ES2051256T1 - Procedimiento para la separacion selectiva cuantitativa y/o obtencion preparativa del factor de necrosis de los tumores (tnf, del aleman "tumor nekrose factor") y/o lipopolisacaridos a partir de liquidos acuosos. - Google Patents
Procedimiento para la separacion selectiva cuantitativa y/o obtencion preparativa del factor de necrosis de los tumores (tnf, del aleman "tumor nekrose factor") y/o lipopolisacaridos a partir de liquidos acuosos.Info
- Publication number
- ES2051256T1 ES2051256T1 ES93116446T ES93116446T ES2051256T1 ES 2051256 T1 ES2051256 T1 ES 2051256T1 ES 93116446 T ES93116446 T ES 93116446T ES 93116446 T ES93116446 T ES 93116446T ES 2051256 T1 ES2051256 T1 ES 2051256T1
- Authority
- ES
- Spain
- Prior art keywords
- lipopolysaccharides
- factor
- aqueous liquids
- tumor
- necrosis factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Anesthesiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PARA LA ELIMINACION SELECTIVA Y CUANTITATIVA Y/O OBTENCION DE LA PREPARACION DE FACTOR (TNF) DE TUMOR-NECROSIS Y/O LIPOPOLISACARIDOS DE FLUIDOS ACUOSOS COMO SANGRE, PLASMA O SUERO, SE CONDUCE EL LIQUIDO ACUOSO POR UN MATERIAL DE ADSORCION QUE CONSISTE EN UN MATERIAL PORTADOR POROSO CON GRUPOS FUNCIONALES UNIDOS COVALENTEMENTE CADENAS DE POLIANIONES SINTETICAS Y/O SEMISINTETICAS Y/O NATURALES EN FORMA LINEAL RAMIFICADA Y SE ELUYE EN CASO DADO LA MOLECULA SEPARADA CROMATOGRAFICAMENTE DEL MATERIAL DE ADSORCION CON UNA SOLUCION DE SAL COMUN. UN DISPOSITIVO CON ARREGLO A LA INVENCION PARA ELIMINACION EXTRACORPORAL DEL FACTOR TUMOR-NECROSIS Y/O LIPOPOLISACARIDOS DE LIQUIDOS ACUOSOS, PARTICULARMENTE SANGRE, PLASMA O SUERO CONSISTE EN UNA CARCASA CILINDRICA QUE ESTA LLENA CON UN MATERIAL DE ABSORCION QUE CONSISTE EN UN MATERIAL PORTADOR POROSO CON GRUPOS FUNCIONALES UNIDOS COVALENTEMENTE A CADENAS DE POLIANIONES SINTETICOS Y/O SEMISINTETICAS Y/O NATURALES EN FORMA LINEAL O RAMIFICADA Y ESTAN PREVISTOS EN EXTREMOS FRONTALES CON TAPAS QUE PRESENTAN UN CONDUCTO DE ENTRADA Y SALIDA CENTRALES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4234363 | 1992-10-12 | ||
DE4331358A DE4331358A1 (de) | 1992-10-12 | 1993-09-15 | Verfahren zur quantitativen selektiven Entfernung oder präparativen Gewinnung von Tumor-Nekrose-Faktor (TNF) oder/und Lipopolysacchariden (LPS) aus wäßrigen Flüssigkeiten |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2051256T1 true ES2051256T1 (es) | 1994-06-16 |
ES2051256T3 ES2051256T3 (es) | 2002-12-01 |
Family
ID=25919399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93116446T Expired - Lifetime ES2051256T3 (es) | 1992-10-12 | 1993-10-11 | Procedimiento para la eliminacion selectiva cuantitativa o la obtencion preparativa de factor de necrosis tumoral (fnt) y lipopolisacaridos (lps) de liquidos acuosos. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5403917A (es) |
EP (1) | EP0592989B1 (es) |
JP (1) | JP2929516B2 (es) |
AT (1) | ATE217324T1 (es) |
DE (2) | DE4331358A1 (es) |
ES (1) | ES2051256T3 (es) |
Families Citing this family (48)
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FR2721217B1 (fr) * | 1994-06-20 | 1996-08-02 | Hospal Ind | Dispositif multifonction pour le traitement du sang. |
DE4435612A1 (de) * | 1994-10-05 | 1996-04-11 | Braun Melsungen Ag | Verfahren zur simultanen Entfernung von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus einer wäßrigen Flüssigkeit |
IT1271593B (it) * | 1994-11-30 | 1997-06-04 | Sanitaria Scaligera Spa | Procedimento ed apparecchiatura per l'immunoadsorbimento specifico di virus hiv, di antigene gp120 e complesso cd4-gp120. |
JPH08257115A (ja) * | 1995-03-20 | 1996-10-08 | Kanegafuchi Chem Ind Co Ltd | 腫瘍壊死因子の吸着剤および吸着除去方法 |
CA2167872C (en) * | 1995-01-27 | 2007-04-03 | Masaru Nakatani | Adsorbent for removing interleukins and tumor necrosis factor, and process for removing the same |
US6127528A (en) * | 1995-02-16 | 2000-10-03 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for adsorbing and removing tumor necrosis factor-α |
EP0810027B1 (en) * | 1995-02-16 | 2002-06-05 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Adsorbent for tumor necrosis factor alpha, method of removal by adsorption, and adsorption device using said adsorbent |
DE19515554C2 (de) * | 1995-04-27 | 1999-06-17 | Braun Melsungen Ag | Verwendung eines Mittels und Vorrichtung zur simultanen extrakorporalen Elimination von Tumor-Nekrose-Faktor alpha und bakteriellen Lipopolysacchariden aus Vollblut oder/und Blutplasma |
DE69722491T2 (de) * | 1996-03-18 | 2004-05-19 | Kaneka Corp. | Adsorbens und Verfahren zur Entfernung von Chemokinen des CC-Subtyps aus Körperflüssigkeiten |
US5851985A (en) * | 1996-08-16 | 1998-12-22 | Tepic; Slobodan | Treatment of tumors by arginine deprivation |
WO1998008556A1 (en) * | 1996-08-26 | 1998-03-05 | Hemasure, Inc. | Method for removing tumor cells from tumor cell-contaminated stem cell products |
JP4046378B2 (ja) * | 1996-09-19 | 2008-02-13 | 株式会社カネカ | エンドトキシン吸着システム |
FR2758394B1 (fr) * | 1997-01-14 | 1999-03-19 | Hospal Ind | Moyens pour la bio-epuration specifique d'un fluide biologique |
US7078224B1 (en) * | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
US6194562B1 (en) | 1998-04-22 | 2001-02-27 | Promega Corporation | Endotoxin reduction in nucleic acid purification |
US8197430B1 (en) | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
DE19845286A1 (de) * | 1998-10-01 | 2000-04-27 | Udo Dunzendorfer | Beschichtete Trägermaterialien für Blut-, Plasma- oder Gewebewäsche und mit diesen Trägermaterialien ausgerüstete Säulen |
US6582386B2 (en) | 2001-03-06 | 2003-06-24 | Baxter International Inc. | Multi-purpose, automated blood and fluid processing systems and methods |
US6884228B2 (en) | 2001-03-06 | 2005-04-26 | Baxter International Inc. | Automated system adaptable for use with different fluid circuits |
US6706008B2 (en) | 2001-03-06 | 2004-03-16 | Baxter International Inc. | Automated system and method for withdrawing compounds from blood |
DE10118446A1 (de) * | 2001-04-12 | 2002-10-17 | Thomas Hartung | Prüfverfahren zur Untersuchung fließfähiger Medien auf Gehalte an mikrobiellen Toxinen |
JP3880036B2 (ja) * | 2001-05-11 | 2007-02-14 | 全国酪農業協同組合連合会 | タンパク質の濃縮方法 |
US6803183B2 (en) * | 2002-07-18 | 2004-10-12 | Clarigen, Inc. | Method for removing pyrogens from plasma and blood for treatment of septic shock |
FR2848223B1 (fr) * | 2002-12-09 | 2005-02-25 | Centre Nat Rech Scient | Nouveau procede d'isolement des endotoxines. |
DE10258944A1 (de) * | 2002-12-17 | 2004-07-01 | B. Braun Medizintechnologie Gmbh | Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie deren Verwendung zur Behandlung von Sepsis |
DE10262333B4 (de) * | 2002-12-17 | 2012-06-14 | B. Braun Avitum Ag | Verwendung von chemisch modifizierten Hohlfasermaterialien zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie deren Verwendung zur Behandlung von Sepsis |
PT1949915E (pt) * | 2004-04-30 | 2012-11-27 | Biopheresis Technologies Inc | Método e sistema para remover rfnt1,rfnt2, e ril2 solúveis em pacientes |
EP1602387B1 (de) * | 2004-06-03 | 2007-03-14 | B. Braun Medizintechnologie GmbH | Vorrichtung zur Entfernung von bakteriellen Lipopolysacchariden oder/und Lipoteichonsäuren aus proteinhaltigen Flüssigkeiten sowie Verwendung zur Herstellung eines Mittels zur Entfernung dieser Stoffe |
