WO1991018618A3 - Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection - Google Patents

Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection Download PDF

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Publication number
WO1991018618A3
WO1991018618A3 PCT/US1991/003460 US9103460W WO9118618A3 WO 1991018618 A3 WO1991018618 A3 WO 1991018618A3 US 9103460 W US9103460 W US 9103460W WO 9118618 A3 WO9118618 A3 WO 9118618A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
prophylactic
treating
useful
immunotherapeutic
Prior art date
Application number
PCT/US1991/003460
Other languages
French (fr)
Other versions
WO1991018618A2 (en
Inventor
Richard A Fisher
Catherine Hession
Linda C Burkly
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of WO1991018618A2 publication Critical patent/WO1991018618A2/en
Publication of WO1991018618A3 publication Critical patent/WO1991018618A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Abstract

Immunotherapeutic, prophylactic and diagnostic compositions useful in treating or preventing diseases in humans caused by infective agents whose primary targets are T4+ lymphocytes, including acquired immune deficiency syndrome, AIDS related complex and human immunodeficiency virus infection. DNA sequences that code for amino acid variants and derivatives of human CD4, or fragments thereof, that elicit in a human antibodies that bind to HIV gp120. Such DNA sequences are useful in the immunotherapeutic, prophylactic and diagnostic compositions of this invention. A novel screening method for selecting amino acid variants and derivatives of human CD4 that elicit in humans antibodies that bind to HIV gp120, human CD4, or both, useful as therapeutic, prophylactic and diagnostic agents for diseases caused by infective agents whose primary targets are T4+ lymphocytes, including acquired immune deficiency syndrome, AIDS related complex and human immunodeficiency virus infection.
PCT/US1991/003460 1990-05-25 1991-05-23 Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection WO1991018618A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52918690A 1990-05-25 1990-05-25
US529,186 1990-05-25

Publications (2)

Publication Number Publication Date
WO1991018618A2 WO1991018618A2 (en) 1991-12-12
WO1991018618A3 true WO1991018618A3 (en) 1992-04-16

Family

ID=24108870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/003460 WO1991018618A2 (en) 1990-05-25 1991-05-23 Immunotherapeutic compositions for treating and preventing aids, arc and hiv infection

Country Status (6)

Country Link
EP (1) EP0491888A4 (en)
JP (1) JPH05502166A (en)
AU (1) AU7976791A (en)
CA (1) CA2062758A1 (en)
OA (1) OA09648A (en)
WO (1) WO1991018618A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692435A1 (en) * 1992-06-19 1993-12-24 Transgene Sa Transgenic rabbit susceptible to HIV, its use as an animal model and its production process.
FR2696188A1 (en) * 1992-09-25 1994-04-01 Curie Paris Vi Univ Pierre Mar Feline CD4 protein and corresp. DNA - for study of feline immunodeficiency virus and for therapy
US20040040061A1 (en) * 2002-02-27 2004-02-26 Michael Horn Expression in plants of HIV-related proteins
US10150970B2 (en) 2011-07-27 2018-12-11 Applied Biotechnology Institute, Inc. Methods to increase antigenicity of membrane-bound polypeptides produced in plants

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001940A1 (en) * 1987-09-04 1989-03-09 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins
EP0330227A2 (en) * 1988-02-24 1989-08-30 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001940A1 (en) * 1987-09-04 1989-03-09 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins
EP0330227A2 (en) * 1988-02-24 1989-08-30 The Trustees Of Columbia University In The City Of New York Derivatives of soluble T-4

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CELL. Vol. 60, 9 March 1990, Cambridge, NA US pages 747 - 754; CAMERINI, D. et al.: 'A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site'. see the whole document. *
MOLECULAR BIOLOGY AND MEDECINE vol. 6, September 1989, ACADEMIC PRESS pages 255 - 261; YU, S. et al.: 'Functional human CD4 protein produced in milk in transgenic mice' see the whole document. *
SCIENCE. Vol. 240, 10 June 1988, Lancaster, PA US pages 1468 - 1474; JAENISH, R.: 'Transgenic Animals' see the whole document. *
SCIENTIFIC AMERICAN October 1988, pages 88 - 97; YARKOAN, R. et al: 'Aids Therapies' see the whole document. *
THE JOURNAL OF EXPERIMENTAL MEDECINE Vol. 170, Octobet 1989, THE ROCKEFELLER UNIV. PRESS pages 1319 - 1334; SATENTAU, Q.J. et al.: 'Structural analysis of the human immunodeficiency virus-binding doamin of CD4'. see the whole document. *

Also Published As

Publication number Publication date
EP0491888A4 (en) 1992-09-02
EP0491888A1 (en) 1992-07-01
OA09648A (en) 1993-05-15
JPH05502166A (en) 1993-04-22
AU7976791A (en) 1991-12-31
WO1991018618A2 (en) 1991-12-12
CA2062758A1 (en) 1991-11-26

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