ES2061422T3 - Metodos para detectar la resorcion osea in vivo. - Google Patents
Metodos para detectar la resorcion osea in vivo.Info
- Publication number
- ES2061422T3 ES2061422T3 ES91900109T ES91900109T ES2061422T3 ES 2061422 T3 ES2061422 T3 ES 2061422T3 ES 91900109 T ES91900109 T ES 91900109T ES 91900109 T ES91900109 T ES 91900109T ES 2061422 T3 ES2061422 T3 ES 2061422T3
- Authority
- ES
- Spain
- Prior art keywords
- bone resorption
- vivo
- methods
- detect bone
- pyridinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000006386 Bone Resorption Diseases 0.000 title abstract 2
- 230000024279 bone resorption Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 102000012422 Collagen Type I Human genes 0.000 abstract 1
- 108010022452 Collagen Type I Proteins 0.000 abstract 1
- ZAHDXEIQWWLQQL-IHRRRGAJSA-N Deoxypyridinoline Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(O)=C(C[C@H](N)C([O-])=O)C(CC[C@H](N)C(O)=O)=C1 ZAHDXEIQWWLQQL-IHRRRGAJSA-N 0.000 abstract 1
- LCYXYLLJXMAEMT-SAXRGWBVSA-N Pyridinoline Chemical compound OC(=O)[C@@H](N)CCC1=C[N+](C[C@H](O)CC[C@H](N)C([O-])=O)=CC(O)=C1C[C@H](N)C(O)=O LCYXYLLJXMAEMT-SAXRGWBVSA-N 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
METODOS DE DETERMINACION DE LA DEGRADACION DEL COLAGENO IN VIVO, MEDIANTE LA CUANTIFICACION DE UN PEPTIDO EN UN CUERPO LIQUIDO, SIENDO EL PEPTIDO UN TELOPEPTIDO DE COLAGENO DEL TIPO II C-TERMINAL QUE CONTIENE UNA LIGADURA TRANSVERSAL DE PIRIDINOLINA DE HIDROXILISILO O UN TELEPEPTIDO DE COLAGENO DE TIPO III QUE CONTIENE UNA LIGADURA TRANSVERSAL DE PIRIDINOLINA DE HIDROXILISILO. ALGUNOS METODOS ADECUADOS PARA LA CUANTIFICACION INCLUYEN ENSAYOS INMUNOMETRICOS, ENSAYOS FLUOROMETRICOS Y VALORACIONES ELECTROQUIMICAS. SE DESCRIBEN LAS ESTRUCTURAS DE PEPTIDOS ESPECIFICOS CON LIGADURAS TRANSVERSALES Y EFECTOS PARA CUANTIFICAR ESTOS PEPTIDOS EN UN CUERPO LIQUIDO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/444,881 US5140103A (en) | 1987-11-06 | 1989-12-01 | Peptide fragments containing HP and LP cross-links |
US07/614,719 US5300434A (en) | 1987-11-06 | 1990-11-21 | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2061422T1 ES2061422T1 (es) | 1994-12-16 |
ES2061422T3 true ES2061422T3 (es) | 1996-03-16 |
Family
ID=27034100
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91900109T Expired - Lifetime ES2061422T3 (es) | 1989-12-01 | 1990-11-30 | Metodos para detectar la resorcion osea in vivo. |
ES95201176T Expired - Lifetime ES2133656T3 (es) | 1989-12-01 | 1990-11-30 | Metodos para detectar in vivo la degradacion de colageno. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95201176T Expired - Lifetime ES2133656T3 (es) | 1989-12-01 | 1990-11-30 | Metodos para detectar in vivo la degradacion de colageno. |
Country Status (13)
Country | Link |
---|---|
US (5) | US5300434A (es) |
EP (6) | EP0682257B1 (es) |
JP (6) | JP2782017B2 (es) |
AT (3) | ATE179521T1 (es) |
AU (1) | AU645049B2 (es) |
DE (4) | DE502928T1 (es) |
DK (3) | DK0682257T3 (es) |
ES (2) | ES2061422T3 (es) |
GR (3) | GR940300047T1 (es) |
IE (1) | IE65280B1 (es) |
NO (1) | NO309483B1 (es) |
RU (1) | RU2139541C1 (es) |
WO (1) | WO1991008478A2 (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2551939B1 (fr) * | 1983-09-14 | 1985-10-11 | Cit Alcatel | Dispositif de transfert et de traitement de voies de donnees ou de signalisation d'un ensemble de lignes multiplex |
US6027903A (en) * | 1987-11-06 | 2000-02-22 | Washington Research Foundation | Kit for detecting analyte indicative of type I collagen resorption in vivo |
US5320970A (en) * | 1987-11-06 | 1994-06-14 | Washington Research Foundation | Detection of collagen degradation in vivo |
US4973666A (en) * | 1987-11-06 | 1990-11-27 | Washington Research Foundation | Peptide fragments containing HP and LP cross-links |
