ES2060014T3 - Composiciones y metodo para el tratamiento de ciertas enfermedades. - Google Patents
Composiciones y metodo para el tratamiento de ciertas enfermedades.Info
- Publication number
- ES2060014T3 ES2060014T3 ES90300855T ES90300855T ES2060014T3 ES 2060014 T3 ES2060014 T3 ES 2060014T3 ES 90300855 T ES90300855 T ES 90300855T ES 90300855 T ES90300855 T ES 90300855T ES 2060014 T3 ES2060014 T3 ES 2060014T3
- Authority
- ES
- Spain
- Prior art keywords
- compositions
- certain diseases
- treatment
- arylpropionic
- implicated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPOSICIONES SINERGISTICAS QUE CONSTAN DE UN ANTIOXIDANTE Y DE UN FARMACO ANTIINFLAMATORIO ARILPROPIONICO NO ESTEROIDAL UTILIZADO EN EL TRATAMIENTO DE CIERTAS ENFERMEDADES. LAS COMPOSICIONES INHIBEN LA PRODUCCION DE PRODUCTOS FINALES CON CASCADAS DE ACIDO ARAQUIDONICO QUE HAYAN SIDO CAUSA DE DESTRUCCION DE TEJIDOS EN ENFERMEDADES PERIODONTOLOGICAS. LAS COMPOSICIONES SE ADMINISTRAN EN COMBINACION CON UN SOPORTE, QUE PUEDE SER UN POLIMERO MUCOSO-ADHESIVO SELECCIONADO DE GRUPOS DE PASTAS SEMISOLIDAS, GELES, POMADAS, LIQUIDOS O PELICULAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/302,210 US5032384A (en) | 1989-01-27 | 1989-01-27 | Compositions and method for the treatment of disease |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2060014T3 true ES2060014T3 (es) | 1994-11-16 |
Family
ID=23166770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90300855T Expired - Lifetime ES2060014T3 (es) | 1989-01-27 | 1990-01-26 | Composiciones y metodo para el tratamiento de ciertas enfermedades. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5032384A (es) |
EP (1) | EP0380367B1 (es) |
JP (1) | JP2764451B2 (es) |
AT (1) | ATE97805T1 (es) |
AU (1) | AU622756B2 (es) |
CA (1) | CA2008739C (es) |
DE (1) | DE69004817T2 (es) |
DK (1) | DK0380367T3 (es) |
ES (1) | ES2060014T3 (es) |
NZ (1) | NZ232250A (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
US5188817A (en) * | 1989-03-27 | 1993-02-23 | Julius Ozick | Method of treatment for periodontitis |
JPH02258718A (ja) * | 1989-03-31 | 1990-10-19 | Nippon Kayaku Co Ltd | ペースト状基剤及び製剤 |
CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
AU661818B2 (en) * | 1990-03-16 | 1995-08-10 | Procter & Gamble Company, The | Use of ketorolac for treatment of periodontal disease |
US5464609A (en) * | 1990-03-16 | 1995-11-07 | The Procter & Gamble Company | Use of ketorolac for treatment of oral diseases and conditions |
CA2061477A1 (en) * | 1991-03-25 | 1992-09-26 | Lawrence J. Daher | Analgesic composition containing beta-carotene |
US5605930A (en) * | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
AU670094B2 (en) * | 1992-04-23 | 1996-07-04 | Berlex Laboratories, Inc. | Bioadhesive solid mineral oil emulsion |
US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
FR2698788B1 (fr) * | 1992-12-09 | 1995-03-03 | Union Pharma Scient Appl | Composition pharmaceutique effervescente contenant de l'ibuprofène et son procédé de préparation. |
WO1994024990A1 (en) * | 1993-04-27 | 1994-11-10 | Sunstar Inc. | Intraoral composition |
FR2710265B1 (fr) * | 1993-09-22 | 1995-10-20 | Adir | Composition pharmaceutique bioadhésive pour la libération contrôlée de principes actifs. |
US5897858A (en) * | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
