EP4190303A1 - Récipient pour médicaments - Google Patents

Récipient pour médicaments Download PDF

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Publication number
EP4190303A1
EP4190303A1 EP21211716.2A EP21211716A EP4190303A1 EP 4190303 A1 EP4190303 A1 EP 4190303A1 EP 21211716 A EP21211716 A EP 21211716A EP 4190303 A1 EP4190303 A1 EP 4190303A1
Authority
EP
European Patent Office
Prior art keywords
container
cap
bead
press
opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21211716.2A
Other languages
German (de)
English (en)
Inventor
Thorsten Kellner
Jennifer Karina SEIB
Andreas DUNZ
Thomas Jakob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wirthwein Medical GmbH and Co KG
Original Assignee
Wirthwein Medical GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wirthwein Medical GmbH and Co KG filed Critical Wirthwein Medical GmbH and Co KG
Priority to EP21211716.2A priority Critical patent/EP4190303A1/fr
Priority to PCT/EP2022/083816 priority patent/WO2023099546A1/fr
Publication of EP4190303A1 publication Critical patent/EP4190303A1/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type

Definitions

  • the invention relates to a medicament container for a medicinal substance or a medicament, the interior of which is accessible via a container opening designed in the manner of a bottle mouth.
  • Medicines in particular for treatment in highly specialized or complex therapies, are usually made available in active ingredient or medicine containers, also referred to as containers or vials.
  • active ingredient or medicine containers also referred to as containers or vials.
  • Such a medicament container is usually designed in the manner of a small bottle and comprises an interior space in which the medicament or the active ingredient is kept and which is accessible via a container opening designed in the manner of a bottle mouth.
  • the active substance is then transferred from such a receptacle or container via suitable transfer systems for the actual administration to suitable systems such as a syringe or an intravenous line which provides fluid access to the patient's circulatory system.
  • medicament containers of the type mentioned above can be provided with a so-called tamper-evident closure.
  • the closure system of such a medication container can be provided with an additional outer closure element in the form of a one-way closure.
  • This one-way closure which can include a sealing lid that can be torn off or is sealed, for example, allows problem-free and reliable identification as to whether the container has already been used for liquid transfer or not, or whether the contents could have been tampered with. It thus makes it easier to determine whether the container has already “opened” and should therefore preferably be used for further liquid removal until it is completely empty and should therefore be disposed of, or whether the contents have even been accessed without authorization.
  • the invention is therefore based on the object of specifying a medicament container of the type mentioned above which offers particularly high-quality and reliable protection against manipulation of its contents.
  • This object is achieved according to the invention by arranging a number, preferably three, of circumferentially attached outer beads on the outside of the container opening, with the outermost or proximal outer bead viewed in the direction of the mouth opening being designed as a limiting outer bead and having a bead width of at least 150% of the bead width of the adjacent outer bead.
  • “Circumferential” is to be understood here in particular as meaning that each of the named outer beads has the contour of a self-contained annular body surrounding the container opening. This is to be distinguished in particular from the threads which are customary, for example, in drinks bottles and are attached in the region of the bottle mouth, by means of which the closure cap can be screwed onto the bottle mouth. Such a thread has thread ribs which, when completely circumnavigating the bottle mouth, move around it in the longitudinal direction, forming the so-called thread pitch. Such a thread-like configuration is not to be regarded as "circumferential" in the sense mentioned above.
  • the invention is based on the consideration that the protection against manipulation usually used in medication containers of the type mentioned, for example in the form of the tear-off or sealed sealing lid mentioned, is definitely reliable protection against manipulation or at least a reliable indication of whether access has been made to the contents of the container case of access in the area of the lid itself.
  • the end area of the lid ie the "lower" edge of the cap pushed onto the bottle mouth, is considered to be a weak point in the present case.
  • the bottle mouth or container opening should also be designed specifically for protection against manipulation from the lower end edge.
  • the bottle mouth has a thickened or widened "lower” or proximal outer bead in the manner of a protective or securing ring in comparison to the other outer beads, which can cover the lower edge of the pushed-on cap and thus protect against unwanted access.
  • the (one or more) "upper”, i. H. External beads arranged adjacent to the mouth opening of the container serve primarily as latching or hooking elements for interaction with corresponding latching or hooking elements on the container cap, so that it can be securely and firmly attached to the bottle mouth.
