ES2000428T3 - Procedimiento para producir un medicamento para el tratamiento de la enfermedad de alzheimer, que contiene galantamina, y dispositivo medico correspondiente. - Google Patents
Procedimiento para producir un medicamento para el tratamiento de la enfermedad de alzheimer, que contiene galantamina, y dispositivo medico correspondiente.Info
- Publication number
- ES2000428T3 ES2000428T3 ES198787100461T ES87100461T ES2000428T3 ES 2000428 T3 ES2000428 T3 ES 2000428T3 ES 198787100461 T ES198787100461 T ES 198787100461T ES 87100461 T ES87100461 T ES 87100461T ES 2000428 T3 ES2000428 T3 ES 2000428T3
- Authority
- ES
- Spain
- Prior art keywords
- alzheimer
- disease
- medication
- procedure
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title abstract 4
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 229960003980 galantamine Drugs 0.000 title abstract 2
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 abstract 1
- LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 abstract 1
- BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 abstract 1
- IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/819,141 US4663318A (en) | 1986-01-15 | 1986-01-15 | Method of treating Alzheimer's disease |
US819141 | 1986-01-15 |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2000428A4 ES2000428A4 (es) | 1988-03-01 |
ES2000428T3 true ES2000428T3 (es) | 1993-10-01 |
ES2000428T9 ES2000428T9 (es) | 2013-08-14 |
Family
ID=25227312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787100461T Expired - Lifetime ES2000428T3 (es) | 1986-01-15 | 1987-01-15 | Procedimiento para producir un medicamento para el tratamiento de la enfermedad de alzheimer, que contiene galantamina, y dispositivo medico correspondiente. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4663318A (en, 2012) |
EP (1) | EP0236684B1 (en, 2012) |
JP (1) | JPH08778B2 (en, 2012) |
AT (1) | ATE76294T1 (en, 2012) |
AU (1) | AU593051B2 (en, 2012) |
DE (3) | DE10199020I2 (en, 2012) |
ES (1) | ES2000428T3 (en, 2012) |
GR (2) | GR880300077T1 (en, 2012) |
LU (1) | LU90710I2 (en, 2012) |
NL (1) | NL300140I2 (en, 2012) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150354A (en) | 1987-01-15 | 2000-11-21 | Bonnie Davis | Compounds for the treatment of Alzheimer's disease |
EP0363415B1 (en) * | 1987-05-04 | 2008-10-15 | Davis, Bonnie | Compounds for the treatment of alzheimer's disease |
IT1222395B (it) * | 1987-07-30 | 1990-09-05 | Pierrel Spa | Composizione farmaceutica per somministrazione intranasale comprendente l'ormone ghrh,un agonista colinergico e/o un sale biliare |
US4897388A (en) * | 1988-12-20 | 1990-01-30 | Geriatric Research Institute, Inc. | Method of treating Alzheimer's disease |
US5519017A (en) * | 1990-03-29 | 1996-05-21 | Lts Lohmann Therapie-Systeme Gmbh + Co. Kg | Pharmaceutic formulation for the treatment of alcoholism |
DE4010079A1 (de) * | 1990-03-29 | 1991-10-02 | Lohmann Therapie Syst Lts | Pharmazeutische formulierung zur behandlung des alkoholismus |
US5336675A (en) * | 1991-05-14 | 1994-08-09 | Ernir Snorrason | Method of treating mania in humans |
EP0584185B1 (en) * | 1991-05-14 | 1999-08-11 | Ernir Snorrason | Treatment of fatigue syndrome with cholinesterase inhibitors |
US5177070A (en) * | 1991-11-15 | 1993-01-05 | Ciba-Geigy Corporation | Method of treating physiologic male erectile impotence |
DE4301783C1 (de) * | 1993-01-23 | 1994-02-03 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Galanthamin als wirksamem Bestandteil |
