ES2179081T3 - Procedimiento para la deteccion de perturbaciones del sistema de proteina c/proteina s. - Google Patents
Procedimiento para la deteccion de perturbaciones del sistema de proteina c/proteina s.Info
- Publication number
- ES2179081T3 ES2179081T3 ES95111554T ES95111554T ES2179081T3 ES 2179081 T3 ES2179081 T3 ES 2179081T3 ES 95111554 T ES95111554 T ES 95111554T ES 95111554 T ES95111554 T ES 95111554T ES 2179081 T3 ES2179081 T3 ES 2179081T3
- Authority
- ES
- Spain
- Prior art keywords
- proteina
- coagulation
- protein
- detection
- disturbances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
- G01N2333/4613—Snake venom
- G01N2333/462—Snake venom from Agkistrodon sp., e.g. acutase, ACTE
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7456—Factor V
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91045—Acyltransferases (2.3)
- G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91045—Acyltransferases (2.3)
- G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
- G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91045—Acyltransferases (2.3)
- G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
- G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)
- G01N2333/91085—Transglutaminases; Factor XIIIq (2.3.2.13)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96461—Protein C (3.4.21.69)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
Abstract
LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO PARA LA DETERMINACION DE PERTURBACIONES DEL SISTEMA PROTEINA C/PROTEINA S MEDIANTE UN PROCESO PARA LA DETERMINACION CUALITATIVA Y PARA LA DETERMINACION CUANTITATIVA DE LA ACTIVIDAD FUNCIONAL DEL SISTEMA PROTEINA C/PROTEINA S DE LA COAGULACION EN UNA PRUEBA DE UN LIQUIDO BIOLOGICO, QUE INCLUYE LOS SIGUIENTES PASOS: A) ADICION DE UN ACTIVADOR DE LA PROTEINA C A LA MUESTRA DILUIDA O NO DILUIDA; B) ADICION OPTIMA DE UN ACTIVADOR DE FASE DE CONTACTO; C) INCUBACION DE LA APLICACION DE REACCION; D) COMIENZO DEL DESARROLLO DE COAGULACION MEDIANTE ADICION DE IONES DE CALCIO Y/O OTROS AGENTES DE DISPARO DE COAGULACION Y E) DETERMINACION DE LA ACTIVIDAD DE COAGULACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4427785A DE4427785A1 (de) | 1994-08-08 | 1994-08-08 | Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2179081T3 true ES2179081T3 (es) | 2003-01-16 |
Family
ID=6525023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95111554T Expired - Lifetime ES2179081T3 (es) | 1994-08-08 | 1995-07-22 | Procedimiento para la deteccion de perturbaciones del sistema de proteina c/proteina s. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5726028A (es) |
EP (1) | EP0696642B1 (es) |
JP (1) | JP3533012B2 (es) |
KR (1) | KR960007789A (es) |
AT (1) | ATE220112T1 (es) |
AU (1) | AU694931B2 (es) |
CA (1) | CA2155503C (es) |
DE (2) | DE4427785A1 (es) |
DK (1) | DK0696642T3 (es) |
ES (1) | ES2179081T3 (es) |
PT (1) | PT696642E (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ261190A (en) * | 1993-01-29 | 1997-12-19 | Bjorn Dahlback | Assaying for functional activity of a blood coagulation component involved in the protein c anticoagulant system (protein c, activated protein c, protein s or anticoagulant factor v) |
ATE198772T1 (de) * | 1994-11-10 | 2001-02-15 | Dade Behring Marburg Gmbh | Verfahren zum spezifischen nachweis eines aktivierten gerinnungsfaktors v mit einer erhöhten stabilität gegenüber aktiviertem protein c |
EP0718628B2 (en) † | 1994-12-23 | 2005-02-23 | Diagnostic Reagents Limited | Method for diagnosis of blood coagulation disorders |
US5780255A (en) * | 1995-06-09 | 1998-07-14 | Instrumentation Laboratory, S.P.A. | Protein C pathway screening test |
US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
