ES2058499T3 - Procedimiento para la preparacion de derivados de penicilina 2 beta-metil sustituidos. - Google Patents

Procedimiento para la preparacion de derivados de penicilina 2 beta-metil sustituidos.

Info

Publication number
ES2058499T3
ES2058499T3 ES89301925T ES89301925T ES2058499T3 ES 2058499 T3 ES2058499 T3 ES 2058499T3 ES 89301925 T ES89301925 T ES 89301925T ES 89301925 T ES89301925 T ES 89301925T ES 2058499 T3 ES2058499 T3 ES 2058499T3
Authority
ES
Spain
Prior art keywords
compound
derivatives
procedure
preparation
penicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89301925T
Other languages
English (en)
Inventor
Sigeru Torii
Hideo Tanaka
Motoaki Tanaka
Shozo Yamada
Akira Nakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
Taiho Pharmaceutical Co Ltd
Original Assignee
Otsuka Chemical Co Ltd
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd, Taiho Pharmaceutical Co Ltd filed Critical Otsuka Chemical Co Ltd
Application granted granted Critical
Publication of ES2058499T3 publication Critical patent/ES2058499T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/06—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCESO PARA PREPARAR UN COMPUESTO DE METILPENICILINA 2 - BETA SUSTITUIDA, DE FORMULA(I), EN LA QUE - NY ES UN GRUPO HETEROCICLICO OPCIONALMENTE SUSTITUIDO QUE CONTIENE DE 2 A 4 ATOMOS DE N COMO HETEROATOMOS EN LA ESTRUCTURA CICLICA, Y R1 ES UN GRUPO PROTECTOR DEL CARBOXILO DE LA PENICILINA, QUE COMPRENDE LA REACCION DE UN COMPUESTO DE DISULFURO DE AZETIDINONA DE FORMULA (III) (EN LA QUE R1 ES ANTES DEFINIDO Y R ES UN GRUPO HETEROCICLICO SUSTITUIDO O SIN SUSTITUIR), CON UN COMPUESTO HETEROCICLICO NITROGENADO DE FORMULA(IV) (EN EL QUE NY ES EL DEFINIDO ANTERIORMENTE), EN PRESENCIA DE UN COMPUESTO METALICO.
ES89301925T 1988-03-01 1989-02-27 Procedimiento para la preparacion de derivados de penicilina 2 beta-metil sustituidos. Expired - Lifetime ES2058499T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63049038A JP2599610B2 (ja) 1988-03-01 1988-03-01 ２β―置換メチルペニシリン誘導体の製造法

Publications (1)

Publication Number Publication Date
ES2058499T3 true ES2058499T3 (es) 1994-11-01

Family

ID=12819915

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89301925T Expired - Lifetime ES2058499T3 (es) 1988-03-01 1989-02-27 Procedimiento para la preparacion de derivados de penicilina 2 beta-metil sustituidos.

Country Status (10)

Country Link
US (1) US4898939A (es)
EP (1) EP0331394B1 (es)
JP (1) JP2599610B2 (es)
KR (1) KR910001308B1 (es)
CN (1) CN1022836C (es)
AT (1) ATE92492T1 (es)
AU (1) AU600403B2 (es)
CA (1) CA1339124C (es)
DE (1) DE68907953T2 (es)
ES (1) ES2058499T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897780B2 (en) * 1993-07-12 2005-05-24 Hill-Rom Services, Inc. Bed status information system for hospital beds
TW200523264A (en) * 2003-10-09 2005-07-16 Otsuka Chemical Co Ltd CMPB crystal and method for producing the same
TW200519119A (en) * 2003-10-10 2005-06-16 Otsuka Chemical Co Ltd PENAM crystal and process for producing the same
CN107033161B (zh) * 2017-05-04 2019-01-01 石家庄万业化工科技有限公司 一种他唑巴坦酸的合成方法
WO2021120063A1 (zh) * 2019-12-18 2021-06-24 凯莱英医药集团（天津）股份有限公司 他唑巴坦中间体的连续合成方法
CN114031629A (zh) * 2021-12-10 2022-02-11 山东安舜制药有限公司 一种合成他唑巴坦中间体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS58225091A (ja) * 1982-06-21 1983-12-27 Taiho Yakuhin Kogyo Kk ペニシリン誘導体及びその製造法
US4464237A (en) * 1982-08-09 1984-08-07 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for preparing β-lactam derivatives
US4562073A (en) * 1982-12-24 1985-12-31 Taiho Pharmaceutical Company Limited Penicillin derivatives
US4496484A (en) * 1983-04-22 1985-01-29 Taiho Pharmaceutical Company, Limited Penicillin derivatives
CA1239392A (en) * 1983-10-13 1988-07-19 Shigeru Yamabe Penicillin derivatives and process for preparing the same
GB2157286B (en) * 1984-04-12 1987-12-31 Leo Pharm Prod Ltd B-lactam antibiotic potentiators
JPS62294686A (ja) * 1987-05-29 1987-12-22 Taiho Yakuhin Kogyo Kk ペニシラン酸誘導体

Also Published As

Publication number Publication date
JP2599610B2 (ja) 1997-04-09
US4898939A (en) 1990-02-06
CA1339124C (en) 1997-07-29
DE68907953D1 (de) 1993-09-09
KR910001308B1 (ko) 1991-03-02
JPH01224377A (ja) 1989-09-07
CN1022836C (zh) 1993-11-24
EP0331394A1 (en) 1989-09-06
ATE92492T1 (de) 1993-08-15
AU3029089A (en) 1989-09-07
CN1036767A (zh) 1989-11-01
EP0331394B1 (en) 1993-08-04
AU600403B2 (en) 1990-08-09
DE68907953T2 (de) 1993-11-18
KR890014554A (ko) 1989-10-24

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