FI865196A - Halostatinsubstituerade renin-inhibitorer. - Google Patents

Halostatinsubstituerade renin-inhibitorer. Download PDF

Info

Publication number
FI865196A
FI865196A FI865196A FI865196A FI865196A FI 865196 A FI865196 A FI 865196A FI 865196 A FI865196 A FI 865196A FI 865196 A FI865196 A FI 865196A FI 865196 A FI865196 A FI 865196A
Authority
FI
Finland
Prior art keywords
halostat
ralin
substitutes
inhibitor
ralin inhibitor
Prior art date
Application number
FI865196A
Other languages
English (en)
Other versions
FI865196A0 (fi
Inventor
Suvit Thaisrivongs
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI865196A publication Critical patent/FI865196A/fi
Publication of FI865196A0 publication Critical patent/FI865196A0/fi
Priority to FI923439A priority Critical patent/FI923439A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI865196A 1985-04-19 1986-12-18 Halostatinsubstituerade renin-inhibitorer. FI865196A0 (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI923439A FI923439A0 (fi) 1985-04-19 1992-07-30 Nya mellanprodukter anvaendbara vid framstaellning av substituerade diahalogenstatin-renininhibitorer.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72519085A 1985-04-19 1985-04-19
US82840786A 1986-02-11 1986-02-11
PCT/US1986/000713 WO1986006379A1 (en) 1985-04-19 1986-04-07 Dihalo-statine substituted renin inhibitors

Publications (2)

Publication Number Publication Date
FI865196A true FI865196A (fi) 1986-12-18
FI865196A0 FI865196A0 (fi) 1986-12-18

Family

ID=27111106

Family Applications (1)

Application Number Title Priority Date Filing Date
FI865196A FI865196A0 (fi) 1985-04-19 1986-12-18 Halostatinsubstituerade renin-inhibitorer.

Country Status (4)

Country Link
EP (1) EP0218688B1 (fi)
DE (1) DE3674131D1 (fi)
FI (1) FI865196A0 (fi)
WO (1) WO1986006379A1 (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486478A3 (en) * 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
CH672792A5 (fi) * 1985-02-19 1989-12-29 Sandoz Ag
HU200473B (en) * 1985-11-01 1990-06-28 Pfizer Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
DE3850818T2 (de) * 1987-07-01 1994-11-17 Pfizer Fluor enthaltende Renin-Inhibitoren.
EP0371179A1 (en) * 1988-10-28 1990-06-06 Merrell Dow Pharmaceuticals Inc. Novel analogs of peptidase substrates
HU210647B (en) * 1991-01-02 1995-06-28 Merrell Dow Pharma Process for producing antiviral difluoro-statone derivatives and pharmaceutical compositions containing them
KR100220876B1 (ko) * 1991-01-02 1999-10-01 슈테펜엘.네스비트 항 바이러스 화합물
US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
IL108031A0 (en) * 1992-12-22 1994-04-12 Procter & Gamble Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
EP0707564B1 (en) * 1993-07-08 2000-09-20 Merrell Pharmaceuticals Inc. Difluoro statone analogs
DE69418050T2 (de) * 1993-09-09 1999-11-25 Merrell Pharma Inc Antivirale analoge von difluorostaton
JP3574455B2 (ja) * 1994-02-04 2004-10-06 メレルファーマスーティカルズ インコーポレイテッド 抗ウイルス剤として有用なマクロ環式ジフルオロスタトン誘導体類
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
WO2017148967A1 (en) * 2016-03-04 2017-09-08 F. Hoffmann-La Roche Ag New difluoroketamide derivatives as htra1 inhibitors
EP3484859B1 (en) * 2016-07-18 2021-09-15 F. Hoffmann-La Roche AG New difluoroketamide derivatives as htra1 inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51409B1 (en) 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
DE3169110D1 (en) 1980-11-24 1985-03-28 Ici Plc Amide derivatives
US4478826A (en) 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
US4384994A (en) 1981-10-08 1983-05-24 Merck & Co., Inc. Renin inhibitory peptides
CA1258748A (en) 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
US4470971A (en) 1981-10-19 1984-09-11 Merck & Co., Inc. Renin inhibitory peptides having His13
CA1245217A (en) 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
EP0104041B1 (en) 1982-09-15 1988-07-27 Aktiebolaget Hässle Enzyme inhibitors
US4595677A (en) 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
DE3381565D1 (de) 1982-12-27 1990-06-21 Merck & Co Inc Reninhemmende tripeptide.
WO1984003044A1 (en) 1983-02-07 1984-08-16 Ferring Ab Enzyme inhibitors
US4485099A (en) * 1983-06-15 1984-11-27 Merck & Co., Inc. Renin inhibitors containing a C-terminal amide cycle
US4636491A (en) * 1984-03-27 1987-01-13 Merck & Co., Inc. Renin inhibitory peptides having improved solubility
US4663310A (en) * 1984-04-04 1987-05-05 Merck & Co., Inc. Renin inhibitors containing 2-substituted statine
EP0486478A3 (en) 1984-08-06 1992-08-12 The Upjohn Company Renin-inhibiting peptides

Also Published As

Publication number Publication date
EP0218688B1 (en) 1990-09-12
WO1986006379A1 (en) 1986-11-06
DE3674131D1 (de) 1990-10-18
FI865196A0 (fi) 1986-12-18
EP0218688A1 (en) 1987-04-22

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Legal Events

Date Code Title Description
FA Application withdrawn

Owner name: THE UPJOHN COMPANY