ES2065291A1 - "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente" - Google Patents

"nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"

Info

Publication number
ES2065291A1
ES2065291A1 ES09301721A ES9301721A ES2065291A1 ES 2065291 A1 ES2065291 A1 ES 2065291A1 ES 09301721 A ES09301721 A ES 09301721A ES 9301721 A ES9301721 A ES 9301721A ES 2065291 A1 ES2065291 A1 ES 2065291A1
Authority
ES
Spain
Prior art keywords
alkylamino
aryloxy
nitrate esters
pharmaceutical composition
corresponding pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09301721A
Other languages
English (en)
Other versions
ES2065291B1 (es
Inventor
Quinones Maria Prat
Sallent Joan Pi
Veit Dagmar Vedrilla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prodesfarma SA
Original Assignee
Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodesfarma SA filed Critical Prodesfarma SA
Priority to ES09301721A priority Critical patent/ES2065291B1/es
Priority to DE69401177T priority patent/DE69401177T2/de
Priority to AT94500111T priority patent/ATE146453T1/de
Priority to EP94500111A priority patent/EP0637583B1/en
Priority to DK94500111.3T priority patent/DK0637583T3/da
Priority to US08/265,960 priority patent/US5502237A/en
Priority to NO942568A priority patent/NO179746C/no
Priority to AU67437/94A priority patent/AU666626B2/en
Priority to CO94031366A priority patent/CO4290296A1/es
Priority to PL94304406A priority patent/PL175707B1/pl
Priority to ZA945435A priority patent/ZA945435B/xx
Priority to CA002128671A priority patent/CA2128671A1/en
Priority to MX9405660A priority patent/MX9405660A/es
Priority to JP6175400A priority patent/JP2777572B2/ja
Priority to NZ264118A priority patent/NZ264118A/en
Priority to HU9402229A priority patent/HU214827B/hu
Priority to KR1019940018560A priority patent/KR950003262A/ko
Publication of ES2065291A1 publication Critical patent/ES2065291A1/es
Priority to US08/514,267 priority patent/US5639904A/en
Application granted granted Critical
Publication of ES2065291B1 publication Critical patent/ES2065291B1/es
Priority to GR970400393T priority patent/GR3022704T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