US5462728A (en) * | 1994-04-05 | 1995-10-31 | Blank; Izhak | Pharmaceutical compositions |
EP0708646A1 (en) * | 1994-05-06 | 1996-05-01 | Alcon Laboratories, Inc. | Use of vitamin e tocopheryl derivatives in ophthalmic compositions |
US5811453A (en) | 1994-12-23 | 1998-09-22 | Alcon Laboratories, Inc. | Viscoelastic compositions and methods of use |
US5643943A (en) * | 1994-12-23 | 1997-07-01 | Alcon Laboratories, Inc. | Systemic administration of esters and amides of antioxidants which may be used as antioxidant prodrug therapy for oxidative and inflammatory pathogenesis |
US5607966A (en) * | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
CA2195119C (en) | 1995-06-09 | 2001-09-11 | Mark Chasin | Formulations and methods for providing prolonged local anesthesia |
FR2742054B1 (fr) * | 1995-12-06 | 1998-01-09 | Synthelabo | Compositions pharmaceutiques contenant un agent anti-inflammatoire et des ceramides vegetales |
WO1997049391A1 (en) | 1996-06-24 | 1997-12-31 | Euro-Celtique, S.A. | Methods for providing safe local anesthesia |
US6046187A (en) * | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
US5827886A (en) * | 1997-05-07 | 1998-10-27 | Thione International, Inc. | Composition for relief of arthritis-induced symptoms |
EP1009390A4 (en) | 1997-07-02 | 2004-05-06 | Euro Celtique Sa | LONG-EFFECT ANESTHESIA INJECTED IN JOINT AND BODY SPACES |
US6138683A (en) * | 1997-09-19 | 2000-10-31 | Thione International, Inc. | Smokeless tobacco products containing antioxidants |
US6228347B1 (en) * | 1997-12-01 | 2001-05-08 | Thione International, Inc. | Antioxidant gel for gingival conditions |
US5922346A (en) * | 1997-12-01 | 1999-07-13 | Thione International, Inc. | Antioxidant preparation |
JP3763075B2 (ja) * | 1998-04-24 | 2006-04-05 | サンスター株式会社 | 歯周病の予防又は治療用の食品組成物、口腔用組成物及び医薬組成物 |
ITMI981586A1 (it) * | 1998-07-10 | 2000-01-10 | Giorgio Panin | Vitamina e e suoi esteri per l'uso nel trattamento topico di patologie delle mucose |
FR2781156B1 (fr) * | 1998-07-20 | 2001-06-29 | Lafon Labor | Composition pharmaceutique destinee notamment a la prevention et au traitement des radiomucites et des chimiomucites |
US6126967A (en) * | 1998-09-03 | 2000-10-03 | Ascent Pediatrics | Extended release acetaminophen particles |
US6254891B1 (en) | 1998-09-03 | 2001-07-03 | Ascent Pediatrics, Inc. | Extended release acetaminophen |
US6201028B1 (en) * | 1998-12-08 | 2001-03-13 | The Rockefeller University | Methods and compositions for prevention and treatment of atherosclerosis and hyperlipidemia with non-steroidal anti-inflammatory drugs |
US6200550B1 (en) | 1998-12-11 | 2001-03-13 | Q-Pharma, Inc. | Oral care compositions comprising coenzyme Q10 |
KR19990068298A (ko) * | 1999-03-12 | 1999-09-06 | 정명우 | 장미씨기름을함유하는치약조성물 |
US7592304B2 (en) * | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
US20030158111A1 (en) * | 1999-10-01 | 2003-08-21 | David Bar-Or | Methods and products for oral care |
US7632803B2 (en) | 1999-10-01 | 2009-12-15 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
JP4886107B2 (ja) * | 2000-10-13 | 2012-02-29 | サンスター株式会社 | 歯周病予防用口腔内溶解錠 |
EP1363602A4 (en) * | 2001-01-25 | 2006-01-11 | Euro Celtique Sa | LOCAL ANESTHESIA, AND METHOD OF USE |
JP4803889B2 (ja) * | 2001-03-01 | 2011-10-26 | 日本ゼトック株式会社 | 非水系練歯磨剤 |
