ES2036214T3 - Un procedimiento para la preparacion de compuestos de dihidropiridinas como agentes antialergicos y antiinflamatorios. - Google Patents
Un procedimiento para la preparacion de compuestos de dihidropiridinas como agentes antialergicos y antiinflamatorios.Info
- Publication number
- ES2036214T3 ES2036214T3 ES198787309674T ES87309674T ES2036214T3 ES 2036214 T3 ES2036214 T3 ES 2036214T3 ES 198787309674 T ES198787309674 T ES 198787309674T ES 87309674 T ES87309674 T ES 87309674T ES 2036214 T3 ES2036214 T3 ES 2036214T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- piperazinyl
- alcoxi
- substitutes
- allergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
COMPUESTOS DE FORMULA (I), EN LA QUE R ES FENILO O FENILO SUSTITUIDO POR UNO O MAS SUSTITUYENTES ELEGIDOS DE NITRO, HALO, ALQUILO C1-C4, ALCOXI C1-C4, ARIL(ALCOXI C1-C4), ALQUILTIO C1-C4, ALQUILSULFONILO C1-C4, HIDROXI, TRIFLUOROMETILO Y CIANO; R1 Y R2 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-C6, O LOS DOS GRUPOS SE PUEDEN UNIR PARA FORMAR CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS UN GRUPO PIRROLIDINILO, PIPERIDINO, MORFOLINO, PIPERAZINILO, N(ALQUIL C1-C4)PIPERAZINILO O N(ALCANOILO C1-C4)PIPERAZINILO; O R2 ES HIDROGENO O ALQUILO C1-C4 Y R1 ES CN, CICLOALQUILO C3-C7, ARILO, HETEROARILO, O UN GRUPO ALQUILO C1-C4 SUSTITUIDO POR UNO O MAS SUSTITUYENTS ELEGIDOS DE CICLOALQUILO C3-C7, ALCOXICARBONILO C1-C4, ARILO Y HETEROARILO; R3 ES HIDROXI, ALQUILOXI C1-C6 ARIL(ALCOXI C1-C4), O NR4R5, DONDE CADA UNO DE R4 Y R5 ES INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-C6, O LOS DOS GRUPOS SE PUEDEN UNIR PARA FORMAR CON EL ATOMO DE HIDROGENO AL QUE ESTAN UNIDOS UN GRUPO PIRROLIDINILO, PIPERIDINO, MORFOLINO, PIPERAZINILO, O N(ALQUILO C1-C4); Y ES UN GRUPO ALQUILENO DE 2 A 8 ATOMOS DE CARBONO, QUE PUEDE SER DE CADENA RECTA O RAMIFICADA, QUE TIENE POR LO MENOS 2 ATOMOS DE CARBONO EN LA CADENA QUE UNE X AL ATOMO DE OXIGENO; X ES BENZIMIDAZOL-1-ILO O BENZIMIDAZOL-2-ILO, OPCIONALMENTE SUSTITUIDOS CON UNO O MAS SUSTITUYENYES ELEGIDOS DE ALQUILO C1-C4, ALCOXI C1-C4, HALO CF3 Y CN; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES SON ANTAGONISTAS DE PAF Y SON UTILES EN EL TRATAMIENTO DE CONDICIONES ALERGICAS, INFLAMATORIAS E HIPERSECRETORAS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868626698A GB8626698D0 (en) | 1986-11-07 | 1986-11-07 | Therapeutic agents |
| GB878709842A GB8709842D0 (en) | 1987-04-25 | 1987-04-25 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2036214T3 true ES2036214T3 (es) | 1993-05-16 |
Family
ID=26291518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198787309674T Expired - Lifetime ES2036214T3 (es) | 1986-11-07 | 1987-11-02 | Un procedimiento para la preparacion de compuestos de dihidropiridinas como agentes antialergicos y antiinflamatorios. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4801598A (es) |
| EP (1) | EP0266989B1 (es) |
| JP (1) | JPH064624B2 (es) |
| KR (1) | KR880006196A (es) |
| CN (1) | CN87107723A (es) |
| AU (1) | AU8089687A (es) |
| DE (1) | DE3763573D1 (es) |
| DK (1) | DK582787A (es) |
| ES (1) | ES2036214T3 (es) |
| FI (1) | FI874866A (es) |
| GR (2) | GR880300183T1 (es) |
| HU (1) | HUT45990A (es) |
| IL (1) | IL84380A0 (es) |
| NO (1) | NO874194L (es) |
| PL (1) | PL268618A1 (es) |
| PT (1) | PT86082B (es) |
| YU (1) | YU201987A (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8712747D0 (en) * | 1987-05-30 | 1987-07-01 | Pfizer Ltd | Therapeutic agents |
| GB8716971D0 (en) * | 1987-07-17 | 1987-08-26 | Pfizer Ltd | Therapeutic agents |
| MY104933A (en) | 1987-09-30 | 1994-07-30 | Pfizer Ltd | Platelet activating factor antagonists |
