DE69331605D1 - Verwendung von phenserin zur herstellung von medikamenten zur behandlung von kognitiven störungen - Google Patents
Verwendung von phenserin zur herstellung von medikamenten zur behandlung von kognitiven störungenInfo
- Publication number
- DE69331605D1 DE69331605D1 DE69331605T DE69331605T DE69331605D1 DE 69331605 D1 DE69331605 D1 DE 69331605D1 DE 69331605 T DE69331605 T DE 69331605T DE 69331605 T DE69331605 T DE 69331605T DE 69331605 D1 DE69331605 D1 DE 69331605D1
- Authority
- DE
- Germany
- Prior art keywords
- phenserin
- medicines
- production
- cognitive disorders
- treating cognitive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/980,399 US5409948A (en) | 1992-11-23 | 1992-11-23 | Method for treating cognitive disorders with phenserine |
PCT/US1993/011423 WO1994012176A1 (en) | 1992-11-23 | 1993-11-23 | Use of phenserine to treat cognitive disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69331605D1 true DE69331605D1 (de) | 2002-03-28 |
DE69331605T2 DE69331605T2 (de) | 2002-10-31 |
Family
ID=25527533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69331605T Expired - Fee Related DE69331605T2 (de) | 1992-11-23 | 1993-11-23 | Verwendung von phenserin zur herstellung von medikamenten zur behandlung von kognitiven störungen |
Country Status (11)
Country | Link |
---|---|
US (1) | US5409948A (de) |
EP (1) | EP0668763B1 (de) |
JP (1) | JP3778363B2 (de) |
AT (1) | ATE213411T1 (de) |
AU (1) | AU693428B2 (de) |
CA (1) | CA2149924C (de) |
DE (1) | DE69331605T2 (de) |
DK (1) | DK0668763T3 (de) |
ES (1) | ES2173111T3 (de) |
PT (1) | PT668763E (de) |
WO (1) | WO1994012176A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU749088C (en) * | 1997-07-09 | 2005-11-03 | Axonyx, Inc. | Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of Alzheimer's disease and dementias |
US20030125609A1 (en) * | 2001-08-03 | 2003-07-03 | Robert Becker | Method for reliable measurement in medical care and patient self monitoring |
US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
US7612078B2 (en) | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
CA2543322A1 (en) | 2003-10-21 | 2005-05-12 | Sention, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
US20050182044A1 (en) * | 2004-02-17 | 2005-08-18 | Bruinsma Gosse B. | Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate |
WO2005092009A2 (en) * | 2004-03-19 | 2005-10-06 | Axonyx, Inc. | Acetylcholinesterase inhibitors and n-methyl-d-aspartate antagonists useful in the treatment of cognitive disorders |
WO2005089746A1 (en) * | 2004-03-19 | 2005-09-29 | Axonyx, Inc. | Dosage titration for treatment of cognitive disorders |
US7488736B2 (en) | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
CA2508585A1 (en) * | 2004-06-01 | 2005-12-01 | Axonyx, Inc. | Transdermal delivery system for treatment of cognitive disorders |
EP1604686A1 (de) * | 2004-06-08 | 2005-12-14 | Axonyx, Inc. | Verwendung von Phenserine und einem HMG CoA reduktase Hemmer zur Verzögerung der Alzheimer Krankheit |
US7576211B2 (en) | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
US7407966B2 (en) | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
US7598265B2 (en) | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
US20060194723A1 (en) * | 2005-02-28 | 2006-08-31 | Rabinoff Michael D | Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement |
WO2006138385A2 (en) * | 2005-06-14 | 2006-12-28 | Cancog Technologies Inc.24 | Use of phenserine and analogs to treat behavioral problems and improve trainability |
JP2010518010A (ja) * | 2007-02-02 | 2010-05-27 | コルシド・ファーマシューティカルズ・インコーポレイテッド | コリンエステラーゼを阻害する化合物 |