  • the "lowermost”, proximal outer bead serves as a security element against unwanted access to the applied closure cap from below, and accordingly it should preferably be sufficiently wide so that it radially sufficiently, preferably completely, surrounds the ensemble of the mouth area of the container and the closure cap pushed on. covers.
  • the delimiting outer bead preferably has a bead width of at least twice, preferably approximately three times, the bead width of the adjacent outer bead positioned further "up" in the direction of the orifice opening.
  • the outer beads can be designed in segments, i. H. the respective outer bead can be formed by a number of bead segments which are arranged rotationally sequentially one behind the other around the bottle mouth and which are positioned sequentially at a distance from one another, ie forming a gap.
  • the outer beads are preferably designed for interaction with the associated components, for example latching elements on the closure cap, in any rotational orientation; it is therefore advantageous for at least one of the outer beads to run all the way around.
  • the limiting outer bead is designed to be comparatively flat on its lower side facing away from the mouth opening and thus accessible even when the closure cap is on and abutting the container wall as far as possible at right angles.
  • the delimiting outer bead has a rectilinear flank on the underside, with its normal line tilted by at most 10° relative to the longitudinal axis of the container opening.
  • the medicament container is designed to a particularly large extent with components of its closure system that are coordinated with one another.
  • the container opening is advantageously closed with a push-on, provided with a sealing element nieprellCAP, on the outer periphery of a number of latching elements which can be brought into latching engagement with one of the outer beads is arranged, with the press-on cap terminating axially on the limiting outer bead when it is pushed completely onto the container opening.
  • the impact cap should not protrude too far laterally or radially, or preferably not at all, beyond the delimiting outer bead.
  • the (proximal) delimiting outer bead also referred to as the "3rd rib"
  • the delimiting outer bead determines the originality protection to a considerable extent.
  • an end face of the or each latching element rests against a contact surface arranged on the mouth-side flank of the delimiting outer bead when the press-on cap is pushed completely onto the container opening.
  • the delimiting outer bead can thus be predetermined analogously to a stop surface which defines the end position of the closure cap to be applied in the axial direction. This automatically gives the desired downward coverage function.
  • the press-on cap should be suitable for the intended snap or snap-in connection on the container opening or a snap-in edge surrounding it, and in particular should be correspondingly stiff.
  • the sealing element should be designed appropriately with regard to the desired slight deformation when producing the sealing effect.
  • the press-on cap is preferably made from a plastic, particularly preferably from polypropylene (PP), a polyolefin, cyclo-olefin copolymer (COC), cyclo-olefin polymer (COP) or polycarbonate.
  • the stopper is made of rubber or TPE.
  • the medication container should be specially secured after the locking system has been attached.
  • it advantageously comprises, as a further component, a locking ring which can be pushed onto the press-on cap and which can be fixed in a latching manner on the press-on cap by means of a number of snap-in ribs formed on the inside and positioned at the end.
  • an RFID chip is arranged on the press-on cap, particularly preferably on its ring cover.
  • This can be provided with a code or identifier that individually identifies the medicament container and/or can contain further information regarding the content, for example the composition of the medicament or active ingredient, a possible expiry date or the like.
  • a code or identifier that individually identifies the medicament container and/or can contain further information regarding the content, for example the composition of the medicament or active ingredient, a possible expiry date or the like.
  • the medicament container in order to form a tamper-evident closure, it comprises a sealing plate which is integrally formed on the outside of the securing ring and can be torn off from it.
  • the tamper-evident closure advantageously comprises a connecting segment which runs between the tear-off ring and the sealing plate and is molded onto the tear-off ring and/or the sealing plate via a number of predetermined breaking points for the firm connection with the press-on cap.
  • the advantages achieved with the invention are, in particular, that by equipping the container opening designed as a bottle mouth with an additional, in the manner of a further or preferably 3rd rib designed limiting outer bead and its widened compared to the other outer beadings provided anyway a particularly effective protection against manipulation "from below" can be achieved.
  • a broadened lower outer bead can also be used very favorably as a suitable contact surface for automated handling of the medication container.
