ES2011679A6 - Procedimiento para la preparacion de polipeptidos sinteticos secuenc iales inmunologicamente activos. - Google Patents

Procedimiento para la preparacion de polipeptidos sinteticos secuenc iales inmunologicamente activos.

Info

Publication number
ES2011679A6
ES2011679A6 ES8803072A ES8803072A ES2011679A6 ES 2011679 A6 ES2011679 A6 ES 2011679A6 ES 8803072 A ES8803072 A ES 8803072A ES 8803072 A ES8803072 A ES 8803072A ES 2011679 A6 ES2011679 A6 ES 2011679A6
Authority
ES
Spain
Prior art keywords
immunological activity
asn
polypeptides
endowed
sequential polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8803072A
Other languages
English (en)
Inventor
Antonio Silvio Verdini
Antonello Pessi
Fabio Bonelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eni Tecnologie SpA
Original Assignee
Eniricerche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche SpA filed Critical Eniricerche SpA
Publication of ES2011679A6 publication Critical patent/ES2011679A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE POLIPEPTIDOS SINTETICOS CONSTITUIDOS POR AL MENOS DOS UNIDADES REPETITIVAS CONSECUTIVAS DE SECUENCIA (ASN-ASN-PRO), CONSISTENTE EN SINTETIZA MEDIANTE CONDENSACION EN FASE HOMOGENEA UN TRIPEPTIDO, EN ACTIVAR DICHO TRIPEPTIDO MEDIANTE REACCION CON DERIVADOS HALOGENADOS DEL FENOL, EN SOMETERLO A UNA ESCISION ACIDA Y LUEGO A UNA REACCION DE POLICONDENSACION EN FASE LIQUIDA, Y FINALMENTE EN RECUPERAR LOS POLIPEPTIDOS ASI OBTENIDOS POR PRECIPITACION Y EVENTUAL FRACCIONAMIENTO DEL PRODUCTO LIOFILICO. DICHOS POLIPEPTIDOS OBTENIBLES EN FORMA PURA SON PARTICULARMENTE UTILES PARA LA FABRICACION DE VACUNAS CONTRA LA MALARIA Y PARA LA DETECCION DE AFECCIONES PALUDICAS.
ES8803072A 1987-09-11 1988-09-09 Procedimiento para la preparacion de polipeptidos sinteticos secuenc iales inmunologicamente activos. Expired - Lifetime ES2011679A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21892/87A IT1223301B (it) 1987-09-11 1987-09-11 Polipeptidi sequenziali immunologicamente attivi

Publications (1)

Publication Number Publication Date
ES2011679A6 true ES2011679A6 (es) 1990-02-01

Family

ID=11188316

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8803072A Expired - Lifetime ES2011679A6 (es) 1987-09-11 1988-09-09 Procedimiento para la preparacion de polipeptidos sinteticos secuenc iales inmunologicamente activos.

Country Status (15)

Country Link
US (1) US5219987A (es)
AT (1) AT398427B (es)
BE (1) BE1003232A3 (es)
CA (1) CA1335320C (es)
CH (1) CH676989A5 (es)
DE (1) DE3830565A1 (es)
ES (1) ES2011679A6 (es)
FR (1) FR2621919B1 (es)
GB (1) GB2209755B (es)
GR (1) GR1000251B (es)
IT (1) IT1223301B (es)
NL (1) NL8802201A (es)
OA (1) OA08951A (es)
SE (1) SE8803062L (es)
ZA (1) ZA885744B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ233255A (en) * 1989-04-11 1993-02-25 Chiron Corp Plasmodium cs protein analogues lacking one or more of the repeat epitopes, and containing at least one nonrepeat flanking epitope
US20070104726A1 (en) * 2002-08-14 2007-05-10 Avidis Sa Multimeric complexes of antigens and adjuvants
WO2005014654A2 (en) * 2003-08-12 2005-02-17 Avidis Sa Product comprising a c4bp core protein and a monomeric antigen, and its use
WO2005034350A1 (ja) * 2003-09-30 2005-04-14 Mitsubishi Denki Kabushiki Kaisha 可変電力分配器並びにその誤差検出方法及び設定値補正方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929756A (en) * 1973-11-21 1975-12-30 Univ Brandeis Synthetically produced tridecapeptide having the same activity as the hypothalamic substance, neurotensin
US4132746A (en) * 1976-07-09 1979-01-02 University Of Alabama, Birmingham Medical & Education Foundation Synthetic elastomeric insoluble cross-linked polypentapeptide
SE453510B (sv) * 1980-12-29 1988-02-08 Toyo Jozo Kk Peptid for analys av humant paratyroidhormon
US4707357A (en) * 1984-06-26 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
NZ213303A (en) * 1984-09-12 1988-09-29 Univ New York Plasmodium protein, dna sequence and vaccine
PT82282B (pt) * 1985-03-28 1988-02-17 Univ New York Processo de preparacao de um conjugado de proteina de suporte-antigeno imunogenico para uso como vacina contra malaria
IT1187710B (it) * 1985-07-25 1987-12-23 Eniricerche Spa Composizione peptidica utile per la preparazione di vaccini per la malaria e di kit diagnostici per la determinazione di affezioni malariche
IT1198225B (it) * 1986-12-04 1988-12-21 Eniricerche Spa Polipeptidi immunologicamente attivi utili per la preparazione di vaccini antimalaria e di kits diagnostici per la determinazione di anticorpi antisporozoita

Also Published As

Publication number Publication date
IT8721892A0 (it) 1987-09-11
GR880100576A (en) 1989-06-22
US5219987A (en) 1993-06-15
GB2209755B (en) 1991-06-05
OA08951A (en) 1990-11-30
FR2621919A1 (fr) 1989-04-21
DE3830565C2 (es) 1991-08-14
DE3830565A1 (de) 1989-03-23
IT1223301B (it) 1990-09-19
CA1335320C (en) 1995-04-18
ATA221488A (de) 1994-04-15
CH676989A5 (es) 1991-03-28
GB8819030D0 (en) 1988-09-14
ZA885744B (en) 1989-04-26
GR1000251B (el) 1992-05-12
SE8803062L (sv) 1989-03-12
BE1003232A3 (fr) 1992-02-04
NL8802201A (nl) 1989-04-03
SE8803062D0 (sv) 1988-09-01
FR2621919B1 (fr) 1991-12-06
GB2209755A (en) 1989-05-24
AT398427B (de) 1994-12-27

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-09-09

FD1A Patent lapsed

Effective date: 20001204