DE4301782C1 (de) * | 1993-01-23 | 1994-08-25 | Lohmann Therapie Syst Lts | Verwendung von Galanthamin zur Behandlung der Nicotinabhängigkeit |
US6316439B1 (en) * | 1993-10-15 | 2001-11-13 | Aventis Pharamaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
US6323196B1 (en) * | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
US6323195B1 (en) | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
DK0787115T3 (da) * | 1994-10-21 | 2000-05-08 | Sanochemia Pharmazeutika Ag | Fremgangsmåde til fremstilling af 4a,5,9,10,11,12-hexahydro-6H-benzofuro[3a,3,2-ef][2]benzazepinderivater |
US6407229B1 (en) | 1994-10-21 | 2002-06-18 | Sanochemia Pharmazeutika Ag | Processes for the preparation of derivatives of 4a,5,9,10,11,12-hexahydro-6H-benzofuro-[3a,3,2-ef][2] benzazapine |
DE19509663A1 (de) * | 1995-03-17 | 1996-09-19 | Lohmann Therapie Syst Lts | Verfahren zur Isolierung von Galanthamin |
GB9514821D0 (en) * | 1995-07-19 | 1995-09-20 | Sod Conseils Rech Applic | Galanthamine derivatives |
AT402691B (de) * | 1996-01-26 | 1997-07-25 | Sanochemia Ltd | Verwendung von galanthamin zum herstellen von arzneimitteln zur behandlung von trisomie 21 oder verwandter trisomie-syndrome |
AT403803B (de) * | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
TW506836B (en) * | 1996-06-14 | 2002-10-21 | Janssen Pharmaceutica Nv | Fast-dissolving galanthamine hydrobromide tablet |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
AU2004242546B2 (en) * | 1998-11-23 | 2008-05-15 | Bonnie Davis | Dosage formulations for acetylcholinesterase inhibitors |
WO2000030446A1 (en) | 1998-11-23 | 2000-06-02 | Bonnie Davis | Dosage formulations for acetylcholinesterase inhibitors |
SI1140105T1 (en) * | 1998-12-24 | 2004-04-30 | Janssen Pharmaceutica N.V. | Controlled release galantamine composition |
US20050063998A1 (en) * | 1999-10-26 | 2005-03-24 | Francois Marc Karel Jozef | Oral solution containing galantamine and a sweetening agent |
ES2243241T3 (es) * | 2000-01-28 | 2005-12-01 | Tricia Grose | Suplemento herbario para el deterioro cognitivo relacionado con la perdida de estrogenos. |
US6426097B2 (en) | 2000-01-28 | 2002-07-30 | Herbaceuticals Inc. | Herbal supplement for cognitive related impairment due to estrogen loss |
NZ516302A (en) | 2000-03-31 | 2004-02-27 | Sanochemia Pharmazeutika Ag | Novel derivatives and analogues of galanthamin |
CA2310926C (en) * | 2000-04-03 | 2002-10-15 | Janssen Pharmaceutica N.V. | A use of galantamine for the treatment of neuropsychiatric behaviour associated with alzheimer's disease |
CA2310990A1 (en) | 2000-04-03 | 2000-10-09 | Michael Pontecorvo | A use of galantamine for the treatment of alzheimer's disease; targeting the underlying cause of the disease |
EP1284729A4 (en) * | 2000-04-13 | 2007-12-19 | Mayo Foundation | REDUCTION AGENTS OF A (BETA) 42 |
JP4721386B2 (ja) * | 2001-07-10 | 2011-07-13 | 第一三共株式会社 | 新規ガランタミン類縁体 |
US20030162770A1 (en) * | 2002-02-22 | 2003-08-28 | Davis Bonnie M. | Use of modulators of nicotinic receptors for treatment of cognitive dysfunction |
DK1514542T3 (da) | 2002-06-14 | 2012-04-10 | Toyama Chemical Co Ltd | Medicinsk sammensætning omfattende Tacrin eller Donepezil til forbedring af hjernefunktionen |
US20040067934A1 (en) * | 2002-10-03 | 2004-04-08 | Parys Wim Louis Julien | Use of galantamine for the treatment of neuropsychiatric behaviour associated with alzheimer's disease |
WO2004037234A2 (en) * | 2002-10-24 | 2004-05-06 | Merz Pharma Gmbh & Co. Kgaa | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors |
US20040097484A1 (en) * | 2002-11-14 | 2004-05-20 | Marc Cantillion | Once a day galantamine pharmaceutical compositions and methods of use |
WO2004071431A2 (en) * | 2003-02-05 | 2004-08-26 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
US20050004104A1 (en) * | 2003-05-30 | 2005-01-06 | Cali Brian M. | Methods for the protection of memory and cognition |
JP2007528857A (ja) * | 2003-07-11 | 2007-10-18 | ミリアド ジェネティクス, インコーポレイテッド | アルツハイマー病の処置のための薬学的方法、投与レジメンおよび投薬形態 |
US20050048543A1 (en) * | 2003-07-11 | 2005-03-03 | Jeroen Aerssens | CHRNA2 genetic markers associated with galantamine response |
BRPI0412919A (pt) * | 2003-07-25 | 2006-09-26 | Hoffmann La Roche | combinação de antagonista de mglur2 e inibidor de ache para o tratamento de distúrbios neurológicos crÈnicos e/ou agudos |
WO2005042762A2 (en) * | 2003-10-28 | 2005-05-12 | Genaissance Pharmaceuticals, Inc. | Lrpap1 genetic markers associated with galantamine response |
BG65658B1 (bg) * | 2003-11-13 | 2009-05-29 | "Софарма" Ад | Комбиниран лекарствен продукт на основата на галантамин |
US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
US7250258B2 (en) * | 2003-12-15 | 2007-07-31 | Pgxhealth Llc | CDK5 genetic markers associated with galantamine response |
CA2552114A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Solid dosage formulations of galantamine |
CA2551946A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Immediate, controlled and sustained release formulations of galantamine |
CN1921844A (zh) * | 2004-02-19 | 2007-02-28 | 诺瓦提斯公司 | 胆碱酯酶抑制剂治疗血管性抑郁症的用途 |
WO2006001877A2 (en) * | 2004-04-13 | 2006-01-05 | Myriad Genetics, Inc. | Combination treatment for neurodegenerative disorders comprising r-flurbiprofen |
CN1946906A (zh) * | 2004-04-29 | 2007-04-11 | 吉斯通护岸系统股份有限公司 | 用于墙、护墙和类似物的饰面 |
US20050267076A1 (en) * | 2004-05-14 | 2005-12-01 | Johns Hopkins University | Method for improving cognitive function |
WO2006004201A1 (ja) * | 2004-07-01 | 2006-01-12 | Eisai R & D Management Co., Ltd. | 神経再生促進剤 |
WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020853A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
AU2005308575A1 (en) * | 2004-11-23 | 2006-06-01 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia |
AU2005322611A1 (en) * | 2004-12-23 | 2006-07-06 | Voyager Pharmaceutical Corporation | Leuprolide acetate and acetylcholinesterase inhibitors or NMDA receptor antagonists for the treatment of Alzheimer's disease |
AU2006244297A1 (en) * | 2005-04-06 | 2006-11-16 | Adamas Pharmaceuticals, Inc. | Methods and compositions for treatment of CNS disorders |
US20080188510A1 (en) * | 2005-05-23 | 2008-08-07 | Eisai R & D Management Co., Ltd. | Novel methods using zonisamide |
US20070015832A1 (en) * | 2005-07-14 | 2007-01-18 | Myriad Genetics, Incorporated | Methods of treating overactive bladder and urinary incontinence |
EA200800360A1 (ru) * | 2005-07-22 | 2008-06-30 | Мириад Дженетикс, Инк. | Формуляции с высоким содержанием лекарства и дозированные формы |
US20080033045A1 (en) * | 2006-07-07 | 2008-02-07 | Myriad Genetics, Incorporated | Treatment of psychiatric disorders |
BRPI0718437A2 (pt) | 2006-10-27 | 2013-11-19 | Medivation Neurology Inc | Métodos e terapias de combinação para tratar a doença de alzheimer usando, entre outros, dimebon e dolepezil |
US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
WO2009120277A1 (en) | 2008-03-27 | 2009-10-01 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