  • the Outer bead thereby serve as a support surface on which suitable lifting elements can act, for example to specifically support the container while it is being filled downwards. In this way, the container can be fixed particularly securely during filling or also during a subsequent closing process and can therefore be handled in a particularly reliable manner.
  • the drug container 1 acc. 1 also referred to as a container or vial, is designed in the manner of a small bottle. It comprises an interior space 4 which is enclosed by a container wall 2 and in which the medicament or the active ingredient is kept.
  • the container wall 2 is made of a suitably selected plastic with or without a barrier layer.
  • a “medical grade” plastic is particularly preferred here, preferably from the material classes COP, COC, such as COP variants 690R® , 790R® , COC variants Topas® 8007S-04, 6013S-04, 6015S-04.
  • the plastic is very particularly preferably selected with regard to the criteria transparent, insensitive to breakage, little or no interaction with the intended drug, medical grade, in particular generally usable as a glass substitute, individually or in combination with one another.
  • the interior 4 is accessible via a container opening 6 designed in the manner of a bottle mouth.
  • the medicament container 1 is designed to a particular extent for the provision of active ingredients or medicaments in which any loss of material through unintentional release into the environment or environment is to be avoided as far as possible. This can be the case, for example, for substances that are toxic, hazardous to health or otherwise dangerous for the people handling them, or also for particularly expensive substances or active ingredients, such as are increasingly being used in modern therapies in particular.
  • the medication container 1 is equipped with a closure system 10 that closes the container opening 6, which is designed on the one hand for particularly high tightness and on the other hand for particularly effective protection against manipulation.
  • the container wall 2 of the medication container 1 is, as shown in the perspective view in 2 as well as the representation in longitudinal section in 3 can clearly be seen, in the area of the container opening 6 with a number of, in the exemplary embodiment two, peripherally attached outer beads 12 as a fastening element for the closure system 10 .
  • a first of these outer beads 12 is arranged immediately adjacent to the mouth opening 14 of the container 1; a second outer bead 12, on the other hand, is located somewhat further away from the mouth opening 14.
  • the two upper outer beads 12 applied circumferentially to the container opening 6 have an approximately or completely equal bead width w.
  • This interpretation is in view of the intended use of these outer beads for locking or fixing selected with associated locking or snap elements of the closure system 10.
  • the lowermost or proximal outer bead 16 seen in the direction of the muzzle opening has a bead width W that is significantly larger than that of the outer beads 12 by about three times, i.e. significantly more than at least 150%, of the bead width w of the adjacent outer bead 12 to improve protection against tampering. executed.
  • the outer beads 12, 16 run completely circumferential.
  • the outer beads 12, 16 could be completely or partially segmented, that is, they could comprise a plurality of segments that follow one another, seen in the direction of rotation, and are positioned at a distance from one another, with the formation of gaps in between.
  • Another particularly preferred aspect of the present invention relates to the cross-sectional profile of the outer bead 16.
  • the delimiting outer bead 16 has on its lower side facing away from the mouth opening 14 a largely rectilinear flank 18 which is tilted with its normal to the longitudinal axis of the container opening 6 by at most 10°.
  • this configuration achieves a particularly reliable, flat covering of the closure system 10 arranged above, and on the other hand, a contact surface that is particularly favorable and suitable for automated handling purposes is formed.
  • the delimiting outer bead 16 has a mouth-side flank 20 on its upper side facing the mouth opening 14 which, as explained below, is specifically designed for a favorable interaction with the closure system 10 .
  • the upper flank 20 of the delimiting outer bead 16 forms a contact surface 22 .
  • FIG. 4 is the mouth area of the medication container 1 together with the associated closure system 10 in an exploded view, In Figure 4a in lateral plan view and in Figure 4b shown in longitudinal section.
  • the essential components of the closure system 10 include a sealing element 24 designed as a closure plug for closing the container opening 6 and a fixing cap 26 with which the sealing element 24 can be firmly attached to the container opening 6 .
  • the fixing cap 26 is designed as a press-on cap 28, on the outer circumference of which a number is arranged by snap hooks or locking elements 30 that can be brought into engagement with the respective outer bead 12 .
  • the press-on cap 28 When attaching the press-on cap 28, it can thus be placed or pressed onto the container opening 6, with the latching elements 30 first being bent outwards by the respective outer bead 12 and then, after being pushed on further, gripping behind the outer bead 12 and in the manner of a snap connection with it snap. Furthermore, in terms of its dimensioning in the longitudinal direction of the container opening 6, the press-on cap 28 is adapted to its outer contour formed by the outer beads 12, 16 in such a way that the end face 34 of the or each latching element 30 formed by the end edge 32 of the press-on cap 28 fits completely onto the Container opening 6 in the pushed-on state of the press-on cap 28 against the contact surface 22 arranged on the mouth-side flank 20 of the limiting outer bead 16 .
