ES2054654T3 - Derivados farmaceuticamente utiles de acido tiazolidina-4-carboxilico. - Google Patents

Derivados farmaceuticamente utiles de acido tiazolidina-4-carboxilico.

Info

Publication number
ES2054654T3
ES2054654T3 ES87201313T ES87201313T ES2054654T3 ES 2054654 T3 ES2054654 T3 ES 2054654T3 ES 87201313 T ES87201313 T ES 87201313T ES 87201313 T ES87201313 T ES 87201313T ES 2054654 T3 ES2054654 T3 ES 2054654T3
Authority
ES
Spain
Prior art keywords
thiazolidine
pharmaceutically useful
compounds
formula
carboxyl acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87201313T
Other languages
English (en)
Inventor
Bella Davide Della
Angelo Carenzi
Dario Chiarino
Franco Pellacini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Application granted granted Critical
Publication of ES2054654T3 publication Critical patent/ES2054654T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE R, R1 E Y TIENEN LOS SIGNIFICADOS DADOS EN LA DESCRIPCION, SU PREPARACION POR CONDENSACION DE UN ALDEHIDO O UNA CETONA CON CISTEINA O UN DERIVADO DE LA MISMA Y SU USO EN EL CAMPO FARMACEUTICO. LOS COMPUESTOS DE FORMULA (I) POSEEN PROPIEDADES ANTIPIRETICAS, ANTIINFLAMATORIAS, MUCOLITICAS Y ANALGESICAS JUNTO CON UNA ESCASA CAPACIDAD PARA PRODUCIR LESIONES GASTRICAS. LOS COMPUESTOS DE FORMULA (I) ADEMAS, SON ESPECIALMENTE UTILES EN EL TRATAMIENTO DE SINDROMES DE ISQUEMIA Y REPERFUSION.
ES87201313T 1986-07-14 1987-07-09 Derivados farmaceuticamente utiles de acido tiazolidina-4-carboxilico. Expired - Lifetime ES2054654T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21112/86A IT1196485B (it) 1986-07-14 1986-07-14 Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica

Publications (1)

Publication Number Publication Date
ES2054654T3 true ES2054654T3 (es) 1994-08-16

Family

ID=11176919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87201313T Expired - Lifetime ES2054654T3 (es) 1986-07-14 1987-07-09 Derivados farmaceuticamente utiles de acido tiazolidina-4-carboxilico.

Country Status (11)

Country Link
US (1) US4840936A (es)
EP (1) EP0254354B1 (es)
JP (1) JP2603639B2 (es)
AT (1) ATE87622T1 (es)
AU (1) AU609406B2 (es)
CA (1) CA1322074C (es)
DE (1) DE3785104T2 (es)
ES (1) ES2054654T3 (es)
IE (1) IE60205B1 (es)
IT (1) IT1196485B (es)
ZA (1) ZA875099B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
IT1223565B (it) * 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
DE3818850A1 (de) * 1988-06-03 1989-12-07 Hoechst Ag Oligopeptide mit zyklischen prolin-analogen aminosaeuren
IT1230706B (it) * 1989-02-10 1991-10-29 Poli Ind Chimica Spa Derivati dell'acido 3 piroglutamoil tiazolidin 4 carbossilico e loro proprieta' farmacologiche.
IT1250736B (it) * 1991-08-01 1995-04-21 Zambon Spa Processo per la preparazione dell'acido 5-(2',4'-difluorofenil) salicilico in forma ii pura
DE19711052C2 (de) 1997-03-03 1999-09-23 Hans Rommelspacher Verwendung von 2-Methyl-thiazolidin-2,4-dicarbonsäure als Mukolytikum
KR20010025470A (ko) * 2000-12-29 2001-04-06 강덕영 치아졸리딘-4-카르복실산 염의 제조방법
WO2003072770A1 (fr) 2002-02-28 2003-09-04 Mitsubishi Chemical Corporation Nouvelle deshydrogenase et gene codant cette derniere
CN117677386A (zh) * 2021-07-23 2024-03-08 瓦伦塔有限责任公司 具有亲溶酶体和抗病毒活性的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210230A1 (de) * 1972-03-03 1973-09-06 Kolmar Laboratories Verwendung bestimmter thioaether als antimikrobielle und zytostatische mittel
US4430344A (en) * 1978-04-08 1984-02-07 Santen Pharmaceutical Co., Ltd. Antihypertensive 4-thiazolidinecarboxylic acids
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
HU195492B (en) * 1984-07-27 1988-05-30 Boehringer Biochemia Srl Process for producing 2-substituted thiazolidine derivatives with antitussive and mucus regulating action and pharmaceuticals comprising these compounds as active ingredient
IT1176983B (it) * 1984-10-16 1987-08-26 Zambon Spa Dipeptidi ad attivita' farmacologica

