ES2018152B3 - Nuevos derivados ciclicos de aminas, medicamentos que contienen estos compuestos y procedimiento para su obtencion. - Google Patents

Nuevos derivados ciclicos de aminas, medicamentos que contienen estos compuestos y procedimiento para su obtencion.

Info

Publication number
ES2018152B3
ES2018152B3 ES86116002T ES86116002T ES2018152B3 ES 2018152 B3 ES2018152 B3 ES 2018152B3 ES 86116002 T ES86116002 T ES 86116002T ES 86116002 T ES86116002 T ES 86116002T ES 2018152 B3 ES2018152 B3 ES 2018152B3
Authority
ES
Spain
Prior art keywords
group
carbon atoms
general formula
hereinbefore
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86116002T
Other languages
English (en)
Inventor
Manfred Psiorz
Joachim Heider
Andreas Bomhard
Manfred Reiffen
Norbert Hauel
Klaus Noll
Berthold Narr
Walter Kobinger
Jurgen Dammgen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Application granted granted Critical
Publication of ES2018152B3 publication Critical patent/ES2018152B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES86116002T 1985-11-27 1986-11-18 Nuevos derivados ciclicos de aminas, medicamentos que contienen estos compuestos y procedimiento para su obtencion. Expired - Lifetime ES2018152B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853541811 DE3541811A1 (de) 1985-11-27 1985-11-27 Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES2018152B3 true ES2018152B3 (es) 1991-04-01

Family

ID=6286902

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86116002T Expired - Lifetime ES2018152B3 (es) 1985-11-27 1986-11-18 Nuevos derivados ciclicos de aminas, medicamentos que contienen estos compuestos y procedimiento para su obtencion.

Country Status (25)

Country Link
EP (1) EP0224794B1 (es)
JP (1) JPH0625128B2 (es)
KR (1) KR950007589B1 (es)
AT (1) ATE56447T1 (es)
AU (1) AU589712B2 (es)
CA (1) CA1321194C (es)
CZ (1) CZ410391A3 (es)
DD (1) DD256132A5 (es)
DE (2) DE3541811A1 (es)
DK (1) DK174564B1 (es)
ES (1) ES2018152B3 (es)
FI (1) FI88299C (es)
GR (1) GR3001107T3 (es)
HK (1) HK123993A (es)
HU (1) HU196787B (es)
IE (1) IE59487B1 (es)
IL (1) IL80758A (es)
MX (1) MX9202813A (es)
NO (1) NO168034C (es)
NZ (1) NZ218412A (es)
PH (1) PH22944A (es)
PT (1) PT83815B (es)
SU (1) SU1442073A3 (es)
UA (1) UA8034A1 (es)
ZA (1) ZA868933B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA1298427C (en) * 1987-03-13 1992-03-31 Johannes Adrianus Maria Van Broekhoven Process for removing palladium catalyst remnants from copolymers of carbon monoxide with one or more olefinically unsaturated compounds
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2634207B1 (fr) * 1988-07-12 1990-09-07 Synthelabo Derives de ((piperidinyl-4)methyl) benzazepines, leur preparation et leur application en therapeutique
DE10018401A1 (de) 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
US20040138306A1 (en) 2002-07-25 2004-07-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
ATE257384T1 (de) * 2002-07-25 2004-01-15 Boehringer Ingelheim Pharma Verwendung von cilobradine oder pharmazeutisch akzeptablen salze zur behandlung oder prävention von herzversagen
EP1762179A1 (en) 2005-09-07 2007-03-14 Boehringer Ingelheim Vetmedica Gmbh Method for improving diagnostic quality in echocardiography
CN103796638A (zh) 2011-08-12 2014-05-14 勃林格殷格翰动物保健有限公司 遮味药物组合物
EP2953612A1 (en) 2013-02-11 2015-12-16 Boehringer Ingelheim Vetmedica GmbH Kit-of-parts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2639718A1 (de) * 1976-09-03 1978-03-16 Thomae Gmbh Dr K Neue phenylaethylamine
CH645632A5 (en) * 1977-01-01 1984-10-15 Thomae Gmbh Dr K Arylalkylamines
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418271A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
SU1442073A3 (ru) 1988-11-30
FI88299B (fi) 1993-01-15
IL80758A0 (en) 1987-02-27
DK174564B1 (da) 2003-06-10
ATE56447T1 (de) 1990-09-15
PT83815B (pt) 1989-06-30
HU196787B (en) 1989-01-30
NZ218412A (en) 1989-05-29
NO168034C (no) 1992-01-08
IL80758A (en) 1991-01-31
FI864785A0 (fi) 1986-11-25
GR3001107T3 (en) 1992-05-12
FI88299C (fi) 1993-04-26
CZ410391A3 (en) 1993-03-17
EP0224794A3 (en) 1988-10-19
JPS62138491A (ja) 1987-06-22
PH22944A (en) 1989-02-03
DE3674159D1 (de) 1990-10-18
HUT43056A (en) 1987-09-28
JPH0625128B2 (ja) 1994-04-06
HK123993A (en) 1993-11-19
IE59487B1 (en) 1994-03-09
KR950007589B1 (ko) 1995-07-12
EP0224794B1 (de) 1990-09-12
DK568386A (da) 1987-05-28
NO864744D0 (no) 1986-11-26
IE863110L (en) 1987-05-27
PT83815A (de) 1986-12-01
DD256132A5 (de) 1988-04-27
UA8034A1 (uk) 1995-12-26
AU589712B2 (en) 1989-10-19
KR870004973A (ko) 1987-06-02
CA1321194C (en) 1993-08-10
AU6576486A (en) 1987-06-04
ZA868933B (en) 1988-07-27
DE3541811A1 (de) 1987-06-04
DK568386D0 (da) 1986-11-26
FI864785A (fi) 1987-05-28
NO168034B (no) 1991-09-30
EP0224794A2 (de) 1987-06-10
MX9202813A (es) 1992-06-30

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