  • the press-on cap 28 includes an annular cover 44 having a central opening 42.
  • the integrally designed per se, in figure 5 The sealing element 24 shown enlarged, on the other hand, comprises a closure plate 46 in the manner of a basic element, on the first plate side of which a thickening 48 that completely fills the central opening 42 of the ring cover 44 and can be brought into engagement with it is formed.
  • the thickening 48 is provided in its connection area with the closure plate 46 with a circumferential groove 50 forming an undercut.
  • the one-piece sealing element 24 is, also with regard to the desired sealing purposes, made of a suitable and also comparatively soft and easily deformable material, in the exemplary embodiment made of rubber or of TPE, preferably "medical grade".
  • This choice of material also ensures that the sealing element 24 can be pierced by means of a suitable instrument, for example a hollow needle, if necessary, ie if the active substance is to be removed from the medication container 1 .
  • a suitable instrument for example a hollow needle
  • the sealing element 24 can be connected almost firmly to the press-on cap 28 by the thickening 48 being introduced into the opening 42 in the ring cover 44 and the peripheral edge of the opening 42 then engaging in the groove 50 and thus the sealing element 24 is fixed to the press-on cap 28 .
  • the sealing element 24 advantageously contributes to the sealing of the container opening 6 in two ways.
  • a sealing effect is achieved, quite comparable to the known system, in that, in the assembled system, the closure plate 46, which is suitably adapted to the mouth edge 52 of the container opening 6 in terms of its dimensions, in particular its outer diameter, is replaced by the snap-on cap that can be snapped onto the mouth edge 52 28 is pressed with its edge of the sealing element 24 onto the mouth edge 52.
  • the closure plate 46 can already develop a sealing effect as a result of the deformability of the material.
  • the provision of radial force components, ie contact forces that press the sealing element 24 in the radial direction against the inside of the container wall 2 in the region of its mouth is also provided for an overall particularly increased sealing effect.
  • a radial sealing element 54 is formed on the second plate side of the closure plate 46 .
  • the cross-sectional shape of the radial sealing element 54 is adapted to the cross-sectional shape of the container opening 6 in the mouth region (both are round in the exemplary embodiment). With regard to its dimensioning, it is also adapted to the clear width I of the container opening 6 and is designed slightly larger than the clear width I of the container opening 6 with regard to the deformability of the material of the sealing element 24 .
  • the container opening can be suitably selected and dimensioned; For example, their clear width can be suitably matched to the standard "13 neck” dimension (corresponds to an outer diameter of the container opening of 13 mm) or to the standard "20 neck” dimension (corresponds to an outer diameter of the container opening of 20 mm).
  • the sealing element 24 is advantageously designed for an even further improved sealing effect in the radial direction.
  • the shape is selected in such a way that the central area of the sealing element 24 that forms the thickening 48 is surrounded by a circumferential groove-like or trench-like depression 56 that extends deep into the closure plate 46 .
  • the indentation 56 can also completely penetrate the material thickness of the closure plate 46, so that the sealing element 24 has a multi-component design in this embodiment.
  • the press-on cap 28 as shown in Figure 6a in perspective view from below and in Figure 6b shown enlarged in a longitudinal section, has a reinforcement ring 58 which is integrally formed on the underside of the ring cover 44 and runs around the opening 42 .
  • this reinforcement ring 58 is introduced into the depression 56 of the sealing element 24 .
  • the dimensions are matched to one another in such a way that the reinforcement ring 58 corresponds to the radial sealing element 54 of the sealing element 24 gives increased strength and rigidity to the outside, ie in the radial direction, and thus improves the radial seal even further.
  • the appropriately selected dimensions of the reinforcement ring 58 can deform the radial sealing element 54 more or less slightly outwards and generate an additional pressing force in the radial direction against the inner wall of the medication container 1 in the area of the container opening 6 .
  • the press-on cap 28 consists of a suitably selected plastic, namely polypropylene (PP), a polyolefin, cyclo-olefin copolymer (COC), cyclo-olefin polymer (COP) or polycarbonate.
  • PP polypropylene
  • COC cyclo-olefin copolymer
  • COP cyclo-olefin polymer
  • the closure system 10 comprises a locking ring 60 which can be pushed onto the press-on cap 28.
