ES2051781T3 - Derivados de imidazodiacepina. - Google Patents
Derivados de imidazodiacepina.Info
- Publication number
- ES2051781T3 ES2051781T3 ES88103739T ES88103739T ES2051781T3 ES 2051781 T3 ES2051781 T3 ES 2051781T3 ES 88103739 T ES88103739 T ES 88103739T ES 88103739 T ES88103739 T ES 88103739T ES 2051781 T3 ES2051781 T3 ES 2051781T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- derivatives
- low
- dimethylene
- trimethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- GXGJIOMUZAGVEH-UHFFFAOYSA-N Chamazulene Chemical class CCC1=CC=C(C)C2=CC=C(C)C2=C1 GXGJIOMUZAGVEH-UHFFFAOYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000003258 trimethylene group Chemical class [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 2
- -1 HYDROGEN ATOMS Chemical group 0.000 abstract 1
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
LOS NUEVOS DERIVADOS DE IRRIDAZODIACEPINA DE LA FORMULA (I): EN QUE A JUNTO CON LOS ATOMOS DE HIDROGENO (ALFA) Y (BETA) SIGNIFICA UNO DE LOS GRUPOS (A), (B) Y (C); R'' UNO DE LOS GRUPOS (D) Y (E); R2 HIDROGENO Y R3 UN ALQUIL BAJO, O R2 Y R3 JUNTOS DIMETILENO O TRIMETILENO, R4 Y R5 POR HIDROGENO, HALOGENO, TRIFLUORMETIL O ALQUIL BAJO, Y R6 HIDROGENO, HALOGENO, ARILO O UN GRUPO DE HIDROCARBURO BAJO SATURADO U OXO, MONO O DISUSTITUIDO POR HIDROXY, UN ALCOXY BAJO O (C3 - C4) CICLOALQUILO; MIENTRAS QUE LAS COMBINACIONES DE LA FORMULA (I) CON RESPECTOS AL ATOMO DE HIDROGENO DEFINIDO POR PRESENTAN LA CONFIGURACION (S) O (R, S), CUANDO R2 Y R3 JUNTOS SIGNIFICAN DIMETILENO O TRIMETILENO, A LA VEZ QUE LA DOBLE UNION CONTENIDA EN EL GRUPO (D) PRESENTA LA CONFIGURACION E Y / O Z, CUANDO R6 ES DISTINTO DEL HIDROGENO, POSEYENDO DICHOS DERIVADOS UNAS VALIOSAS PROPIEDADES FARMACODINAMICAS. SU CARACTERISTICA COMUN ES UNA MARCADA AFINIDAD A LOS RECEPTORES CENTRALES DE BENZADIACEPINA Y O BIEN POSEEN UNAS MARCADAS PROPIEDADES ANSIOLITICAS, ANTICONVULSIVAS, RELAJANTES DE LOS MUSCULOS Y CON EFECTO DE SEDANTE HIPROTICO; Y / O BIEN ANTAGONIZAN SELECTIVAMENTE EN ALGUNOS O TODOS LOS EFECTOS QUE DESARROLLAN LAS BENZODIACEPINAS 1, 4 U OTRAS SUSTANCIAS TRANQUILIZANTES A TRAVES DE LOS RECEPTORES DE BENZODIACEPINA, PARCIAL O COMPLETAMENTE.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH88087 | 1987-03-10 | ||
| CH5988 | 1988-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2051781T3 true ES2051781T3 (es) | 1994-07-01 |
Family
ID=25683391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES88103739T Expired - Lifetime ES2051781T3 (es) | 1987-03-10 | 1988-03-09 | Derivados de imidazodiacepina. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4863920A (es) |
| EP (1) | EP0285837B1 (es) |
| KR (1) | KR880011159A (es) |
| AU (1) | AU604300B2 (es) |
| CA (1) | CA1327571C (es) |
| DE (1) | DE3872559D1 (es) |
| DK (1) | DK127288A (es) |
| ES (1) | ES2051781T3 (es) |
| FI (1) | FI880814A7 (es) |
| GR (1) | GR3005909T3 (es) |
| HU (1) | HU201763B (es) |
| IL (1) | IL85624A0 (es) |
| MC (1) | MC1918A1 (es) |
| NO (1) | NO167027C (es) |
| NZ (1) | NZ223736A (es) |
| PT (1) | PT86925B (es) |
| YU (1) | YU47988A (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327572C (en) * | 1988-08-31 | 1994-03-08 | F. Hoffmann-La Roche Ag | Imidazodiazepine derivatives |
| GB8909700D0 (en) * | 1989-04-27 | 1989-06-14 | Roussel Lab Ltd | Chemical compounds |
| CA2015336A1 (en) * | 1989-05-19 | 1990-11-19 | F. Hoffmann-La Roche Ag | Imidazodiazepines for the treatment of neurological symptoms |
| NZ258552A (en) * | 1992-12-04 | 1996-07-26 | Janssen Pharmaceutica Nv | Azepine derivatives; compounds, preparation of and pharmaceutical compositions containing such compounds |
| CA2573673A1 (en) | 2004-07-16 | 2006-01-26 | Proteosys Ag | Muscarinic antagonists with parp and sir modulating activity as cytoprotective agents |
| EP2379080A1 (en) | 2009-01-13 | 2011-10-26 | ProteoSys AG | Pirenzepine as otoprotective agent |
| US11008323B2 (en) | 2015-11-13 | 2021-05-18 | Domain Therapeutics | Substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of group II metabotropic glutamate receptors |
| EP3621620A1 (en) | 2017-05-12 | 2020-03-18 | Mavalon Therapeutics Limited | Substituted heterocyclic compounds as allosteric modulators of group ii metabotropic glutamate receptors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA755418B (en) * | 1974-09-11 | 1977-06-29 | Hoffmann La Roche | Diazepine derivatives |
| US4280957A (en) * | 1974-09-11 | 1981-07-28 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| CA1143728A (en) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
| CA1174673A (en) * | 1981-02-27 | 1984-09-18 | Walter Hunkeler | Imidazodiazepines |
| DK151808C (da) * | 1982-11-16 | 1988-06-20 | Ferrosan As | Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater |
| EP0150040B1 (de) * | 1984-01-19 | 1994-08-31 | F. Hoffmann-La Roche Ag | Imidazodiazepin-Derivate |
| ATE38671T1 (de) * | 1985-05-17 | 1988-12-15 | Ferrosan As | Oxadiazolylimidazobenzodiazepine, verfahren zu ihrer herstellung und pharmazeutische zubereitungen. |
| DK174086D0 (da) * | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| GB8720414D0 (en) * | 1987-08-28 | 1987-10-07 | Roussel Lab Ltd | Chemical compounds |
| CA1327572C (en) * | 1988-08-31 | 1994-03-08 | F. Hoffmann-La Roche Ag | Imidazodiazepine derivatives |
-
1988
- 1988-02-22 FI FI880814A patent/FI880814A7/fi not_active Application Discontinuation
- 1988-02-23 CA CA000559547A patent/CA1327571C/en not_active Expired - Fee Related
- 1988-03-03 IL IL85624A patent/IL85624A0/xx unknown
- 1988-03-03 US US07/163,441 patent/US4863920A/en not_active Expired - Fee Related
- 1988-03-03 NZ NZ223736A patent/NZ223736A/en unknown
- 1988-03-04 AU AU12710/88A patent/AU604300B2/en not_active Ceased
- 1988-03-07 HU HU881085A patent/HU201763B/hu not_active IP Right Cessation
- 1988-03-07 MC MC881954A patent/MC1918A1/fr unknown
- 1988-03-09 DK DK127288A patent/DK127288A/da not_active Application Discontinuation
- 1988-03-09 YU YU00479/88A patent/YU47988A/xx unknown
- 1988-03-09 DE DE8888103739T patent/DE3872559D1/de not_active Expired - Lifetime
- 1988-03-09 PT PT86925A patent/PT86925B/pt not_active IP Right Cessation
- 1988-03-09 KR KR1019880002420A patent/KR880011159A/ko not_active Withdrawn
- 1988-03-09 EP EP88103739A patent/EP0285837B1/de not_active Expired - Lifetime
- 1988-03-09 ES ES88103739T patent/ES2051781T3/es not_active Expired - Lifetime
- 1988-03-09 NO NO881054A patent/NO167027C/no unknown
-
1992
- 1992-10-08 GR GR920402228T patent/GR3005909T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4863920A (en) | 1989-09-05 |
| HUT47282A (en) | 1989-02-28 |
| HU201763B (en) | 1990-12-28 |
| EP0285837A1 (de) | 1988-10-12 |
| KR880011159A (ko) | 1988-10-26 |
| NO167027B (no) | 1991-06-17 |
| NO881054D0 (no) | 1988-03-09 |
| EP0285837B1 (de) | 1992-07-08 |
| YU47988A (en) | 1991-04-30 |
| FI880814A0 (fi) | 1988-02-22 |
| GR3005909T3 (es) | 1993-06-07 |
| PT86925B (pt) | 1992-05-29 |
| AU604300B2 (en) | 1990-12-13 |
| CA1327571C (en) | 1994-03-08 |
| DK127288D0 (da) | 1988-03-09 |
| FI880814A7 (fi) | 1988-09-11 |
| DK127288A (da) | 1988-09-11 |
| PT86925A (pt) | 1988-04-01 |
| IL85624A0 (en) | 1988-08-31 |
| NO881054L (no) | 1988-09-12 |
| MC1918A1 (fr) | 1989-04-06 |
| AU1271088A (en) | 1988-09-15 |
| DE3872559D1 (de) | 1992-08-13 |
| NZ223736A (en) | 1992-01-29 |
| NO167027C (no) | 1991-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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