| GB8804439D0 (en) * | 1988-02-25 | 1988-03-23 | Pfizer Ltd | Dihydropyridines |
| GB8906324D0 (en) * | 1989-03-20 | 1989-05-04 | Pfizer Ltd | 1,4-dihydropyridines |
| DE4237617A1 (de) * | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
| US5496855A (en) * | 1995-01-27 | 1996-03-05 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
| DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| US6566359B1 (en) | 2002-05-20 | 2003-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | 2,4,6-trimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid esters as neuroprotective drugs |
| CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
| KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료 |
| PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
| TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| JP7148192B1 (ja) | 2022-05-09 | 2022-10-05 | 有限会社Amplus | 表示制御装置および方法並びにプログラム |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3363743D1 (en) * | 1982-07-22 | 1986-07-03 | Pfizer Ltd | Dihydropyridine anti-ischaemic and antihypertensive agents |
| HUT39179A (en) * | 1984-12-10 | 1986-08-28 | Sandoz Ag | Process for production of derivatives of 1,4-dihydro-piridin |
| HU199796B (en) * | 1985-08-06 | 1990-03-28 | Boehringer Biochemia Srl | Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds |
| EP0225175A3 (en) * | 1985-11-28 | 1988-12-28 | FISONS plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof |
-
1987
- 1987-10-06 NO NO874194A patent/NO874194L/no unknown
- 1987-10-30 US US07/115,213 patent/US4801598A/en not_active Expired - Fee Related
- 1987-11-02 ES ES198787309674T patent/ES2036214T3/es not_active Expired - Lifetime
- 1987-11-02 EP EP87309674A patent/EP0266989B1/en not_active Expired - Lifetime
- 1987-11-02 DE DE8787309674T patent/DE3763573D1/de not_active Expired - Lifetime
- 1987-11-04 FI FI874866A patent/FI874866A/fi not_active IP Right Cessation
- 1987-11-05 IL IL84380A patent/IL84380A0/xx unknown
- 1987-11-05 PT PT86082A patent/PT86082B/pt not_active IP Right Cessation
- 1987-11-05 PL PL26861887A patent/PL268618A1/xx unknown
- 1987-11-05 KR KR870012409A patent/KR880006196A/ko not_active Application Discontinuation
- 1987-11-06 JP JP62280832A patent/JPH064624B2/ja not_active Expired - Lifetime
- 1987-11-06 AU AU80896/87A patent/AU8089687A/en not_active Abandoned
- 1987-11-06 HU HU874984A patent/HUT45990A/hu unknown
- 1987-11-06 DK DK582787A patent/DK582787A/da not_active Application Discontinuation
- 1987-11-06 YU YU02019/87A patent/YU201987A/xx unknown
- 1987-11-07 CN CN198787107723A patent/CN87107723A/zh active Pending
-
1989
- 1989-06-22 GR GR88300183T patent/GR880300183T1/el unknown
-
1990
- 1990-07-18 GR GR90400486T patent/GR3000820T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU201987A (en) | 1988-12-31 |
| KR880006196A (ko) | 1988-07-22 |
| JPS63139167A (ja) | 1988-06-10 |
| NO874194L (no) | 1988-05-09 |
| FI874866A0 (fi) | 1987-11-04 |
| PL268618A1 (en) | 1988-09-01 |
| NO874194D0 (no) | 1987-10-06 |
| US4801598A (en) | 1989-01-31 |
| DE3763573D1 (de) | 1990-08-09 |
| PT86082B (pt) | 1990-11-20 |
| EP0266989B1 (en) | 1990-07-04 |
| CN87107723A (zh) | 1988-05-18 |
| DK582787D0 (da) | 1987-11-06 |
| EP0266989A3 (en) | 1988-09-28 |
| EP0266989A2 (en) | 1988-05-11 |
| JPH064624B2 (ja) | 1994-01-19 |
| IL84380A0 (en) | 1988-04-29 |
| GR3000820T3 (en) | 1991-11-15 |
| FI874866A (fi) | 1988-05-08 |
| HUT45990A (en) | 1988-09-28 |
| PT86082A (en) | 1987-12-01 |
| AU8089687A (en) | 1988-05-12 |
| GR880300183T1 (en) | 1989-06-22 |
| DK582787A (da) | 1988-05-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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