ES2001696A6 - Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida - Google Patents
Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamidaInfo
- Publication number
- ES2001696A6 ES2001696A6 ES8602069A ES8602069A ES2001696A6 ES 2001696 A6 ES2001696 A6 ES 2001696A6 ES 8602069 A ES8602069 A ES 8602069A ES 8602069 A ES8602069 A ES 8602069A ES 2001696 A6 ES2001696 A6 ES 2001696A6
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolidin
- oxo
- hydroxy
- acetic acid
- alkyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO PARA PREPARAR 4-HIDROXI-2-OXO-PIRROLIDIN-1-ILACETAMIDA EN EL QUE SE HACEN REACCIONAR ESTERES ALQUILICOS DE ACIDO 4-ALCOXI-3-PIRROLIN-2-ON-1-IL-ACETICO DE FORMULA DONDE R1 Y R2 SON ALQUILO, CON TRICLOROMETILSILANO EN PRESENCIA DE UN YODURO ALCALINO O EN UN MEDIO ANHIDRO ACIDO, PARA DAR EL ESTER ALQUILICO DE ACIDO 2,4-DIOXO-PIRROLIDIN-1-IL-ACETICO, SE AISLA EVENTUALMENTE ESTE ESTER Y A CONTINUACION SE HIDROGENA CON BOROHIDRURO SODICO PARA DAR UN ESTER ALQUILICO DE ACIDO 4-HIDROXI-2-OXO-PIRROLIDIN-1-IL-ACETICO, EL CUAL SE TRANSFORMA MEDIANTE AMIDACION CON AMONIACO EN EL PRODUCTO FINAL DESEADO. ESTE PRODUCTO FINAL SE CARACTERIZA POR SU ACCION CEREBRAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH412685A CH664957A5 (de) | 1985-09-24 | 1985-09-24 | Verfahren zur herstellung von 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetamid. |
CH202386A CH666481A5 (de) | 1986-05-20 | 1986-05-20 | Verfahren zur herstellung von 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetamid. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2001696A6 true ES2001696A6 (es) | 1988-06-01 |
Family
ID=25689290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8602069A Expired ES2001696A6 (es) | 1985-09-24 | 1986-09-22 | Procedimiento para preparar 4-hidroxi-2-oxo-pirrolidin-1-il-acetamida |
Country Status (7)
Country | Link |
---|---|
US (1) | US4824966A (es) |
EP (1) | EP0216325A3 (es) |
DK (1) | DK453586A (es) |
ES (1) | ES2001696A6 (es) |
HU (1) | HUT43039A (es) |
IL (1) | IL80071A0 (es) |
NO (1) | NO863769L (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK356288A (da) * | 1987-07-30 | 1989-01-31 | Lonza Ag | Fremgangsmaade til fremstilling af n-((4-hydroxy-pyrrolidin-2-on-1-yl)-acetyl)-glycinamid |
JPH02115162A (ja) * | 1988-09-06 | 1990-04-27 | Lonza Ag | 5―アルキルテトラム酸およびその製造方法 |
CH680293A5 (es) * | 1990-06-26 | 1992-07-31 | Lonza Ag | |
CN105820102A (zh) * | 2016-05-10 | 2016-08-03 | 武汉工程大学 | 奥拉西坦的合成工艺 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2784191A (en) * | 1957-03-05 | Process for the production of lactams | ||
US2535010A (en) * | 1948-10-02 | 1950-12-19 | Rohm & Haas | Transetherification of beta-ethersubstituted esters |
DE850007C (de) * | 1950-12-22 | 1952-09-22 | Basf Ag | Verfahren zur Herstellung von N-Aryl-ª‡-pyrrolidonen |
US3299095A (en) * | 1964-04-16 | 1967-01-17 | Merck & Co Inc | 1-benzyl tetramic acid derivatives |
JPS4941521A (es) * | 1972-06-02 | 1974-04-18 | ||
AR211398Q (es) * | 1975-08-13 | 1977-12-15 | Isf Spa | Un procedimiento para preparar derivados de ( -pirrolin -2- on -1- il)-acilamida |
IT1045043B (it) * | 1975-08-13 | 1980-04-21 | Isf Spa | Derivati pirrolidinici |
IT1075280B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
IT1075564B (it) * | 1977-02-11 | 1985-04-22 | Isf Spa | Procedimento per la preparazione di derivati pirrolidinici |
JPS5812272B2 (ja) * | 1981-04-28 | 1983-03-07 | 電気化学工業株式会社 | 4−ヒドロキシ−2−ピロリドンの製造法 |
FI83510C (fi) * | 1985-02-22 | 1991-07-25 | Ciba Geigy Ag | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara bi-2h- pyrroli(di)ndioner. |
-
1986
- 1986-09-17 IL IL80071A patent/IL80071A0/xx unknown
- 1986-09-19 EP EP86112952A patent/EP0216325A3/de not_active Withdrawn
- 1986-09-22 ES ES8602069A patent/ES2001696A6/es not_active Expired
- 1986-09-22 NO NO863769A patent/NO863769L/no unknown
- 1986-09-23 DK DK453586A patent/DK453586A/da not_active Application Discontinuation
- 1986-09-24 HU HU864071A patent/HUT43039A/hu unknown
-
1988
- 1988-05-04 US US07/188,702 patent/US4824966A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK453586A (da) | 1987-03-25 |
NO863769L (no) | 1987-03-25 |
IL80071A0 (en) | 1986-12-31 |
NO863769D0 (no) | 1986-09-22 |
DK453586D0 (da) | 1986-09-23 |
US4824966A (en) | 1989-04-25 |
HUT43039A (en) | 1987-09-28 |
EP0216325A3 (de) | 1987-08-26 |
EP0216325A2 (de) | 1987-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20010301 |