EP2478099B1 (en) | 2009-09-18 | 2019-06-05 | Chase Pharmaceuticals Corporation | Combination for treating alzheimer-type dementia |
CA2781826A1 (en) | 2009-11-26 | 2011-06-03 | Usv Limited | Controlled release pharmaceutical compositions of galantamine |
CA2789014C (en) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
FR2962335B1 (fr) | 2010-07-12 | 2013-01-18 | Cll Pharma | Utilisation du nonapeptide pat dans le traitement et la prevention des maladies neurodegeneratives |
BR122016020434A2 (pt) | 2012-09-05 | 2019-08-27 | Chase Pharmaceuticals Corp | combinação farmacêutica e uso de um nspacha, de um achei e de um naaea |
HK1215170A1 (zh) | 2012-11-14 | 2016-08-19 | The Johns Hopkins University | 治療精神分裂症的方法和組合物 |
BG66818B1 (bg) | 2013-03-07 | 2019-01-31 | Berbee Beheer B. V. | Състав на екстракт от hippeastrum papilio за производство на лекарствени средства и хранителни добавки |
US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
EP3033082B1 (en) | 2013-08-16 | 2021-06-16 | Universiteit Maastricht | Treatment of cognitive impairment with pde4 inhibitor |
CN112843005B (zh) | 2015-05-22 | 2023-02-21 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
-
1986
- 1986-01-15 US US06/819,141 patent/US4663318A/en not_active Expired - Lifetime
-
1987
- 1987-01-15 ES ES198787100461T patent/ES2000428T3/es not_active Expired - Lifetime
- 1987-01-15 EP EP87100461A patent/EP0236684B1/en not_active Expired - Lifetime
- 1987-01-15 DE DE2001199020 patent/DE10199020I2/de active Active
- 1987-01-15 AT AT87100461T patent/ATE76294T1/de not_active IP Right Cessation
- 1987-01-15 DE DE198787100461T patent/DE236684T1/de active Pending
- 1987-01-15 AU AU67609/87A patent/AU593051B2/en not_active Expired
- 1987-01-15 DE DE8787100461T patent/DE3779149D1/de not_active Expired - Lifetime
- 1987-01-16 JP JP62007684A patent/JPH08778B2/ja not_active Expired - Fee Related
-
1988
- 1988-10-21 GR GR88300077T patent/GR880300077T1/el unknown
-
1992
- 1992-08-20 GR GR920400780T patent/GR3005447T3/el unknown
-
2001
- 2001-01-03 LU LU90710C patent/LU90710I2/fr unknown
-
2003
- 2003-12-04 NL NL300140C patent/NL300140I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DE10199020I1 (de) | 2001-05-23 |
EP0236684B1 (en) | 1992-05-20 |
GR880300077T1 (en) | 1988-10-21 |
GR3005447T3 (en, 2012) | 1993-05-24 |
DE3779149D1 (de) | 1992-06-25 |
JPH08778B2 (ja) | 1996-01-10 |
ATE76294T1 (de) | 1992-06-15 |
DE10199020I2 (de) | 2004-05-06 |
LU90710I2 (fr) | 2001-03-05 |
EP0236684A2 (en) | 1987-09-16 |
JPS62215527A (ja) | 1987-09-22 |
DE236684T1 (de) | 1988-04-28 |
ES2000428A4 (es) | 1988-03-01 |
AU6760987A (en) | 1987-07-16 |
US4663318A (en) | 1987-05-05 |
ES2000428T9 (es) | 2013-08-14 |
NL300140I2 (nl) | 2004-04-01 |
EP0236684A3 (en) | 1988-12-14 |
AU593051B2 (en) | 1990-02-01 |
NL300140I1 (nl) | 2004-02-02 |
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Legal Events
Date | Code | Title | Description |
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FG2A | Definitive protection |
Ref document number: 236684 Country of ref document: ES |
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SPCF | Request for supplementary protection certificate filed |
Free format text: GALANTAMINA (REMINYL) Spc suppl protection certif: C200100009 Filing date: 20010201 |
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SPCG | Supplementary protection certificate granted |
Free format text: GALANTAMINA (REMINYL) Spc suppl protection certif: C200100009 Filing date: 20010201 Expiry date: 20120115 Effective date: 20031211 |