ES2050340T3 - Preparados de pancreatina. - Google Patents
Preparados de pancreatina.Info
- Publication number
- ES2050340T3 ES2050340T3 ES90122360T ES90122360T ES2050340T3 ES 2050340 T3 ES2050340 T3 ES 2050340T3 ES 90122360 T ES90122360 T ES 90122360T ES 90122360 T ES90122360 T ES 90122360T ES 2050340 T3 ES2050340 T3 ES 2050340T3
- Authority
- ES
- Spain
- Prior art keywords
- pancreatin
- mass
- solvent
- pancreatin preparations
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN PROCESO PARA LA PREPARACION DE UNA PANCREATINA SECA QUE SE CARACTERIZA PORQUE LA MASA DE PANCREATINA HUMEDA TODAVIA, QUE SE OBTIENE DESPUES DE LA EXTRACCION CON UN DISOLVENTE O MEZCLA DISOLVENTE, SE TRATA, ANTES DE RETIRAR FINALMENTE LOS DISOLVENTES, DURANTE UN CORTO ESPACIO DE TIEMPO EN UNA MAQUINA DE CORTAR AL VACIO, HASTA QUE SE HA DIVIDIDO LA MASA Y SE LE HA DADO LA FORMA DE PEQUEÑAS PARTICULAS ESFERICAS Y DESPUES SE SECA FINALMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT268889 | 1989-11-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2050340T3 true ES2050340T3 (es) | 1994-05-16 |
Family
ID=3538711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90122360T Expired - Lifetime ES2050340T3 (es) | 1989-11-24 | 1990-11-23 | Preparados de pancreatina. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5674532A (es) |
EP (1) | EP0436110B1 (es) |
JP (1) | JP3025528B2 (es) |
KR (1) | KR100229754B1 (es) |
AT (1) | ATE102026T1 (es) |
AU (1) | AU638784B2 (es) |
CA (1) | CA2030581C (es) |
DE (1) | DE69007055T2 (es) |
DK (1) | DK0436110T3 (es) |
ES (1) | ES2050340T3 (es) |
HK (1) | HK102996A (es) |
PH (1) | PH30058A (es) |
WO (1) | WO1991007948A1 (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9302777D0 (sv) * | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
US5874063A (en) * | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
SE9101090D0 (sv) * | 1991-04-11 | 1991-04-11 | Astra Ab | Process for conditioning of water-soluble substances |
US5260074A (en) * | 1992-06-22 | 1993-11-09 | Digestive Care Inc. | Compositions of digestive enzymes and salts of bile acids and process for preparation thereof |
AU6123296A (en) * | 1995-05-31 | 1996-12-18 | Akzo Nobel N.V. | Enteric coated compressed pancreatin particles |
CA2198317C (en) * | 1997-02-24 | 2003-01-07 | Mouhsine El Abboudi | Method for preparing pancreatin which contains low amounts of residual organic solvent and product thereof |
US7122207B2 (en) | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
UA69413C2 (uk) * | 1998-05-22 | 2004-09-15 | Брістол-Майерс Сквібб Компані | Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції |
UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
US6632429B1 (en) | 1999-12-17 | 2003-10-14 | Joan M. Fallon | Methods for treating pervasive development disorders |
KR100367659B1 (ko) * | 2000-05-08 | 2003-01-14 | 주식회사 바이넥스 | 선택적 안정화제의 첨가에 따른 자가분해(autolysis)를 통한 고역가 판크레아틴의 제조방법 |
US20070053895A1 (en) | 2000-08-14 | 2007-03-08 | Fallon Joan M | Method of treating and diagnosing parkinsons disease and related dysautonomic disorders |
IT1319655B1 (it) | 2000-11-15 | 2003-10-23 | Eurand Int | Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione. |
US8030002B2 (en) | 2000-11-16 | 2011-10-04 | Curemark Llc | Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions |
US7153504B2 (en) * | 2004-07-30 | 2006-12-26 | Can Technologies, Inc. | Stabilized pancreas product |
KR101555058B1 (ko) | 2005-07-29 | 2015-09-22 | 애보트 래버러토리즈 게엠베하 | 살균된 판크레아틴 분말의 제조방법 |
US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
