ES2033277T3 - Nuevo procedimiento para la obtencion de derivados de cefalosporina. - Google Patents

Nuevo procedimiento para la obtencion de derivados de cefalosporina.

Info

Publication number
ES2033277T3
ES2033277T3 ES198787114592T ES87114592T ES2033277T3 ES 2033277 T3 ES2033277 T3 ES 2033277T3 ES 198787114592 T ES198787114592 T ES 198787114592T ES 87114592 T ES87114592 T ES 87114592T ES 2033277 T3 ES2033277 T3 ES 2033277T3
Authority
ES
Spain
Prior art keywords
cephtazidime
pentahydrate
obtaining
new procedure
cephalosporin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787114592T
Other languages
English (en)
Inventor
Bernhard Christian Prager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Application granted granted Critical
Publication of ES2033277T3 publication Critical patent/ES2033277T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO NUEVO PARA LA FABRICACION DE PENTAHIDRATO DE CEFTAZIDIN, DONDE EN LA FORMULA ES CARACTERISTICO, QUE EL GRUPO ESTER DE LA COMBINACION DE LA FORMULA O UN SAL ACIDO ADICIONAL, SE DESDOBLE BAJO LA UNICA APLICACION DE ACIDO CLORHIDRICO ACUOSO Y DE ESTO, PRODUCIDO CEFTAZIDIM, SE CRISTALIZA DE LA MEZCLA DE LA REACCION DIRECTAMENTE A TRAVES DE LA ADICION BASICA COMO PENTAHIDRATO, O PRIMERO SE AISLA A TRAVES DE LA ASICION DE ACETONA Y/O ETANOL O DE UN ANTEIDISOLVENTE MISCIBLE CON AGUA DE DILUIDROCLORID DE CEFTAZIDIM Y ESTO SE TRANSFORMA EB PENTAHIDRATO DE LA MANERA Y CONOCIDA.
ES198787114592T 1986-10-07 1987-10-06 Nuevo procedimiento para la obtencion de derivados de cefalosporina. Expired - Lifetime ES2033277T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0265786A AT387390B (de) 1986-10-07 1986-10-07 Verfahren zur herstellung des antibiotikums (6r,7r)-7-(2-(2-amino-4-thiazolyl)-2-(2-carboxy

Publications (1)

Publication Number Publication Date
ES2033277T3 true ES2033277T3 (es) 1993-03-16

Family

ID=3538212

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787114592T Expired - Lifetime ES2033277T3 (es) 1986-10-07 1987-10-06 Nuevo procedimiento para la obtencion de derivados de cefalosporina.

Country Status (9)

Country Link
EP (1) EP0267427B1 (es)
JP (2) JP2507505B2 (es)
KR (1) KR950010597B1 (es)
AT (2) AT387390B (es)
DE (1) DE3777537D1 (es)
ES (1) ES2033277T3 (es)
GR (1) GR3004109T3 (es)
HK (1) HK68295A (es)
WO (1) WO1988002752A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106317081B (zh) * 2016-08-22 2018-08-31 山东罗欣药业集团恒欣药业有限公司 一种抗感染药物头孢他啶晶体化合物及其药物组合物
CN106397458A (zh) * 2016-09-23 2017-02-15 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢他啶晶体化合物
CN106432280A (zh) * 2016-09-23 2017-02-22 临沂草之美医药科技有限公司 一种治疗外科手术感染的药物头孢他啶晶体化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329453A (en) * 1979-10-02 1982-05-11 Glaxo Group Limited Cephalosporin antibiotic
US4537959A (en) * 1984-03-26 1985-08-27 Eli Lilly And Company Crystalline cephalosporin antibiotic salt
US4616080A (en) * 1984-07-02 1986-10-07 Eli Lilly And Company Simplified process of forming crystalline ceftazidime pentahydrate
CA1239389A (en) * 1984-11-08 1988-07-19 Melvin G. Pleiss, Jr. Crystallization process

Also Published As

Publication number Publication date
ATE73809T1 (de) 1992-04-15
JPH01500906A (ja) 1989-03-30
GR3004109T3 (es) 1993-03-31
WO1988002752A1 (en) 1988-04-21
ATA265786A (de) 1988-06-15
KR880701723A (ko) 1988-11-04
AT387390B (de) 1989-01-10
EP0267427A1 (de) 1988-05-18
JP2507505B2 (ja) 1996-06-12
HK68295A (en) 1995-05-12
KR950010597B1 (ko) 1995-09-20
DE3777537D1 (de) 1992-04-23
JP2594780B2 (ja) 1997-03-26
EP0267427B1 (de) 1992-03-18
JPH08283272A (ja) 1996-10-29

Similar Documents

Publication Publication Date Title
AU2507088A (en) Amino acid derivatives of phosphorus acids
PT83104A (en) Novel guanidinomethylbenzoic acid derivatives
DE69328962T2 (de) Verfahren zur herstellng von cyano-methoxyiminomethylderivaten
DE3882895D1 (de) Imid-derivate, ihre herstellung und verwendung.
DK546489D0 (da) Thienopyridin-mevalonolactoner, fremgangsmaade til fremstilling heraf og farmaceutisk praeparat omfattende samme
UA6022A1 (uk) СПОСІБ ОТРИМАННЯ ЦИКЛОАЛКОМЕДІВ (8-beta)-1АЛКІЛ-6-(ЗАМІЩЕНОГО) ЕРГОЛІНУ АБО ЇХ ФАРМАЦЕВТИЧНО ПРИДАТНИХ КИСЛОТНО-АДИТИВНИХ СОЛЕЙ
ES2033277T3 (es) Nuevo procedimiento para la obtencion de derivados de cefalosporina.
ES2039213T3 (es) Procedimiento para producir nuevos compuestos relacionados con espergualina.
NO170154C (no) Fremgangsmaate for fremstilling av kinolincarboxylsyrer
DE3854109T2 (de) Verfahren zur herstellung von chinolincarbonsäuren.
ES554671A0 (es) Procedimiento para la fabricacion de acidos 6-alcoxi (inferior)-5-halo-1-naftoicos y sus esteres correspondientes
ATE172734T1 (de) Verfahren zur herstellung von ceftriaxon
ATE80875T1 (de) Verfahren zur herstellung grobkristalliner nicotinsaeure hoher reinheit.
ES2130392T3 (es) Procedimiento para la preparacion de acido clavulanico.
RU94019424A (ru) Способ получения кристаллического моногидрата лоракарбефа из кристаллического дигидрата лоракарбефа
ZA9610804B (en) 4-Imidazolidinone compound process for its preparation and the pharmaceutical compositions which contain it
GR880100409A (en) Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids
DE69127238D1 (de) Verfahren zur Herstellung von Pyrido[1,2-a]pyrimidinderivaten
ES2037813T3 (es) Procedimiento para la preparacion de ester metilico de aspartil-fenil-alanina a partir de ester metilico de n-formil-aspartil-fenilalanina.
TH7749EX (th) อนุพันธ์ไธอีโน (3,4-4,5) อิมิดาโซ (2,1-บี) ไธอะโซลต่าง ๆต่าง ๆ กระบวนการสำหรับการผลิตและการใช้ประโยชน์ทางยา

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 267427

Country of ref document: ES