ES2057214T3 - Mediciones en capas de material centrifugado efectuadas en un tubo donde se ha hecho el vacio. - Google Patents

Mediciones en capas de material centrifugado efectuadas en un tubo donde se ha hecho el vacio.

Info

Publication number
ES2057214T3
ES2057214T3 ES90103894T ES90103894T ES2057214T3 ES 2057214 T3 ES2057214 T3 ES 2057214T3 ES 90103894 T ES90103894 T ES 90103894T ES 90103894 T ES90103894 T ES 90103894T ES 2057214 T3 ES2057214 T3 ES 2057214T3
Authority
ES
Spain
Prior art keywords
tube
centrifugated
measurements
layer
vacuum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90103894T
Other languages
English (en)
Inventor
Robert Aaron Levine
Stephen Clark Wardlaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2057214T3 publication Critical patent/ES2057214T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150473—Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Ecology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LAS MEDIDAS DE LA CAPA DE MATERIAL CENTRIFUGADO SE HACEN EN UN TUBO DE CRISTAL EVACUADO O DE PLASTICO TRANSPARENTE (2) QUE CONTIENE UN FLOTADOR (6). CUANDO MATERIALES POSIBLEMENTE CONTAMINADOS, TALES COMO LA SANGRE, HAN DE SER COMPROBADOS EL USO DEL TUBO EVACUADO PERMITE QUE LAS MEDIDAS SEA HECHAS SIN QUE EL TECNICO SEA EXPUESTO A LA SANGRE. LAS TOLERANCIAS DIMENSIONALES CON RELACION A LAS DE UN TUBO CAPILAR SON MENOS RIGIDAS PARA EL TUBO Y EL FLOTADOR DEBIDO A LA MAYOR CAPACIDAD DE LA MUESTRA. LAS BANDAS CELULARES (32) SE ESTABILIZAN POR MEDIO DE UNA CAPA DE UN MATERIAL FLUIBLE QUE SE ASIENTA SOBRE LA CAPA DE PLASMA (34) DURANTE LA CENTRIFUGACION Y FORMA UNA PELICULA SOBRE EL MISMO.
ES90103894T 1989-05-24 1990-02-28 Mediciones en capas de material centrifugado efectuadas en un tubo donde se ha hecho el vacio. Expired - Lifetime ES2057214T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35607789A 1989-05-24 1989-05-24

Publications (1)

Publication Number Publication Date
ES2057214T3 true ES2057214T3 (es) 1994-10-16

Family

ID=23400019

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90103894T Expired - Lifetime ES2057214T3 (es) 1989-05-24 1990-02-28 Mediciones en capas de material centrifugado efectuadas en un tubo donde se ha hecho el vacio.

Country Status (15)