WO1998049562A1 (de) * | 1997-04-25 | 1998-11-05 | Pentapharm Ag | Verfahren zum funktionellen nachweis von störungen im protein c-system |
DE19734648A1 (de) * | 1997-08-11 | 1999-02-18 | Dade Behring Marburg Gmbh | Verwendung von Annexinen als Lupus Antikoagulans Kontrolle oder Standard in Gerinnungstesten |
DE19749197A1 (de) * | 1997-11-07 | 1999-05-12 | Dade Behring Marburg Gmbh | Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe |
AUPP159698A0 (en) * | 1998-02-02 | 1998-02-26 | Life Therapeutics Limited | Improved blood coagulation test |
US6576478B1 (en) * | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
JP2003524187A (ja) * | 2000-02-23 | 2003-08-12 | ベッスト−テスト アンパーツゼルスカブ | 体液、例えば尿におけるマーカーと血液凝固活性とを相互関連づけるための方法 |
US6743596B1 (en) | 2000-10-27 | 2004-06-01 | Biomerieux, Inc. | Method of determining global coagulability hemostatic potential |
US6645768B1 (en) * | 2000-10-27 | 2003-11-11 | Biomerieux, Inc. | Reagent and kit for determining global coagulability and hemostatic potential |
CA2432118C (en) * | 2000-12-19 | 2008-12-09 | Instrumentation Laboratory Company | Protein s functional assay |
US6855509B2 (en) | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
JP2009198506A (ja) * | 2009-04-10 | 2009-09-03 | Shino Test Corp | 血液凝固反応抑制血漿タンパク質の活性測定方法及び活性測定試薬 |
WO2014020183A1 (de) | 2012-08-03 | 2014-02-06 | Ici Immunochemical Intelligence Gmbh | In-vitro-assay zur diagnose von störungen der hämostase |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0182929A1 (de) * | 1984-11-26 | 1986-06-04 | American Hospital Supply Corporation | Koaktivator zur Aktivierung von Protein C |
US4849403A (en) * | 1985-05-29 | 1989-07-18 | Pentapharm Ag | Protein C activator, methods of preparation and use thereof |
DE3607559A1 (de) * | 1986-03-07 | 1987-09-10 | Boehringer Mannheim Gmbh | Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet |
IT1230744B (it) * | 1989-07-07 | 1991-10-29 | Instrumentation Lab Spa | Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano. |
SE464135B (sv) * | 1989-07-14 | 1991-03-11 | Kabivitrum Ab | Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov |
US5308756A (en) * | 1991-11-20 | 1994-05-03 | Baxter Diagnostics Inc. | Protein S chromogenic assay |
-
1994
- 1994-08-08 DE DE4427785A patent/DE4427785A1/de not_active Ceased
-
1995
- 1995-07-22 DE DE59510255T patent/DE59510255D1/de not_active Expired - Lifetime
- 1995-07-22 DK DK95111554T patent/DK0696642T3/da active
- 1995-07-22 ES ES95111554T patent/ES2179081T3/es not_active Expired - Lifetime
- 1995-07-22 PT PT95111554T patent/PT696642E/pt unknown
- 1995-07-22 EP EP95111554A patent/EP0696642B1/de not_active Expired - Lifetime
- 1995-07-22 AT AT95111554T patent/ATE220112T1/de active
- 1995-08-04 US US08/511,248 patent/US5726028A/en not_active Expired - Lifetime
- 1995-08-04 CA CA002155503A patent/CA2155503C/en not_active Expired - Lifetime
- 1995-08-07 AU AU28416/95A patent/AU694931B2/en not_active Ceased
- 1995-08-07 KR KR1019950024271A patent/KR960007789A/ko not_active Application Discontinuation
- 1995-08-07 JP JP20078395A patent/JP3533012B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE4427785A1 (de) | 1996-02-15 |
JP3533012B2 (ja) | 2004-05-31 |
ATE220112T1 (de) | 2002-07-15 |
CA2155503C (en) | 2008-10-14 |
AU694931B2 (en) | 1998-08-06 |
PT696642E (pt) | 2002-11-29 |
EP0696642A1 (de) | 1996-02-14 |
CA2155503A1 (en) | 1996-02-09 |
KR960007789A (ko) | 1996-03-22 |
DE59510255D1 (de) | 2002-08-08 |
JPH0889293A (ja) | 1996-04-09 |
DK0696642T3 (da) | 2002-10-28 |
EP0696642B1 (de) | 2002-07-03 |
US5726028A (en) | 1998-03-10 |
AU2841695A (en) | 1996-02-22 |
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