US20080058282A1 (en) * | 2005-08-30 | 2008-03-06 | Fallon Joan M | Use of lactulose in the treatment of autism |
US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
US20090117180A1 (en) * | 2007-02-20 | 2009-05-07 | Giovanni Ortenzi | Stable digestive enzyme compositions |
CN103933555B (zh) | 2007-02-20 | 2018-06-01 | 阿普塔利斯制药有限公司 | 稳定的消化酶组合物 |
WO2009109856A2 (en) | 2008-03-07 | 2009-09-11 | Axcan Pharma Inc. | Method for detecting infectious parvovirus in pharmaceutical preparations |
US8658163B2 (en) | 2008-03-13 | 2014-02-25 | Curemark Llc | Compositions and use thereof for treating symptoms of preeclampsia |
US8084025B2 (en) | 2008-04-18 | 2011-12-27 | Curemark Llc | Method for the treatment of the symptoms of drug and alcohol addiction |
US9320780B2 (en) | 2008-06-26 | 2016-04-26 | Curemark Llc | Methods and compositions for the treatment of symptoms of Williams Syndrome |
WO2010002972A1 (en) | 2008-07-01 | 2010-01-07 | Curemark, Llc | Methods and compositions for the treatment of symptoms of neurological and mental health disorders |
US10776453B2 (en) | 2008-08-04 | 2020-09-15 | Galenagen, Llc | Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain |
EP2165717A1 (de) | 2008-08-27 | 2010-03-24 | Nordmark Arzneimittel GmbH & Co.KG | Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte |
US20100092447A1 (en) | 2008-10-03 | 2010-04-15 | Fallon Joan M | Methods and compositions for the treatment of symptoms of prion diseases |
CN105031628B (zh) | 2009-01-06 | 2020-10-02 | 加尔纳根有限责任公司 | 治疗或预防大肠杆菌导致的经口感染的组合物和方法 |
US9107419B2 (en) | 2009-01-06 | 2015-08-18 | Curelon Llc | Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces |
BRPI0922653B8 (pt) | 2009-01-29 | 2021-05-25 | Nordmark Arzneimittel Gmbh & Co Kg | uso de uma lipase bacteriana do tipo pseudomonas em solução aquosa |
US9056050B2 (en) | 2009-04-13 | 2015-06-16 | Curemark Llc | Enzyme delivery systems and methods of preparation and use |
EP2295039B2 (de) * | 2009-08-28 | 2022-10-26 | Nordmark Pharma GmbH | Verfahren zur Herstellung von Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und hiernach hergestellte Pankreatin-Pellets |
US9511125B2 (en) | 2009-10-21 | 2016-12-06 | Curemark Llc | Methods and compositions for the treatment of influenza |
EP2621476B8 (en) | 2010-10-01 | 2020-12-23 | Société des Produits Nestlé S.A. | Enteric coated, low-strength pancrelipase formulations |
EP2489349B1 (de) | 2011-02-17 | 2014-05-28 | Nordmark Arzneimittel GmbH & Co.KG | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung |
DE202011000728U1 (de) | 2011-03-30 | 2011-06-09 | Nordmark Arzneimittel GmbH & Co. KG, 25436 | Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets |
EP2701733B1 (en) | 2011-04-21 | 2019-04-03 | Curemark, LLC | Compounds for the treatment of neuropsychiatric disorders |
ES2558756T3 (es) | 2011-08-08 | 2016-02-08 | Aptalis Pharma Limited | Método para la prueba de disolución de composiciones sólidas que contienen enzimas digestivas |
US10350278B2 (en) | 2012-05-30 | 2019-07-16 | Curemark, Llc | Methods of treating Celiac disease |
CA2920844A1 (en) | 2013-08-09 | 2015-02-12 | Allergan Pharmaceuticals International Limited | Digestive enzyme composition suitable for enteral administration |
WO2015193730A1 (en) | 2014-06-19 | 2015-12-23 | Aptalis Pharma Ltd. | Methods for removing viral contaminants from pancreatic extracts |
DE102015119006A1 (de) | 2015-11-05 | 2017-05-11 | Nordmark Arzneimittel Gmbh & Co. Kg | Verfahren zur Reduzierung der Belastung von Pankreatin mit Mikroorganismen |
DE102017104482A1 (de) * | 2017-03-03 | 2018-09-06 | Nordmark Arzneimittel Gmbh & Co. Kg | Pharmazeutische Zusammensetzung umfassend Pankreatin und einen lipasehaltigen Überzug |
FR3079146B1 (fr) * | 2018-03-23 | 2020-04-17 | Karim Ioualalen | Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive. |
MD20220054A2 (ro) * | 2020-06-10 | 2023-05-31 | Kusum Healthcare Private Limited | Compoziţie farmaceutică de pancreatină |
US11541009B2 (en) | 2020-09-10 | 2023-01-03 | Curemark, Llc | Methods of prophylaxis of coronavirus infection and treatment of coronaviruses |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3956483A (en) * | 1968-10-24 | 1976-05-11 | Wilson Pharmaceutical & Chemical Corporation | Preparing pancreatin |
FR2059978A1 (en) * | 1969-08-20 | 1971-06-11 | Sogeras | Enteric coating of sensitive medicaments inp |
JPS4946073B1 (es) * | 1970-04-08 | 1974-12-07 | ||
JPS57791B2 (es) * | 1973-11-23 | 1982-01-07 | ||
DE2512746C3 (de) * | 1975-03-22 | 1980-04-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Verfahren zur Herstellung von keimarmem, faserfreiem Pankreatin |
GB1509866A (en) * | 1975-06-10 | 1978-05-04 | Johnson & Johnson | Enteric coated digestive enzyme compositions |
DE2923279B1 (de) * | 1979-06-08 | 1980-11-20 | Kali Chemie Pharma Gmbh | Verfahren zur Herstellung von Pankreatin-Pellets |
EP0115023B1 (de) * | 1982-12-30 | 1988-07-27 | Nordmark Arzneimittel GmbH | Verfahren zur Gewinnung von Pankreatin |
EP0166315B1 (de) * | 1984-06-19 | 1989-08-23 | BASF Aktiengesellschaft | Magensaftresistent überzogene zylindrische Pankreatin-Mikrotabletten |
DE3445301A1 (de) * | 1984-12-12 | 1986-06-12 | Hoechst Ag, 6230 Frankfurt | Pankreasenzympraeparate und verfahren zu deren herstellung |
-
1990
- 1990-11-22 KR KR1019900018928A patent/KR100229754B1/ko not_active IP Right Cessation
- 1990-11-22 CA CA002030581A patent/CA2030581C/en not_active Expired - Lifetime
- 1990-11-22 PH PH41598A patent/PH30058A/en unknown
- 1990-11-22 JP JP2320550A patent/JP3025528B2/ja not_active Expired - Lifetime
- 1990-11-23 DE DE69007055T patent/DE69007055T2/de not_active Expired - Lifetime
- 1990-11-23 EP EP90122360A patent/EP0436110B1/en not_active Expired - Lifetime
- 1990-11-23 DK DK90122360.2T patent/DK0436110T3/da not_active Application Discontinuation
- 1990-11-23 AT AT90122360T patent/ATE102026T1/de not_active IP Right Cessation
- 1990-11-23 ES ES90122360T patent/ES2050340T3/es not_active Expired - Lifetime
- 1990-11-26 AU AU68701/91A patent/AU638784B2/en not_active Expired
- 1990-11-26 WO PCT/EP1990/002016 patent/WO1991007948A1/en unknown
-
1995
- 1995-06-06 US US08/466,303 patent/US5674532A/en not_active Expired - Lifetime
-
1996
- 1996-06-13 HK HK102996A patent/HK102996A/xx not_active IP Right Cessation
-
1997
- 1997-06-19 US US08/879,240 patent/US5861177A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69007055D1 (de) | 1994-04-07 |
EP0436110A1 (en) | 1991-07-10 |
DK0436110T3 (da) | 1994-06-20 |
AU638784B2 (en) | 1993-07-08 |
KR100229754B1 (ko) | 1999-11-15 |
US5861177A (en) | 1999-01-19 |
HK102996A (en) | 1996-06-21 |
AU6870191A (en) | 1991-06-26 |
KR910009282A (ko) | 1991-06-28 |
CA2030581A1 (en) | 1991-05-25 |
JPH03172181A (ja) | 1991-07-25 |
US5674532A (en) | 1997-10-07 |
DE69007055T2 (de) | 1994-08-25 |
JP3025528B2 (ja) | 2000-03-27 |
PH30058A (en) | 1996-11-08 |
CA2030581C (en) | 2000-06-27 |
EP0436110B1 (en) | 1994-03-02 |
WO1991007948A1 (en) | 1991-06-13 |
ATE102026T1 (de) | 1994-03-15 |
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