CA2046016A1 - Hiv monoclonal antibody - Google Patents

Hiv monoclonal antibody

Info

Publication number
CA2046016A1
CA2046016A1 CA 2046016 CA2046016A CA2046016A1 CA 2046016 A1 CA2046016 A1 CA 2046016A1 CA 2046016 CA2046016 CA 2046016 CA 2046016 A CA2046016 A CA 2046016A CA 2046016 A1 CA2046016 A1 CA 2046016A1
Authority
CA
Canada
Prior art keywords
htlv
binding
iii
monoclonal antibody
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2046016
Other languages
French (fr)
Other versions
CA2046016C (en
Inventor
Yasuyuki Eda
Kiyoshi Osatomi
Kouichi Shiosaki
Sachio Tokiyoshi
Shuzo Matsushita
Toshio Hattori
Kiyoshi Takatsuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Publication of CA2046016A1 publication Critical patent/CA2046016A1/en
Application granted granted Critical
Publication of CA2046016C publication Critical patent/CA2046016C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A monoclonal antibody is described capable of binding to a glycoprotein antigen having a molecular weight of about 12 x 10 4 daltons (gp120) present in the envelope of human immunodeficiency virus (HIV) and capable of substantially neutralizing the HIV, or fragments thereof. It has the characteristics of immunoglobulin class IgG, k, being capable of binding to glycoprotein antigen having a molecular weight of 12 x 10 4 daltons (gp120) of HTLV-III MN, being capable of recognizing at least one epitope which is present in the region of the amino acid sequence 303 to 325 of gp120 of HTLV-III MN, being capable of binding to the surface of HTLV-III MN viral particles and thereby inhibiting the infection of the viral particles to CD4-positive cells, and being capable of binding to the surface of cells infected with HTLV-III MN and thereby inhibiting the syncytium formation induced by interaction between the infected cells and uninfected cells. The monoclonal antibody is useful for the prophylaxis, treatment and diagnosis of AIDS.
CA 2046016 1990-07-02 1991-06-28 Hiv monoclonal antibody Expired - Fee Related CA2046016C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17507590 1990-07-02
JP175075/1990 1990-07-02

Publications (2)

Publication Number Publication Date
CA2046016A1 true CA2046016A1 (en) 1992-01-03
CA2046016C CA2046016C (en) 2002-10-29

Family

ID=15989798

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2046016 Expired - Fee Related CA2046016C (en) 1990-07-02 1991-06-28 Hiv monoclonal antibody

Country Status (1)

Country Link
CA (1) CA2046016C (en)

Also Published As

Publication number Publication date
CA2046016C (en) 2002-10-29

Similar Documents

Publication Publication Date Title
Nara et al. Persistent infection of chimpanzees with human immunodeficiency virus: serological responses and properties of reisolated viruses
Nara et al. Purified envelope glycoproteins from human immunodeficiency virus type 1 variants induce individual, type-specific neutralizing antibodies
ATE122237T1 (en) HIV-1 NEUTRALIZING MONOCLONAL ANTIBODIES.
AU8010791A (en) Hiv monoclonal antibody
Cavacini et al. Binding and neutralization activity of human IgG1 and IgG3 from serum of HIV-infected individuals
CA2073031A1 (en) Anti-cd4 antibody homologs useful in prophylaxis and treatment of aids, arc and hiv infection
WO2002020554A3 (en) Hiv peptides from conserved regions in gag p17 and 924 and their application in e.g. vaccines
CA2091263A1 (en) Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus
CA2170034A1 (en) Recombinant humanized anti-human immunodeficiency virus antibody
KR930702509A (en) Human immunodeficiency virus (HIV) immunotherapy
Alsmadi et al. Antibody-dependent cellular cytotoxicity directed against cells expressing human immunodeficiency virus type 1 envelope of primary or laboratory-adapted strains by human and chimpanzee monoclonal antibodies of different epitope specificities
Broliden et al. Identification of amino acids in the V3 region of gp120 critical for virus neutralization by human HIV-1-specific antibodies.
JP4243187B2 (en) Peptides that mimic the gp41 cryptic epitope of HIV-1
AU659839B2 (en) Human immunodeficiency virus-related immune preparation
CA2046016A1 (en) Hiv monoclonal antibody
CA2160696A1 (en) Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus
KR100871455B1 (en) Natural antibodies active against HIV virus
WO1991018618A3 (en) Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection
AU651113B2 (en) HIV GP120 monoclonal antibodies
Mathiesen et al. Fine analysis of intrathecally synthesized anti-HIV IgG1-4 by peptide mapping
Broliden The specificity and function of HIV antibody response.
BROLIDEN et al. Identification of cross-reactive antigenic target regions for HIV type 1-specific antibody-dependent cellular cytotoxicity
AU627540B2 (en) Drug for the treatment or prevention by passive immunization, of the hiv-infection and process for preparation thereof
ATE201698T1 (en) IMMUNOTHERAPEUTICS AGAINST HIV
CA2157874A1 (en) Anti-hiv monoclonal antibody

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed