ES2060578T3 - Sintesis de compuestos tipo podofilotoxina. - Google Patents

Sintesis de compuestos tipo podofilotoxina.

Info

Publication number
ES2060578T3
ES2060578T3 ES86117433T ES86117433T ES2060578T3 ES 2060578 T3 ES2060578 T3 ES 2060578T3 ES 86117433 T ES86117433 T ES 86117433T ES 86117433 T ES86117433 T ES 86117433T ES 2060578 T3 ES2060578 T3 ES 2060578T3
Authority
ES
Spain
Prior art keywords
podofilotoxina
synthesis
compounds type
compounds
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86117433T
Other languages
English (en)
Inventor
Abraham Nudelman
Jaacov Herzig
Ehud Keinan
Ben Zion Weiner
J Sterling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Bar Ilan University
Yeda Research and Development Co Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Bar Ilan University
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Bar Ilan University, Yeda Research and Development Co Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of ES2060578T3 publication Critical patent/ES2060578T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

HAY PREVISTO UN NUEVO PROCESO PARA LA PRODUCCION DE EPIPODOFILOTOXINA GLICOSIDO, ELOPOIDE Y TERNIPOSIDA. HAY ADEMAS PROVISTO DERIVADOS 4'' DIMETIL - EPIPO PLILOTOXINA DE LA FORMULA (I) DONDE W ES HIDROGENO O 2,3-DI-O-ACETIL-4,6,0-ETILIDEN-D-GLUCOPIRANO-1-YL. ESTOS INTERMEDIOS SON FACILMENTE TRANSFORMADOS EN ETOPOSIDO Y TENIPOSIDO Y ADEMAS EN DERIVADOS DE ESTA SERIE.
ES86117433T 1985-12-16 1986-12-15 Sintesis de compuestos tipo podofilotoxina. Expired - Lifetime ES2060578T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL77334A IL77334A (en) 1985-12-16 1985-12-16 Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Publications (1)

Publication Number Publication Date
ES2060578T3 true ES2060578T3 (es) 1994-12-01

Family

ID=11056474

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86117433T Expired - Lifetime ES2060578T3 (es) 1985-12-16 1986-12-15 Sintesis de compuestos tipo podofilotoxina.

Country Status (8)

Country Link
US (1) US4900814A (es)
EP (1) EP0226202B1 (es)
JP (2) JP2546659B2 (es)
AU (1) AU599618B2 (es)
DE (1) DE3689304T2 (es)
ES (1) ES2060578T3 (es)
IL (1) IL77334A (es)
ZA (1) ZA869317B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US4935504A (en) * 1987-12-18 1990-06-19 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-acyl derivatives
ZA886810B (en) * 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
US5061791A (en) * 1988-12-21 1991-10-29 Warner-Lambert Company 4-bromo-4'-demethylepipodophyllotoxin derivatives
EP0366122A3 (en) * 1988-10-26 1991-03-20 Warner-Lambert Company Demethylepipodophyllotoxin derivatives
DE3913326A1 (de) * 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
FR2655047A1 (fr) * 1989-11-24 1991-05-31 Pf Medicament Derives d'etoposide, leur preparation et leur application comme intermediaires de synthese.
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5463040A (en) * 1994-06-28 1995-10-31 Teva Pharmaceutical Industries, Ltd. Method of preparing etoposide
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
AU2011274229A1 (en) 2010-07-02 2013-01-10 Angiochem Inc. Short and D-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
CN112079879B (zh) * 2020-08-21 2022-01-14 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法
CN115141208B (zh) * 2022-08-05 2024-03-08 贵州大学 一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
AU559498B2 (en) * 1982-02-10 1987-03-12 Nippon Kayaku Kabushiki Kaisha Production of 4:-demethyl-epipodophyllotoxin-beta-d- ethylidene-glucoside, and derivatives
JPS59212500A (ja) * 1983-05-18 1984-12-01 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法
JPS5998098A (ja) * 1982-11-26 1984-06-06 Nippon Kayaku Co Ltd ４′―デメチル―エピポドフィロトキシン―β―Ｄ―エチリデングルコシドの新規製造法
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS6032799A (ja) * 1983-07-29 1985-02-19 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフィロトキシン誘導体
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4609644A (en) * 1984-06-15 1986-09-02 St. Jude Children's Research Hospital Epipodophyllotoxinquinone glucoside derivatives, method of production and use
JPH06156193A (ja) * 1992-11-30 1994-06-03 Alpha Corp 車両用イグニッションロック装置

Also Published As

Publication number Publication date
JPS62181292A (ja) 1987-08-08
EP0226202A3 (en) 1989-04-05
US4900814A (en) 1990-02-13
AU599618B2 (en) 1990-07-26
ZA869317B (en) 1988-07-27
JP2546659B2 (ja) 1996-10-23
EP0226202A2 (en) 1987-06-24
AU6645786A (en) 1987-06-18
DE3689304T2 (de) 1994-05-19
JPH09151187A (ja) 1997-06-10
EP0226202B1 (en) 1993-11-18
IL77334A (en) 1991-04-15
DE3689304D1 (de) 1993-12-23

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