ES2052735T3 - Un metodo para producir un agente hipotensor ocular. - Google Patents

Un metodo para producir un agente hipotensor ocular.

Info

Publication number
ES2052735T3
ES2052735T3 ES88308299T ES88308299T ES2052735T3 ES 2052735 T3 ES2052735 T3 ES 2052735T3 ES 88308299 T ES88308299 T ES 88308299T ES 88308299 T ES88308299 T ES 88308299T ES 2052735 T3 ES2052735 T3 ES 2052735T3
Authority
ES
Spain
Prior art keywords
producing
eye
agent
hypotension agent
eye hypotension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88308299T
Other languages
English (en)
Spanish (es)
Inventor
Ryuzo Ueno
Ryuji Ueno
Tomio Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R Tech Ueno Ltd
Original Assignee
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26532381&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2052735(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by R Tech Ueno Ltd filed Critical R Tech Ueno Ltd
Application granted granted Critical
Publication of ES2052735T3 publication Critical patent/ES2052735T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES88308299T 1987-09-18 1988-09-08 Un metodo para producir un agente hipotensor ocular. Expired - Lifetime ES2052735T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23589087 1987-09-18
JP33403787 1987-12-29

Publications (1)

Publication Number Publication Date
ES2052735T3 true ES2052735T3 (es) 1994-07-16

Family

ID=26532381

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88308299T Expired - Lifetime ES2052735T3 (es) 1987-09-18 1988-09-08 Un metodo para producir un agente hipotensor ocular.

Country Status (11)