Also Published As

Publication number Publication date
DE3785104D1 (de) 1993-05-06
IT1196485B (it) 1988-11-16
AU7556687A (en) 1988-01-21
IT8621112A0 (it) 1986-07-14
ZA875099B (en) 1988-04-27
AU609406B2 (en) 1991-05-02
EP0254354B1 (en) 1993-03-31
DE3785104T2 (de) 1993-09-02
CA1322074C (en) 1993-09-07
JPS6323876A (ja) 1988-02-01
EP0254354A1 (en) 1988-01-27
ATE87622T1 (de) 1993-04-15
IE871872L (en) 1988-01-14
IT8621112A1 (it) 1988-01-14
IE60205B1 (en) 1994-06-15
US4840936A (en) 1989-06-20
JP2603639B2 (ja) 1997-04-23

Similar Documents

Publication Publication Date Title
ES2059497T3 (es) Derivados del acido tiazolidin-4-carboxilico dotados de actividad farmacologica.
FI872864A0 (fi) Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
AR005703A1 (es) Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen
ES2061094T3 (es) Un procedimiento para la obtencion de una formulacion para disminuir el deseo imperioso de alcohol (craving) en el tratamiento del alcoholismo cronico.
SE8602723L (sv) Tiazoler, deras framstellning och farmaceutiska kompositioner innehallande dem
ES2082755T3 (es) Derivados de acido 3-desmetil-mevalonico, procedimiento para su preparacion, preparados farmaceuticos a base de estos compuestos, su utilizacion asi como productos intermedios.
AR026064A1 (es) Compuestos de oxabispidina, formulacion farmaceutica, uso de estos compuestos para la manufactura de medicamentos, proceso para la preparacion de estos compuestos, e intermediarios.
ES2053429T3 (es) El uso de buspirona para la preparacion de composiciones farmaceuticas para aliviar la ansiedad fobica.
KR890700125A (ko) 신규 벤즈이미다졸 유도체, 그 제조방법 및 이 화합물을 함유하는 제약 조성물
FI940696A (fi) Uudet pyratsiinijohdannaiset, niiden valmistus ja käyttö
DK10488D0 (da) Benzen-derivater med antiinflammatorisk virkning og fremgangsmaade til fremstilling deraf
GR3022742T3 (en) New derivatives of non-steroidal anti-inflammatory, analgesic and/or antipyretic substances, their use and pharmaceutical formulations containing them
ES2054654T3 (es) Derivados farmaceuticamente utiles de acido tiazolidina-4-carboxilico.
MX9200396A (es) Derivados de benciloxifenilo, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9201324A (es) Nuevos compuestos para inhibir la secrecion acida gastrica en mamiferos, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9202544A (es) Compuestos de diaminoftalimidas substituidas y analogas, procedimiento para su preparacion y preparados farmaceuticos que los contienen.
ES2020171T3 (es) Eteres de 1-bencil-3-hidroximetilindazol con 2-hidroxiacidos alifaticos.
ES2058228T3 (es) Compuestos activos sobre el sistema cardiovascular.
MX9301157A (es) Derivados de bencimidazolona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
NO912414L (no) Forbindelse med mavesyreinhiberende effekt og fremgangsmaate for dens fremstilling.
ES2043943T3 (es) Procedimiento para la preparacion de compuestos con actividad analgesica central.
IT1197516B (it) Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono
ES2046528T3 (es) Derivados heterotetraciclicos de lactamas, proceso para su preparacion y composiciones farmaceuticas a base de los mismos.
UY27372A1 (es) Derivados de bencimidazol 1-aril-2-n, s u o-sustituidos, su uso para la obtención de medicamentos y preparados farmacéuticos que contienen estos derivados
ITMI911845A1 (it) Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 254354

Country of ref document: ES