RU2327480C1 (ru) | 2007-05-23 | 2008-06-27 | Виктор Иванович Рощин | Активный ингредиент лекарственного средства, лекарственное средство, фармацевтическая композиция и способ лечения больных с дементным синдромом |
US20090048229A1 (en) * | 2007-07-18 | 2009-02-19 | Rupniak Nadia M J | Methods for promoting wakefulness |
US8593728B2 (en) * | 2009-02-19 | 2013-11-26 | Toyota Motor Engineering & Manufacturing North America, Inc. | Multilayer photonic structures |
EP2445877B1 (de) | 2008-12-03 | 2014-07-23 | Nanotherapeutics, Inc. | Bicyclische verbindungen und verfahren zu deren herstellung und deren verwendung |
KR101757003B1 (ko) * | 2009-07-17 | 2017-07-11 | 알러간, 인코포레이티드 | 인지 장애를 치료하기 위한 콜린에스테라아제 저해물질을 포함한 조성물 |
US20120225922A1 (en) * | 2011-03-04 | 2012-09-06 | Qr Pharma | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
US10111860B1 (en) | 2016-01-15 | 2018-10-30 | Aristea Translational Medicine Corporation | Compositions and methods for treating concussion |
US10864192B2 (en) | 2016-01-15 | 2020-12-15 | Aristea Translational Medicine Corporation | Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions |
WO2018217892A1 (en) | 2017-05-24 | 2018-11-29 | Qr Pharma, Inc. | Prevention or treatment of disease states due to metal dis-homeostasis via administration of posiphen to healthy or sick humans |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US479107A (en) * | 1892-07-19 | oesterreich | ||
US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
DE3843239C1 (de) * | 1988-12-22 | 1990-02-22 | Lohmann Therapie Syst Lts | |
US4971992A (en) * | 1989-03-27 | 1990-11-20 | Hoechst-Roussel Pharmaceuticals Inc. | Carbonate derivatives of eseroline |
US4996201A (en) * | 1989-08-02 | 1991-02-26 | Warner-Lambert Co. | 4-(N-substituted amino)-2-butynyl-1-carbamates and thiocarbamates and derivatives thereof as centrally acting muscarinic agents |
US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
US5077289A (en) * | 1989-11-30 | 1991-12-31 | Hoechst Roussel Pharmaceuticals Inc. | Memory enhancing and analgesic aminocarbonylcarbamates related to physostigmine |
US5171750A (en) * | 1991-09-26 | 1992-12-15 | The United States Of America As Represented By The Department Of Health And Human Services | Substituted phenserines as specific inhibitors of acetylcholinesterase |
-
1992
- 1992-11-23 US US07/980,399 patent/US5409948A/en not_active Expired - Lifetime
-
1993
- 1993-11-23 CA CA002149924A patent/CA2149924C/en not_active Expired - Fee Related
- 1993-11-23 ES ES94903295T patent/ES2173111T3/es not_active Expired - Lifetime
- 1993-11-23 AU AU57290/94A patent/AU693428B2/en not_active Ceased
- 1993-11-23 PT PT94903295T patent/PT668763E/pt unknown
- 1993-11-23 DK DK94903295T patent/DK0668763T3/da active
- 1993-11-23 JP JP51335894A patent/JP3778363B2/ja not_active Expired - Fee Related
- 1993-11-23 DE DE69331605T patent/DE69331605T2/de not_active Expired - Fee Related
- 1993-11-23 EP EP94903295A patent/EP0668763B1/de not_active Expired - Lifetime
- 1993-11-23 AT AT94903295T patent/ATE213411T1/de not_active IP Right Cessation
- 1993-11-23 WO PCT/US1993/011423 patent/WO1994012176A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO1994012176A1 (en) | 1994-06-09 |
PT668763E (pt) | 2002-08-30 |
AU693428B2 (en) | 1998-07-02 |
EP0668763B1 (de) | 2002-02-20 |
ATE213411T1 (de) | 2002-03-15 |
DE69331605T2 (de) | 2002-10-31 |
ES2173111T3 (es) | 2002-10-16 |
JP3778363B2 (ja) | 2006-05-24 |
JPH08505130A (ja) | 1996-06-04 |
DK0668763T3 (da) | 2002-06-03 |
CA2149924C (en) | 2006-01-31 |
US5409948A (en) | 1995-04-25 |
CA2149924A1 (en) | 1994-06-09 |
AU5729094A (en) | 1994-06-22 |
EP0668763A1 (de) | 1995-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |