ES2067486T3 - Proteina inhibidora de factor de necrosis tumoral (tnf) y su purificacion. - Google Patents

Proteina inhibidora de factor de necrosis tumoral (tnf) y su purificacion.

Info

Publication number
ES2067486T3
ES2067486T3 ES88830365T ES88830365T ES2067486T3 ES 2067486 T3 ES2067486 T3 ES 2067486T3 ES 88830365 T ES88830365 T ES 88830365T ES 88830365 T ES88830365 T ES 88830365T ES 2067486 T3 ES2067486 T3 ES 2067486T3
Authority
ES
Spain
Prior art keywords
tnf
necrosis factor
tumor necrosis
purification
inhibitor protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88830365T
Other languages
English (en)
Other versions
ES2067486T5 (es
Inventor
David Wallach
Hartmut Engelmann
Dan Aderka
Menachem Rubinstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11058172&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2067486(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of ES2067486T3 publication Critical patent/ES2067486T3/es
Application granted granted Critical
Publication of ES2067486T5 publication Critical patent/ES2067486T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE AISLA LA PROTEINA INHIBIDORA DE TNF Y SE PURIFICA SUSTANCIALMENTE. LA CITADA PROTEINA TIENE CAPACIDAD PARA INHIBIR: A) LA UNION DE TNF A SUS RECEPTORES, Y B) EL EFECTO CITOTOXICO DEL TNF. LA PROTEINA INHIBIDORA DE TNF, SUS SALES, SUS DERIVADOS FUNCIONALES Y LAS FRACCIONES ACTIVAS DE ELLA, ASI COMO LAS MEZCLAS DE CUALQUIERA DE LOS PRECEDENTES PUEDEN EMPLEARSE PARA ANTAGONIZAR LOS EFECTOS DELETEREOS DEL TNF.
ES88830365T 1987-09-13 1988-09-13 Proteina inhibidora de factor de necrosis tumoral (tnf) y su purificacion. Expired - Lifetime ES2067486T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL83878 1987-09-13
IL8387887A IL83878A (en) 1987-09-13 1987-09-13 Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it

Publications (2)

Publication Number Publication Date
ES2067486T3 true ES2067486T3 (es) 1995-04-01
ES2067486T5 ES2067486T5 (es) 2005-04-16

Family

ID=11058172

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88830365T Expired - Lifetime ES2067486T5 (es) 1987-09-13 1988-09-13 Proteina inhibidora de factor de necrosis tumoral (tnf) y su purificacion.

Country Status (11)

Country Link
US (3) US5695953A (es)
EP (1) EP0308378B2 (es)
JP (2) JP2755394B2 (es)
AT (1) ATE114715T1 (es)
AU (1) AU619482B2 (es)
CA (1) CA1341575C (es)
DE (1) DE3852255T3 (es)
ES (1) ES2067486T5 (es)
GR (1) GR3014976T3 (es)
IL (1) IL83878A (es)
ZA (1) ZA886818B (es)

Families Citing this family (101)

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Also Published As

Publication number Publication date
US5695953A (en) 1997-12-09
JPH09118631A (ja) 1997-05-06
AU2206888A (en) 1989-03-16
US20050245731A1 (en) 2005-11-03
JPH02200A (ja) 1990-01-05
DE3852255T2 (de) 1995-05-18
AU619482B2 (en) 1992-01-30
ATE114715T1 (de) 1994-12-15
ZA886818B (en) 1990-01-31
IL83878A0 (en) 1988-02-29
DE3852255D1 (de) 1995-01-12
ES2067486T5 (es) 2005-04-16
CA1341575C (en) 2008-06-17
DE3852255T3 (de) 2005-06-02
EP0308378B2 (en) 2004-09-01
EP0308378A2 (en) 1989-03-22
EP0308378A3 (en) 1990-05-09
JP2755394B2 (ja) 1998-05-20
GR3014976T3 (en) 1995-05-31
IL83878A (en) 1995-07-31
EP0308378B1 (en) 1994-11-30
US5981701A (en) 1999-11-09

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