US5962639A (en) * | 1987-11-06 | 1999-10-05 | Washington Research Foundation | Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites |
US6153732A (en) * | 1987-11-06 | 2000-11-28 | Washington Research Foundation | Kit for detecting analyte indicative of type II collagen resorption in vivo |
US5300434A (en) * | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
GB8929366D0 (en) * | 1989-12-30 | 1990-02-28 | Rowett Research Inst | Method to detect connective tissue disorder in humans and animals |
GB9105893D0 (en) * | 1991-03-20 | 1991-05-08 | Orion Yhtymae Oy | Bone resorption assay based on a peptide liberated during collagen degradation |
US5350855A (en) * | 1992-09-30 | 1994-09-27 | Metra Biosystems, Inc. | Derivatized D-acyl pyridinium reagent |
US6132976A (en) * | 1992-12-04 | 2000-10-17 | Shriners Hospitals For Children | Immunoassays for the measurement of collagen denaturation and cleavage in cartilage |
WO1994014072A1 (en) * | 1992-12-17 | 1994-06-23 | Metra Biosystems, Inc. | Serum pyridinium crosslinks assay |
US5736344A (en) * | 1992-12-17 | 1998-04-07 | Metra Biosystems, Inc. | Serum pyridinium crosslinks assay |
CA2152667C (en) * | 1992-12-28 | 2003-02-11 | David J. Baylink | Bone resorption assay |
DK104093D0 (da) † | 1993-09-17 | 1993-09-17 | Osteometer A S | Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen |
US6110689A (en) | 1994-01-21 | 2000-08-29 | Osteometer A/S | Method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen |
US5516699A (en) * | 1994-02-16 | 1996-05-14 | Institute Of Molecular Biology, Inc. | Pyridinoline crosslinks as markers of periodontal and peri-implant disease activity |
GB9506050D0 (en) | 1995-03-24 | 1995-05-10 | Osteometer A S | Assaying collagen fragments in body fluids |
AU3746295A (en) | 1994-10-17 | 1996-05-06 | Osteometer Biotech As | Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen |
US5661039A (en) * | 1995-03-01 | 1997-08-26 | Metra Biosystems, Inc. | Perspiration assay for bone resorption |
DE19518232A1 (de) * | 1995-05-12 | 1996-11-14 | Ruediger Dr Schade | Aviäre, vitelline, gegen Stützgewebe gerichtete Antikörper |
US5750647A (en) * | 1995-05-19 | 1998-05-12 | Washington Research Foundation | Synthetic peptide analogs of NTx |
US6107047A (en) * | 1996-03-21 | 2000-08-22 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
CA2255669A1 (en) * | 1996-05-16 | 1997-11-20 | The Texas A & M University System | Collagen binding protein compositions and methods of use |
GB9617616D0 (en) | 1996-08-22 | 1996-10-02 | Osteometer Biotech As | Assaying protein fragments in body fluids |
DE69705423T2 (de) | 1996-12-09 | 2002-05-16 | Osteometer Biotech As Herlev | Sandwichtest zum nachweis von kollagenfragmenten |
US5834610A (en) * | 1997-05-06 | 1998-11-10 | Johnson; Gary M. | Conversion of pyridinoline to deoxypyridinoline |
US5989925A (en) | 1997-06-27 | 1999-11-23 | Serex, Inc. | Antibody to and assay for peptide linked-pyridinoline as indicator of bone resorption level |
ATE258310T1 (de) * | 1997-07-31 | 2004-02-15 | Metra Biosystems Inc | Testverfahren für collagenpeptid |
US6117646A (en) * | 1997-09-22 | 2000-09-12 | Osteometer Biotech A/S | Assaying protein fragments in body fluids |
US6030792A (en) * | 1997-11-13 | 2000-02-29 | Pfizer Inc | Assays for measurement of protein fragments in biological media |
JP4436972B2 (ja) | 1998-06-19 | 2010-03-24 | ワシントン リサーチ ファンデーション | 軟骨吸収アッセイ |
US6916903B2 (en) * | 1998-06-19 | 2005-07-12 | Washington Research Foundation | Collagen type III synthetic peptides for collagen resorption assays |
US6602980B1 (en) | 1998-06-19 | 2003-08-05 | Washington Research Foundation | Collagen type III synthetic peptides for collagen resorption assays |
