ES2010537A6 - Procedimiento para la preparacion de derivados de oxazol e isoxazol. - Google Patents

Procedimiento para la preparacion de derivados de oxazol e isoxazol.

Info

Publication number
ES2010537A6
ES2010537A6 ES8801315A ES8801315A ES2010537A6 ES 2010537 A6 ES2010537 A6 ES 2010537A6 ES 8801315 A ES8801315 A ES 8801315A ES 8801315 A ES8801315 A ES 8801315A ES 2010537 A6 ES2010537 A6 ES 2010537A6
Authority
ES
Spain
Prior art keywords
oxazol
ilo
procedure
preparation
isoxazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801315A
Other languages
English (en)
Inventor
Peter James Machin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858525578A external-priority patent/GB8525578D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES2010537A6 publication Critical patent/ES2010537A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE OXAZOL E ISOXAZOL, DE FORMULA GENERAL (I), EN DONDE A ES C1-6-ALQUILENO, HET ES UN OXAZOL-2-ILO, OXAZOL-4-ILO, OXAZOL-5-ILO, ISOXAZOL-3-ILO O ISOXAZOL-5-ILO SUSTITUIDO; R1 Y R2þ SON C1-6-ALQUILO, R3 ES HIDROXILO, C1-6-ALCOXILO, O UN GRUPO -NR4R5; R4 Y R5 SON HIDROGENO O C1-6-ALQUILO, O -NR4R5 ES UN GRUPO HETEROMONOCICLICO. EL PROCEDIMIENTO CON SISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (IV) CON UN COMPUESTO DE FORMULA (V), EN PRESENCIA DE UNA BASE EN UN DISOLVENTE ORGANICO, A UNA TEMPERATURA DE HASTA LA TEMPERATURA DE REFLUJO. ESTOS PRODUCTOS TIENEN VALIOSAS PROPIEDADES FARMACOLOGICAS, ESPECIALMENTE COMO ANTI-ARTRITICOS.
ES8801315A 1985-10-17 1988-04-29 Procedimiento para la preparacion de derivados de oxazol e isoxazol. Expired ES2010537A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858525578A GB8525578D0 (en) 1985-10-17 1985-10-17 Heterocyclic compounds
GB868617503A GB8617503D0 (en) 1985-10-17 1986-07-17 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
ES2010537A6 true ES2010537A6 (es) 1989-11-16

Family

ID=26289895

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8602629A Expired ES2002420A6 (es) 1985-10-17 1986-10-16 Procedimiento para la preparacion de derivados del oxazol e isoxazol
ES8801315A Expired ES2010537A6 (es) 1985-10-17 1988-04-29 Procedimiento para la preparacion de derivados de oxazol e isoxazol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES8602629A Expired ES2002420A6 (es) 1985-10-17 1986-10-16 Procedimiento para la preparacion de derivados del oxazol e isoxazol

Country Status (18)

Country Link
US (1) US4774253A (es)
EP (1) EP0220573B1 (es)
AU (1) AU594382B2 (es)
CA (1) CA1287058C (es)
CS (1) CS255881B2 (es)
DE (1) DE3682873D1 (es)
DK (1) DK470886A (es)
ES (2) ES2002420A6 (es)
FI (1) FI864052A7 (es)
HU (1) HU195792B (es)
IL (1) IL80290A (es)
MC (1) MC1770A1 (es)
NO (1) NO167284C (es)
NZ (1) NZ217871A (es)
PH (1) PH23022A (es)
PT (1) PT83565B (es)
SU (1) SU1514245A3 (es)
ZW (1) ZW19786A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149820A (en) * 1987-03-11 1992-09-22 Norsk Hydro A.S. Deuterated compounds
US5239080A (en) * 1989-02-08 1993-08-24 Takeda Chemical Industries, Ltd. Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents
US5114960A (en) * 1989-07-20 1992-05-19 Hoffmann-La Roche Inc. Substituted isoxazole derivatives
EP0440183A1 (en) * 1990-02-01 1991-08-07 Takeda Chemical Industries, Ltd. Oxazole compounds, their production and use
US5348969A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Diphenyloxazolyl-oxazoles as platelet aggregation inhibitors
FR2699172B1 (fr) * 1992-12-11 1995-01-20 Adir Nouveaux dérivés de 4-méthyl-1,3-oxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
ES2125161B1 (es) * 1996-03-21 1999-11-16 Grupo Farmaceutico Almirall S Nuevos derivados de 2-(3h)-oxazolona.
ID22176A (id) 1996-10-14 1999-09-09 Bayer Ag Turunan pirazola tersubstitusi-heterosiklilmetil yang baru
CN1130361C (zh) * 1998-03-30 2003-12-10 日本烟草产业株式会社 异噁唑烷二酮化合物的制备方法
US7144906B2 (en) * 2000-05-26 2006-12-05 Nippon Shinyaku Co., Ltd. Heterocyclic compounds
WO2004041275A1 (en) * 2002-11-08 2004-05-21 F. Hoffmann-La Roche Ag Substituted 4-alkoxyoxazol derivatives as ppar agonists
GB0712653D0 (en) 2007-06-28 2007-08-08 Syngenta Ltd Novel herbicides
EP2844644B1 (en) * 2012-05-03 2018-11-14 DSM IP Assets B.V. Process for preparation of 4-methyloxazole-5-carboxylic ester

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3401120A (en) * 1965-10-23 1968-09-10 Gaf Corp Corrosion inhibitors
GB1164510A (en) * 1967-06-15 1969-09-17 Ici Ltd Novel Isoxazole Derivatives, the preparation thereof, and Compositions containing the same
GB1180268A (en) * 1967-09-26 1970-02-04 Ici Ltd Pharmaceutically Active Phenyl-Heterocyclic-Alkanol Derivatives
JPS57188587A (en) * 1981-05-15 1982-11-19 Tanabe Seiyaku Co Ltd Thienyloxazolylacetic acid derivative and its preparation
JPS58183676A (ja) * 1982-04-19 1983-10-26 Takeda Chem Ind Ltd オキサゾ−ル誘導体
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents

Also Published As

Publication number Publication date
DK470886D0 (da) 1986-10-02
DE3682873D1 (de) 1992-01-23
US4774253A (en) 1988-09-27
NO864128D0 (no) 1986-10-16
NZ217871A (en) 1990-03-27
DK470886A (da) 1987-04-18
CS741586A2 (en) 1987-07-16
HU195792B (en) 1988-07-28
CS255881B2 (en) 1988-03-15
NO864128L (no) 1987-04-21
FI864052A7 (fi) 1987-04-18
EP0220573B1 (de) 1991-12-11
FI864052A0 (fi) 1986-10-07
HUT44245A (en) 1988-02-29
AU6383886A (en) 1987-04-30
ES2002420A6 (es) 1988-08-01
IL80290A0 (en) 1987-01-30
NO167284B (no) 1991-07-15
AU594382B2 (en) 1990-03-08
PH23022A (en) 1989-03-03
MC1770A1 (fr) 1987-07-17
PT83565B (pt) 1989-05-31
ZW19786A1 (en) 1988-05-18
CA1287058C (en) 1991-07-30
PT83565A (en) 1986-11-01
SU1514245A3 (ru) 1989-10-07
IL80290A (en) 1990-11-29
EP0220573A1 (de) 1987-05-06
NO167284C (no) 1991-10-23

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