ES2000255A6 - Un metodo para sintetizar al menos una porcion de toxina del tetanos o un peptido que comprende al menos un epitopo de la misma. - Google Patents

Un metodo para sintetizar al menos una porcion de toxina del tetanos o un peptido que comprende al menos un epitopo de la misma.

Info

Publication number
ES2000255A6
ES2000255A6 ES8600021A ES8600021A ES2000255A6 ES 2000255 A6 ES2000255 A6 ES 2000255A6 ES 8600021 A ES8600021 A ES 8600021A ES 8600021 A ES8600021 A ES 8600021A ES 2000255 A6 ES2000255 A6 ES 2000255A6
Authority
ES
Spain
Prior art keywords
cloned antigen
cloned
antigen
vaccines
cloning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600021A
Other languages
English (en)
Inventor
Fairweather Neil Fraser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES2000255A6 publication Critical patent/ES2000255A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA SECUENCIA DE ADN QUE CODIFICA LA NEUROTOXINA DE C. TETANI SE CLONA EN UN PLASMIDO (POR EJEMPLO PAT 153) Y SE EMPLEA PARA TRANSFORMAR UN HOSPEDANTE (POR EJEMPLO E. COLI JM101). EL CLON RECOMBINANTE DESEADO SE SELECCIONA Y EMPLEA PARA OBTENER CLONES ADICIONALES DE MODO QUE SE GENERE UNA SECUENCIA DE ADN QUE CODIFICA LA TOXINA DEL TETANOS. LA SECUENCIA DE ADN CLONADA SE INSERTA EN UN PLASMIDO DE EXPRESION Y EL VECTOR RESULTANTE SE EMPLEA PARA TRANSFORMAR UN HOSPEDANTE (POR EJEMPLO E. COLI). EL TRANSFORMANTE DESEADO SE SELECCIONA Y CULTIVA PARA OBTENER LA TOXINA DEL TETANOS, QUE SE AISLA Y SE EMPLEA COMO BASE PARA UNA VACUNA.
ES8600021A 1985-06-28 1986-06-27 Un metodo para sintetizar al menos una porcion de toxina del tetanos o un peptido que comprende al menos un epitopo de la misma. Expired ES2000255A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858516442A GB8516442D0 (en) 1985-06-28 1985-06-28 Cloned antigen

Publications (1)

Publication Number Publication Date
ES2000255A6 true ES2000255A6 (es) 1988-02-01

Family

ID=10581498

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600021A Expired ES2000255A6 (es) 1985-06-28 1986-06-27 Un metodo para sintetizar al menos una porcion de toxina del tetanos o un peptido que comprende al menos un epitopo de la misma.

Country Status (9)

Country Link
EP (1) EP0209281A1 (es)
JP (1) JPS6251994A (es)
AU (1) AU5941486A (es)
DK (1) DK307986A (es)
ES (1) ES2000255A6 (es)
FI (1) FI862761A (es)
GB (1) GB8516442D0 (es)
IL (1) IL79270A0 (es)
ZA (1) ZA864805B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8914122D0 (en) * 1989-06-20 1989-08-09 Wellcome Found Polypeptide expression
US5601826A (en) * 1989-06-30 1997-02-11 The United States Of America As Represented By The Department Of Health And Human Services Peptide which produces protective immunity against tetanus
GB9209118D0 (en) * 1992-04-28 1992-06-10 Sb 120 Amsterdam Bv Vaccine compositions
AU4545393A (en) * 1992-06-30 1994-01-24 United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Peptide which produces protective immunity against tetanus
KR950702635A (ko) * 1992-07-31 1995-07-29 크리스틴 헬렌 수덴 감쇠 박테리아에서 재조합 융합 단백질의 발현(Expression of recombinant fusion proteins in attenuated bacteria)
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
EP0845270B1 (en) 1996-03-23 2004-10-27 The Research Foundation For Microbial Diseases Of Osaka University Functional fragment antigen of tetanus toxin and tetanus vaccine
US7923216B2 (en) * 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
GB9914861D0 (en) * 1999-06-25 1999-08-25 Imperial College Tetanus toxin polypeptides
GB0108364D0 (en) 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
JP4870895B2 (ja) 2000-06-29 2012-02-08 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン組成物
EP1824971B1 (en) 2004-11-22 2016-01-13 New York University Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof
ES2387582T3 (es) 2006-09-07 2012-09-26 Glaxosmithkline Biologicals S.A. Vacuna de combinación con cantidades reducidas del antígeno del virus de la polio
EP2142211A1 (en) 2007-05-02 2010-01-13 GlaxoSmithKline Biologicals S.A. Vaccine
EP2528941A4 (en) 2010-01-25 2013-05-29 Univ New York RECOMBINANT BOTULINUM NEUROTOXIN DERIVATIVES MODIFIED FOR TRAFFIC STUDIES AND NEURONAL DELIVERY
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
DK2948174T3 (da) 2013-01-28 2019-12-02 Univ New York Fremgangsmåder til behandling under anvendelse af atoksiske neurotoksinderivater
SG11201506858SA (en) 2013-03-08 2015-09-29 Crucell Holland Bv Acellular pertussis vaccine
US11897921B2 (en) 2014-12-09 2024-02-13 New York University Propeptide fusion comprising a mutated clostridium botulinum neurotoxin and a VHH domain
US11173199B2 (en) * 2019-11-13 2021-11-16 Alopexx Inc. Low contaminant compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2634584C3 (de) * 1976-07-31 1979-11-08 Behringwerke Ag, 3550 Marburg Atoxisches, immunogenes Produkt aus Tetanus-Toxin