NITRATO ESTERES DE 1-ARILOXI-3-ALQUILAMINO-2-PROPANOLES, UTILIZACION Y COMPOSICION FARMACEUTICA CORRESPONDIENTE. SON DE FORMULA I *FORMULA* Y SU SALES TERAPEUTICAMENTE ACEPTABLES. R1 REPRESENTA UNA CADENA DE FORMULA GENERAL I-(C H2)M -Z-R2, EN LA QUE: M ES 1 O 2; Z SIGNIFICA UNA FUNCION ETER -O-, A MIDA -CONH O ESTER -COO-; Y R2 UNA CADENA ALQUILICA LINEAL O RAMIFICADA D E 2 O 3 ATOMOS DE CARBONO, QUE PRESENTA COMO SUSTITUYENTE AL MENOS UN GRUPO NITROOXI; Y AR REPRESENTA UN ANILLO BENCENICO CUANDO Z REPRESENTA LA FUNCION ETER O ESTER, Y UN ANILLO NAFTALENICO CUANDO Z REPRESENTA LA FUNCION AMIDA. ESTOS COMPUESTOS SON DE UTILIDAD PARA EL TRATAMIENTO DE AFECCIONES CARDIOVASCULARES.
ES09301721A 1993-07-30 1993-07-30 "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente" Expired - Lifetime ES2065291B1 (es)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ES09301721A ES2065291B1 (es) 1993-07-30 1993-07-30 "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
DE69401177T DE69401177T2 (de) 1993-07-30 1994-06-23 1-Aryloxy-3-alkylamino-2 propanol nitrat Ester, ihre Anwendung und korrespondierende pharmazeutische Zusammensetzungen
AT94500111T ATE146453T1 (de) 1993-07-30 1994-06-23 1-aryloxy-3-alkylamino-2 propanol nitrat ester, ihre anwendung und korrespondierende pharmazeutische zusammensetzungen
EP94500111A EP0637583B1 (en) 1993-07-30 1994-06-23 1-Aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition
DK94500111.3T DK0637583T3 (da) 1993-07-30 1994-06-23 1-Aryloxy-3-alkylamino-2-propanol-nitratestere, anvendelse heraf og tilsvarende farmaceutisk præparat
US08/265,960 US5502237A (en) 1993-07-30 1994-06-27 1-aryloxy-3-alkylamino-2-propanol-nitrate esters, the use thereof and corresponding pharmaceutical composition
NO942568A NO179746C (no) 1993-07-30 1994-07-07 1-aryloksy-3-alkylamino-2-propanolnitratestere, deres anvendelse og tilsvarende farmasöytiske blanding
AU67437/94A AU666626B2 (en) 1993-07-30 1994-07-14 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharamceutical composition
CO94031366A CO4290296A1 (es) 1993-07-30 1994-07-18 Compuestos nitrato esteres de 1-ariloxi-3-alquilamino-2-pro- panoles, su utilizacion para la obtencion de un medicamento y la composicion farmaceutica correspondiente.
ZA945435A ZA945435B (en) 1993-07-30 1994-07-22 1-aryloxy-3-alkylamino-2-propanol nitrate esters the use thereof and corresponding pharmaceutical composition
PL94304406A PL175707B1 (pl) 1993-07-30 1994-07-22 Nowe estry 1-aryloksy-3-alkiloamino-2-propanolu
CA002128671A CA2128671A1 (en) 1993-07-30 1994-07-22 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition
MX9405660A MX9405660A (es) 1993-07-30 1994-07-25 Nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion ycomposicion farmaceutica correspondiente.
JP6175400A JP2777572B2 (ja) 1993-07-30 1994-07-27 １−アリールオキシ−３−アルキルアミノ−２−プロパノール硝酸エステルおよびこれを有効成分とする医薬組成物
NZ264118A NZ264118A (en) 1993-07-30 1994-07-28 1-aryloxy-3-alkylamino-2-propanol nitrate esters; medicaments
HU9402229A HU214827B (hu) 1993-07-30 1994-07-29 1-(Aril-oxi)-3-(alkil-amino)-2-propanol-nitrát-észterek, és ezeket tartalmazó gyógyászati készítmények
KR1019940018560A KR950003262A (ko) 1993-07-30 1994-07-29 1- 아릴옥시-3- 알킬아미노-2-프로판올 니트레이트 에스테르, 이의 용도 및 상응하는 약제학적 조성물
US08/514,267 US5639904A (en) 1993-07-30 1995-08-11 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition
GR970400393T GR3022704T3 (en) 1993-07-30 1997-02-28 1-Aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09301721A ES2065291B1 (es) 1993-07-30 1993-07-30 "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"

Publications (2)

Publication Number Publication Date
ES2065291A1 true ES2065291A1 (es) 1995-02-01
ES2065291B1 ES2065291B1 (es) 1995-10-01

Family

ID=8282739

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09301721A Expired - Lifetime ES2065291B1 (es) 1993-07-30 1993-07-30 "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"

Country Status (18)

