ES2039264T3 - Preparado acuoso o pulverulento, dispersable en agua de un producto activo farmaceutico dificilmente soluble en agua y procedimiento para su obtencion. - Google Patents

Preparado acuoso o pulverulento, dispersable en agua de un producto activo farmaceutico dificilmente soluble en agua y procedimiento para su obtencion.

Info

Publication number
ES2039264T3
ES2039264T3 ES198888100742T ES88100742T ES2039264T3 ES 2039264 T3 ES2039264 T3 ES 2039264T3 ES 198888100742 T ES198888100742 T ES 198888100742T ES 88100742 T ES88100742 T ES 88100742T ES 2039264 T3 ES2039264 T3 ES 2039264T3
Authority
ES
Spain
Prior art keywords
water
aqueous
procedure
obtaining
pharmaceutically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888100742T
Other languages
English (en)
Inventor
Dieter Dr. Horn
Reinhard Dr. Spengler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2039264T3 publication Critical patent/ES2039264T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTA UN PREPARADO FARMACEUTICO ACUOSO O EN POLVO DISPERSABLE EN AGUA, QUE CONTIENE UN EMULSIFICANTE, UN COLOIDE PROTECTOR Y UN ACEITE O GRASA COMESTIBLE EN FORMA MICRODISPERSA EN EL QUE ESTA DISUELTO UN PRINCIPIO ACTIVO DIFICILMENTE SOLUBLE EN AGUA. SE PRESENTA IGUALMENTE UN PROCEDIMIENTO PARA SU OBTENCION.
ES198888100742T 1987-01-24 1988-01-20 Preparado acuoso o pulverulento, dispersable en agua de un producto activo farmaceutico dificilmente soluble en agua y procedimiento para su obtencion. Expired - Lifetime ES2039264T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873702029 DE3702029A1 (de) 1987-01-24 1987-01-24 Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung

Publications (1)

Publication Number Publication Date
ES2039264T3 true ES2039264T3 (es) 1993-09-16

Family

ID=6319439

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888100742T Expired - Lifetime ES2039264T3 (es) 1987-01-24 1988-01-20 Preparado acuoso o pulverulento, dispersable en agua de un producto activo farmaceutico dificilmente soluble en agua y procedimiento para su obtencion.

Country Status (8)

