ES2063779T3 - Nuevos esteres de polisacaridos. - Google Patents

Nuevos esteres de polisacaridos.

Info

Publication number
ES2063779T3
ES2063779T3 ES89108628T ES89108628T ES2063779T3 ES 2063779 T3 ES2063779 T3 ES 2063779T3 ES 89108628 T ES89108628 T ES 89108628T ES 89108628 T ES89108628 T ES 89108628T ES 2063779 T3 ES2063779 T3 ES 2063779T3
Authority
ES
Spain
Prior art keywords
esters
carboximetil
polysaccharides
new esters
acidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89108628T
Other languages
English (en)
Inventor
Valle Francesco Dr Della
Aurelio Prof Romeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2063779T3 publication Critical patent/ES2063779T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/02—Alkyl or cycloalkyl ethers
    • C08B11/04—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals
    • C08B11/10—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals
    • C08B11/12—Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals, e.g. carboxymethylcellulose [CMC]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/54—Polymers characterized by specific structures/properties
    • A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
    • A61K2800/5424—Polymers characterized by specific structures/properties characterized by the charge anionic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/15—Suppositories
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/904—Tampons

Abstract

SE PRESENTAN NUEVOS ESTERES DE POLISACARUROS Y MAS PRECISAMENTE ESTERES DE POLISACARUROS ACIDICOS ESCOGIDOS ENTRE EL GRUPO FORMADO POR CARBOXIMETIL CELULOSA, ALMIDON DE CARBOXIMETIL Y CARBOXIMETIL - CITINA. ESTOS NUEVOS ESTERES Y ALGUNOS ESTERES DEL TIPO YA CONOCIDO SON UTILES COMO MEDICAMENTOS PARA LA PRODUCCION DE PREPARACIONES FARMACEUTICAS Y COSMETICAS EN EL CAMPO DE LOS MATERIALES PLASTICOS BIODEGRADABLES Y ADEMAS, PARA LA MANUFACTURA DE ARTICULOS MEDICOS, QUIRURGICOS Y SANITARIOS, ASI COMO NUMEROSOS OTROS SECTORES INDUSTRIALES EN LUGAR DE LOS POLISACARUROS ACIDICOS QUE SE USAN NORMALMENTE HOY DIA.
ES89108628T 1988-05-13 1989-05-12 Nuevos esteres de polisacaridos. Expired - Lifetime ES2063779T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47963/88A IT1219942B (it) 1988-05-13 1988-05-13 Esteri polisaccaridici

Publications (1)

Publication Number Publication Date
ES2063779T3 true ES2063779T3 (es) 1995-01-16

Family

ID=11263638

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89108628T Expired - Lifetime ES2063779T3 (es) 1988-05-13 1989-05-12 Nuevos esteres de polisacaridos.

Country Status (16)

Country Link
US (2) US5122598A (es)
EP (2) EP0615979A3 (es)
JP (1) JP2958373B2 (es)
KR (1) KR940011646B1 (es)
AT (1) ATE114322T1 (es)
AU (1) AU629551B2 (es)
CA (1) CA1336087C (es)
DE (1) DE68919435T2 (es)
DK (1) DK10890A (es)
ES (1) ES2063779T3 (es)
FI (1) FI900187A0 (es)
HU (1) HU208440B (es)
IL (1) IL90273A (es)
IT (1) IT1219942B (es)
NZ (1) NZ229099A (es)
WO (1) WO1989010940A1 (es)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US5387431A (en) 1991-10-25 1995-02-07 Fuisz Technologies Ltd. Saccharide-based matrix
IT1219942B (it) * 1988-05-13 1990-05-24 Fidia Farmaceutici Esteri polisaccaridici
IL98087A (en) * 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
ES2048133T3 (es) * 1990-05-04 2000-01-16 Perio Prod Ltd Sistema de descarga de farmacos para el colon.
DE4022944A1 (de) * 1990-07-19 1992-01-23 Merck Patent Gmbh Sucralfat-kautablette
EP0544000B1 (en) * 1990-08-17 1997-05-02 Drug Delivery System Institute, Ltd. N-acetylcarboxymethylchitosan derivative and production thereof
GB9109757D0 (en) * 1991-05-04 1991-06-26 Procter & Gamble Cosmetic compositions
US5486582A (en) * 1991-07-03 1996-01-23 Shin-Etsu Chemical Co., Ltd. Polymer scale preventive process using a coating of chitosan salt and phenothiazine
IT1254119B (it) * 1991-09-13 1995-09-08 Fidia Esteri di derivati carbossilici di polisaccaridi
IT1263755B (it) * 1991-09-16 1996-08-29 Fidia Spa Uso di esteri della colina con polisaccaridi acidi come agenti antiulcera e gastroprotettivi
EP0571671B1 (en) * 1992-05-26 1997-09-17 The Procter & Gamble Company A Pharmaceutical composition in powder form
US5648074A (en) * 1993-05-25 1997-07-15 Allergan Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation
IT1263394B (it) * 1993-07-30 1996-08-05 Fidia Advanced Biopolymers Srl Composizioni farmaceutiche per uso topico a base di acido ialuronico e suoi derivati
US5462740A (en) * 1993-09-17 1995-10-31 Athena Neurosciences, Inc. Rectally-administered, epileptic-seizure-inhibiting composition
WO1995007672A1 (en) * 1993-09-17 1995-03-23 Athena Neurosciences, Inc. Rectally-administered, epileptic-seizure-inhibiting composition
NL9302163A (nl) * 1993-12-10 1995-07-03 Univ Delft Tech Gecarboxymethyleerde oligo- en polysacchariden als kristallisatie inhibitors.
IT1268955B1 (it) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Esteri attivi di polisaccaridi carbossilici
US6024954A (en) * 1994-12-12 2000-02-15 Allergan Compositions and methods for disinfecting contact lenses and preserving contact lens care products
CA2212519C (en) * 1995-02-07 2005-08-23 Fidia Advanced Biopolymers, S.R.L. Process for the coating of objects with hyaluronic acid, derivatives thereof, and semisynthetic polymers
US5645844A (en) * 1995-06-07 1997-07-08 Chitogenics, Inc. Negatively charged chitosan derivative semiochemical delivery system
FR2736552B1 (fr) * 1995-07-12 1997-10-03 Textile Hi Tec Sa Soc Procede pour prolonger la duree de bioresorption d'un materiau implantable dans l'organisme a base de chitine ou de chitosane et materiau obtenu
TW389694B (en) * 1995-08-17 2000-05-11 Novartis Ag Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
US5770711A (en) * 1996-09-30 1998-06-23 Kimberly-Clark Worldwide, Inc. Polysaccharides substituted with polycarboxylated moieties
FR2755856B1 (fr) * 1996-11-21 1999-01-29 Merck Clevenot Laboratoires Microcapsules de chitine ou de derives de chitine contenant une substance hydrophobe, notamment un filtre solaire et procede de preparation de telles microcapsules
KR100362960B1 (ko) * 1997-09-15 2002-11-30 더 프록터 앤드 갬블 캄파니 세탁된 직물에 외관 및 보존성 잇점을 제공하는셀룰로스계 중합체를 갖는 세탁 세제 조성물
US6384011B1 (en) 1997-09-15 2002-05-07 The Procter & Gamble Company Laundry detergent compositions with cellulosic based polymers to provide appearance and integrity benefits to fabrics laundered therewith
CA2303110A1 (en) * 1997-09-15 1999-03-25 The Procter & Gamble Company Laundry detergent and fabric conditioning compositions with oxidized cyclic amine based polymers
ATE305224T1 (de) * 1999-01-11 2005-10-15 Calpis Co Ltd Verfahren zur herstellung von sauermilch enthaltend ein inhibitionspeptid fuer ein angiotensin konvertierendes enzym sowie ein verfahren zur herstellung von milchserum
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
US7514097B1 (en) 1999-11-09 2009-04-07 Denki Kagaku Kogyo Kabushiki Kaisha Use of soluble cellulose derivative having been made hardly soluble in water and process for producing the same
GB0007656D0 (en) * 2000-03-29 2000-05-17 Unilever Plc Laundry treatment for fabrics
WO2001081524A1 (en) * 2000-04-20 2001-11-01 The Procter & Gamble Company Modified starch-based polymer-containing fabric care compositions and methods employing same
US7060297B2 (en) 2000-11-06 2006-06-13 Alcon, Inc. Carrageenan viscoelastics for ocular surgery
US20030060447A1 (en) * 2002-04-24 2003-03-27 Mutlu Karakelle Non-aspirating transitional viscoelastics for use in surgery
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
US6764988B2 (en) 2001-04-18 2004-07-20 Kimberly-Clark Worldwide, Inc. Skin cleansing composition incorporating anionic particles
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
PL217085B1 (pl) 2002-09-11 2014-06-30 Fresenius Kabi Gmbh Koniugat hydroksyalkiloskrobi i polipeptydu, sposób wytwarzania koniugatu hydroksyalkiloskrobi i polipeptydu, zastosowanie koniugatu hydroksyalkiloskrobi i polipeptydu oraz kompozycja farmaceutyczna koniugatu hydroksyalkiloskrobi i polipeptydu
AU2003273413A1 (en) 2002-10-08 2004-05-04 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
DE10248314A1 (de) * 2002-10-16 2004-04-29 Dr. Suwelack Skin & Health Care Ag Verwendung von Formkörpern zur äußeren Anwendung
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
US8313765B2 (en) 2003-12-04 2012-11-20 Industrial Technology Research Institute Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition
GB2408741B (en) * 2003-12-04 2008-06-18 Ind Tech Res Inst Hyaluronic acid derivative with urethane linkage
US20050158329A1 (en) * 2004-01-21 2005-07-21 Ghosh Swapan K. Novel phytol derived immunoadjuvants and their use in vaccine formulations
WO2005092391A2 (en) * 2004-03-11 2005-10-06 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
DE202005021885U1 (de) 2004-03-11 2011-03-03 Fresenius Kabi Deutschland Gmbh Hydroxyalkylstärke-Protein-Konjugate, durch reduktive Aminierung hergestellt
ITMI20041373A1 (it) * 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
US20100124583A1 (en) * 2008-04-30 2010-05-20 Xyleco, Inc. Processing biomass
US20090062233A1 (en) 2007-08-09 2009-03-05 Xin Ji Modified starch material of biocompatible hemostasis
CN101455857B (zh) * 2007-12-11 2014-03-12 纪欣 生物相容性变性淀粉海绵
EP2070950A1 (en) 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkyl starch derivatives and process for their preparation
AU2008339362B2 (en) 2007-12-17 2013-01-10 Teijin Limited Cellulose derivative and hydrogel thereof
US9376648B2 (en) 2008-04-07 2016-06-28 The Procter & Gamble Company Foam manipulation compositions containing fine particles
NZ733050A (en) 2008-04-30 2019-01-25 Xyleco Inc Processing biomass with irradiation
US9387206B2 (en) * 2009-11-03 2016-07-12 Pharnext Therapeutic approaches for treating Alzheimer's disease
TWI561535B (en) 2011-10-06 2016-12-11 Bvw Holding Ag Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption
CU24372B1 (es) 2012-10-10 2018-11-06 Xyleco Inc Procesamiento de biomasa
UA117352C2 (uk) 2012-10-10 2018-07-25 Ксілеко, Інк. Обробка біомаси
NZ743055A (en) 2013-03-08 2020-03-27 Xyleco Inc Equipment protecting enclosures