Country Link
US (2) US5502237A (es)
EP (1) EP0637583B1 (es)
JP (1) JP2777572B2 (es)
KR (1) KR950003262A (es)
AT (1) ATE146453T1 (es)
AU (1) AU666626B2 (es)
CA (1) CA2128671A1 (es)
CO (1) CO4290296A1 (es)
DE (1) DE69401177T2 (es)
DK (1) DK0637583T3 (es)
ES (1) ES2065291B1 (es)
GR (1) GR3022704T3 (es)
HU (1) HU214827B (es)
MX (1) MX9405660A (es)
NO (1) NO179746C (es)
NZ (1) NZ264118A (es)
PL (1) PL175707B1 (es)
ZA (1) ZA945435B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1295694B1 (it) * 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
CN1083824C (zh) * 1999-09-24 2002-05-01 许景峰 具有心血管药理活性的合成化合物及制备方法
US20070010571A1 (en) * 2003-08-20 2007-01-11 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
EP1748994B1 (en) * 2003-12-02 2009-02-18 NicOx S.A. Nitrooxyderivatives of antihypertensive drugs
DE602004005748T2 (de) * 2003-12-02 2007-12-27 Nicox S.A., Sophia Antipolis Nitrooxy-derivate von carvedilol und anderen betablockern als antihypertensiva
WO2006052899A2 (en) * 2004-11-08 2006-05-18 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods for the treatment of ophthalmic disorders
KR102324664B1 (ko) 2017-08-01 2021-11-10 주식회사 이강테크 듀얼 프레스를 이용한 복층유리 제조장치
KR102240153B1 (ko) 2017-08-01 2021-04-14 강흥섭 복층유리제조용 듀얼 프레싱장치
KR200494614Y1 (ko) 2017-09-08 2021-11-17 주식회사 이강테크 복층 유리 제조에 적용되는 유리판 검사장치
KR102240154B1 (ko) 2017-09-08 2021-04-14 강흥섭 유리판 다중 공급장치
KR20210020341A (ko) 2019-08-14 2021-02-24 주식회사 아이지스 복층 유리 제조를 위한 컨베어용 자동 분배 공급장치
KR102163495B1 (ko) 2019-08-22 2020-10-07 주식회사 아이지스 복층유리의 가스 주입을 갖는 더블 프레스 장치

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES484086A1 (es) * 1978-09-11 1980-05-16 Dolorgiet Arzneimittelfabrik Procedimiento para la preparacion de compuestos de isopropi-lamina
EP0359335A2 (en) * 1988-09-15 1990-03-21 Cedona Pharmaceuticals B.V. Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance
WO1992001668A1 (en) * 1990-07-26 1992-02-06 Italfarmaco S.P.A. Benzoic acid substituted derivatives having cardiovascular activity
ES2026756A6 (es) * 1990-09-24 1992-05-01 Prodesfarma Sa Procedimiento para la obtencion de nitratos de 1-ariloxi-3 amino-2-propilo.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE354851B (es) * 1970-02-18 1973-03-26 Haessle Ab
JPS56113748A (en) * 1980-02-13 1981-09-07 Kowa Co Aminoethanol derivative and its preparation
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
JPS58109461A (ja) * 1981-12-24 1983-06-29 Kowa Co 新規ベンズアミド誘導体
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES484086A1 (es) * 1978-09-11 1980-05-16 Dolorgiet Arzneimittelfabrik Procedimiento para la preparacion de compuestos de isopropi-lamina
EP0359335A2 (en) * 1988-09-15 1990-03-21 Cedona Pharmaceuticals B.V. Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance
WO1992001668A1 (en) * 1990-07-26 1992-02-06 Italfarmaco S.P.A. Benzoic acid substituted derivatives having cardiovascular activity
ES2026756A6 (es) * 1990-09-24 1992-05-01 Prodesfarma Sa Procedimiento para la obtencion de nitratos de 1-ariloxi-3 amino-2-propilo.

Also Published As

Publication number Publication date
CO4290296A1 (es) 1996-04-17
JP2777572B2 (ja) 1998-07-16
HU214827B (hu) 1998-06-29
NO179746C (no) 1996-12-11
MX9405660A (es) 1995-01-31
PL175707B1 (pl) 1999-01-29
NZ264118A (en) 1995-04-27
DE69401177D1 (de) 1997-01-30
ATE146453T1 (de) 1997-01-15
DK0637583T3 (da) 1997-05-12
DE69401177T2 (de) 1997-04-24
ZA945435B (en) 1995-05-11
EP0637583B1 (en) 1996-12-18
GR3022704T3 (en) 1997-05-31
US5502237A (en) 1996-03-26
EP0637583A1 (en) 1995-02-08
HU9402229D0 (en) 1994-09-28
NO942568L (no) 1995-01-31
KR950003262A (ko) 1995-02-16
CA2128671A1 (en) 1995-01-31
HUT71813A (en) 1996-02-28
JPH0789910A (ja) 1995-04-04
NO179746B (no) 1996-09-02
PL304406A1 (en) 1995-02-06
AU6743794A (en) 1995-02-09
US5639904A (en) 1997-06-17
ES2065291B1 (es) 1995-10-01
NO942568D0 (no) 1994-07-07
AU666626B2 (en) 1996-02-15

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