Country Link
US (2) US4935245A (es)
EP (1) EP0276735B1 (es)
JP (1) JP2695173B2 (es)
AT (1) ATE74268T1 (es)
CA (1) CA1332225C (es)
DE (2) DE3702029A1 (es)
ES (1) ES2039264T3 (es)
GR (1) GR3004531T3 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
ATE94057T1 (de) * 1988-12-20 1993-09-15 Medicontrol Corp Durch hitze dehydratisierte emulsionen.
GB8919172D0 (en) * 1989-08-23 1989-10-04 Univ Nottingham Useful composition
DE3936053A1 (de) * 1989-10-28 1991-05-02 Basf Ag Verfahren zur verbesserung der bioverfuegbarkeit von pharmazeutischen wirkstoffen mit peptidbindungen
IE65045B1 (en) * 1990-04-28 1995-10-04 Takeda Chemical Industries Ltd Granulated preparations and method of producing the same
DE4015108A1 (de) * 1990-05-11 1991-11-14 Leopold Pharma Gmbh Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe
DE4023241A1 (de) * 1990-07-21 1992-01-23 Knoll Ag Stabile wirkstoff-formulierung
TW209174B (es) * 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
DE4120918A1 (de) * 1991-06-25 1993-01-07 Basf Ag Pulverfoermige praeparate aus einer wasserunloeslichen kernsubstanz und einer schutzhuelle
US5326570A (en) * 1991-07-23 1994-07-05 Pharmavene, Inc. Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
EP0663818A4 (en) * 1992-09-03 1996-04-24 Ibah Inc TASTE-COVERING PHARMACEUTICAL SUMMARY AND METHOD FOR PRODUCING THE SAME.
CA2091152C (en) * 1993-03-05 2005-05-03 Kirsten Westesen Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
EP0682943B1 (de) * 1994-05-20 2003-08-20 GESELLSCHAFT FÜR MEDIZINISCHE FORSCHUNG UND WEITERBILDUNG e.V. GMF Lormetazepamhaltige Öl-in-Wasser-Emulsion
US5560931A (en) * 1995-02-14 1996-10-01 Nawosystems L.L.C. Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
US6426078B1 (en) * 1997-03-17 2002-07-30 Roche Vitamins Inc. Oil in water microemulsion
DE19757224A1 (de) * 1997-12-22 1999-07-01 Bayer Ag Verfahren und Vorrichtung zur in-situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation
US6146656A (en) * 1998-01-22 2000-11-14 Nitto Denko Corporation Percutaneous absorption preparation
JP4027535B2 (ja) * 1998-05-26 2007-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 脂溶性薬物を含有した粉末
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
DE19856432A1 (de) 1998-12-08 2000-06-15 Basf Ag Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
US6555139B2 (en) * 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
ATE292455T1 (de) * 1999-12-09 2005-04-15 Dsm Ip Assets Bv Fettlösliche vitamine enthaltende zusammensetzungen
DE10205362A1 (de) * 2002-02-08 2003-08-21 Abbott Gmbh & Co Kg Verfahren zur Herstellung wasserdispergierbarer Trockenpulver von in Wasser schwer löslichen Verbindungen
US6936279B2 (en) * 2002-06-18 2005-08-30 Zeavision Llc Microcrystalline zeaxanthin with high bioavailability in oily carrier formulations
PT1748756E (pt) * 2004-03-10 2009-07-20 Bayer Schering Pharma Ag Composições compreendendo drospirenona molecularmente dispersa
DE102004057587A1 (de) * 2004-11-29 2006-06-08 Basf Ag Wässrige Dispersionen eines Gemisches schwer wasserlöslicher oder wasserunlöslicher Wirkstoffe und eines Einzellerproteinmaterials und daraus hergestellte Trockenpulver
ES2407407T3 (es) 2005-06-01 2013-06-12 Glaxosmithkline Intellectual Property Development Limited Formulación de vitamina
DE102005026755A1 (de) * 2005-06-09 2006-12-14 Basf Ag Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung
EP1815752A1 (en) * 2006-02-02 2007-08-08 Nestec S.A. Improvement of cold liquid solubility of fat-containing powders
ZA200807571B (en) * 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
JP4759413B2 (ja) * 2006-03-10 2011-08-31 富士フイルム株式会社 皮膚外用剤
AU2007263091B2 (en) * 2006-06-21 2012-03-08 Basf Se Azolylmethyloxiranes, their use for controlling phytopathogenic fungi and compositions comprising them
ATE495170T1 (de) * 2006-06-23 2011-01-15 Basf Se Azolylmethyloxirane, ihre verwendung zur bekämpfung von pflanzenpathogenen pilzen sowie sie enthaltende mittel
JP2009541250A (ja) * 2006-06-23 2009-11-26 ビーエーエスエフ ソシエタス・ヨーロピア アゾリルメチルオキシラン、植物病原菌類を防除するためのその使用、およびそれを含む組成物
BRPI0713450A2 (pt) * 2006-07-05 2012-01-31 Basf Se compostos, uso de compostos, composição de proteção de colheita, semente, e, processo para combater fungos fitopatogênicos
JP2009541430A (ja) * 2006-07-05 2009-11-26 ビーエーエスエフ ソシエタス・ヨーロピア アゾリルメチルオキシラン、植物病原菌類を防除するためのその使用、およびそれを含む薬剤
CN101495473A (zh) * 2006-07-24 2009-07-29 巴斯夫欧洲公司 唑基甲基环氧乙烷，它们在防治植物病原性真菌中的用途和包含它们的组合物
CN101490043A (zh) * 2006-07-25 2009-07-22 巴斯夫欧洲公司 唑基甲基环氧乙烷及其在防治植物病原性真菌中的用途和包含它们的试剂
CN101568259A (zh) * 2006-12-22 2009-10-28 巴斯夫欧洲公司 唑基甲基环氧乙烷、其在防治植物病原性真菌中的用途以及包含它们的组合物
ITTV20090026A1 (it) * 2009-02-24 2010-08-25 Labomar S R L Metodo per produzione di una composizione solida idro-dispersibile di substrati insolubili e composizione ottenibile tramite tale metodo.
AU2015274698B9 (en) 2014-06-11 2017-03-09 Poviva Corp. Food and beverage compositions infused with lipophilic active agents and methods of use thereof
MX2017017157A (es) * 2015-12-09 2019-07-10 Poviva Tea Llc Composiciones de bebida lista para beber estables que comprende agentes activos lipofilos.
EP4117684A4 (en) 2020-04-20 2023-10-04 Poviva Corp. COMPOSITIONS AND METHODS FOR IMPROVED DELIVERY OF ANTIVIRAL AGENTS