  • This can be pushed onto the press-on cap 28 from the outside after the press-on cap 28 has been pressed open and has been locked in place with the outer beads 12. He thus fixes the locking elements 30 radially so that they can no longer deviate to the outside. This means that the locking of the press-on cap 28 with the outer bead 12 can no longer be easily released and is therefore fixed.
  • the securing ring 60 in turn has a number of snap ribs 62 formed on the inside and positioned at the ends, by means of which it can be fixed to the press-on cap 28 in a latching manner.
  • the medicament container 1 closed with the closure system 10 has a tamper-evident closure 70 as a component.
  • a tamper-evident closure 70 as a component. In the manner of a one-way closure, this should ensure that the user can determine in a simple and reliable manner whether the medication container 1 has already been used for liquid transfer or not, ie whether active substance has already been removed or not. It thus makes it easier to determine whether the container has already "opened” and should therefore preferably be used for further liquid removal until it is completely empty and should therefore be disposed of.
  • the tamper-evident closure 70 is designed as a sealing plate 72 molded onto the securing ring 60 .
  • the sealing plate 72 is dimensioned and positioned in such a way that, in the installed state, it completely covers the central opening 42 of the ring cover 44 and thus the exposed surface of the sealing element 24 that is accessible via it. In order to gain access to the interior of the medicament container 1, ie to remove active substance, the sealing plate 72 must first be removed so that the sealing element 24 can be pierced.
  • the attachment of the closure system 10 to the medication container 1 is in 7 shown as a sequence of steps.
  • a first step, in Figure 7a shown the closure system 10 is first preassembled in a sequence considered to be independently inventive.
  • the tamper-evident closure 70 is connected to the press-on cap 28 and the thickening 48 of the sealing element 24 is snapped into the opening 42 of the ring cover 44 of the press-on cap 28 .
  • the in Figure 7b intermediate step shown are carried out.
  • the embodiment provided in the exemplary embodiment is used, in which two circumferential outer beads 12 are provided on the outside in the mouth area of the container opening 6 in the manner of a double bead.
  • the outer beads 12 are separated from one another by a groove 74 extending therebetween.
  • Such a design makes it possible to push the closure system 10 in a first step only far enough onto the container opening 6 that the latching hooks 76 formed on the latching elements 30 only engage in the groove 74 and initially lock the system there.
  • This position can be used, for example, for freeze-drying, also referred to as lyophilization, lyophilization or sublimation drying, of the active substance in the medicament container 1 .
  • freeze-drying also referred to as lyophilization, lyophilization or sublimation drying
  • This is a process that is now widespread for the gentle drying of products, which is used for a large number of medicines or active ingredients in order to make them durable.
  • it may be necessary to be able to release gases or vapors, in particular water vapor, into the environment, and such a possibility is offered by the Figure 7b shown positioning of the components.
  • the process of closing then exited and the system into the in Figure 7c shown, fully closed state transferred.
  • the push-on cap 28 is first moved further over the container opening, so that the sealing element 24 now penetrates with its radial sealing element 54 into the container opening 6 until the closure plate 46 rests with its outer edge on the mouth edge 52 of the container 1 and then, under Slight deformation of the closure plate 46 seen in the longitudinal direction of the container opening 6, the latching hooks 76 of the AufprellCAP 28 engage below the second or lower outer bead 12.
  • the locking ring 60 is then pushed down so that it encompasses the press-on cap 28 on the outside.
  • the latching elements 30 are thus locked in their position and the medication container 1 in the Figure 7c position shown is securely locked.
  • an RFID chip 80 is arranged on its ring cover 44, preferably injected into it.
  • the RFID chip 80 can be provided with a code or identifier that individually identifies the drug container and/or other information regarding the content, for example the drug or active ingredient composition, a possible expiry date, a batch number, the raw materials used, production and manufacturing information of the manufacturer or the like.
  • a code or identifier that individually identifies the drug container and/or other information regarding the content, for example the drug or active ingredient composition, a possible expiry date, a batch number, the raw materials used, production and manufacturing information of the manufacturer or the like.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Closures For Containers (AREA)
EP21211716.2A 2021-12-01 2021-12-01 Récipient pour médicaments Pending EP4190303A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP21211716.2A EP4190303A1 (fr) 2021-12-01 2021-12-01 Récipient pour médicaments
PCT/EP2022/083816 WO2023099546A1 (fr) 2021-12-01 2022-11-30 Récipient pour médicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP21211716.2A EP4190303A1 (fr) 2021-12-01 2021-12-01 Récipient pour médicaments