Country Link
US (1) US5001153A (enExample)
EP (2) EP0308135B1 (enExample)
JP (2) JPH02108A (enExample)
KR (1) KR930000051B1 (enExample)
AT (2) ATE108330T1 (enExample)
CA (1) CA1328075C (enExample)
DE (2) DE3850676T2 (enExample)
ES (1) ES2052735T3 (enExample)
GB (1) GB2209939B (enExample)
GR (1) GR3006319T3 (enExample)
NZ (1) NZ226197A (enExample)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1322749C (en) * 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
US5236907A (en) * 1988-10-01 1993-08-17 R-Tech Ueno Ltd. Ocular hypotensive agents
US6420422B1 (en) 1987-09-18 2002-07-16 Sucampo Pharmaceuticals, Inc. Ocular hypotensive agents
JP2597629B2 (ja) 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化
EP1300151A3 (en) * 1988-09-06 2003-05-14 Pharmacia Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP0364417B9 (en) * 1988-09-06 2004-10-06 Pharmacia AB Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP0366279B1 (en) * 1988-10-01 1994-09-21 R-Tech Ueno Ltd. Ocular hypotensive agents
US5194429A (en) * 1988-10-01 1993-03-16 K.K. Ueno Seiyaku Oyo Kenkyujo Ocular hypotensive agents
US5234954A (en) * 1989-07-27 1993-08-10 K.K. Ueno Seiyaku Oyo Kenkyujo Treatment of hyperlipidemia with 15-keto-prostaglandin compounds
ATE122563T1 (de) * 1989-07-27 1995-06-15 Ueno Seiyaku Oyo Kenkyujo Kk Verwendung von 15-keto-prostansäure-derivaten zur herstellung eines medikaments für die verbesserung der ausscheidung des kaliumions.
DE69018903T2 (de) * 1989-08-09 1995-08-24 Ueno Seiyaku Oyo Kenkyujo Kk Verwendung von Prostansäurederivaten zur Herstellung von Arzneimitteln zur Verbesserung der Ausscheidung von Nichtprotein in die Därme.
CA2027814C (en) * 1989-10-20 1996-07-30 Ryuji Ueno Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds
US5256696A (en) * 1989-11-22 1993-10-26 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds
US5254588A (en) * 1989-11-22 1993-10-19 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
EP0471856B1 (en) * 1990-03-08 1995-03-22 Shionogi & Co., Ltd. 15-deoxyprostaglandin derivative
CA2039420C (en) * 1990-04-04 1996-12-10 Ryuji Ueno Treatment of cataract with 15-keto-prostaglandin compounds
DE69130586T2 (de) * 1990-05-01 1999-06-17 R-Tech Ueno, Ltd., Osaka Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten
US5175189A (en) * 1990-05-22 1992-12-29 K.K. Ueno Seiyaku Oyo Kenkyujo Treatment of ocular hypertension with a synergistic combination for ophthalmic use
DK0458589T3 (da) * 1990-05-22 1995-04-03 R Tech Ueno Ltd Behandling af okulær hypertension med en okulær synergistisk kombination
EP0458587B1 (en) * 1990-05-22 1993-07-14 R-Tech Ueno Ltd. Synergistic combination for ophthalmic use
ATE132750T1 (de) * 1990-05-22 1996-01-15 R Tech Ueno Ltd Behandlung von intraokularem druck mit einer synergischen kombination
DK0458588T3 (da) * 1990-05-22 1995-03-13 R Tech Ueno Ltd Behandling af okulær hypertension med en synergistisk kombination til okulær administration
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
US5270049A (en) * 1990-11-09 1993-12-14 Allergan, Inc. 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives
US5139491A (en) * 1990-12-06 1992-08-18 Allergan, Inc. 2-decarboxyl-2-alkoxyalkyl prostaglandins as ocular hypotensives
TW210287B (enExample) * 1991-03-01 1993-08-01 Kabushikaisha Ueno Seiyaku Oyo Kenkyujo
EP0503887B1 (en) * 1991-03-14 1996-08-28 R-Tech Ueno Ltd. Promotion of wound-healing with 15-keto-prostaglandin compounds
CA2065889C (en) * 1991-10-02 2002-08-27 Tetsuya Sugiyama Increasing the choroidal blood flow
EP0668076B1 (en) * 1992-08-26 2002-09-04 Sucampo AG Stabilization of a prostanoic acid compound
FR2707295A1 (fr) * 1993-06-07 1995-01-13 Rhone Poulenc Agrochimie Fongicides pyrazoles substitués en position 3 par un hétérocycle.
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6184250B1 (en) 1993-08-03 2001-02-06 Alcon Laboratories, Inc. Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
US5387608A (en) * 1993-08-17 1995-02-07 Allergan, Inc. Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl sulfonamidomethyl and derivatives thereof as therapeutic agents
JP2769294B2 (ja) * 1993-12-15 1998-06-25 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物及びそのためのプロスタグランジン化合物
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
TW420611B (en) * 1995-03-10 2001-02-01 R Tech Ueno Ltd Pharmaceutical composition containing prostanoic acid compounds for the treatment of optic nerve disorder
WO1997023225A1 (en) * 1995-12-22 1997-07-03 Alcon Laboratories, Inc. Combinations of dp and fp type prostaglandins for lowering iop
CA2269853A1 (en) 1996-11-12 1998-05-22 Paul W. Zinke Use of cis-.delta.4 analogs of prostaglandins as ocular hypotensives
EP0938472B1 (en) 1996-11-12 2001-06-27 Alcon Laboratories, Inc. 15-fluoro prostaglandins as ocular hypotensives
US6680339B2 (en) 1996-11-12 2004-01-20 Alcon Manufacturing, Ltd. 15-fluoro prostaglandins as ocular hypotensives
CA2279967C (en) 1997-02-04 2006-08-22 Murray A. Johnstone Method of enhancing hair growth
US6172109B1 (en) 1997-03-07 2001-01-09 Alcon Laboratories, Inc. 13-Thia prostaglandins for use in glaucoma therapy
US6770675B2 (en) 1997-03-17 2004-08-03 Novartis Ag Compositions and methods for reducing ocular hypertension
WO1999018969A1 (en) 1997-10-13 1999-04-22 R-Tech Ueno, Ltd. Remedial composition for intraocular hypertension or glaucoma
US6156785A (en) * 1998-01-23 2000-12-05 Merck Sharp & Dohme B.V. Method for increasing oxygen tension in the optic nerve and retina
US6096783A (en) * 1998-12-15 2000-08-01 Alcon Laboratories, Inc. Cyclobutane prostaglandin analogues as ocular hypotensive agents
WO2000038689A1 (en) * 1998-12-25 2000-07-06 Sucampo, A.G. Drug compositions for the treatment of ocular hypertension or glaucoma
SE9900672D0 (sv) 1999-02-25 1999-02-25 Synphora Ab Method and composition for prevention of scar formation in glaucoma filtration bleb and drainage fistula
AU766163B2 (en) 1999-03-05 2003-10-09 Duke University C16 unsaturated fp-selective prostaglandins analogs
TWI225398B (en) 1999-07-14 2004-12-21 R Tech Ueno Ltd Composition for treatment of external secretion disorders
AU2603301A (en) 1999-12-22 2001-07-03 Alcon Universal Limited 6-keto prostaglandin F1alpha and analogs for treating dry eye
US6548535B2 (en) * 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
CA2396319A1 (en) * 2000-01-18 2001-07-26 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
RU2002127733A (ru) * 2000-03-16 2004-03-27 Сукампо Аг (Ch) Способ лечения или профилактики повышенного глазного давления и глаукомы, фармацевтическая композиция и способ получения соединения простагландинов
US6458836B1 (en) 2000-03-16 2002-10-01 Sucampo, A.G. Treatment of ocular hypertension and glaucoma
TWI284535B (en) 2000-03-24 2007-08-01 Sucampo Ag Apoptosis inhibitor
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
PE20020146A1 (es) * 2000-07-13 2002-03-31 Upjohn Co Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20020035148A1 (en) * 2000-07-20 2002-03-21 Ryuji Ueno Treatment of ocular hypertension
US6414021B1 (en) * 2000-08-25 2002-07-02 Sucampo Ag Control of intraocular pressure during surgery
EP1321144B1 (en) * 2000-09-13 2010-12-08 Santen Pharmaceutical Co., Ltd. Eye drops
US6291522B1 (en) * 2000-09-27 2001-09-18 Allergan Sales, Inc. Cyclopentane heptan(ENE)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
US7351404B2 (en) 2002-02-04 2008-04-01 Allergan, Inc. Method of enhancing hair growth
