ES2060180T3 - Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico. - Google Patents

Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico.

Info

Publication number
ES2060180T3
ES2060180T3 ES90909482T ES90909482T ES2060180T3 ES 2060180 T3 ES2060180 T3 ES 2060180T3 ES 90909482 T ES90909482 T ES 90909482T ES 90909482 T ES90909482 T ES 90909482T ES 2060180 T3 ES2060180 T3 ES 2060180T3
Authority
ES
Spain
Prior art keywords
acid
threo
propionico
metoxifenilo
aminofenilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909482T
Other languages
English (en)
Inventor
Elemer Fogassy
Maria Acs
Tibor Gizur
Kalman Harsanyi
Tischler Zsuzsanna Aracsne
Katalin Berki
Laszlo Toke
Jaszay Zsuzsa Martonffyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU333689A external-priority patent/HU204774B/hu
Priority claimed from HU333589A external-priority patent/HU205896B/hu
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of ES2060180T3 publication Critical patent/ES2060180T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA RESOLUCION DE UN ACIDO MEZCLA (EN ADELANTE: TRIACIDO MEZCLA) QUE CONTIENE ACIDO (+) -TRIO-3-[(2-AMINOFENIL) TIO] -2-HIDROXI-3-(4-METOXIFENIL) PROPIONICO [EN ADELANTE: ACIDO (+) -TRIO] Y ACIDO (-) -TRIO-3-[(2-AMINOFENIL) TIO] -2-HIDROXI-3(4-METOXIFENIL) PROPIONICO [EN ADELANTE: ACIDO (-) -TRIO]. EL PROCESO PARA LA INVENCION COMPRENDE A) I) PREPARANDO UNA SOLUCION QUE CONTENGA (-) -FENILGLICINAMIDA [EN ADELANTE: (-) -PGA] PARTIENDO DE UNA MEZCLA QUE CONTIENE L-(+) -FENILGLICINAMIDA [EN ADELANTE: (+) -PGA] Y (-) -PGA Y MEDIANTE EL ACIDO (-) -TRIO COMO AGENTE DE RESOLUCION Y UTILIZANDO LA SOLUCION OBTENIDA COMO AGENTE DE RESOLUCION PARA LA RESOLUCION DE LA MEZCLA DEL ACIDO (-) -TRIO; O II) UTILIZANDO UNA SAL CON ADICION DE ACIDO DE (-) -PGA EN UN SOLIDO O EN UNA FORMA DISUELTA COMO AGENTE DE RESOLUCION PARA OBTENER ACIDO (-) TRIO; B) I) PREPARANDO UNA SOLUCION QUE CONTENGA (+) -FENILGLICINAMIDA [EN ADELANTE:(+) -PGA] DE UNA MEZCLA DE QUE CONTENGA (+) -PGA Y (-) -FENILGLICINAMIDA [EN ADELANTE: (-) -PGA ] MEDIANTE EL ACIDO (+) -TRIO COMO AGENTE DE RESOLUCION Y UTILIZANDO LA SOLUCION OBTENIDA COMO AGENTE DE RESOLUCION DE LA MEZCLA DEL ACIDO TRIO; O II) UTILIZANDO UNA SAL CON ADICION DE ACIDO DE (+) -PGA EN UN SOLIDO O FORMA DISUELTA COMO AGENTE DE RESOLUCION PARA OBTENER ACIDO (+) -TRIO.
ES90909482T 1989-06-30 1990-06-29 Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico. Expired - Lifetime ES2060180T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU333689A HU204774B (en) 1989-06-30 1989-06-30 Process for resolving alpha-phenylglycineamide
HU333589A HU205896B (en) 1989-06-30 1989-06-30 Process for resolving treo-3-//2-amino-phenyl/-thio/-2-hydroxy-3-/4-methoxy-phenyl/-propionic acid

Publications (1)

Publication Number Publication Date
ES2060180T3 true ES2060180T3 (es) 1994-11-16

Family

ID=26317626

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909482T Expired - Lifetime ES2060180T3 (es) 1989-06-30 1990-06-29 Procedimiento de separacion del acido treo-3-((2-aminofenilo)-tio)-2-hidroxi-3-(4-metoxifenilo) propionico.

Country Status (10)

Country Link
US (1) US5292933A (es)
EP (1) EP0431121B1 (es)
JP (1) JPH04500528A (es)
AT (1) ATE93516T1 (es)
DE (1) DE69002924T2 (es)
DK (1) DK0431121T3 (es)
ES (1) ES2060180T3 (es)
IE (1) IE62410B1 (es)
IL (1) IL94914A (es)
WO (1) WO1991000270A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
BR112021018733A2 (pt) * 2019-03-22 2022-03-15 Tyme Inc Composições de d-metirosina e métodos para preparar as mesmas
EA202193111A1 (ru) 2019-05-14 2022-02-10 Тайм, Инк. Композиции и способы для лечения рака
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
EP4175938A1 (en) * 2020-07-01 2023-05-10 Tyme, Inc. Crystalline forms of metyrosine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7413843A (nl) * 1974-10-23 1976-04-27 Stamicarbon Optische scheiding van fenylglycine-amide.
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
EP0320532A1 (en) * 1986-07-15 1989-06-21 Nihon Iyakuhin Kogyo Co., Ltd. Novel optically active carboxylic acid derivative l-lysine salt and process for production thereof
IT1217988B (it) * 1988-01-28 1990-03-30 Ind Chimica Profarmaco Spa Procedimento per la risoluzione ottica di un pacemo
FR2630107B1 (fr) * 1988-04-19 1990-06-08 Synthelabo Procede de preparation du (+) - (2s,3s) (amino-2 phenyl)thio)-3 hydroxy-2 (methoxy-4 phenyl)-3 propionate de methyle
US5008433A (en) * 1988-05-18 1991-04-16 Marion Laboratories, Inc. 2-hydroxy-3-(4-methoxyphenyl)-3-(2-aminophenylthio)propionic acid, 8'-phenylmenthyl ester, especially for diltiazem
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus

Also Published As

Publication number Publication date
US5292933A (en) 1994-03-08
EP0431121B1 (en) 1993-08-25
IL94914A0 (en) 1991-04-15
DK0431121T3 (da) 1993-10-11
IE62410B1 (en) 1995-01-25
DE69002924D1 (en) 1993-09-30
ATE93516T1 (de) 1993-09-15
IE902360A1 (en) 1991-06-19
JPH04500528A (ja) 1992-01-30
WO1991000270A1 (en) 1991-01-10
EP0431121A1 (en) 1991-06-12
IL94914A (en) 1994-07-31
DE69002924T2 (de) 1993-12-23
IE902360L (en) 1990-12-30

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