IL77334A - Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor - Google Patents

Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Info

Publication number
IL77334A
IL77334A IL77334A IL7733485A IL77334A IL 77334 A IL77334 A IL 77334A IL 77334 A IL77334 A IL 77334A IL 7733485 A IL7733485 A IL 7733485A IL 77334 A IL77334 A IL 77334A
Authority
IL
Israel
Prior art keywords
synthesis
novel intermediates
intermediates therefor
glucoside derivatives
epipodophyllotoxin glucoside
Prior art date
Application number
IL77334A
Other languages
English (en)
Inventor
Sterling Jeffrey
Weiner Ben-Zion
Nudelman Abraham
Herzig Yaakob
Keinan Ehud
Original Assignee
Univ Bar Ilan
Teva Pharma
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bar Ilan, Teva Pharma, Yeda Res & Dev filed Critical Univ Bar Ilan
Priority to IL77334A priority Critical patent/IL77334A/xx
Priority to ZA869317A priority patent/ZA869317B/xx
Priority to AU66457/86A priority patent/AU599618B2/en
Priority to US06/943,203 priority patent/US4900814A/en
Priority to ES86117433T priority patent/ES2060578T3/es
Priority to JP61298614A priority patent/JP2546659B2/ja
Priority to EP86117433A priority patent/EP0226202B1/de
Priority to DE3689304T priority patent/DE3689304T2/de
Publication of IL77334A publication Critical patent/IL77334A/xx
Priority to JP6334686A priority patent/JPH09151187A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL77334A 1985-12-16 1985-12-16 Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor IL77334A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IL77334A IL77334A (en) 1985-12-16 1985-12-16 Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
ZA869317A ZA869317B (en) 1985-12-16 1986-12-10 Synthesis of podophylotoxin type compounds
AU66457/86A AU599618B2 (en) 1985-12-16 1986-12-12 Synthesis of podophylotoxin type compounds
US06/943,203 US4900814A (en) 1985-12-16 1986-12-15 Synthesis of podophyllotoxin derivatives
ES86117433T ES2060578T3 (es) 1985-12-16 1986-12-15 Sintesis de compuestos tipo podofilotoxina.
JP61298614A JP2546659B2 (ja) 1985-12-16 1986-12-15 ポドフイロトキシン型化合物の製造方法
EP86117433A EP0226202B1 (de) 1985-12-16 1986-12-15 Synthese von Verbindungen vom Podophylotoxintyp
DE3689304T DE3689304T2 (de) 1985-12-16 1986-12-15 Synthese von Verbindungen vom Podophylotoxintyp.
JP6334686A JPH09151187A (ja) 1985-12-16 1994-12-20 ４′−デメチルエピポドフィロトキシン誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL77334A IL77334A (en) 1985-12-16 1985-12-16 Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Publications (1)

Publication Number Publication Date
IL77334A true IL77334A (en) 1991-04-15

Family

ID=11056474

Family Applications (1)

Application Number Title Priority Date Filing Date
IL77334A IL77334A (en) 1985-12-16 1985-12-16 Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor

Country Status (8)

Country Link
US (1) US4900814A (de)
EP (1) EP0226202B1 (de)
JP (2) JP2546659B2 (de)
AU (1) AU599618B2 (de)
DE (1) DE3689304T2 (de)
ES (1) ES2060578T3 (de)
IL (1) IL77334A (de)
ZA (1) ZA869317B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
ZA886812B (en) * 1987-11-23 1989-07-26 Bristol Myers Co Anti-tumor prodrugs
ZA886810B (en) * 1987-12-18 1989-08-30 Bristol Myers Co Epipodophyllotoxin glucoside 4'-acyl derivatives
US4935504A (en) * 1987-12-18 1990-06-19 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-acyl derivatives
US4912204A (en) * 1988-09-06 1990-03-27 Bristol-Myers Company Fluoro-substituted epipodophyllotoxin glucosides
US5061791A (en) * 1988-12-21 1991-10-29 Warner-Lambert Company 4-bromo-4'-demethylepipodophyllotoxin derivatives
EP0366122A3 (de) * 1988-10-26 1991-03-20 Warner-Lambert Company Demethylepipodophyllotoxin Derivate
DE3913326A1 (de) * 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
FR2655047A1 (fr) * 1989-11-24 1991-05-31 Pf Medicament Derives d'etoposide, leur preparation et leur application comme intermediaires de synthese.
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5463040A (en) * 1994-06-28 1995-10-31 Teva Pharmaceutical Industries, Ltd. Method of preparing etoposide
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20090130017A1 (en) * 2007-11-19 2009-05-21 Searete Llc Targeted short-lived drug delivery
CA2803646A1 (en) 2010-07-02 2012-01-05 Angiochem Inc. Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
CN112079879B (zh) * 2020-08-21 2022-01-14 华润双鹤药业股份有限公司沧州分公司 一种替尼泊苷中间体的合成新方法及替尼泊苷的合成方法
CN115141208B (zh) * 2022-08-05 2024-03-08 贵州大学 一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
AU559498B2 (en) * 1982-02-10 1987-03-12 Nippon Kayaku Kabushiki Kaisha Production of 4:-demethyl-epipodophyllotoxin-beta-d- ethylidene-glucoside, and derivatives
JPS59212500A (ja) * 1983-05-18 1984-12-01 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS5998098A (ja) * 1982-11-26 1984-06-06 Nippon Kayaku Co Ltd ４′―デメチル―エピポドフィロトキシン―β―Ｄ―エチリデングルコシドの新規製造法
JPS6032799A (ja) * 1983-07-29 1985-02-19 Microbial Chem Res Found 新規４′−デメチル−４−エピポドフィロトキシン誘導体
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4609644A (en) * 1984-06-15 1986-09-02 St. Jude Children's Research Hospital Epipodophyllotoxinquinone glucoside derivatives, method of production and use
JPH06156193A (ja) * 1992-11-30 1994-06-03 Alpha Corp 車両用イグニッションロック装置

Also Published As

Publication number Publication date
JPH09151187A (ja) 1997-06-10
US4900814A (en) 1990-02-13
DE3689304T2 (de) 1994-05-19
JP2546659B2 (ja) 1996-10-23
ES2060578T3 (es) 1994-12-01
EP0226202A3 (en) 1989-04-05
ZA869317B (en) 1988-07-27
EP0226202A2 (de) 1987-06-24
EP0226202B1 (de) 1993-11-18
JPS62181292A (ja) 1987-08-08
AU6645786A (en) 1987-06-18
DE3689304D1 (de) 1993-12-23
AU599618B2 (en) 1990-07-26

Similar Documents

Publication Publication Date Title
IL77334A (en) Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
ZA889659B (en) Synthesis of 1,2-dioxetanes and intermediates therefor
GB2157687B (en) Synthesis of urea
EP0331524A3 (en) Synthesis of trichostatins
GB8619931D0 (en) Production of synthesis gas
EP0196078A3 (en) Synthesis of improved zeolites
ZA868714B (en) Synthesis of optically active aryloxypropanolamines and arylethanolamines
GB8804372D0 (en) Synthesis of dihydroqinghaosu derivatives
ZA868713B (en) Synthesis of aryloxypropanolamines and arylethanolamines
IL86787A0 (en) Novel synthesis of 3-amino-2-methylbenzotrifluoride
RU1819255C (en) Method of isobutylene synthesis
NZ215815A (en) Preparation of azetidine derivatives; and intermediates therein
IL74630A (en) Preparation of 2-oxindole-1-carboxamides and n-chlorosulfonyl-2-oxindole-1-carboxamide intermediates therefor
GB2179056B (en) Production of synthesis gas
EG17986A (en) Synthesis of tricyclazole
GB8628049D0 (en) Use of tetrahydrobenzothienylurea derivatives
NZ214836A (en) Preparation of 4,4-dialkyl-2-azetidinone derivatives and intermediates
IL71812A0 (en) Synthesis of(+)-4-demethoxydaunomycinone and intermediates therefor
ZA869438B (en) Synthesis of nizatidine
JPS6490139A (en) Synthesis of cis-9-tricocene
GB8416903D0 (en) Synthesis of clavulone derivatives
GB8508301D0 (en) Synthesis of brassinolide
ZA856353B (en) Synthesis of silicophosphoaluminates
EP0217272A3 (en) Preparation of terpinen-4-ols and intermediates
GB8515687D0 (en) Asymmetric synthesis of azetidinone derivatives

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed