DE3689304D1 - Synthese von Verbindungen vom Podophylotoxintyp. - Google Patents

Synthese von Verbindungen vom Podophylotoxintyp.

Info

Publication number
DE3689304D1
DE3689304D1 DE86117433T DE3689304T DE3689304D1 DE 3689304 D1 DE3689304 D1 DE 3689304D1 DE 86117433 T DE86117433 T DE 86117433T DE 3689304 T DE3689304 T DE 3689304T DE 3689304 D1 DE3689304 D1 DE 3689304D1
Authority
DE
Germany
Prior art keywords
podophylotoxin
synthesis
type compounds
compounds
type
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE86117433T
Other languages
English (en)
Other versions
DE3689304T2 (de
Inventor
Abraham Nudelman
Jaacov Herzig
Ehud Keinan
Ben Zion Weiner
J Sterling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Bar Ilan University
Yeda Research and Development Co Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Bar Ilan University
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd, Bar Ilan University, Yeda Research and Development Co Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of DE3689304D1 publication Critical patent/DE3689304D1/de
Application granted granted Critical
Publication of DE3689304T2 publication Critical patent/DE3689304T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE3689304T 1985-12-16 1986-12-15 Synthese von Verbindungen vom Podophylotoxintyp. Expired - Fee Related DE3689304T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL77334A IL77334A (en) 1985-12-16 1985-12-16 Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Publications (2)

Publication Number Publication Date
DE3689304D1 true DE3689304D1 (de) 1993-12-23
DE3689304T2 DE3689304T2 (de) 1994-05-19

Family

ID=11056474

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3689304T Expired - Fee Related DE3689304T2 (de) 1985-12-16 1986-12-15 Synthese von Verbindungen vom Podophylotoxintyp.

Country Status (8)

Country Link
US (1) US4900814A (de)
EP (1) EP0226202B1 (de)
JP (2) JP2546659B2 (de)
AU (1) AU599618B2 (de)
DE (1) DE3689304T2 (de)
ES (1) ES2060578T3 (de)
IL (1) IL77334A (de)
ZA (1) ZA869317B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
US4935504A (en) * 1987-12-18 1990-06-19 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-acyl derivatives
ZA886810B (en) * 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
EP0366122A3 (de) * 1988-10-26 1991-03-20 Warner-Lambert Company Demethylepipodophyllotoxin Derivate
US5061791A (en) * 1988-12-21 1991-10-29 Warner-Lambert Company 4-bromo-4'-demethylepipodophyllotoxin derivatives
DE3913326A1 (de) * 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
FR2655047A1 (fr) * 1989-11-24 1991-05-31 Pf Medicament Derives d'etoposide, leur preparation et leur application comme intermediaires de synthese.
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5463040A (en) * 1994-06-28 1995-10-31 Teva Pharmaceutical Industries, Ltd. Method of preparing etoposide
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
CN112079879B (zh) * 2020-08-21 2022-01-14 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法
CN115141208B (zh) * 2022-08-05 2024-03-08 贵州大学 一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
AU559498B2 (en) * 1982-02-10 1987-03-12 Nippon Kayaku Kabushiki Kaisha Production of 4:-demethyl-epipodophyllotoxin-beta-d- ethylidene-glucoside, and derivatives
JPS59212500A (ja) * 1983-05-18 1984-12-01 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS5998098A (ja) * 1982-11-26 1984-06-06 Nippon Kayaku Co Ltd ４′―デメチル―エピポドフィロトキシン―β―Ｄ―エチリデングルコシドの新規製造法
JPS6032799A (ja) * 1983-07-29 1985-02-19 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフィロトキシン誘導体
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4609644A (en) * 1984-06-15 1986-09-02 St. Jude Children's Research Hospital Epipodophyllotoxinquinone glucoside derivatives, method of production and use
JPH06156193A (ja) * 1992-11-30 1994-06-03 Alpha Corp 車両用イグニッションロック装置

Also Published As

Publication number Publication date
ES2060578T3 (es) 1994-12-01
JPS62181292A (ja) 1987-08-08
JPH09151187A (ja) 1997-06-10
JP2546659B2 (ja) 1996-10-23
EP0226202A3 (en) 1989-04-05
IL77334A (en) 1991-04-15
EP0226202A2 (de) 1987-06-24
ZA869317B (en) 1988-07-27
US4900814A (en) 1990-02-13
EP0226202B1 (de) 1993-11-18
AU599618B2 (en) 1990-07-26
AU6645786A (en) 1987-06-18
DE3689304T2 (de) 1994-05-19

Similar Documents

Publication Publication Date Title
DE3689304D1 (de) Synthese von Verbindungen vom Podophylotoxintyp.
DE68923255D1 (de) Synthese von Methylaluminoxanen.
DE3675422D1 (de) Lipoxygenasehemmende verbindungen.
ATE123037T1 (de) Synthese von carbonylverbindungen.
DE3485403D1 (de) Asymmetrische synthese von alpha-substituierten alpha-cyanomethylalkoholen.
DE3670951D1 (de) Di-t-butylphenol-verbindungen.
DE3675421D1 (de) Lypoxygenasehemmende verbindungen.
DE3672236D1 (de) Synthese von zeolithen.
DE3877505D1 (de) Isomerisierungsverfahren der nebenprodukte in der bisphenolsynthese.
DE3575072D1 (de) Pharmazeutische zusammensetzungen von mikrobenerzeugtem interleukin-2.
DE3772294D1 (de) Ammoniaksynthesekonverter.
DE3772176D1 (de) Synthese von aromatischen bis(etherphthalimid)-verbindungen.
DE69223684D1 (de) Synthese von Squaryliumverbindungen
DE3586114D1 (de) Synthese von ammoniak.
DE3771893D1 (de) Ammoniak-synthese.
IT8522425A0 (it) Procedimento di sintesi dell'amikacina.
DE3576336D1 (de) Synthese von molybdaen-alkylenglycol-komplexen verwendbar als epoxydationskatalysatoren.
DE69226706D1 (de) Synthese von smektit-tonmineralen
DE3482556D1 (de) Synthese von silicophosphoaluminaten.
DE3785275D1 (de) Prodrogen von antihypercholesterolemischen verbindungen.
KR870700571A (ko) 온도 조절 암모니아 합성방법
DE3688407D1 (de) Covulkanisierbare zusammensetzungen von fluorelastomeren.
DE3871672D1 (de) Fluessig-phase-isomerisierung von jodaromatischen verbindungen.
DE3782702D1 (de) Vorlaeufer von antihypercholesterinaemischen verbindungen.
ES2023930B3 (es) Sintesis de ditioles.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee