ES2061744T3 - Inmunogeno y su aplicacion para la obtencion de anticuerpos especificos contra hba1c. - Google Patents

Inmunogeno y su aplicacion para la obtencion de anticuerpos especificos contra hba1c.

Info

Publication number
ES2061744T3
ES2061744T3 ES89101835T ES89101835T ES2061744T3 ES 2061744 T3 ES2061744 T3 ES 2061744T3 ES 89101835 T ES89101835 T ES 89101835T ES 89101835 T ES89101835 T ES 89101835T ES 2061744 T3 ES2061744 T3 ES 2061744T3
Authority
ES
Spain
Prior art keywords
immunogen
application
antibodies against
specific antibodies
obtaining specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89101835T
Other languages
English (en)
Inventor
Christian Dr Rer Nat Klein
Christa Dr Rer Hubner-Parajsz
Hans-Georg Dr Rer Nat Batz
Wolfgang Dr Rer Nat Rollinger
Ulrich Dr Rer Nat Essig
Lorenz Dr Rer Nat Kerscher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2061744T3 publication Critical patent/ES2061744T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN INMUNOGENO PARA LA OBTENCION DE ANTICUERPOS ESPECIFICOS DE HBA1C CON FORMULA GENERAL I: DONDE M ES 1-40, T ES UNA PROTEINA PORTADORA Y A ES UN ESPACIADOR QUE MUESTRA UNA LONGITUD DE CADENA DE 10 A 20 ATOMOS CON LA SIGUIENTE FORMULA II: DONDE X ES S O NH, N ES 1-4 Y B ES UN RESTO ORGANICO QUE CONTIENE UN GRUPO SUCCINIMIDA.
ES89101835T 1988-02-04 1989-02-02 Inmunogeno y su aplicacion para la obtencion de anticuerpos especificos contra hba1c. Expired - Lifetime ES2061744T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3803330 1988-02-04
DE3806198A DE3806198A1 (de) 1988-02-04 1988-02-26 Immunogen und seine verwendung zur gewinnung von antikoerpern gegen hba(pfeil abwaerts)1(pfeil abwaerts)(pfeil abwaerts)c(pfeil abwaerts)

Publications (1)

Publication Number Publication Date
ES2061744T3 true ES2061744T3 (es) 1994-12-16

Family

ID=25864554

Family Applications (2)

Application Number Title Priority Date Filing Date
ES89101835T Expired - Lifetime ES2061744T3 (es) 1988-02-04 1989-02-02 Inmunogeno y su aplicacion para la obtencion de anticuerpos especificos contra hba1c.
ES93101522T Expired - Lifetime ES2078072T3 (es) 1988-02-04 1989-02-02 Inmunogeno y su utilizacion para la obtencion de anticuerpos contra hba1c.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES93101522T Expired - Lifetime ES2078072T3 (es) 1988-02-04 1989-02-02 Inmunogeno y su utilizacion para la obtencion de anticuerpos contra hba1c.

Country Status (7)

Country Link
US (2) US5646255A (es)
EP (2) EP0329994B1 (es)
JP (2) JP2540362B2 (es)
AT (1) ATE124539T1 (es)
DE (3) DE3806198A1 (es)
DK (1) DK175191B1 (es)
ES (2) ES2061744T3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484735A (en) * 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
DK608589D0 (da) * 1989-12-01 1989-12-01 Holm Arne Kemisk fremgangsmaade
JP2596322B2 (ja) * 1992-06-10 1997-04-02 富士レビオ株式会社 総ヘモグロビンに対する糖化ヘモグロビンの割合の測定方法
US5470759A (en) * 1992-06-10 1995-11-28 Fujirebio, Inc. Anti-glycated hemoglobin monoclonal antibody and method for measuring glycated hemoglobin
AU661207B2 (en) * 1992-11-17 1995-07-13 Boehringer Mannheim Gmbh Simultaneous determination of HbA1c and haemoglobin variants with a glycation analogus to HbA1c
DE19709090A1 (de) * 1997-03-06 1998-09-10 Boehringer Mannheim Gmbh Analytisches Testelement mit flüssigkeitsgefüllten Blister
EP1015028A2 (en) 1997-09-19 2000-07-05 Serex, Inc. Methods to improve immunogenicity of antigens and specificity of antibodies
WO2002006310A1 (fr) * 2000-07-14 2002-01-24 Matsushita Electric Industrial Co., Ltd. Fructose peptidique et complexe de ce dernier associe a une proteine de liaison
JP2007003411A (ja) * 2005-06-24 2007-01-11 Sekisui Chem Co Ltd ヘモグロビンＡ１ｃの測定方法及びヘモグロビンＡ１ｃ測定用キット
JP6785011B2 (ja) 2019-03-30 2020-11-18 株式会社写真化学 攪拌・脱泡装置
CN110724671A (zh) * 2019-10-31 2020-01-24 浙江蓝盾药业有限公司 杂交瘤细胞株1g8、抗体及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB185870A (en) * 1921-06-21 1922-09-21 Samuel Theodore Sherrill Improvements in and relating to electric current detectors
GB2024829B (en) * 1978-06-28 1982-08-04 Amicon Corp Method and product for separation of glycoproteins
US4478744A (en) * 1982-01-25 1984-10-23 Sherwood Medical Company Method of obtaining antibodies
US4629692A (en) * 1982-12-06 1986-12-16 Miles Laboratories, Inc. Immunoassay for nonenzymatically glucosylated proteins and protein fragments an index of glycemia
CA1339952C (en) * 1984-10-29 1998-07-14 William J. Knowles Immunoassays for denatured protein analytes, particularly hb alc, and monoclonal antibodies thereto
US4727036A (en) * 1985-08-08 1988-02-23 Molecular Diagnostics, Inc. Antibodies for use in determining hemoglobin A1c
US4647654A (en) * 1984-10-29 1987-03-03 Molecular Diagnostics, Inc. Peptides useful in preparing hemoglobin A1c immunogens
DE3439610A1 (de) * 1984-10-30 1986-04-30 Boehringer Mannheim Gmbh, 6800 Mannheim Immunogene, verfahren zu deren herstellung sowie damit gewonnene antikoerper gegen glykosiliertes haemoglobin
DK145385D0 (da) * 1985-03-29 1985-04-01 Novo Industri As Monoklonalt antistof til immunkemisk analyse
DE3532868A1 (de) * 1985-09-14 1987-03-26 Boehringer Mannheim Gmbh Verfahren und reagenz zur bestimmung von glykosiliertem haemoglobin sowie hierzu geeignete verbindungen und verfahren zu deren herstellung
US4806468A (en) * 1987-02-05 1989-02-21 Becton, Dickinson And Company Measurement of glycosylated hemoglobin by immunoassay

Also Published As

Publication number Publication date
ES2078072T3 (es) 1995-12-01
DE58906510D1 (de) 1994-02-10
EP0329994B1 (de) 1993-12-29
EP0547029B1 (de) 1995-06-28
US5632993A (en) 1997-05-27
DE58909328D1 (de) 1995-08-03
DE3806198A1 (de) 1989-08-17
ATE124539T1 (de) 1995-07-15
EP0329994A1 (de) 1989-08-30
DK175191B1 (da) 2004-07-05
DK52589D0 (da) 1989-02-03
JPH028743A (ja) 1990-01-12
JPH0892300A (ja) 1996-04-09
JP2540362B2 (ja) 1996-10-02
DK52589A (da) 1989-08-05
US5646255A (en) 1997-07-08
EP0547029A1 (de) 1993-06-16
JP2717392B2 (ja) 1998-02-18

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