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE957938C (de) * 1957-01-24 Henkel S. Cie GmbH, Dusseldorf-Holthausen Verfahren zur Herstellung der Ester von Celluloseathercarbonsauren
US2912430A (en) * 1954-12-07 1959-11-10 Henkel & Compagnie G M B H Method of preparing esters of cellulose ether carboxylic acids
US3092619A (en) * 1954-12-22 1963-06-04 Henkel & Cie Gmbh High molecular carbohydrate ether carboxylic acid esters
GB1094268A (en) * 1963-12-10 1967-12-06 Unilever Ltd Fatty compositions
JPS4918981A (es) * 1972-06-12 1974-02-19
JPS5590505A (en) * 1978-12-29 1980-07-09 Kureha Chem Ind Co Ltd Carboxyalkylchitin and preparation of deacetylated product thereof
JPS6017444B2 (ja) * 1982-09-01 1985-05-02 ダイセル化学工業株式会社 カルボキシメチルセルロ−スエステルおよびその製法
IT1203814B (it) * 1986-06-30 1989-02-23 Fidia Farmaceutici Esteri dell'acido alginico
IT1219942B (it) * 1988-05-13 1990-05-24 Fidia Farmaceutici Esteri polisaccaridici

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AU3571889A (en) 1989-11-29
DE68919435D1 (de) 1995-01-05
US5122598A (en) 1992-06-16
IL90273A (en) 1995-11-27
IL90273A0 (en) 1989-12-15
JPH02504164A (ja) 1990-11-29
NZ229099A (en) 1992-02-25
ATE114322T1 (de) 1994-12-15
KR940011646B1 (ko) 1994-12-22
CA1336087C (en) 1995-06-27
IT8847963A0 (it) 1988-05-13
AU629551B2 (en) 1992-10-08
WO1989010940A1 (en) 1989-11-16
EP0342557B1 (en) 1994-11-23
US5466461A (en) 1995-11-14
HU208440B (en) 1993-10-28
FI900187A0 (fi) 1990-01-12
EP0615979A2 (en) 1994-09-21
DE68919435T2 (de) 1995-07-06
DK10890D0 (da) 1990-01-12
DK10890A (da) 1990-03-12
HU893005D0 (en) 1990-07-28
IT1219942B (it) 1990-05-24
HUT53127A (en) 1990-09-28
EP0342557A1 (en) 1989-11-23
KR900701848A (ko) 1990-12-04
JP2958373B2 (ja) 1999-10-06
EP0615979A3 (en) 1994-12-28

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