EP4085126C0 - Einwegzellzüchtungsbehälter mit zwei oder mehreren in-situ-online-sensoren - Google Patents

Einwegzellzüchtungsbehälter mit zwei oder mehreren in-situ-online-sensoren

Info

Publication number
EP4085126C0
EP4085126C0 EP20842243.6A EP20842243A EP4085126C0 EP 4085126 C0 EP4085126 C0 EP 4085126C0 EP 20842243 A EP20842243 A EP 20842243A EP 4085126 C0 EP4085126 C0 EP 4085126C0
Authority
EP
European Patent Office
Prior art keywords
cell culture
culture containers
disposable cell
online sensors
situ online
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20842243.6A
Other languages
English (en)
French (fr)
Other versions
EP4085126B1 (de
EP4085126A1 (de
Inventor
Christian Schwald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=69105717&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP4085126(C0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP4085126A1 publication Critical patent/EP4085126A1/de
Application granted granted Critical
Publication of EP4085126B1 publication Critical patent/EP4085126B1/de
Publication of EP4085126C0 publication Critical patent/EP4085126C0/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20—Degassing; Venting; Bubble traps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP20842243.6A 2020-01-02 2020-12-30 Einwegzellzüchtungsbehälter mit zwei oder mehreren in-situ-online-sensoren Active EP4085126B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20150132 2020-01-02
PCT/EP2020/088013 WO2021136798A1 (en) 2020-01-02 2020-12-30 Single-use cell culture container with one or more in-situ online sensors

Publications (3)

Publication Number Publication Date
EP4085126A1 EP4085126A1 (de) 2022-11-09
EP4085126B1 EP4085126B1 (de) 2024-07-03
EP4085126C0 true EP4085126C0 (de) 2024-07-03

Family

ID=69105717

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20842243.6A Active EP4085126B1 (de) 2020-01-02 2020-12-30 Einwegzellzüchtungsbehälter mit zwei oder mehreren in-situ-online-sensoren

Country Status (12)

Country Link
US (1) US20220411736A1 (de)
EP (1) EP4085126B1 (de)
JP (1) JP7778076B2 (de)
KR (1) KR20220120582A (de)
CN (1) CN114945659A (de)
AU (1) AU2020419442A1 (de)
BR (1) BR112022013019A2 (de)
CA (1) CA3164000A1 (de)
ES (1) ES2987046T3 (de)
IL (1) IL294268A (de)
MX (1) MX2022008083A (de)
WO (1) WO2021136798A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025507790A (ja) * 2022-03-02 2025-03-21 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 高力価抗体のための製造プロセス
CN115353962A (zh) * 2022-09-13 2022-11-18 深圳市同信生物科技有限公司 一种一次性生物反应器及其制造方法
WO2025159985A1 (en) * 2024-01-23 2025-07-31 Global Life Sciences Solutions Usa Llc Small-scale bioreactor

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01102352A (ja) * 1987-10-16 1989-04-20 Toshiba Corp バイオセンサー
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
KR20070015178A (ko) * 2004-04-27 2007-02-01 백스터 인터내셔널 인코포레이티드 교반-탱크 반응기 시스템
SG10201503987WA (en) * 2006-05-13 2015-06-29 Pall Life Sciences Belgium Disposable Bioreactor
US8057092B2 (en) * 2006-11-30 2011-11-15 Corning Incorporated Disposable spinner flask
DE102012010155B4 (de) 2012-05-24 2015-06-11 Pan-Biotech Gmbh Zellkulturbehälter für den Einmalgebrauch
KR20150056548A (ko) * 2012-09-18 2015-05-26 바이엘 테크놀로지 서비시즈 게엠베하 1회용 병 반응기 탱크
JP6463275B2 (ja) 2013-01-08 2019-01-30 イエール ユニバーシティ ヒトおよび大型哺乳動物の肺のバイオリアクター
US10059914B2 (en) 2013-11-21 2018-08-28 Distek, Inc. Disposable bioreactors and methods for construction and use thereof
KR102621101B1 (ko) * 2015-08-08 2024-01-05 스토베 게엠베하 생물학적 활동을 지원하는 일회용 생물 공정 시스템
JP6929882B2 (ja) 2016-02-23 2021-09-01 コーニング インコーポレイテッド 灌流バイオリアクタおよび連続細胞培養を実施するためのその使用方法
SG11202002339XA (en) 2017-10-16 2020-04-29 Regeneron Pharma Perfusion bioreactor and related methods of use
CN111801411B (zh) 2018-04-10 2023-07-18 Emd密理博公司 包括具有通道的可伸缩孔板的一次性容器
AU2019309101A1 (en) * 2018-07-27 2021-03-04 Univercells Technologies S.A. System and method for the production of biomolecules
NL2021470B1 (en) * 2018-08-15 2020-02-24 Applikon Biotechnology B V Lid configuration for a bioreactor
US20220041973A1 (en) * 2018-10-18 2022-02-10 University Of Maryland, College Park Integrated capsule system for real-time bioprocess monitoring and method of using the same
EP3924097A4 (de) * 2019-02-11 2022-11-16 Culture Biosciences, Inc. Bioreaktorbehälter für ein automatisiertes fermentationssystem

Also Published As

Publication number Publication date
US20220411736A1 (en) 2022-12-29
MX2022008083A (es) 2022-07-11
WO2021136798A1 (en) 2021-07-08
JP7778076B2 (ja) 2025-12-01
BR112022013019A2 (pt) 2022-09-06
EP4085126B1 (de) 2024-07-03
AU2020419442A1 (en) 2022-06-09
EP4085126A1 (de) 2022-11-09
CN114945659A (zh) 2022-08-26
KR20220120582A (ko) 2022-08-30
IL294268A (en) 2022-08-01
ES2987046T3 (es) 2024-11-13
JP2023509434A (ja) 2023-03-08
CA3164000A1 (en) 2021-07-08

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