FR2832630B1 (fr) * | 2001-11-28 | 2005-01-14 | Oreal | Composition cosmetique et/ou dermatologique contenant au moins un actif hydrophile sensible a l'oxydation stabilise par au moins un copolymere de n-vinylimidazole |
DE10163543A1 (de) * | 2001-12-21 | 2003-07-31 | Basf Ag | Tocopherol-haltige Superabsorber |
DE10224612A1 (de) * | 2002-06-04 | 2003-12-24 | Lohmann Therapie Syst Lts | Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung |
DE60302389T2 (de) * | 2002-06-20 | 2006-07-13 | L'oreal S.A. | Kosmetische und/oder dermatologische Verwendung einer Zusammensetzung, die mindestens einen oxidationsempfindlichen hydrophilen Wirkstoff enthält, der mit mindestens einem Copolymer von Maleinsäureanhydrid stabilisiert ist |
CA2499882C (en) * | 2002-09-28 | 2010-11-09 | Mcneil-Ppc, Inc. | Modified release dosage form with two cores |
JP4495901B2 (ja) * | 2002-10-02 | 2010-07-07 | 日本澱粉工業株式会社 | 口腔用剤用活性阻害剤 |
CN1980948B (zh) * | 2002-11-27 | 2011-08-10 | Dmi生物科学公司 | 治疗由增强磷酸化介导的疾病和病况 |
CA2523000A1 (en) * | 2003-05-07 | 2004-11-25 | Dmi Biosciences, Inc. | Oral care methods and products |
KR20060088543A (ko) * | 2003-09-25 | 2006-08-04 | 디엠아이 바이오사이언스 인코포레이티드 | 앤-아실-엘-아스파틱산을 이용하는 방법 및 제품 |
KR100564934B1 (ko) * | 2003-12-09 | 2006-03-30 | 학교법인 건국대학교 | 녹차로부터 추출한 폴리페놀을 함유한 가식성 필름의 제조방법 |
US8168161B2 (en) * | 2004-12-22 | 2012-05-01 | Hill's Pet Nutrition, Inc. | Method to promote oral health in companion animals |
PL1998762T3 (pl) * | 2006-03-16 | 2011-04-29 | Novartis Ag | Stałe postacie dawkowania zawierające składnik czynny o zamaskowanym smaku |
JP2009269851A (ja) * | 2008-05-07 | 2009-11-19 | Nikko Chemical Co Ltd | プロスタグランジンe2産生抑制剤及びその利用 |
US8956161B2 (en) | 2008-11-04 | 2015-02-17 | Duane C Keller | Article and method for controlling oral-originated systemic disease |
US8905760B2 (en) * | 2008-11-04 | 2014-12-09 | Duane C. Keller | Methods and systems for progressively treating and controlling oral periopathogens causing systemic inflammations |
TWI435733B (zh) * | 2010-01-29 | 2014-05-01 | Colgate Palmolive Co | 用於口臭控制之口腔保健調配物 |
US8591229B2 (en) | 2010-12-16 | 2013-11-26 | Duane C. Keller | Devices and methods for creating a positive pressure environment for treatment of oral biofilms associated with periodontal disease |
RU2763874C1 (ru) * | 2021-05-04 | 2022-01-11 | Светлана Николаевна Саблина | Способ лечения воспалительных заболеваний пародонта у женщин в мено- и постменопаузальном периодах |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411885A (en) * | 1980-09-30 | 1983-10-25 | Barels Ronald R | Vitamin E oil based dentifrice |
JPS57139013A (en) * | 1981-02-19 | 1982-08-27 | Eisai Co Ltd | Prophylactic or remedy for periodontosis |
AU556817B2 (en) * | 1982-02-03 | 1986-11-20 | Efamol Limited | Topical application of a lithium salt and dihomo-alpha- linolenic acid |
CH655656B (es) * | 1982-10-07 | 1986-05-15 | ||
JPS59122422A (ja) * | 1982-12-29 | 1984-07-14 | Toko Yakuhin Kogyo Kk | 口腔用消炎鎮痛ゲル剤 |
JPS59222406A (ja) * | 1983-06-01 | 1984-12-14 | Teijin Ltd | 歯周疾患治療用製剤及びその製造法 |
US4627850A (en) * | 1983-11-02 | 1986-12-09 | Alza Corporation | Osmotic capsule |
DE3346525A1 (de) * | 1983-12-22 | 1985-07-04 | A. Nattermann & Cie GmbH, 5000 Köln | Pharmazeutische zubereitung mit speziellen 1,2-diacyl-glycero-3-phosphocholinen zur behandlung von erkrankungen im magen-darmbereich |
JPH0647533B2 (ja) * | 1984-08-10 | 1994-06-22 | 裕 水島 | 4−ビフエニリル酢酸系化合物含有脂肪乳剤 |
