ES2051256T1 - Procedimiento para la separacion selectiva cuantitativa y/o obtencion preparativa del factor de necrosis de los tumores (tnf, del aleman "tumor nekrose factor") y/o lipopolisacaridos a partir de liquidos acuosos. - Google Patents

Procedimiento para la separacion selectiva cuantitativa y/o obtencion preparativa del factor de necrosis de los tumores (tnf, del aleman "tumor nekrose factor") y/o lipopolisacaridos a partir de liquidos acuosos.

Info

Publication number
ES2051256T1
ES2051256T1 ES93116446T ES93116446T ES2051256T1 ES 2051256 T1 ES2051256 T1 ES 2051256T1 ES 93116446 T ES93116446 T ES 93116446T ES 93116446 T ES93116446 T ES 93116446T ES 2051256 T1 ES2051256 T1 ES 2051256T1
Authority
ES
Spain
Prior art keywords
lipopolysaccharides
factor
aqueous liquids
tumor
necrosis factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES93116446T
Other languages
English (en)
Other versions
ES2051256T3 (es
Inventor
Karl-Siegfried Prof Dr Boos
Dietrich Prof Dr Seidel
Der Haar Friedrich Prof Dr Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Melsungen AG
Original Assignee
B Braun Melsungen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by B Braun Melsungen AG filed Critical B Braun Melsungen AG
Publication of ES2051256T1 publication Critical patent/ES2051256T1/es
Application granted granted Critical
Publication of ES2051256T3 publication Critical patent/ES2051256T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • External Artificial Organs (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PARA LA ELIMINACION SELECTIVA Y CUANTITATIVA Y/O OBTENCION DE LA PREPARACION DE FACTOR (TNF) DE TUMOR-NECROSIS Y/O LIPOPOLISACARIDOS DE FLUIDOS ACUOSOS COMO SANGRE, PLASMA O SUERO, SE CONDUCE EL LIQUIDO ACUOSO POR UN MATERIAL DE ADSORCION QUE CONSISTE EN UN MATERIAL PORTADOR POROSO CON GRUPOS FUNCIONALES UNIDOS COVALENTEMENTE CADENAS DE POLIANIONES SINTETICAS Y/O SEMISINTETICAS Y/O NATURALES EN FORMA LINEAL RAMIFICADA Y SE ELUYE EN CASO DADO LA MOLECULA SEPARADA CROMATOGRAFICAMENTE DEL MATERIAL DE ADSORCION CON UNA SOLUCION DE SAL COMUN. UN DISPOSITIVO CON ARREGLO A LA INVENCION PARA ELIMINACION EXTRACORPORAL DEL FACTOR TUMOR-NECROSIS Y/O LIPOPOLISACARIDOS DE LIQUIDOS ACUOSOS, PARTICULARMENTE SANGRE, PLASMA O SUERO CONSISTE EN UNA CARCASA CILINDRICA QUE ESTA LLENA CON UN MATERIAL DE ABSORCION QUE CONSISTE EN UN MATERIAL PORTADOR POROSO CON GRUPOS FUNCIONALES UNIDOS COVALENTEMENTE A CADENAS DE POLIANIONES SINTETICOS Y/O SEMISINTETICAS Y/O NATURALES EN FORMA LINEAL O RAMIFICADA Y ESTAN PREVISTOS EN EXTREMOS FRONTALES CON TAPAS QUE PRESENTAN UN CONDUCTO DE ENTRADA Y SALIDA CENTRALES.
ES93116446T 1992-10-12 1993-10-11 Procedimiento para la eliminacion selectiva cuantitativa o la obtencion preparativa de factor de necrosis tumoral (fnt) y lipopolisacaridos (lps) de liquidos acuosos. Expired - Lifetime ES2051256T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4234363 1992-10-12
DE4331358A DE4331358A1 (de) 1992-10-12 1993-09-15 Verfahren zur quantitativen selektiven Entfernung oder präparativen Gewinnung von Tumor-Nekrose-Faktor (TNF) oder/und Lipopolysacchariden (LPS) aus wäßrigen Flüssigkeiten

Publications (2)

Publication Number Publication Date
ES2051256T1 true ES2051256T1 (es) 1994-06-16
ES2051256T3 ES2051256T3 (es) 2002-12-01

Family

ID=25919399

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93116446T Expired - Lifetime ES2051256T3 (es) 1992-10-12 1993-10-11 Procedimiento para la eliminacion selectiva cuantitativa o la obtencion preparativa de factor de necrosis tumoral (fnt) y lipopolisacaridos (lps) de liquidos acuosos.