US9216183B2 (en) 2002-02-04 2015-12-22 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US8758733B2 (en) 2002-02-04 2014-06-24 Allergan, Inc. Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists
US20050124595A1 (en) * 2002-03-15 2005-06-09 Goetz Michael A. Compositions and methods for treating glaucoma and ocular hypertension
WO2003103664A1 (en) * 2002-06-06 2003-12-18 Merck Frosst Canada & Co. 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
EP1515721A4 (en) * 2002-06-14 2006-07-26 Merck & Co Inc OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA
US7279490B2 (en) * 2002-06-17 2007-10-09 Merck & Co, Inc. Ophthalmic compositions for treating ocular hypertension
AU2003245531A1 (en) * 2002-06-17 2003-12-31 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
EP1515974A4 (en) * 2002-06-17 2007-02-28 Merck & Co Inc NEW MAXI-K CHANNEL BLOCKS, METHOD OF USE AND METHOD FOR THE PRODUCTION THEREOF
US8580851B2 (en) 2002-08-21 2013-11-12 Sucampo Ag Ophthalmic solution
CA2495917A1 (en) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
TWI350170B (en) * 2002-08-29 2011-10-11 Santen Pharmaceutical Co Ltd Treating agent for glaucoma comprising rho kinase inhibitor and prostaglandin
JP2006505572A (ja) * 2002-10-25 2006-02-16 メルク フロスト カナダ アンド カンパニー Ｅｐ４受容体アゴニストとしての２−ピロリドン
AU2003280812A1 (en) 2002-11-18 2004-06-15 Santen Pharmaceutical Co., Ltd. REMEDY FOR GLAUCOMA COMPRISING Rho KINASE INHIBITOR AND Beta-BLOCKER
CA2519899A1 (en) * 2003-03-27 2004-10-14 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
DE602004024427D1 (de) * 2003-07-31 2010-01-14 Santen Pharmaceutical Co Ltd Prostaglandin enthaltendes produkt
TWI495471B (zh) * 2003-08-12 2015-08-11 R Tech Ueno Ltd 促進毛髮生長之組成物及方法
US20080139652A1 (en) * 2003-11-07 2008-06-12 Yusuke Sakai Pharmaceutical Composition Containing Prostaglandin
JP2006187602A (ja) * 2004-12-09 2006-07-20 Santen Pharmaceut Co Ltd 分子内にフッ素原子を有するプロスタグランジン含有製品
EP1829545B1 (en) * 2004-12-24 2012-05-02 Santen Pharmaceutical Co., Ltd. Prostaglandin f2 alpha derivative containing products
CA2589081C (en) * 2004-12-29 2013-03-19 Masato Iino Composition and method for scalp and hair treatment
US8143316B2 (en) * 2005-03-04 2012-03-27 Sucampo Ag Method for treating peripheral vascular diseases
JP4648340B2 (ja) * 2006-02-07 2011-03-09 株式会社アールテック・ウエノ １５−ケトプロスタグランジンｅ誘導体の製造法
CN104224704A (zh) * 2006-03-13 2014-12-24 株式会社·R-技术上野 水性组合物
US20090018204A1 (en) * 2007-07-13 2009-01-15 Brinkenhoff Michael C Composition and method for enhancing hair growth
US7705001B2 (en) * 2008-03-18 2010-04-27 Allergan, Inc Therapeutic substituted gamma lactams
WO2009132085A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as prostaglandin ep2 agonists
CA2722529A1 (en) 2008-04-24 2009-10-29 Allergan, Inc. Substituted gamma lactams as therapeutic agents
US8623918B2 (en) 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US20100204335A1 (en) * 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
CA2780267C (en) 2009-11-09 2020-06-30 Allergan, Inc. Compositions and methods for stimulating hair growth
US9149484B2 (en) 2009-11-09 2015-10-06 Allergan, Inc. Compositions and methods for stimulating hair growth
CA2807301C (en) 2010-08-02 2018-11-27 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
US8859616B2 (en) 2011-01-21 2014-10-14 Allergan, Inc. Compounds and methods for enhancing hair growth
EP2671586B1 (en) 2011-02-04 2018-05-30 Kowa Co., Ltd. Drug therapy for preventing or treating glaucoma
CN103561748A (zh) 2011-04-07 2014-02-05 苏坎波公司 治疗眼疲劳的方法
CA2842455A1 (en) * 2011-08-05 2013-02-14 Sucampo Ag Method for treating schizophrenia
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
UA124698C2 (uk) 2014-10-20 2021-11-03 Сентіс Фарма Прайвет Лімітед Офтальмологічний розчин

