FI865196A0 - Halostatinsubstituerade renin-inhibitorer. - Google Patents
Halostatinsubstituerade renin-inhibitorer.Info
- Publication number
- FI865196A0 FI865196A0 FI865196A FI865196A FI865196A0 FI 865196 A0 FI865196 A0 FI 865196A0 FI 865196 A FI865196 A FI 865196A FI 865196 A FI865196 A FI 865196A FI 865196 A0 FI865196 A0 FI 865196A0
- Authority
- FI
- Finland
- Prior art keywords
- halostat
- ralin
- substitutes
- inhibitor
- ralin inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI923439A FI923439A0 (fi) | 1985-04-19 | 1992-07-30 | Nya mellanprodukter anvaendbara vid framstaellning av substituerade diahalogenstatin-renininhibitorer. |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72519085A | 1985-04-19 | 1985-04-19 | |
US82840786A | 1986-02-11 | 1986-02-11 | |
PCT/US1986/000713 WO1986006379A1 (en) | 1985-04-19 | 1986-04-07 | Dihalo-statine substituted renin inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
FI865196A FI865196A (fi) | 1986-12-18 |
FI865196A0 true FI865196A0 (fi) | 1986-12-18 |
Family
ID=27111106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI865196A FI865196A0 (fi) | 1985-04-19 | 1986-12-18 | Halostatinsubstituerade renin-inhibitorer. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0218688B1 (fi) |
DE (1) | DE3674131D1 (fi) |
FI (1) | FI865196A0 (fi) |
WO (1) | WO1986006379A1 (fi) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK356085A (da) * | 1984-08-06 | 1986-02-07 | Upjohn Co | Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf |
US5496927A (en) * | 1985-02-04 | 1996-03-05 | Merrell Pharmaceuticals Inc. | Peptidase inhibitors |
CH672792A5 (fi) * | 1985-02-19 | 1989-12-29 | Sandoz Ag | |
HU200473B (en) * | 1985-11-01 | 1990-06-28 | Pfizer | Process for producing polypeptides containing difluorocyclostatine and pharmaceutical compositions comprising same |
GB8619182D0 (en) * | 1986-08-06 | 1986-09-17 | Sandoz Ltd | Peptides & derivatives |
ATE109157T1 (de) * | 1987-07-01 | 1994-08-15 | Pfizer | Fluor enthaltende renin-inhibitoren. |
EP0371179A1 (en) * | 1988-10-28 | 1990-06-06 | Merrell Dow Pharmaceuticals Inc. | Novel analogs of peptidase substrates |
US5559140A (en) * | 1991-01-02 | 1996-09-24 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
NZ241099A (en) * | 1991-01-02 | 1994-08-26 | Merrell Dow Pharma | Difluorostatone analogues and derivatives and pharmaceutical compositions |
US5972990A (en) * | 1992-04-10 | 1999-10-26 | Brigham And Women's Hospital, Inc. | Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims |
IL108031A0 (en) * | 1992-12-22 | 1994-04-12 | Procter & Gamble | Difluoro pentapeptide derivatives and pharmaceutical compositions containing them |
AU680009B2 (en) | 1993-07-08 | 1997-07-17 | Aventisub Ii Inc. | Difluoro statone analogs |
AU683927B2 (en) * | 1993-09-09 | 1997-11-27 | Merrell Pharmaceuticals Inc. | Difluoro statone antiviral analogs |
US5969132A (en) * | 1994-02-04 | 1999-10-19 | Merrell Pharmaceuticals Inc. | Macrocyclic difluorostatone derivatives useful as antiviral agents |
US6114380A (en) * | 1995-12-18 | 2000-09-05 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
WO2017148967A1 (en) * | 2016-03-04 | 2017-09-08 | F. Hoffmann-La Roche Ag | New difluoroketamide derivatives as htra1 inhibitors |
CN109415330A (zh) * | 2016-07-18 | 2019-03-01 | 豪夫迈·罗氏有限公司 | 作为htra1抑制剂的新型二氟酮酰胺衍生物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE51409B1 (en) | 1980-07-24 | 1986-12-24 | Ici Ltd | Amide derivatives |
NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
DE3169110D1 (en) | 1980-11-24 | 1985-03-28 | Ici Plc | Amide derivatives |
CA1258748A (en) | 1981-10-08 | 1989-08-22 | Daniel F. Veber | Renin inhibitory peptides |
US4384994A (en) | 1981-10-08 | 1983-05-24 | Merck & Co., Inc. | Renin inhibitory peptides |
US4478826A (en) | 1981-10-08 | 1984-10-23 | Merck & Co., Inc. | Renin inhibitory peptides |
US4470971A (en) | 1981-10-19 | 1984-09-11 | Merck & Co., Inc. | Renin inhibitory peptides having His13 |
CA1245217A (en) | 1981-12-10 | 1988-11-22 | Joshua S. Boger | Renin inhibitory peptides having phe su13 xx deletion |
EP0104041B1 (en) | 1982-09-15 | 1988-07-27 | Aktiebolaget Hässle | Enzyme inhibitors |
US4595677A (en) | 1982-12-03 | 1986-06-17 | Ciba-Geigy Corporation | Substituted tetrapeptides |
DE3381565D1 (de) | 1982-12-27 | 1990-06-21 | Merck & Co Inc | Reninhemmende tripeptide. |
AU573735B2 (en) | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
US4485099A (en) * | 1983-06-15 | 1984-11-27 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal amide cycle |
US4636491A (en) * | 1984-03-27 | 1987-01-13 | Merck & Co., Inc. | Renin inhibitory peptides having improved solubility |
US4663310A (en) * | 1984-04-04 | 1987-05-05 | Merck & Co., Inc. | Renin inhibitors containing 2-substituted statine |
DK356085A (da) | 1984-08-06 | 1986-02-07 | Upjohn Co | Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf |
-
1986
- 1986-04-07 EP EP86902677A patent/EP0218688B1/en not_active Expired - Lifetime
- 1986-04-07 WO PCT/US1986/000713 patent/WO1986006379A1/en active Application Filing
- 1986-04-07 DE DE8686902677T patent/DE3674131D1/de not_active Expired - Fee Related
- 1986-12-18 FI FI865196A patent/FI865196A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FI865196A (fi) | 1986-12-18 |
EP0218688A1 (en) | 1987-04-22 |
WO1986006379A1 (en) | 1986-11-06 |
DE3674131D1 (de) | 1990-10-18 |
EP0218688B1 (en) | 1990-09-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Application withdrawn |
Owner name: THE UPJOHN COMPANY |