Country Status (6)

Country Link
US (1) US5403917A (es)
EP (1) EP0592989B1 (es)
JP (1) JP2929516B2 (es)
AT (1) ATE217324T1 (es)
DE (2) DE4331358A1 (es)
ES (1) ES2051256T3 (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2721217B1 (fr) * 1994-06-20 1996-08-02 Hospal Ind Dispositif multifonction pour le traitement du sang.
DE4435612A1 (de) * 1994-10-05 1996-04-11 Braun Melsungen Ag Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit
IT1271593B (it) * 1994-11-30 1997-06-04 Sanitaria Scaligera Spa Procedimento ed apparecchiatura per l'immunoadsorbimento specifico di virus hiv, di antigene gp120 e complesso cd4-gp120.
CA2167872C (en) * 1995-01-27 2007-04-03 Masaru Nakatani Adsorbent for removing interleukins and tumor necrosis factor, and process for removing the same
JPH08257115A (ja) * 1995-03-20 1996-10-08 Kanegafuchi Chem Ind Co Ltd 腫瘍壊死因子の吸着剤および吸着除去方法
US6127528A (en) * 1995-02-16 2000-10-03 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for adsorbing and removing tumor necrosis factor-α
DE69621597T2 (de) * 1995-02-16 2003-01-16 Kanegafuchi Kagaku Kogyo K.K., Osaka Adsorbens für tumornekrosefaktor alpha, methode zur entfernung durch adsorption und adsorptionsvorrichtung unter verwendung des adsorbens
DE19549420A1 (de) * 1995-04-27 1997-09-18 Braun Melsungen Ag Verfahren zur simultanen extrakorporalen Elimination von Tumor-Nekrose Faktor alpha (TNF alpha) und bakteriellen Lipopolysacchariden (LPS) aus Vollblut oder/und Blutplasma
US6559290B1 (en) * 1996-03-18 2003-05-06 Kaneka Corporation Method for removing a chemokine
US5851985A (en) * 1996-08-16 1998-12-22 Tepic; Slobodan Treatment of tumors by arginine deprivation
CN1228713A (zh) 1996-08-26 1999-09-15 海马舒尔公司 从肿瘤细胞污染的干细胞产品中除去肿瘤细胞的方法
JP4046378B2 (ja) * 1996-09-19 2008-02-13 株式会社カネカ エンドトキシン吸着システム
FR2758394B1 (fr) * 1997-01-14 1999-03-19 Hospal Ind Moyens pour la bio-epuration specifique d'un fluide biologique
US6194562B1 (en) 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US8197430B1 (en) * 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
DE19845286A1 (de) * 1998-10-01 2000-04-27 Udo Dunzendorfer Beschichtete Trägermaterialien für Blut-, Plasma- oder Gewebewäsche und mit diesen Trägermaterialien ausgerüstete Säulen
US6884228B2 (en) 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
US6706008B2 (en) 2001-03-06 2004-03-16 Baxter International Inc. Automated system and method for withdrawing compounds from blood
US6582386B2 (en) 2001-03-06 2003-06-24 Baxter International Inc. Multi-purpose, automated blood and fluid processing systems and methods
DE10118446A1 (de) * 2001-04-12 2002-10-17 Thomas Hartung Prüfverfahren zur Untersuchung fließfähiger Medien auf Gehalte an mikrobiellen Toxinen
JP3880036B2 (ja) * 2001-05-11 2007-02-14 全国酪農業協同組合連合会 タンパク質の濃縮方法
US6803183B2 (en) * 2002-07-18 2004-10-12 Clarigen, Inc. Method for removing pyrogens from plasma and blood for treatment of septic shock
FR2848223B1 (fr) * 2002-12-09 2005-02-25 Centre Nat Rech Scient Nouveau procede d'isolement des endotoxines.
DE10258944A1 (de) * 2002-12-17 2004-07-01 B. Braun Medizintechnologie Gmbh Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie deren Verwendung zur Behandlung von Sepsis
DE10262333B4 (de) * 2002-12-17 2012-06-14 B. Braun Avitum Ag Verwendung von chemisch modifizierten Hohlfasermaterialien zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie deren Verwendung zur Behandlung von Sepsis
CA2565215C (en) * 2004-04-30 2014-04-15 Biopheresis Technologies, Inc. Method and system to remove soluble tnfr1, tnfr2, and il2 in patients
EP1602387B1 (de) * 2004-06-03 2007-03-14 B. Braun Medizintechnologie GmbH Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie Verwendung zur Herstellung eines Mittels zur Entfernung dieser Stoffe
DE102005002969A1 (de) 2005-01-21 2006-08-03 Profos Ag Verfahren zum Nachweis und zur Entfernung von Endotoxin
CA2613094A1 (en) * 2005-07-01 2007-01-11 Promega Corporation Network of buoyant particles for biomolecule purification
WO2007070381A2 (en) 2005-12-09 2007-06-21 Promega Corporation Nucleic acid purification with a binding matrix
WO2007069983A1 (en) 2005-12-13 2007-06-21 Exthera Ab Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood
WO2007092735A2 (en) 2006-02-02 2007-08-16 Innovative Bio Therapies An extracorporeal cell-based therapeutic device and delivery system
US9029144B2 (en) * 2008-06-18 2015-05-12 Innovative Bio Therapies, Inc. Methods for enhanced propagation of cells
CN101609678B (zh) 2008-12-30 2011-07-27 华为技术有限公司 信号压缩方法及其压缩装置
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8222397B2 (en) * 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
JP5925693B2 (ja) 2009-12-01 2016-05-25 エクステラ・メディカル・コーポレーション 表面固定した多糖類を用いた、血液からのサイトカイン除去法
WO2012112724A1 (en) 2011-02-15 2012-08-23 Exthera Medical, Llc Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines
DK2861273T3 (da) 2012-06-13 2017-11-27 Exthera Medical Corp Anvendelse af heparin og kulhydrater til behandling af cancer.
BR112015032134B1 (pt) 2013-06-24 2022-05-10 Exthera Medical Corporation Método de ligação em ponto de extremidade de uma manose não redutora a um substrato e esfera possuindo uma manose ligada em ponto de extremidade
MX382486B (es) 2013-11-08 2025-03-13 Exthera Medical Corp Métodos para diagnosticar enfermedades infecciosas usando medio de adsorción.
US10905818B2 (en) * 2014-03-31 2021-02-02 Zoll Medical Corporation Blood filtering of inflammatory biomarkers to treat post-resuscitation syndrome
CN106255520B (zh) 2014-04-24 2022-08-12 艾克塞拉医疗公司 使用高流速从血液除去细菌的方法
CN106714669B (zh) 2014-09-22 2021-05-14 艾克塞拉医疗公司 可穿戴的血液灌流装置
WO2017151797A1 (en) 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
MX2021013515A (es) 2019-05-16 2022-01-04 Exthera Medical Corp Metodo para modular la estructura del glucocaliz endotelial.

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959128A (en) * 1974-12-27 1976-05-25 Preventive Systems, Inc Process for removing endotoxin from biological fluids
US4491660A (en) * 1980-01-10 1985-01-01 Abbott Laboratories Matrix polymers for binding endotoxins
GB2092470B (en) * 1981-02-10 1984-07-18 Tanabe Seiyaku Co Method for reducing the pyrogen content of or removing pyrogens from solutions contaminated therewith
US4381239A (en) * 1981-02-10 1983-04-26 Tanabe Seiyaku Co., Ltd. Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith
EP0074610B1 (de) * 1981-09-10 1987-05-20 Intermedicat GmbH Verfahren zur selektiven extrakorporalen Präzipitation von Low Density Lipoproteinen aus Vollserum oder Plasma
CA1221307A (en) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US5059654A (en) * 1983-02-14 1991-10-22 Cuno Inc. Affinity matrices of modified polysaccharide supports
US4576927A (en) * 1983-11-25 1986-03-18 Asahi Kasei Kogyo Kabushiki Kaisha Porous adsorbent for adsorbing low density lipoproteins
DE3421731A1 (de) * 1984-06-12 1985-12-12 Boehringer Ingelheim International GmbH, 6507 Ingelheim Humaner-tumor-nekrose-faktor
DE3422494A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Verfahren und vorrichtung zur spezifischen adsorption von heparin
JPS6156133A (ja) * 1984-08-24 1986-03-20 Chemo Sero Therapeut Res Inst 発熱物質の除去方法
JPS61124392A (ja) * 1984-11-22 1986-06-12 Asahi Chem Ind Co Ltd 遺伝子組換体の産生する生理活性物質の精製法
DE3526096A1 (de) * 1985-07-22 1987-01-22 Basf Ag Verfahren zur reinigung von htnf
US4777242A (en) * 1986-10-10 1988-10-11 Phillips Petroleum Company Purification of recombinant tumor necrosis factor
JPS6429399A (en) * 1987-07-24 1989-01-31 Denki Kagaku Kogyo Kk Method for separating human lymphotoxin
EP0377046B1 (en) * 1988-04-05 1993-08-04 Kanebo Ltd. Fine particles of porous ion-exchange cellulose, process for their production, and affinity carrier
US5055447A (en) * 1988-07-28 1991-10-08 Genentech, Inc. Method and compositions for the treatment and prevention of septic shock
DE3926539A1 (de) * 1989-08-11 1991-02-14 Braun Melsungen Ag Verwendung von tentakel-kationenaustauschern zur selektiven eliminierung von low-density-lipoproteinen (ldl), fibrinogen und/oder harnstoff aus fluessigkeiten
DE3932971C2 (de) * 1989-10-03 2003-03-13 Fresenius Ag Zur Eliminierung von Biomakromolekülen, insbesondere LDL und Endotoxinen, aus Vollblut in extrakorporalem Kreislauf geeignetes Adsorbens
US5136032A (en) * 1989-12-07 1992-08-04 Daicel Chemical Industries, Ltd. Method for separating phosphopolyol compounds using a separating agent
US5178864A (en) * 1990-08-14 1993-01-12 Mit Lipoprotein removal by soluble enzymes
KR930007780B1 (ko) * 1990-11-19 1993-08-19 삼성전자 주식회사 로보트의 위치 제어방법
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification

Also Published As

Publication number Publication date
ES2051256T3 (es) 2002-12-01
DE59310284D1 (de) 2002-06-13
EP0592989A2 (de) 1994-04-20
US5403917A (en) 1995-04-04
EP0592989A3 (en) 1995-12-13
JP2929516B2 (ja) 1999-08-03
DE4331358A1 (de) 1994-04-14
JPH06211900A (ja) 1994-08-02
ATE217324T1 (de) 2002-05-15
EP0592989B1 (de) 2002-05-08

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