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1476661A (en) * 1974-05-13 1977-06-16 American Cyanamid Co Prostaglandins
US4599353A (en) * 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
EP0242580B1 (en) * 1986-03-13 1993-04-28 The Trustees Of Columbia University In The City Of New York Use of a, b and c prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
US4824857A (en) * 1986-05-16 1989-04-25 Yasumasa Goh Use of prostaglandin D2 -active substances
CA1323364C (en) * 1987-01-28 1993-10-19 Ryuzo Ueno Prostaglandins e and anti ulcer agents containing same
CA1322749C (en) * 1987-01-28 1993-10-05 Ryuzo Ueno Prostaglandins of the d series, and tranquilizers and soporifics containing the same
CA1324129C (en) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
ES2038289T3 (es) * 1987-05-15 1993-07-16 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Utilizacion de 15-ceto-pges para la fabricacion de un medicamento para aumentar la temperatura corporal.
JPS6453101A (en) * 1987-05-25 1989-03-01 Kurashiki Boseki Kk Equal tilt angle interference type film thickness gauge
JP2597629B2 (ja) * 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化

Also Published As

Publication number Publication date
EP0308135A3 (en) 1989-06-14
GB8821104D0 (en) 1988-10-05
GB2209939B (en) 1992-01-02
KR930000051B1 (ko) 1993-01-06
ATE108330T1 (de) 1994-07-15
JP2592204B2 (ja) 1997-03-19
EP0308135A2 (en) 1989-03-22
DE3850676T2 (de) 1994-11-03
AU2231388A (en) 1989-03-23
EP0455264A3 (en) 1991-11-27
CA1328075C (en) 1994-03-29
DE3850676D1 (de) 1994-08-18
JPH02108A (ja) 1990-01-05
ATE82499T1 (de) 1992-12-15
NZ226197A (en) 1992-02-25
US5001153A (en) 1991-03-19
EP0455264A2 (en) 1991-11-06
GB2209939A (en) 1989-06-01
KR890004707A (ko) 1989-05-09
GR3006319T3 (enExample) 1993-06-21
DE3876050D1 (de) 1992-12-24
JPH0571567B2 (enExample) 1993-10-07
AU600168B2 (en) 1990-08-02
EP0455264B1 (en) 1994-07-13
EP0308135B1 (en) 1992-11-19
DE3876050T2 (de) 1993-03-25
JPH0680571A (ja) 1994-03-22

Similar Documents

Publication Publication Date Title
ES2052735T3 (es) Un metodo para producir un agente hipotensor ocular.
DE69017191D1 (de) Bearbeitungsverfahrens mittels laser.
FI914927A0 (fi) Fungicida oxazolidinoner.
FI871768A0 (fi) Mjukgoerande detergentkompositioner innehaollande amidmjukgoeringsmedel.
DE59005551D1 (de) Alkalistabile antischaummittel.
KR900700420A (ko) 2,3-디플루오로벤젠의 제조방법
FI892534A7 (fi) Menetelmä 1,3-diolien valmistamiseksi epoksideista
DE3861916D1 (de) Laserbearbeitungswerkzeug.
DE3862920D1 (de) Werkzeugmaschine.
IT8020229A0 (it) Tingibilita'.procedimento per produrre poliammidi a modificata
DE3883627D1 (de) 1,4-Dihydropyridin-Enantiomere.
ES539847A0 (es) Un metodo de preparar un agente encolante a base de anhidri-do alquenil-succinico,emulsionado
NO884333L (no) 1,4-dihydropyridiner.
IT8519908A0 (it) Procedimento per produrre difenilammine oppure n,n'-difenil-fenilendiammine.
IT1227385B (it) Apparecchiatura per collegare due parti di macchina, soprattutto due parti di utensile di macchine utensili'
FI873604A7 (fi) Menetelmä 1,3-glykolien valmistamiseksi epoksideista.
FI891473A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 4-aryyli-4-piperidiinikarbinolien valmistamiseksi
FI883266A0 (fi) 4-aminosubstituerade 1,2-dihydronaftalenderivat.
DE3765956D1 (de) Verfahren zur herstellung von 1-methyl-3,5,7-triaza-1-azoniatricyclodecan-halogeniden.
DE59001106D1 (de) Verfahren zur herstellung von 1,1,1-trifluor-2-chlorethan.
ES2063295T3 (es) Composicion artropodicida que comprende tiodicarb y un fenilpirazol.
ES491921A0 (es) Procedimiento para preparar agentes para el tratamiento de fibras queratinicas
EP0678601A3 (de) Regulierstreckwerk.
DE3863898D1 (de) Werkzeugmaschine.
IT8783399A0 (it) Martellatrice multiuso.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 308135

Country of ref document: ES