Also Published As

Publication number Publication date
DK307986D0 (da) 1986-06-27
JPS6251994A (ja) 1987-03-06
ZA864805B (en) 1988-02-24
FI862761A (fi) 1986-12-29
FI862761A0 (fi) 1986-06-27
EP0209281A1 (en) 1987-01-21
IL79270A0 (en) 1986-09-30
DK307986A (da) 1986-12-29
GB8516442D0 (en) 1985-07-31
AU5941486A (en) 1987-01-08

Similar Documents

Publication Publication Date Title
ES2000255A6 (es) Un metodo para sintetizar al menos una porcion de toxina del tetanos o un peptido que comprende al menos un epitopo de la misma.
DK82293D0 (da) Normalt sporulerende bacillus uden evne til at udskille subtilisin eller neutral protease, kulturer deraf og fremgangsmaade til fremstilling af heterologe proteiner dermed
DK163187C (da) Fremgangsmaader til fremstilling af humant immuninterferon (gamma-interferon) samt dna-fragmenter, rekombinante klonings- og udtrykkelsesvektorer og rekombinante mikroorganismer og cellekulturer til anvendelse herved
UA27706C2 (uk) Спосіб одержання гетерологічного поліпептиду
EP0244234A3 (en) Transformation of trichoderma
ES8205263A1 (es) Un procedimiento para la produccion de una proteina activadora del piasminogeno.
EP0150126A3 (en) The synthesis of protein with an identification peptide
ES8500324A1 (es) Procedimiento para la obtencion de proteina heterologa.
ZA885535B (en) Dna constructs containing a kluyveromyces alpha-factor leader sequence for directing secretion of heterologous polypeptides
IL68366A (en) Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
JPS57181099A (en) Bacillus cloning vector, recombinant dna molecule, bacillus host transformed thereby and manufacture of polypeptide expressing dna order and being coded thereby
NZ331829A (en) Clostridium perfringens vaccines
ZA8860B (en) Pancreatic secretory trypsin inhibitor and variants thereof produced by a recombinant host,process,expression vector and recombinant host therefor and pharmaceutical use thereof
DK0688362T3 (da) Kloning og rekombinant fremstilling af vespidgiftenzymer, såsom phospholipase og hyaluronidase, og immunologiske terapier baseret derpå
ES8800691A1 (es) Un metodo para purificar la proteina inhibidora de fosfolipasa humana (hpip)
DE69836520D1 (de) Clostridium perfringens Impfstoff
ATE108831T1 (de) Rinder-interleukin-1-alpha.
ATE403675T1 (de) Bordetella-stamm die eine hybride-fha exprimiert
HK1060147A1 (en) Mouse glucuronyl c5-epimerase, dna encoding the same and use thereof.
FI882238A (fi) Foerbaettringar i samband med organiska foereningar
EP0302838A3 (en) Cloning of the gene coding the isoamylase enzyme and its use in the production of said enzyme
DE3583752D1 (de) In bacillus-subtilis verwendbare expressionsplasmide.
EP0183272A3 (en) Vector capable of efficient gene expression and utilization of such vector
ATE52805T1 (de) Psm112-plasmidvektor zur expression in bacillus subtilis.
NO934572D0 (no) Fremgangsmaate for fremstilling av rekombinante proteiner og de benyttede vertsceller

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401