DE102005002969A1 (de) | 2005-01-21 | 2006-08-03 | Profos Ag | Verfahren zum Nachweis und zur Entfernung von Endotoxin |
EP1907585A4 (en) * | 2005-07-01 | 2010-04-07 | Promega Corp | FLOATING PARTICLE ARRAY FOR PURIFYING BIOMOLECULES AND USES THEREOF OR FLOATING PARTICLE ARRAY FOR PURIFYING BIOMOLECULES |
EP1963526A4 (en) | 2005-12-09 | 2009-11-18 | Promega Corp | PURIFICATION OF NUCLEIC ACID WITH A BINDING MATRIX |
JP5715325B2 (ja) | 2005-12-13 | 2015-05-07 | エクステラ・メディカル・コーポレーション | 血液からの病原性微生物、炎症性細胞または炎症性タンパク質の体外除去法 |
JP2009525781A (ja) | 2006-02-02 | 2009-07-16 | イノベーティブ バイオ セラピーズ | 細胞をベースとする体外治療装置および送達システム |
CN102171332A (zh) * | 2008-06-18 | 2011-08-31 | 创新生物制剂疗法公司 | 促进肾前体细胞增殖的方法 |
CN101609678B (zh) | 2008-12-30 | 2011-07-27 | 华为技术有限公司 | 信号压缩方法及其压缩装置 |
US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
US8222397B2 (en) * | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
JP5925693B2 (ja) | 2009-12-01 | 2016-05-25 | エクステラ・メディカル・コーポレーション | 表面固定した多糖類を用いた、血液からのサイトカイン除去法 |
WO2012112724A1 (en) | 2011-02-15 | 2012-08-23 | Exthera Medical, Llc | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
ES2647577T3 (es) | 2012-06-13 | 2017-12-22 | Exthera Medical Corporation | Uso de heparina y carbohidratos para tratar el cáncer |
EP3013445B1 (en) | 2013-06-24 | 2019-11-06 | ExThera Medical Corporation | Blood filtration system containing mannose coated substrate |
JP6806563B2 (ja) | 2013-11-08 | 2021-01-06 | エクステラ・メディカル・コーポレーション | 吸着媒体を使用する感染症の診断法 |
WO2015153287A1 (en) * | 2014-03-31 | 2015-10-08 | Zoll Medical Corporation | Blood filtering of inflammatory biomarkers to treat post-resuscitation syndrome |
KR20170020749A (ko) | 2014-04-24 | 2017-02-24 | 엑스테라 메디컬 코퍼레이션 | 고유속을 이용한 혈액으로부터 세균의 제거방법 |
BR112017004059A2 (pt) | 2014-09-22 | 2017-12-05 | Exthera Medical Corp | dispositivo de hemoperfusão utilizável |
US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
US10786615B2 (en) | 2016-03-02 | 2020-09-29 | Exthera Medical Corporation | Method for treating drug intoxication |
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JPS6429399A (en) * | 1987-07-24 | 1989-01-31 | Denki Kagaku Kogyo Kk | Method for separating human lymphotoxin |
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DE3932971C2 (de) * | 1989-10-03 | 2003-03-13 | Fresenius Ag | Zur Eliminierung von Biomakromolekülen, insbesondere LDL und Endotoxinen, aus Vollblut in extrakorporalem Kreislauf geeignetes Adsorbens |
US5136032A (en) * | 1989-12-07 | 1992-08-04 | Daicel Chemical Industries, Ltd. | Method for separating phosphopolyol compounds using a separating agent |
US5178864A (en) * | 1990-08-14 | 1993-01-12 | Mit | Lipoprotein removal by soluble enzymes |
KR930007780B1 (ko) * | 1990-11-19 | 1993-08-19 | 삼성전자 주식회사 | 로보트의 위치 제어방법 |
US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
-
1993
- 1993-09-15 DE DE4331358A patent/DE4331358A1/de not_active Withdrawn
- 1993-10-06 US US08/132,316 patent/US5403917A/en not_active Expired - Lifetime
- 1993-10-11 DE DE59310284T patent/DE59310284D1/de not_active Expired - Lifetime
- 1993-10-11 ES ES93116446T patent/ES2051256T3/es not_active Expired - Lifetime
- 1993-10-11 EP EP93116446A patent/EP0592989B1/de not_active Expired - Lifetime
- 1993-10-11 AT AT93116446T patent/ATE217324T1/de active
- 1993-10-12 JP JP5254222A patent/JP2929516B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2051256T3 (es) | 2002-12-01 |
JPH06211900A (ja) | 1994-08-02 |
JP2929516B2 (ja) | 1999-08-03 |
EP0592989A3 (en) | 1995-12-13 |
EP0592989B1 (de) | 2002-05-08 |
US5403917A (en) | 1995-04-04 |
EP0592989A2 (de) | 1994-04-20 |
ATE217324T1 (de) | 2002-05-15 |
DE4331358A1 (de) | 1994-04-14 |
DE59310284D1 (de) | 2002-06-13 |
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