Country Link
US (1) US5086784A (es)
EP (1) EP0399151B1 (es)
JP (1) JPH0721492B2 (es)
CN (1) CN1023153C (es)
AR (1) AR242902A1 (es)
AT (1) ATE109643T1 (es)
AU (1) AU620213B2 (es)
BR (1) BR9002418A (es)
CA (1) CA2011100C (es)
DE (1) DE69011410T2 (es)
DK (1) DK0399151T3 (es)
ES (1) ES2057214T3 (es)
FI (2) FI100436B (es)
NO (1) NO179394C (es)
RU (2) RU2052186C1 (es)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0774772B2 (ja) * 1990-12-31 1995-08-09 エイ． レビン ロバート 血液サンプリング組立体、ターゲット細胞の採取方法およびターゲット成分の採取方法
AU644037B2 (en) * 1992-01-21 1993-12-02 Robert A. Levine Constituent layer harvesting from a centrifuged sample in a tube
US5342790A (en) * 1992-10-30 1994-08-30 Becton Dickinson And Company Apparatus for indirect fluorescent assay of blood samples
US5533518A (en) * 1994-04-22 1996-07-09 Becton, Dickinson And Company Blood collection assembly including mechanical phase separating insert
GB9703185D0 (en) * 1997-02-15 1997-04-02 Thurnall Plc Individual septum capped microtubes
US6979307B2 (en) * 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US5938621A (en) * 1997-09-12 1999-08-17 Becton Dickinson And Company Collection container assembly
US6197523B1 (en) 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
US6911315B2 (en) * 1997-11-24 2005-06-28 David L. Rimm Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood
US7947236B2 (en) 1999-12-03 2011-05-24 Becton, Dickinson And Company Device for separating components of a fluid sample
US20030133845A1 (en) * 2002-01-14 2003-07-17 Eureka Group Identification device for explosives or other materials
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US20030205538A1 (en) * 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7832566B2 (en) * 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
AU2003249642A1 (en) 2002-05-24 2003-12-12 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US7074577B2 (en) * 2002-10-03 2006-07-11 Battelle Memorial Institute Buffy coat tube and float system and method
US7220593B2 (en) * 2002-10-03 2007-05-22 Battelle Memorial Institute Buffy coat separator float system and method
EP1825317B1 (en) * 2004-11-24 2013-04-17 Battelle Memorial Institute Optical system for cell imaging
JP4609323B2 (ja) * 2006-01-06 2011-01-12 ニプロ株式会社 検体採取液容器
JP4609252B2 (ja) * 2005-09-07 2011-01-12 ニプロ株式会社 検体採取液容器
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
JP5479319B2 (ja) * 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー ブイ式懸濁液分画システム
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
EP2259774B1 (en) 2008-02-27 2012-12-12 Biomet Biologics, LLC Methods and compositions for delivering interleukin-1 receptor antagonist
EP2254991B1 (en) 2008-02-29 2018-08-22 Biomet Manufacturing, LLC A system and process for separating a material
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
ES2452534T3 (es) 2008-07-21 2014-04-01 Becton, Dickinson And Company Dispositivo de separación de fases de densidad
AU2009274104B2 (en) 2008-07-21 2012-06-07 Becton, Dickinson And Company Density phase separation device
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
SG10201709511WA (en) 2009-05-15 2018-03-28 Becton Dickinson Co Density phase separation device
EP2443450A2 (en) * 2009-06-16 2012-04-25 Robert Aaron Levine Harvesting target materials from centrifuged suspensions
US9011800B2 (en) * 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US20120016320A1 (en) * 2010-07-13 2012-01-19 Lin Michael T Method and Device for Liquid Delivery
US20120308447A1 (en) * 2011-05-31 2012-12-06 Timothy Alan Abrahamson Tube and float systems for density-based fluid separation
ES2437541B1 (es) * 2012-07-03 2014-11-25 Biotechnology Institute, I Mas D, S.L. Dispositivo para la extracción, el almacenamiento y/o el procesado de sangre u otras sustancias de origen humano o animal, y para la aplicación de compuestos sanguíneos u otros compuestos biológicos
US8984932B2 (en) 2012-07-18 2015-03-24 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes
SG10201605479QA (en) 2012-07-18 2016-08-30 Theranos Inc Rapid measurement of formed blood component sedimentation rate from small sample volumes
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US10088391B2 (en) 2013-02-21 2018-10-02 Regenexx, LLC Blood and marrow draw processing devices and methods
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
RU2548787C1 (ru) * 2014-04-09 2015-04-20 Александр Георгиевич Рожков Кювета для исследования коллоидных свойств жидкостных сред организма человека (варианты)
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid
ES2593042B1 (es) * 2015-06-03 2017-10-03 Biotechnology Institute, I Mas D, S.L. Dispositivo de recolección de sangre o de un compuesto sanguíneo
RU176274U1 (ru) * 2017-07-10 2018-01-15 Виктор Андреевич Линд Устройство для пробоподготовки крови для определения концентрации глюкозы в плазме крови
US20220088589A1 (en) 2019-01-21 2022-03-24 Eclipse Medcorp, Llc Methods, Systems and Apparatus for Separating Components of a Biological Sample
CN114452684A (zh) * 2020-11-10 2022-05-10 菲尔德森(江苏)生物技术有限公司 一种富血小板血浆提取分离套装及提取方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931018A (en) * 1974-08-09 1976-01-06 Becton, Dickinson And Company Assembly for collection, separation and filtration of blood
US4012325A (en) * 1975-01-08 1977-03-15 Eastman Kodak Company Biological fluid dispenser and separator
US4180465A (en) * 1975-12-19 1979-12-25 Sherwood Medical Industries Inc. Fluid collection device with phase separation means
JPS5278167A (en) * 1975-12-19 1977-07-01 Sherwood Medical Ind Inc Liquid sampling system
US4088582A (en) * 1976-01-16 1978-05-09 Sherwood Medical Industries Inc. Blood phase separation means
US4055501A (en) * 1976-01-16 1977-10-25 Sherwood Medical Industries Inc. Fluid collection device with phase partitioning means
US4027660A (en) * 1976-04-02 1977-06-07 Wardlaw Stephen C Material layer volume determination
US4235725A (en) * 1978-08-16 1980-11-25 Owens-Illinois, Inc. Sterile blood-collecting and separating device
CA1178257A (en) * 1980-05-08 1984-11-20 Toshiji Ichikawa Apparatus for separating blood
US4315892A (en) * 1980-07-18 1982-02-16 Sherwood Medical Industries, Inc. Fluid collection device having phase partitioning means
US4492634A (en) * 1982-09-28 1985-01-08 Emde Medical Research Pre-evacuated blood collection tube with anti-hemolysis baffle system and centrifugation propelled filtration disc and efficient serum-from cells separator
JPS6053845A (ja) * 1983-09-05 1985-03-27 Terumo Corp 血液分離管
US4567754A (en) * 1985-03-29 1986-02-04 Wardlaw Stephen C Measurement of small heavy constituent layer in stratified mixture
SE448323B (sv) * 1985-08-27 1987-02-09 Ersson Nils Olof Forfarande och anordnig att separera serum eller plasma fran blod
US4774965A (en) * 1987-07-01 1988-10-04 Becton Dickinson And Co., Inc. Material layer volume determination with correction band
US4867887A (en) * 1988-07-12 1989-09-19 Becton Dickinson And Company Method and apparatus for separating mononuclear cells from blood

Also Published As

Publication number Publication date
FI972084A (fi) 1997-05-15
DE69011410D1 (de) 1994-09-15
RU2052186C1 (ru) 1996-01-10
BR9002418A (pt) 1991-08-06
NO902289L (no) 1990-11-26
CN1023153C (zh) 1993-12-15
EP0399151B1 (en) 1994-08-10
CA2011100C (en) 1996-06-11
CA2011100A1 (en) 1990-11-24
DE69011410T2 (de) 1994-12-15
ATE109643T1 (de) 1994-08-15
NO179394C (no) 1996-10-02
AU5017790A (en) 1990-11-29
AU620213B2 (en) 1992-02-13
FI100436B (fi) 1997-11-28
US5086784A (en) 1992-02-11
EP0399151A1 (en) 1990-11-28
JPH02311761A (ja) 1990-12-27
NO179394B (no) 1996-06-24
AR242902A1 (es) 1993-06-30
CN1047570A (zh) 1990-12-05
FI902200A0 (fi) 1990-05-02
DK0399151T3 (da) 1994-10-03
FI972084A0 (fi) 1997-05-15
JPH0721492B2 (ja) 1995-03-08
RU94024565A (ru) 1996-09-27
RU2095024C1 (ru) 1997-11-10
NO902289D0 (no) 1990-05-23

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