ES2002140A6 - Procedimiento para producir preparados de derivados de acido arilpropionico resorbibles por via transdermal y acuosos - Google Patents

Procedimiento para producir preparados de derivados de acido arilpropionico resorbibles por via transdermal y acuosos

Info

Publication number
ES2002140A6
ES2002140A6 ES8601785A ES8601785A ES2002140A6 ES 2002140 A6 ES2002140 A6 ES 2002140A6 ES 8601785 A ES8601785 A ES 8601785A ES 8601785 A ES8601785 A ES 8601785A ES 2002140 A6 ES2002140 A6 ES 2002140A6
Authority
ES
Spain
Prior art keywords
weight
acid derivatives
arylpropionic
preparation
aqueous compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601785A
Other languages
English (en)
Inventor
Manfred Lohner
Hans Henrich Wagener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dolorgiet GmbH and Co KG
Original Assignee
Dolorgiet GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dolorgiet GmbH and Co KG filed Critical Dolorgiet GmbH and Co KG
Publication of ES2002140A6 publication Critical patent/ES2002140A6/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR PREPARADOS DE DERIVADOS DE ACIDO ARILPROPIONICO, RESORBIBLES POR VIA TRANSDERMAL Y ACUOSOS, EN EL QUE SE CALIENTAN A UNA TEMPERATURA DE 40JC A 90JC, EVENTUALMENTE BAJO SOBREPRESION Y CON AGITACION, Y LUEGO SE ENFRIAN NUEVAMENTE, 1 A 15% EN PESO DE SUSTANCIA ACTIVA, 10 A 40% EN PESO DE COPOLIMEROS DE POLIOXIETILENO-POLIOXIPROPILENO, 10 A 50% EN PESO DE UNO O VARIOS DISOLVENTES ORGANICOS FISIOLOGICAMENTE COMPATIBLES, EVENTUALMENTE HASTA 1% EN PESO DE SUSTANCIAS CONSERVANTES, HASTA 1% EN PESO DE COLORANTES Y HASTA 1% EN PESO DE PERFUMES Y AL MENOS 10% EN PESO DE AGUA. ESTOS PREPARADOS PUEDEN PRESENTARSE EN FORMA DE GELES EMPLEANDO COPOLIMEROS DE POLIOXIETILENO-POLIOXIPROPILENO DE MAS DE 6.0000 DE MASA MOLAR RELATIVA Y OBSERVANDO DETERMINADAS PROPORCIONES CUANTITATIVAS. LOS PREPARADOS OBTENIDOS SON ESPECIALMENTE UTILES COMO MEDICAMENTOS PARA REUMOTERAPIA.
ES8601785A 1985-09-12 1986-09-11 Procedimiento para producir preparados de derivados de acido arilpropionico resorbibles por via transdermal y acuosos Expired ES2002140A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853532562 DE3532562A1 (de) 1985-09-12 1985-09-12 Transdermal resorbierbare, wasserhaltige zubereitungen von arylpropionsaeurederivaten und verfahren zur herstellung derselben

Publications (1)

Publication Number Publication Date
ES2002140A6 true ES2002140A6 (es) 1988-07-16

Family

ID=6280783

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601785A Expired ES2002140A6 (es) 1985-09-12 1986-09-11 Procedimiento para producir preparados de derivados de acido arilpropionico resorbibles por via transdermal y acuosos

Country Status (10)

Country Link
US (1) US4849418A (es)
EP (1) EP0215423B1 (es)
JP (1) JPH078786B2 (es)
AT (1) ATE63220T1 (es)
CA (1) CA1269328A (es)
DE (2) DE3532562A1 (es)
ES (1) ES2002140A6 (es)
NO (1) NO172028C (es)
YU (1) YU46012B (es)
ZA (1) ZA866917B (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8701392D0 (en) * 1987-01-22 1987-02-25 Boots Co Plc Therapeutic agents
US5104656A (en) * 1989-06-16 1992-04-14 Seth Pyare L Percutaneous treatment with a high potency non-steroidal anti-inflammatory agent
US5093133A (en) * 1990-01-24 1992-03-03 Mcneil-Ppc, Inc. Method for percutaneous delivery of ibuprofen using hydroalcoholic gel
IT1243342B (it) * 1990-07-13 1994-06-10 Farcon Ag Composizioni farmaceutiche orali liquide ad attivita' antiinfiammatoria
US5210099A (en) * 1991-02-11 1993-05-11 American Home Products Corporation Analgesic compositions
US5308621A (en) * 1991-02-18 1994-05-03 Commonwealth Scientific And Industrial Research Organisation Ascorbic acid composition and transdermal administration method
DE4140185C2 (de) * 1991-12-05 1996-02-01 Alfatec Pharma Gmbh Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
DE4140172C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Ibuprofen enthaltendes Arzneimittel
DE4140183C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Flurbiprofen enthaltendes Arzneimittel
DE4140184C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Flurbiprofen enthaltendes Arzneimittel
ATE138561T1 (de) * 1992-02-12 1996-06-15 Janssen Cilag S P A Liposomale itraconazol formulierungen
WO1993015718A1 (en) * 1992-02-12 1993-08-19 Janssen Farmaceutici S.P.A. Liposomal piroxicam formulations
ATE137959T1 (de) * 1992-02-12 1996-06-15 Janssen Cilag S P A Liposomale piroxycam formulierung
CN1106259A (zh) * 1994-02-05 1995-08-09 日东制药株式会社 含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂
JP3782834B2 (ja) * 1994-10-26 2006-06-07 株式会社トクホン 鎮痛抗炎症貼付剤
US5702720A (en) * 1995-12-22 1997-12-30 Minnesota Mining And Manufacturing Company Transdermal device for the delivery of flurbiprofen
NZ511708A (en) 1998-12-01 2003-12-19 Univ Kentucky Res Found A method for enhancing protective cellular responses to genotoxic stress in skin
ES2282134T3 (es) * 1999-09-11 2007-10-16 THE PROCTER & GAMBLE COMPANY Copolimeros de polioxialquileno que contienen vehiculos liquidos fluidos.
DE10001096A1 (de) * 2000-01-13 2001-07-26 Lohmann Therapie Syst Lts TTS mit Reservoirschicht zur Aufnahme und Abgabe von Duftstoffen
US7138133B2 (en) * 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
CA2486553C (en) * 2002-06-17 2012-01-10 Taro Pharmaceuticals U.S.A., Inc. Ibuprofen suspension
DE102005019628A1 (de) * 2005-04-26 2006-11-09 Technische Universität Braunschweig Formulierung zur dermalen Anwendung
DE102005033543A1 (de) * 2005-07-14 2007-01-18 Grünenthal GmbH Ein einen Duftstoff aufweisendes transdermales therapeutisches System
US20080317684A1 (en) * 2006-09-06 2008-12-25 Isw Group, Inc. Topical Compositions
DE502007003850D1 (de) * 2007-04-19 2010-07-01 August Wolff Gmbh & Co Kg Arzn Gel zur Behandlung von Wunden
GB0921686D0 (en) * 2009-12-11 2010-01-27 Reckitt Benckiser Healthcare I Topical formulation
PT2704703T (pt) 2011-05-03 2019-10-25 Aponia Laboratories Inc Composições transdermais de ibuprofeno e seus métodos de utilização.
NZ606177A (en) * 2012-01-30 2014-03-28 Dolorgiet Gmbh & Co Kg Compositions for the treatment of actinic keratosis
EP3213744A1 (de) * 2016-03-01 2017-09-06 Chemische Fabrik Kreussler & Co. Gmbh Galenische zubereitung von nsaid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740421A (en) * 1966-09-19 1973-06-19 Basf Wyandotte Corp Polyoxyethylene-polyoxypropylene aqueous gels
DE1617480B2 (de) * 1967-08-01 1973-02-01 Farbwerke Hoechst AG, vormals Mei ster Lucius & Brunmg, 6000 Frankfurt Gelgrundlagen
US4100271A (en) * 1976-02-26 1978-07-11 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
JPS5829706A (ja) * 1981-08-14 1983-02-22 Toko Yakuhin Kogyo Kk 消炎鎮痛外用剤
DE3205504C2 (de) * 1982-02-16 1983-12-01 Dolorgiet Gmbh & Co Kg, 5300 Bonn Äußerlich anwendbares, Ibuprofen enthaltendes Arzneimittel
JPS59222409A (ja) * 1983-06-01 1984-12-14 Nippon Redarii Kk 消炎鎮痛ゲル軟膏剤
US4511563A (en) * 1983-07-15 1985-04-16 Basf Wyandotte Corporation Clear analgesic gels with reduced tackiness
JPS60209515A (ja) * 1984-04-03 1985-10-22 Hokuriku Seiyaku Co Ltd 消炎鎮痛クリ−ム剤
JPS6127920A (ja) * 1984-07-16 1986-02-07 Akiyoshi Masataka 消炎鎮痛性外用医薬組成物
DE3437599A1 (de) * 1984-10-13 1986-04-17 Dolorgiet GmbH & Co KG, 5205 St Augustin Ibuprofen enthaltende weichgelatinekapseln und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPS6261917A (ja) 1987-03-18
DE3532562A1 (de) 1987-03-12
NO863636D0 (no) 1986-09-11
US4849418A (en) 1989-07-18
EP0215423A3 (en) 1988-03-23
ZA866917B (en) 1987-05-27
NO863636L (no) 1987-03-13
EP0215423B1 (de) 1991-05-08
CA1269328A (en) 1990-05-22
JPH078786B2 (ja) 1995-02-01
DE3679128D1 (de) 1991-06-13
YU46012B (sh) 1992-12-21
NO172028C (no) 1993-06-02
ATE63220T1 (de) 1991-05-15
YU126186A (en) 1989-10-31
EP0215423A2 (de) 1987-03-25
NO172028B (no) 1993-02-22

Similar Documents

Publication Publication Date Title
ES2002140A6 (es) Procedimiento para producir preparados de derivados de acido arilpropionico resorbibles por via transdermal y acuosos
IE940583L (en) Topical antimicrobial pharmaceutical compositions
CA2009890A1 (en) Valproic acid
TW262461B (es)
HUT61989A (en) Process for producing 2-deoxy-2,3-didehydro-n-acetylneuraminic acid derivatives and analogs, as well as pharmaceutical compositions comprising same as active ingredient
ES2058411T3 (es) Sustancia fr 901228 y su preparacion.
AU2905092A (en) Pharmaceutical dipeptide compositions and methods of use thereof
CA2209167A1 (en) Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof
DE3766200D1 (de) L-dopa enthaltendes arzneimittel.
CA2107669A1 (en) Preparation for treating wounds and hemorrhoides
IL102814A0 (en) Pyrazine derivatives,their preparation and pharmaceutical compositions comprising them
IE873367L (en) Ranitidine-ethanol formulation
AU6756287A (en) Nicorandil-containing preparation for injection
WO1994022441A3 (en) Use of cis- or transurocanic acid for the treatment of photodermatoses and immunogenic skin diseases
MY129946A (en) Compound with gastric acid inhibitory effect and process for its preparation.
EP0253143A3 (en) Pharmaceutical compositions for suppository
IE821796L (en) Waterless thixotropic composition
NO973401L (no) Kortikosteroidinneholdende sammensetninger og fremstilling derav
HUT54166A (en) Process for producing 1,1-dioxocefem-4-carbothiol acid derivatives and pharmaceutical compositions comprising same as active ingredient
DE69103773T2 (de) Derivate von hydroxaminsäure die lipoxygenase hemmen.
JPS5750914A (en) Betamethasone external pharmaceutical
IE780921L (en) 1-acyl-2-hydroxy-1,3-diamino-propanes.
MY101266A (en) Pharmaceutical formulations
GR1000429B (el) Συνθεση με βαση την τριμεβουτινη παρατεταμενης απελευθερωσης και μεθοδος παρασκευης της.
EP0056681A3 (en) Levonantradol and n-methyllevonantradol formulations

Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2006-09-11

FD1A Patent lapsed

Effective date: 20060912