US6348320B1 (en) | 1998-06-19 | 2002-02-19 | Washington Research Foundation | Cartilage resorption assays measuring type II collagen fragments |
AU776137B2 (en) * | 1999-01-06 | 2004-08-26 | University Of Southern California | Method and composition for angiogenesis inhibition |
DE69920981T2 (de) * | 1999-06-17 | 2005-07-21 | Washington Research Foundation, Seattle | Knorpelresorptionsassays |
AU2001293964B2 (en) * | 2000-10-03 | 2007-06-14 | Rowett Research Institute | Method of assaying pyrrole-containing biological compounds |
WO2002074324A1 (en) * | 2001-03-15 | 2002-09-26 | The Texas A & M University System | Collagen-binding adhesin from staphylococcus epidermidis and method of use |
CA2574086A1 (en) * | 2004-07-21 | 2006-02-23 | Medtronic, Inc. | Medical devices and methods for reducing localized fibrosis |
EP1773993A2 (en) * | 2004-07-21 | 2007-04-18 | Medtronic, Inc. | METHODS FOR REDUCING OR PREVENTING LOCALIZED FIBROSIS USING SiRNA |
WO2007089303A2 (en) | 2005-11-01 | 2007-08-09 | Abbott Biotechnology Ltd. | Methods and compositions for diagnosing ankylosing spondylitis using biomarkers |
JP2007162988A (ja) * | 2005-12-12 | 2007-06-28 | Sanden Corp | 蒸気圧縮式冷凍サイクル |
CN101932935A (zh) * | 2007-06-20 | 2010-12-29 | 先灵公司 | 用于炎性关节病抗白介素-17a治疗的关节破坏生物标记 |
DK2208073T3 (da) * | 2007-11-05 | 2020-03-30 | Nordic Bioscience As | Biokemiske markører til cvd-risikovurdering |
WO2009153783A1 (en) * | 2008-06-16 | 2009-12-23 | Mor Research Applications Ltd. | Monitoring skin metabolism products for evaluating burn injury |
KR20120064072A (ko) * | 2009-09-16 | 2012-06-18 | 시오노기세야쿠 가부시키가이샤 | 콜라겐 네오에피토프 항체 |
US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
US9777055B2 (en) | 2012-04-20 | 2017-10-03 | Thomas Jefferson University | Engineered antibody for inhibition of fibrosis |
US10391498B2 (en) | 2015-12-11 | 2019-08-27 | Spartan Bioscience Inc. | Systems and methods for nucleic acid amplification |
WO2023068249A1 (ja) * | 2021-10-20 | 2023-04-27 | 積水メディカル株式会社 | I型コラーゲン架橋n-テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法 |
WO2023068248A1 (ja) * | 2021-10-20 | 2023-04-27 | 積水メディカル株式会社 | I型コラーゲン架橋n-テロペプチドの免疫測定方法及び免疫測定キット、並びに抗体又はその抗体断片 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6716836A (es) * | 1967-12-11 | 1969-06-13 | ||
JPS5164788A (ja) * | 1974-12-03 | 1976-06-04 | Orion Yakuhin Kogyo Kk | Shodokuyomennometsukinhoho |
US4094646A (en) * | 1977-06-02 | 1978-06-13 | The Baltimore Spice Company | Rapid method of assaying collagen in meat and meat products |
LU78457A1 (fr) * | 1977-11-04 | 1979-06-13 | Prayon Soc | Procede de fabrication d'acide phosphorique |
DE2816841A1 (de) * | 1978-04-18 | 1979-10-31 | Max Planck Gesellschaft | Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii) |
US4298593A (en) * | 1979-08-21 | 1981-11-03 | Abbott Laboratories | Reagents and methods utilizing labeled Fab bound to antigens |
US4371374A (en) * | 1980-11-17 | 1983-02-01 | The Rockefeller University | Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine |
DE3209149A1 (de) * | 1982-03-13 | 1983-10-06 | Hoechst Ag | Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum |
EP0128041A3 (en) * | 1983-06-06 | 1986-12-03 | David Jeston Baylink | Polypeptides exhibiting skeletal growth factor activity |
JPS60198156A (ja) * | 1984-03-19 | 1985-10-07 | 凸版印刷株式会社 | プラスチツク製品の殺菌方法 |
JPS60256457A (ja) * | 1984-06-01 | 1985-12-18 | 大日本印刷株式会社 | 包装材料の殺菌方法 |
US4731326A (en) * | 1984-06-04 | 1988-03-15 | Ortho Diagnostic Systems Inc. | Disease diagnosis by detection of shed normal tissue antigens |
US4774227A (en) * | 1986-02-14 | 1988-09-27 | Collagen Corporation | Collagen compositions for bone repair containing autogeneic marrow |
EP0289314B1 (en) * | 1987-04-28 | 1994-10-12 | Roche Diagnostics GmbH | Use of IGF-II in the treatment of bone disorders |