Publications (1)

Publication Number Publication Date
EP4190303A1 true EP4190303A1 (fr) 2023-06-07

Family

ID=78821050

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21211716.2A Pending EP4190303A1 (fr) 2021-12-01 2021-12-01 Récipient pour médicaments

Country Status (2)

Country Link
EP (1) EP4190303A1 (fr)
WO (1) WO2023099546A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244479A (en) * 1978-12-13 1981-01-13 Owens-Illinois, Inc. Tamperproof closure member
US4449639A (en) * 1982-12-13 1984-05-22 Johnsen & Jorgensen (Plastics) Ltd. Tamper-resistant and child-resistant closures
US6073810A (en) * 1996-02-15 2000-06-13 International Plastics And Equipment Corporation Tamper-evident closure
US20090159553A1 (en) * 2006-08-31 2009-06-25 Hans-Rainer Hoffmann Closure system for containers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL237351B1 (pl) * 2018-12-11 2021-04-06 Reend Spolka Z Ograniczona Odpowiedzialnoscia Zespół zamknięcia pojemnika z tworzywa sztucznego, zwłaszcza na napoje

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4244479A (en) * 1978-12-13 1981-01-13 Owens-Illinois, Inc. Tamperproof closure member
US4449639A (en) * 1982-12-13 1984-05-22 Johnsen & Jorgensen (Plastics) Ltd. Tamper-resistant and child-resistant closures
US6073810A (en) * 1996-02-15 2000-06-13 International Plastics And Equipment Corporation Tamper-evident closure
US20090159553A1 (en) * 2006-08-31 2009-06-25 Hans-Rainer Hoffmann Closure system for containers

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Publication number Publication date
WO2023099546A1 (fr) 2023-06-08

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