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2885322A (en) * 1956-05-01 1959-05-05 Lloyd Brothers Inc Dioctyl sodium sulfosuccinate solutions in capsules
GB929227A (en) * 1958-12-22 1963-06-19 Upjohn Co Encapsulated emulsions and processes for their preparation
US3004892A (en) * 1959-03-27 1961-10-17 Baxter Don Inc Fat emulsion and process of producing same
US3147187A (en) * 1962-09-10 1964-09-01 Don Hall Lab Sustained release pharmaceutical
US3872024A (en) * 1970-05-27 1975-03-18 Ncr Co Encapsulation process by simple coacervation using inorganic polymers
US4273672A (en) * 1971-08-23 1981-06-16 Champion International Corporation Microencapsulation process
JPS582927B2 (ja) * 1973-10-30 1983-01-19 協和醗酵工業株式会社 フンマツセイヒンノ セイゾウホウ
JPS5729213B2 (es) * 1974-11-12 1982-06-21
JPS5515681A (en) * 1978-07-21 1980-02-02 Kuraray Co Ltd Production of microcapsule
DE3119383A1 (de) * 1981-05-15 1982-12-02 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von feinverteilten, pulverfoermigen carotinodpraeparaten
JPS58128141A (ja) * 1982-01-26 1983-07-30 Sumitomo Chem Co Ltd 自己乳化分散型カロチノイド類含有ソフトカプセル剤の製法
DE3237814A1 (de) * 1982-10-12 1984-04-12 Warner-Lambert Co., 07950 Morris Plains, N.J. Wasserfreie emulsionen und verwendung derselben
GB8305693D0 (en) * 1983-03-02 1983-04-07 Scherer Ltd R P Pharmaceutical compositions
FR2561916B1 (fr) * 1984-03-30 1987-12-11 Lafon Labor Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
US4722838A (en) * 1986-05-09 1988-02-02 E. I. Du Pont De Nemours And Company Self-microencapsulating controlled release pesticide compositions
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
CH668553A5 (de) * 1987-02-02 1989-01-13 Mepha Ag Arzneimittel mit verzoegerter wirkstofffreisetzung.

Also Published As

Publication number Publication date
EP0276735A2 (de) 1988-08-03
DE3869629D1 (de) 1992-05-07
GR3004531T3 (es) 1993-04-28
EP0276735B1 (de) 1992-04-01
CA1332225C (en) 1994-10-04
US4935245A (en) 1990-06-19
DE3702029A1 (de) 1988-08-04
JP2695173B2 (ja) 1997-12-24
ATE74268T1 (de) 1992-04-15
EP0276735A3 (en) 1989-01-11
US5118511A (en) 1992-06-02
JPS63192715A (ja) 1988-08-10

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