DE3686275T2 (de) * | 1985-01-11 | 1993-03-18 | Teijin Ltd | Praeparate mit verzoegerter freisetzung. |
ATE46265T1 (de) * | 1985-01-23 | 1989-09-15 | Asta Pharma Ag | Synergistische kombination von flupirtin und nicht-steroidalen antiphlogistika. |
GB8507058D0 (en) * | 1985-03-19 | 1985-04-24 | Efamol Ltd | Pharmaceutical & dietary compositions |
US4772470A (en) * | 1985-04-27 | 1988-09-20 | Nitto Electric Industrial Co., Ltd. | Oral bandage and oral preparations |
EP0207638B1 (en) * | 1985-06-04 | 1990-12-19 | Teijin Limited | Sustained-release pharmaceutical preparation |
JPH0676314B2 (ja) * | 1985-09-30 | 1994-09-28 | 花王株式会社 | 坐剤基剤及び坐剤 |
JPS62223112A (ja) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 歯周病治療剤 |
JPS62223115A (ja) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 歯周病治療剤 |
US4946870A (en) * | 1986-06-06 | 1990-08-07 | Union Carbide Chemicals And Plastics Company Inc. | Delivery systems for pharmaceutical or therapeutic actives |
JPH0744940B2 (ja) * | 1986-12-24 | 1995-05-17 | ライオン株式会社 | 口腔貼付用基材 |
EP0279867A3 (de) * | 1987-01-12 | 1988-10-05 | EFEKA Friedrich & Kaufmann GmbH & Co KG | Verwendung von Vitamin-E und Vitamin-E-Kombination mit nichtsteroidalen Antirheumatika und Schmerzmittel zur Behandlung von rheumatischen Erkrankungen |
US4847071A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
US4847069A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent |
US4946671A (en) * | 1987-10-22 | 1990-08-07 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent |
US4847072A (en) * | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate |
US4954332A (en) * | 1987-10-22 | 1990-09-04 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
US4869897A (en) * | 1987-10-22 | 1989-09-26 | The Procter & Gamble Company | Photoprotection compositions comprising sorbohydroxamic acid |
US4939135A (en) * | 1988-10-03 | 1990-07-03 | Alcon Laboratories, Inc. | Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irradiation |
US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
-
1989
- 1989-01-27 US US07/302,210 patent/US5032384A/en not_active Expired - Lifetime
-
1990
- 1990-01-24 AU AU48761/90A patent/AU622756B2/en not_active Expired
- 1990-01-25 NZ NZ232250A patent/NZ232250A/en unknown
- 1990-01-26 DK DK90300855.5T patent/DK0380367T3/da active
- 1990-01-26 AT AT90300855T patent/ATE97805T1/de not_active IP Right Cessation
- 1990-01-26 EP EP90300855A patent/EP0380367B1/en not_active Expired - Lifetime
- 1990-01-26 JP JP2017688A patent/JP2764451B2/ja not_active Expired - Lifetime
- 1990-01-26 CA CA002008739A patent/CA2008739C/en not_active Expired - Lifetime
- 1990-01-26 ES ES90300855T patent/ES2060014T3/es not_active Expired - Lifetime
- 1990-01-26 DE DE90300855T patent/DE69004817T2/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU622756B2 (en) | 1992-04-16 |
DE69004817D1 (de) | 1994-01-13 |
JP2764451B2 (ja) | 1998-06-11 |
DK0380367T3 (da) | 1994-02-28 |
EP0380367A1 (en) | 1990-08-01 |
NZ232250A (en) | 1991-04-26 |
ATE97805T1 (de) | 1993-12-15 |
EP0380367B1 (en) | 1993-12-01 |
AU4876190A (en) | 1990-08-09 |
CA2008739A1 (en) | 1990-07-27 |
DE69004817T2 (de) | 1994-04-14 |
JPH02270815A (ja) | 1990-11-05 |
CA2008739C (en) | 1998-06-23 |
US5032384A (en) | 1991-07-16 |
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