Nissin Food Products Ltd | Rekombinanter humanisierter Antikörper gegen menschlichen Immunschwächevirus |
-
1993
- 1993-08-24 DE DE69332911T patent/DE69332911T2/de not_active Expired - Fee Related
- 1993-08-24 AT AT93919473T patent/ATE238420T1/de not_active IP Right Cessation
- 1993-08-24 AU AU49687/93A patent/AU685397B2/en not_active Ceased
- 1993-08-24 EP EP93919473A patent/EP0714439B1/de not_active Expired - Lifetime
- 1993-08-24 WO PCT/GB1993/001798 patent/WO1995006119A1/en active IP Right Grant
- 1993-08-24 KR KR1019960700925A patent/KR100304333B1/ko not_active IP Right Cessation
- 1993-08-24 JP JP50739195A patent/JP3741221B2/ja not_active Expired - Fee Related
- 1993-08-24 CA CA002170034A patent/CA2170034C/en not_active Expired - Fee Related
-
1994
- 1994-07-13 US US08/275,053 patent/US5607847A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2170034A1 (en) | 1995-03-02 |
WO1995006119A1 (en) | 1995-03-02 |
AU685397B2 (en) | 1998-01-22 |
DE69332911D1 (de) | 2003-05-28 |
US5607847A (en) | 1997-03-04 |
CA2170034C (en) | 2005-03-15 |
JPH09501838A (ja) | 1997-02-25 |
EP0714439A1 (de) | 1996-06-05 |
EP0714439B1 (de) | 2003-04-23 |
JP3741221B2 (ja) | 2006-02-01 |
ATE238420T1 (de) | 2003-05-15 |
KR100304333B1 (ko) | 2001-11-30 |
AU4968793A (en) | 1995-03-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69332911T2 (de) | Rekombinanter humanisierter Antikörper gegen menschlichen Immunschwächevirus | |
DE3853779D1 (de) | Hiv-1 neutralisierende monoklonale antikörper. | |
DE69435126D1 (de) | Synthetische humane neutralisierende monoklonale antikörper gegen hiv | |
Pietzsch et al. | Anti-gp41 antibodies cloned from HIV-infected patients with broadly neutralizing serologic activity | |
ES2067866T3 (es) | Reactivos inmunologicos que reaccionan con un epitopo constante del virus inmunodeficiente humano del tipo i (vih-1)gp120 y metodos de utilizacion. | |
CA2124126A1 (en) | Monoclonal antibodies and fv specific for cd2 antigen | |
DE3855134D1 (de) | Monoklonale menschliche antikörper gegen hiv-i | |
DE69737736D1 (de) | Induktion rev- und tat-spezifischer zytotoxischer t-zellen zur prävention und behandlung einer infektion durch humanen immundefizienz-virus (hiv) | |
KR930702509A (ko) | 사람 면역결핍 바이러스(hiv)면역치료제 | |
MC2308A1 (fr) | Peptides utilises dans la vaccination et l'induction d'anticorps neutralisant contre le virus de l'immunodeficience humaine | |
ATE335835T1 (de) | Antikörper gegen einen komplex aus cd4 und einer chemokinrezeptordomäne, sowie deren verwendung gegen hiv infektionen | |
EP0470184A4 (en) | Antibodies specific for cd4-binding domain of hiv | |
RU93005284A (ru) | Моноклональные антитела линии клеток, фармацевтические композиции, способы лечения, фрагмент антитела | |
Alsmadi et al. | Antibody-dependent cellular cytotoxicity directed against cells expressing human immunodeficiency virus type 1 envelope of primary or laboratory-adapted strains by human and chimpanzee monoclonal antibodies of different epitope specificities | |
DE60215676D1 (de) | Gegen ein peptid, das ein kryptisches epitop von gp41 aus hiv-1 nachahmt gerichteter antikörper | |
Braibant et al. | Cross-group neutralization of HIV-1 and evidence for conservation of the PG9/PG16 epitopes within divergent groups | |
Pal et al. | Conformational perturbation of the envelope glycoprotein gp120 of human immunodeficiency virus type 1 by soluble CD4 and the lectin succinyl Con A | |
ATE201698T1 (de) | Immuntherapeutika gegen hiv | |
AU4832097A (en) | Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus | |
PT1368478E (pt) | Polipeptido indutor de anticorpos neutralizantes de vih | |
KR920000333A (ko) | HIV gp120 모노클로날 항체 | |
CA2046016A1 (en) | Hiv monoclonal antibody | |
ES2073287T3 (es) | Metodo para el diagnostico in vitro de infecciones con virus hiv-1. | |
ATE137801T1 (de) | Gegen hiv 1 gp48 spezifische antikörper | |
Ramirez Valdez | Identification, isolation and characterization of monoclonal antibodies against HIV-1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: SRD PHARMACEUTICALS,INC., WESTPORT, CONN., US |
|
8339 | Ceased/non-payment of the annual fee |