ES2051781T3 - Derivados de imidazodiacepina. - Google Patents

Derivados de imidazodiacepina.

Info

Publication number
ES2051781T3
ES2051781T3 ES88103739T ES88103739T ES2051781T3 ES 2051781 T3 ES2051781 T3 ES 2051781T3 ES 88103739 T ES88103739 T ES 88103739T ES 88103739 T ES88103739 T ES 88103739T ES 2051781 T3 ES2051781 T3 ES 2051781T3
Authority
ES
Spain
Prior art keywords
hydrogen
derivatives
low
dimethylene
trimethylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88103739T
Other languages
English (en)
Inventor
Walter Dr Hunkeler
Emilio Dr Kyburz
Marc Meier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2051781T3 publication Critical patent/ES2051781T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LOS NUEVOS DERIVADOS DE IRRIDAZODIACEPINA DE LA FORMULA (I): EN QUE A JUNTO CON LOS ATOMOS DE HIDROGENO (ALFA) Y (BETA) SIGNIFICA UNO DE LOS GRUPOS (A), (B) Y (C); R'' UNO DE LOS GRUPOS (D) Y (E); R2 HIDROGENO Y R3 UN ALQUIL BAJO, O R2 Y R3 JUNTOS DIMETILENO O TRIMETILENO, R4 Y R5 POR HIDROGENO, HALOGENO, TRIFLUORMETIL O ALQUIL BAJO, Y R6 HIDROGENO, HALOGENO, ARILO O UN GRUPO DE HIDROCARBURO BAJO SATURADO U OXO, MONO O DISUSTITUIDO POR HIDROXY, UN ALCOXY BAJO O (C3 - C4) CICLOALQUILO; MIENTRAS QUE LAS COMBINACIONES DE LA FORMULA (I) CON RESPECTOS AL ATOMO DE HIDROGENO DEFINIDO POR PRESENTAN LA CONFIGURACION (S) O (R, S), CUANDO R2 Y R3 JUNTOS SIGNIFICAN DIMETILENO O TRIMETILENO, A LA VEZ QUE LA DOBLE UNION CONTENIDA EN EL GRUPO (D) PRESENTA LA CONFIGURACION E Y / O Z, CUANDO R6 ES DISTINTO DEL HIDROGENO, POSEYENDO DICHOS DERIVADOS UNAS VALIOSAS PROPIEDADES FARMACODINAMICAS. SU CARACTERISTICA COMUN ES UNA MARCADA AFINIDAD A LOS RECEPTORES CENTRALES DE BENZADIACEPINA Y O BIEN POSEEN UNAS MARCADAS PROPIEDADES ANSIOLITICAS, ANTICONVULSIVAS, RELAJANTES DE LOS MUSCULOS Y CON EFECTO DE SEDANTE HIPROTICO; Y / O BIEN ANTAGONIZAN SELECTIVAMENTE EN ALGUNOS O TODOS LOS EFECTOS QUE DESARROLLAN LAS BENZODIACEPINAS 1, 4 U OTRAS SUSTANCIAS TRANQUILIZANTES A TRAVES DE LOS RECEPTORES DE BENZODIACEPINA, PARCIAL O COMPLETAMENTE.
ES88103739T 1987-03-10 1988-03-09 Derivados de imidazodiacepina. Expired - Lifetime ES2051781T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH88087 1987-03-10
CH5988 1988-01-08

Publications (1)

Publication Number Publication Date
ES2051781T3 true ES2051781T3 (es) 1994-07-01

Family

ID=25683391

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88103739T Expired - Lifetime ES2051781T3 (es) 1987-03-10 1988-03-09 Derivados de imidazodiacepina.

Country Status (17)

Country Link
US (1) US4863920A (es)
EP (1) EP0285837B1 (es)
KR (1) KR880011159A (es)
AU (1) AU604300B2 (es)
CA (1) CA1327571C (es)
DE (1) DE3872559D1 (es)
DK (1) DK127288A (es)
ES (1) ES2051781T3 (es)
FI (1) FI880814A (es)
GR (1) GR3005909T3 (es)
HU (1) HU201763B (es)
IL (1) IL85624A0 (es)
MC (1) MC1918A1 (es)
NO (1) NO167027C (es)
NZ (1) NZ223736A (es)
PT (1) PT86925B (es)
YU (1) YU47988A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives
GB8909700D0 (en) * 1989-04-27 1989-06-14 Roussel Lab Ltd Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
US8466144B2 (en) 2004-07-16 2013-06-18 Proteosys Ag Muscarinic antagonists with parp and sir modulating activity as cytoprotective agents
EP2387405A2 (en) 2009-01-13 2011-11-23 ProteoSys AG Pirenzepine as an agent in cancer treatment
AU2016354661B2 (en) * 2015-11-13 2020-12-10 Domain Therapeutics Substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of group II metabotropic glutamate receptors
US11472806B2 (en) 2017-05-12 2022-10-18 Domain Therapeutics Substituted heterocyclic compounds as allosteric modulators of group II metabotropic glutamate receptors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA755418B (en) * 1974-09-11 1977-06-29 Hoffmann La Roche Diazepine derivatives
US4280957A (en) * 1974-09-11 1981-07-28 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
ZW985A1 (en) * 1984-01-19 1985-08-28 Hoffmann La Roche Imidazodiazepine derivatives
EP0202441B1 (en) * 1985-05-17 1988-11-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepines, process for their preparation and pharmaceutical compositions
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives

Also Published As

Publication number Publication date
DK127288A (da) 1988-09-11
MC1918A1 (fr) 1989-04-06
DK127288D0 (da) 1988-03-09
NO167027C (no) 1991-09-25
US4863920A (en) 1989-09-05
FI880814A (fi) 1988-09-11
HUT47282A (en) 1989-02-28
NZ223736A (en) 1992-01-29
CA1327571C (en) 1994-03-08
NO881054D0 (no) 1988-03-09
YU47988A (en) 1991-04-30
NO167027B (no) 1991-06-17
EP0285837B1 (de) 1992-07-08
GR3005909T3 (es) 1993-06-07
KR880011159A (ko) 1988-10-26
AU1271088A (en) 1988-09-15
AU604300B2 (en) 1990-12-13
PT86925B (pt) 1992-05-29
EP0285837A1 (de) 1988-10-12
FI880814A0 (fi) 1988-02-22
HU201763B (en) 1990-12-28
NO881054L (no) 1988-09-12
PT86925A (pt) 1988-04-01
IL85624A0 (en) 1988-08-31
DE3872559D1 (de) 1992-08-13

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