ES2065002T3 - Procedimiento para preparar derivados de pirimidintrionas. - Google Patents

Procedimiento para preparar derivados de pirimidintrionas.

Info

Publication number
ES2065002T3
ES2065002T3 ES91903577T ES91903577T ES2065002T3 ES 2065002 T3 ES2065002 T3 ES 2065002T3 ES 91903577 T ES91903577 T ES 91903577T ES 91903577 T ES91903577 T ES 91903577T ES 2065002 T3 ES2065002 T3 ES 2065002T3
Authority
ES
Spain
Prior art keywords
pct
pyrimidintrionas
procedure
preparing derivatives
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91903577T
Other languages
English (en)
Inventor
Bernard Siegfried
Jindrich Vachta
Karel Valter
Stephane Hugentobler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sapos SA
Original Assignee
Sapos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapos SA filed Critical Sapos SA
Application granted granted Critical
Publication of ES2065002T3 publication Critical patent/ES2065002T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60Three or more oxygen or sulfur atoms
    • C07D239/62Barbituric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA (I), DONDE R SUB 1 Y R SUB 2, QUE PUEDEN SER LOS MISMOS O DIFERENTES, REPRESENTAN GRUPOS ALIFATICOS, ARALIFATICOS O ARILO; R REPRESENTA UN GRUPO -CH SUB 2-CH(OCONH SUB 2)-CH SUB 2OX, EN EL QUE X ES UN GRUPO ALQUILO C SUB 1-5, QUE CONSTA DE UN COMPUESTO REACTIVO DE FORMULA (II), DONDE R SUB 1 Y R SUB 2, Y X SON LOS DEFINIDOS ANTERIORMENTE Y Z ES UN GRUPO DE FORMULA -SO SUB 2Y O -POY SUB 2, DONDE Y ES UN ATOMO DE HALOGENO SEGUIDO POR LA HIDROLISIS DEL COMPUESTO DE FORMULA (III). TAMBIEN SE DESCRIBEN VARIOS DERIVADOS PERIMIDINETRIONE N-DIHIDROXIFOSFORILO QUE SON INTERMEDIOS EN EL PROCESO ANTERIOR, ALGUNO DE LOS CUALES SON UTILES COMO PREMEDICAMENTOS SOLUBLES EN AGUA DE CIERTOS COMPUESTOS DE PIRIMIDINETRIONE.
ES91903577T 1990-02-08 1991-02-05 Procedimiento para preparar derivados de pirimidintrionas. Expired - Lifetime ES2065002T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909002890A GB9002890D0 (en) 1990-02-08 1990-02-08 Process for preparing pyrimidinetrione derivatives

Publications (1)

Publication Number Publication Date
ES2065002T3 true ES2065002T3 (es) 1995-02-01

Family

ID=10670669

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91903577T Expired - Lifetime ES2065002T3 (es) 1990-02-08 1991-02-05 Procedimiento para preparar derivados de pirimidintrionas.

Country Status (26)

Country Link
US (1) US5262402A (es)
EP (1) EP0466887B1 (es)
JP (1) JPH04505460A (es)
KR (1) KR920701173A (es)
CN (2) CN1034806C (es)
AT (1) ATE113589T1 (es)
BG (1) BG60269B1 (es)
CA (1) CA2049991A1 (es)
CS (1) CS31191A3 (es)
DE (1) DE69104920T2 (es)
DK (1) DK0466887T3 (es)
ES (1) ES2065002T3 (es)
GB (1) GB9002890D0 (es)
GE (1) GEP19970892B (es)
HR (1) HRP950155A2 (es)
HU (2) HUT64077A (es)
IE (1) IE62606B1 (es)
LT (1) LT3316B (es)
LV (1) LV10259B (es)
PL (2) PL168051B1 (es)
PT (1) PT96694B (es)
RO (1) RO109334B1 (es)
RU (1) RU2050353C1 (es)
TW (1) TW216792B (es)
WO (1) WO1991012244A1 (es)
YU (1) YU47836B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2107064A1 (de) * 2008-04-02 2009-10-07 Basf Se Verfahren zur Herstellung von Triamiden aus Ammoniak und Amido-Dichloriden

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2051846A (en) * 1936-08-25 Production of barbituric acid
US2161212A (en) * 1939-06-06 Substituted barbituric acids con
US2876225A (en) * 1959-03-03 Manufacture of therapeutic substances
US814496A (en) * 1904-11-08 1906-03-06 Firm Of E Merck Process of making barbituric acids.
GB1581834A (en) 1976-11-01 1980-12-31 Sapos Sa Complexes of barbituric acid derivatives
FR2424262A1 (fr) * 1978-04-24 1979-11-23 Sapos Sa Nouveaux complexes tetrameres de derives de la malonyl-uree a action psychotrope et procede de preparation
GB8309813D0 (en) * 1983-04-12 1983-05-18 Sapos Sa Pyrimidinetrione derivatives

Also Published As

Publication number Publication date
LT3316B (en) 1995-06-26
HUT64077A (en) 1993-11-29
EP0466887B1 (en) 1994-11-02
TW216792B (es) 1993-12-01
GB9002890D0 (en) 1990-04-04
DK0466887T3 (da) 1994-12-27
CS31191A3 (en) 1992-02-19
KR920701173A (ko) 1992-08-11
HU9300285D0 (en) 1993-04-28
HU913183D0 (en) 1992-02-28
LV10259A (lv) 1994-10-20
JPH04505460A (ja) 1992-09-24
CA2049991A1 (en) 1991-08-09
DE69104920T2 (de) 1995-03-16
HRP950155A2 (en) 1996-06-30
LTIP612A (en) 1994-12-25
LV10259B (en) 1995-08-20
PL292559A1 (es) 1993-02-08
IE62606B1 (en) 1995-02-22
BG60269B2 (en) 1994-03-31
PT96694B (pt) 1998-07-31
GEP19970892B (en) 1997-04-15
RU2050353C1 (ru) 1995-12-20
HUT59380A (en) 1992-05-28
HU207722B (en) 1993-05-28
IE910409A1 (en) 1991-08-14
YU47836B (sr) 1996-01-09
BG60269B1 (bg) 1994-03-31
PT96694A (pt) 1991-10-31
ATE113589T1 (de) 1994-11-15
CN1034806C (zh) 1997-05-07
PL168051B1 (pl) 1995-12-30
CN1121070A (zh) 1996-04-24
WO1991012244A1 (en) 1991-08-22
PL165990B1 (pl) 1995-03-31
RO109334B1 (ro) 1995-01-30
DE69104920D1 (de) 1994-12-08
US5262402A (en) 1993-11-16
YU21791A (sh) 1994-04-05
CN1054592A (zh) 1991-09-18
EP0466887A1 (en) 1992-01-22

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