GB2205643B (en) * | 1987-05-08 | 1991-03-13 | Farmos Group Limited | Type iii collagen degradation assay |
US4973666A (en) * | 1987-11-06 | 1990-11-27 | Washington Research Foundation | Peptide fragments containing HP and LP cross-links |
US5300434A (en) * | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
US5320970A (en) * | 1987-11-06 | 1994-06-14 | Washington Research Foundation | Detection of collagen degradation in vivo |
GB8815174D0 (en) * | 1988-06-25 | 1988-08-03 | Rowett Research Inst | Method of monitoring collagen degradation |
JPH04502854A (ja) * | 1988-10-24 | 1992-05-28 | カターソン,ブルース | 変形性関節症の初期段階の診断、モニタリングならびに治療の方法および組成物 |
WO1990008195A1 (en) * | 1989-01-13 | 1990-07-26 | President And Fellows Of Harvard College | Monoclonal antibody to human type ix collagen |
GB9105893D0 (en) * | 1991-03-20 | 1991-05-08 | Orion Yhtymae Oy | Bone resorption assay based on a peptide liberated during collagen degradation |
-
1990
- 1990-11-21 US US07/614,719 patent/US5300434A/en not_active Expired - Lifetime
- 1990-11-30 DK DK95201176T patent/DK0682257T3/da active
- 1990-11-30 WO PCT/US1990/007015 patent/WO1991008478A2/en not_active Application Discontinuation
- 1990-11-30 AU AU68898/91A patent/AU645049B2/en not_active Ceased
- 1990-11-30 DE DE0502928T patent/DE502928T1/de active Pending
- 1990-11-30 DE DE69034170T patent/DE69034170T2/de not_active Expired - Fee Related
- 1990-11-30 AT AT95201176T patent/ATE179521T1/de not_active IP Right Cessation
- 1990-11-30 DK DK91900109.9T patent/DK0502928T3/da active
- 1990-11-30 DK DK95201148T patent/DK0682256T3/da active
- 1990-11-30 RU SU5052245A patent/RU2139541C1/ru not_active IP Right Cessation
- 1990-11-30 AT AT95201148T patent/ATE279730T1/de not_active IP Right Cessation
- 1990-11-30 ES ES91900109T patent/ES2061422T3/es not_active Expired - Lifetime
- 1990-11-30 EP EP95201176A patent/EP0682257B1/en not_active Revoked
- 1990-11-30 EP EP05077420A patent/EP1632502A1/en not_active Ceased
- 1990-11-30 AT AT91900109T patent/ATE133790T1/de not_active IP Right Cessation
- 1990-11-30 DE DE69025199T patent/DE69025199T2/de not_active Revoked
- 1990-11-30 JP JP3500884A patent/JP2782017B2/ja not_active Expired - Lifetime
- 1990-11-30 EP EP91900109A patent/EP0502928B1/en not_active Revoked
- 1990-11-30 DE DE69033082T patent/DE69033082T2/de not_active Expired - Fee Related
- 1990-11-30 EP EP04104918A patent/EP1560026A1/en not_active Ceased
- 1990-11-30 ES ES95201176T patent/ES2133656T3/es not_active Expired - Lifetime
- 1990-11-30 EP EP95201148A patent/EP0682256B1/en not_active Expired - Lifetime
- 1990-11-30 EP EP98202404A patent/EP0890840A3/en not_active Ceased
- 1990-12-03 IE IE434490A patent/IE65280B1/en not_active IP Right Cessation
-
1992
- 1992-05-29 NO NO922149A patent/NO309483B1/no not_active IP Right Cessation
-
1994
- 1994-04-01 US US08/221,705 patent/US5473052A/en not_active Expired - Lifetime
- 1994-07-29 GR GR940300047T patent/GR940300047T1/el unknown
-
1995
- 1995-06-01 US US08/457,831 patent/US5576189A/en not_active Expired - Lifetime
- 1995-12-04 US US08/567,618 patent/US5656439A/en not_active Expired - Fee Related
-
1996
- 1996-02-01 GR GR960400036T patent/GR3018852T3/el unknown
- 1996-06-13 US US08/664,102 patent/US5677198A/en not_active Expired - Fee Related
- 1996-07-08 JP JP8195242A patent/JP2999416B2/ja not_active Expired - Lifetime
-
1998
- 1998-01-07 JP JP10011978A patent/JP2999444B2/ja not_active Expired - Lifetime
-
1999
- 1999-06-30 GR GR990401732T patent/GR3030646T3/el unknown
- 1999-07-16 JP JP20334599A patent/JP3299941B2/ja not_active Expired - Lifetime
- 1999-09-01 JP JP11247011A patent/JP2000050865A/ja active Pending
-
2001
- 2001-10-16 JP JP2001317594A patent/JP2002139492A/ja active Pending
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