ES2055655A1 - Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil. - Google Patents

Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil.

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Publication number
ES2055655A1
ES2055655A1 ES09201893A ES9201893A ES2055655A1 ES 2055655 A1 ES2055655 A1 ES 2055655A1 ES 09201893 A ES09201893 A ES 09201893A ES 9201893 A ES9201893 A ES 9201893A ES 2055655 A1 ES2055655 A1 ES 2055655A1
Authority
ES
Spain
Prior art keywords
obtaining
isobutyl
dihydropyridine
acetoacetate
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09201893A
Other languages
English (en)
Other versions
ES2055655B1 (es
Inventor
Garcia Carolina Burgos
Ceinos M Luisa Izquierdo
Navio Jose Luis Garcia
Lopez Juan Jose Vaquero
Gomez Julio Alvarez-Builla
Robisco Jose Luis Novella
Arinero Jose Calatayud
Jimenez Antonio F Montoro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BYK LEO LABORATORIO FARMACEUTICO, S.L.
Original Assignee
ELMUQUIMICA FARM SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ELMUQUIMICA FARM SL filed Critical ELMUQUIMICA FARM SL
Priority to ES9201893A priority Critical patent/ES2055655B1/es
Publication of ES2055655A1 publication Critical patent/ES2055655A1/es
Application granted granted Critical
Publication of ES2055655B1 publication Critical patent/ES2055655B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Hydrogenated Pyridines (AREA)

Abstract

NUEVO PROCEDIMIENTO DE OBTENCION DE 2,6-DIMETIL-4-(2''-NITROFENIL) -3,5-PIRIDINADICARBOXILATO DE 3-ISOBUTIL-5-METIL VERIFICADO EN CUATRO PASOS. OBTENCION DEL ACETOACETATO DE ISOBUTILO A PARTIR DE 2,2,6-TRIMETIL-1,3-DIOXEN-4-ONA E ISOBUTANOL. PREPARACION DEL 3-AMINOCROTONATO DE ISOBUTILO A PARTIR DEL ACETOACETATO DE ISOBUTILO Y ACETATO AMONICO. OBTENCION DEL BENCILIDEN DERIVADO A PARTIR DEL ACETOACETATO Y EL BENZALDEHIDO CORRESPONDIENTE. CONDENSACION DEL BENCILIDEN DERIVADO CON EL 3-AMINOCROTONATO, EN PRESENCIA DE ALUMINA ACTIVADA PARA RENDIR EL DERIVADO DIHIDROPIRIDINICO. VENTAJAS QUE SE OBTIENEN MEDIANTE ESTE PROCEDIMIENTO EN RELACION AL ESTADO ANTERIOR DE LA TECNICA: A) PROCESOS REALIZADOS EN CONDICIONES RAPIDAS SUAVES Y SENCILLAS, OBTENIENDOSE PRODUCTOS DE ALTA CALIDAD. B) EL ULTIMO PASO SE REALIZA EN FASE SOLIDA, EVITANDO TRAZAS DE DIHIDROPIRIDINAS SIMETRICAS. C) OBTENCION DE LA DIHIDROPIRIDINA SIN DISOLVENTE, MINIMA PRODUCCION DE EFLUENTES CONTAMINANTES. D) UTILIZACION DE CATALIZADORESBASICOS O ACIDOS RECICLABLES. E) BAJO COSTO DE LOS PROCESOS, MINIMIZACION DE REACTIVOS Y RESIDUOS. F) BAJO IMPACTO AMBIENTAL.
ES9201893A 1992-09-22 1992-09-22 Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil. Expired - Fee Related ES2055655B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9201893A ES2055655B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201893A ES2055655B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil.

Publications (2)

Publication Number Publication Date
ES2055655A1 true ES2055655A1 (es) 1994-08-16
ES2055655B1 ES2055655B1 (es) 1995-03-01

Family

ID=8278209

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9201893A Expired - Fee Related ES2055655B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil.

Country Status (1)

Country Link
ES (1) ES2055655B1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2177409A1 (es) * 2000-08-02 2002-12-01 Liconsa Liberacion Controlada Procedimiento para la obtencion de 1,4-dihidropiridinas substituida utiles para el tratamiento de la hipertension.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234776A2 (en) * 1986-02-12 1987-09-02 Merck & Co. Inc. Process for 1,4-dihydropyridine compounds
EP0383320A1 (en) * 1989-02-17 1990-08-22 Boehringer Mannheim Italia S.P.A. A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234776A2 (en) * 1986-02-12 1987-09-02 Merck & Co. Inc. Process for 1,4-dihydropyridine compounds
EP0383320A1 (en) * 1989-02-17 1990-08-22 Boehringer Mannheim Italia S.P.A. A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2177409A1 (es) * 2000-08-02 2002-12-01 Liconsa Liberacion Controlada Procedimiento para la obtencion de 1,4-dihidropiridinas substituida utiles para el tratamiento de la hipertension.

Also Published As

Publication number Publication date
ES2055655B1 (es) 1995-03-01

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Date Code Title Description
PC2A Transfer of patent

Owner name: BYK LEO LABORATORIO FARMACEUTICO, S.L.

FD1A Patent lapsed

Effective date: 20060923