ES2055653A1 - Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil. - Google Patents

Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil.

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Publication number
ES2055653A1
ES2055653A1 ES09201891A ES9201891A ES2055653A1 ES 2055653 A1 ES2055653 A1 ES 2055653A1 ES 09201891 A ES09201891 A ES 09201891A ES 9201891 A ES9201891 A ES 9201891A ES 2055653 A1 ES2055653 A1 ES 2055653A1
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ES
Spain
Prior art keywords
isopropyl
obtaining
dihydropyridine
acetoacetate
dicarboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09201891A
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English (en)
Other versions
ES2055653B1 (es
Inventor
Garcia Carolina Burgos
Ceinos Maria Luisa Izquierdo
Navio Jose Luis Garcia
Lopez Juan Jose Vaquero
Gomez Julio Alvarez-Builla
Robisco Jose Luis Novella
Arinero Jose Calatayud
Jimenez Antonio F Montoro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECORDATI ELMU, S.L.
Original Assignee
ELMUQUIMICA FARM SL
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Publication date
Application filed by ELMUQUIMICA FARM SL filed Critical ELMUQUIMICA FARM SL
Priority to ES9201891A priority Critical patent/ES2055653B1/es
Publication of ES2055653A1 publication Critical patent/ES2055653A1/es
Application granted granted Critical
Publication of ES2055653B1 publication Critical patent/ES2055653B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

NUEVO PROCEDIMIENTO DE OBTENCION DEL 2,6-DIMETIL-4- (3''-NITROFENIL) -1,4-DIHIDROPIRIDIN-3, 5-DICARBOXILATO DE 3-ISOPROPIL-5- (2''-METOXI)ETIL, VERIFICADO EN TRES PASOS. OBTENCION DEL 2-(3''-NITRO) BENCILIDENACETOACETATO DE ISOPROPILO A PARTIR DEL 3-NITROBENZALDEHIDO Y ACETOACETATO DE ISOPROPILO EN PRESENCIA DE PIPERIDINA, ACIDO ACETICO GLACIAL E ISOPROPANOL. UN SEGUNDO PASO DONDE SE OBTIENE EL 3-AMINOCROTONATO DE 2-METOXIETILO AL TRATAR EL ACETOACETATO DE 2-METOXIETILO CON ACETATO AMONICO. EN EL TERCER PASO SE TRATAN LOS PRODUCTOS OBTENIDOS ANTERIORMENTE EN PRESENCIA DE ALUMINA ACTIVADA PARA RENDIR EL PRODUCTO TITULADO. VENTAJAS QUE SE OBTIENEN EN RELACION AL ESTADO ANTERIOR DE LA TECNICA: A) PROCESOS REALIZADOS EN CONDICIONES RAPIDAS, SUAVES Y SENCILLAS OBTENIENDOSE PRODUCTOS DE ALTA CALIDAD. B) SE REDUCE EL TIEMPO EN EL ULTIMO PASO. C) EL ULTIMO PASO SE REALIZA EN FASE SOLIDA, EVITANDO TRAZAS DE DIHIDROPIRIDINAS SIMETRICAS. D) OBTENCION DE LA DIHIDROPIRIDINA SIN DISOLVENTE MINIMA PRODUCCIONDE EFLUENTES CONTAMINANTES. E) UTILIZACION DE CATALIZADORES BASICOS O ACIDOS RECICLABLES. F) BAJO COSTO POR LA MINIMIZACION DE REACTIVOS Y RESIDUOS.
ES9201891A 1992-09-22 1992-09-22 Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil. Expired - Fee Related ES2055653B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9201891A ES2055653B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201891A ES2055653B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil.

Publications (2)

Publication Number Publication Date
ES2055653A1 true ES2055653A1 (es) 1994-08-16
ES2055653B1 ES2055653B1 (es) 1995-03-01

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Family Applications (1)

Application Number Title Priority Date Filing Date
ES9201891A Expired - Fee Related ES2055653B1 (es) 1992-09-22 1992-09-22 Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil.

Country Status (1)

Country Link
ES (1) ES2055653B1 (es)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234776A2 (en) * 1986-02-12 1987-09-02 Merck & Co. Inc. Process for 1,4-dihydropyridine compounds
EP0383320A1 (en) * 1989-02-17 1990-08-22 Boehringer Mannheim Italia S.P.A. A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0234776A2 (en) * 1986-02-12 1987-09-02 Merck & Co. Inc. Process for 1,4-dihydropyridine compounds
EP0383320A1 (en) * 1989-02-17 1990-08-22 Boehringer Mannheim Italia S.P.A. A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines

Also Published As

Publication number Publication date
ES2055653B1 (es) 1995-03-01

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PC2A Transfer of patent

Owner name: RECORDATI ELMU, S.L.

FD1A Patent lapsed

Effective date: 19960923