ES2062098T3 - Derivados de bencimidazol farmacologicamente activos. - Google Patents

Derivados de bencimidazol farmacologicamente activos.

Info

Publication number
ES2062098T3
ES2062098T3 ES89830312T ES89830312T ES2062098T3 ES 2062098 T3 ES2062098 T3 ES 2062098T3 ES 89830312 T ES89830312 T ES 89830312T ES 89830312 T ES89830312 T ES 89830312T ES 2062098 T3 ES2062098 T3 ES 2062098T3
Authority
ES
Spain
Prior art keywords
pharmacologically active
elected
group
bencimidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89830312T
Other languages
English (en)
Inventor
Roberto Giani
Ettore Parini
Giancarlo Tonon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe Farmaceutici SpA
Original Assignee
Dompe Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Farmaceutici SpA filed Critical Dompe Farmaceutici SpA
Application granted granted Critical
Publication of ES2062098T3 publication Critical patent/ES2062098T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S165/00—Heat exchange
    • Y10S165/009—Heat exchange having a solid heat storage mass for absorbing heat from one fluid and releasing it to another, i.e. regenerator
    • Y10S165/013—Movable heat storage mass with enclosure
    • Y10S165/016—Rotary storage mass
    • Y10S165/02—Seal and seal-engaging surface are relatively movable
    • Y10S165/024—Circumferential seal

Abstract

SE DESCRIBEN NUEVOS DERIVADOS DE BENCIMIDAZOL, DE FORMULA (I), DONDE A ES -CH2-CH(CH3)- O -CH(CH3)CH2-; N ES 0 O 1; M ES 0 O UN NUMERO ENTERO DE 1-5, PREVIENDO QUE CUANDO N ES 0, M ES UN ENTERO DE 2-5; X ES UN RADICAL ELEGIDO DEL GRUPO QUE CONSTA DE BENCILO, FLUOROBENCILO, ALCOXIALQUILO Y TETRAHIDROFURFURILO; R1 Y R2 REPRESENTAN CADA UNO UN RADICAL ALQUILO SATURADO O INSATURADO QUE TIENE DE 1-4 ATOMOS DE CARBONO O PUEDEN FORMAR, JUNTO CON EL ATOMO DE NITROGENO ADYACENTE, UN ANILLO HETEROCICLICO OPCIONALMENTE SUSTITUIDO, ELEGIDO DEL GRUPO QUE CONSTA DE PIRROLIDINA Y PIRIDINA, Y LAS CORRESPONDIENTES SALES DE ADICION DE ACIDO FARMACOLOGICAMENTE ACEPTABLES, NO TOXICAS. LOS COMPUESTOS (I) ESTAN DOTADOS DE UNA INTERESANTE ACTIVIDAD ANTIHISTAMINICA.
ES89830312T 1988-07-07 1989-07-06 Derivados de bencimidazol farmacologicamente activos. Expired - Lifetime ES2062098T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8821271A IT1226100B (it) 1988-07-07 1988-07-07 Derivati benzimidazolici farmacologicamente attivi.

Publications (1)

Publication Number Publication Date
ES2062098T3 true ES2062098T3 (es) 1994-12-16

Family

ID=11179331

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89830312T Expired - Lifetime ES2062098T3 (es) 1988-07-07 1989-07-06 Derivados de bencimidazol farmacologicamente activos.

Country Status (7)

Country Link
US (1) US4971980A (es)
EP (1) EP0350467B1 (es)
JP (1) JPH0267272A (es)
AT (1) ATE99295T1 (es)
DE (1) DE68911773T2 (es)
ES (1) ES2062098T3 (es)
IT (1) IT1226100B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.
CA2097317C (en) * 1990-12-14 2002-02-12 Albert A. Carr Antiallergic piperdinyl benzimidazoles
TW263504B (es) * 1991-10-03 1995-11-21 Pfizer
IT1264456B1 (it) * 1993-05-14 1996-09-23 Dompe Farmaceutici Spa Derivati del 2-(benzimidazol-2-il)-1,3-diaminopropano farmacologicamente attivi.
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
KR100494448B1 (ko) * 1996-06-04 2005-12-02 화브리까 에스파놀라 데 프로둑또스 뀌미꼬스 이 화르마세우띠꼬스 쏘시에떼 아노님 항히스타민활성을가지는신규한벤조이미다졸유도체
ATE254131T1 (de) 1997-02-13 2003-11-15 Glaxo Group Ltd Benzimidazolderivate
WO1998056761A2 (en) 1997-06-10 1998-12-17 Glaxo Group Limited Benzimidazole derivatives
NZ502882A (en) 1997-07-30 2002-02-01 Glaxo Group Ltd Lyxofuranosyl benzimidazoles as antiviral agents
KR20020022728A (ko) * 1999-06-28 2002-03-27 무네유키 가코우 벤즈 이미다졸 화합물 및 그것을 함유하는 의약
SI1196408T1 (en) * 1999-06-28 2005-02-28 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
JP4560259B2 (ja) 1999-06-30 2010-10-13 富士フイルム株式会社 ベンズイミダゾール化合物及びそれを含む医薬
CA2378007C (en) 1999-07-07 2006-11-28 Fuji Photo Film Co., Ltd. Benzimidazole compounds
US6349662B1 (en) * 2000-12-29 2002-02-26 Taco Metals, Inc. Rub rail
NZ594746A (en) * 2005-12-19 2013-03-28 Genentech Inc Inhibitors of iap

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1023792A (en) * 1963-04-17 1966-03-23 Smith & Nephew Benzimidazole derivatives and processes for making them
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US4462992A (en) * 1982-02-08 1984-07-31 Research Corporation Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof
JPS59199679A (ja) * 1983-04-27 1984-11-12 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
US4728741A (en) * 1985-01-08 1988-03-01 Smithkline Beckman Corporation 1-substituted-2-mercapto benzimidazole compounds and intermediates

Also Published As

Publication number Publication date
IT1226100B (it) 1990-12-10
DE68911773T2 (de) 1994-07-07
US4971980A (en) 1990-11-20
EP0350467B1 (en) 1993-12-29
IT8821271A0 (it) 1988-07-07
JPH0267272A (ja) 1990-03-07
EP0350467A1 (en) 1990-01-10
DE68911773D1 (de) 1994-02-10
ATE99295T1 (de) 1994-01-15
JPH0567624B2 (es) 1993-09-27

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