EP3968963A4 - Formulations d'imatinib, leur fabrication et leurs utilisations - Google Patents
Formulations d'imatinib, leur fabrication et leurs utilisations Download PDFInfo
- Publication number
- EP3968963A4 EP3968963A4 EP20806383.4A EP20806383A EP3968963A4 EP 3968963 A4 EP3968963 A4 EP 3968963A4 EP 20806383 A EP20806383 A EP 20806383A EP 3968963 A4 EP3968963 A4 EP 3968963A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- manufacture
- imatinib formulations
- imatinib
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962849058P | 2019-05-16 | 2019-05-16 | |
US201962849054P | 2019-05-16 | 2019-05-16 | |
US201962849059P | 2019-05-16 | 2019-05-16 | |
US201962849056P | 2019-05-16 | 2019-05-16 | |
US201962877575P | 2019-07-23 | 2019-07-23 | |
US201962942408P | 2019-12-02 | 2019-12-02 | |
US202062958481P | 2020-01-08 | 2020-01-08 | |
US202062984037P | 2020-03-02 | 2020-03-02 | |
PCT/US2020/032872 WO2020232236A1 (fr) | 2019-05-16 | 2020-05-14 | Formulations d'imatinib, leur fabrication et leurs utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3968963A1 EP3968963A1 (fr) | 2022-03-23 |
EP3968963A4 true EP3968963A4 (fr) | 2023-02-01 |
Family
ID=73228465
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20806383.4A Pending EP3968963A4 (fr) | 2019-05-16 | 2020-05-14 | Formulations d'imatinib, leur fabrication et leurs utilisations |
EP20806763.7A Pending EP3969111A4 (fr) | 2019-05-16 | 2020-05-14 | Formulations inhalables pour l'inhibition de kinases |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP20806763.7A Pending EP3969111A4 (fr) | 2019-05-16 | 2020-05-14 | Formulations inhalables pour l'inhibition de kinases |
Country Status (14)
Country | Link |
---|---|
US (13) | US20200360277A1 (fr) |
EP (2) | EP3968963A4 (fr) |
JP (1) | JP2022532431A (fr) |
KR (1) | KR20220050839A (fr) |
CN (1) | CN114514016A (fr) |
AU (1) | AU2020274521A1 (fr) |
BR (1) | BR112021023014A2 (fr) |
CA (1) | CA3140641A1 (fr) |
IL (1) | IL288111A (fr) |
JO (1) | JOP20210305A1 (fr) |
MX (1) | MX2021014029A (fr) |
SG (1) | SG11202112719XA (fr) |
WO (2) | WO2020232238A1 (fr) |
ZA (1) | ZA202109070B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3172586A1 (fr) | 2013-07-31 | 2015-02-05 | Avalyn Pharma Inc. | Composes d'imatinib en aerosol et utilisations connexes |
CN114514016A (zh) * | 2019-05-16 | 2022-05-17 | 埃渃维特治疗学公司 | 伊马替尼调配物、制造和其用途 |
KR20230131179A (ko) * | 2020-11-17 | 2023-09-12 | 유나이티드 쎄러퓨틱스 코포레이션 | 폐 고혈압 분야를 위한 흡입형 이마티닙 |
WO2022109458A1 (fr) * | 2020-11-23 | 2022-05-27 | Aerovate Therapeutics, Inc. | Formulations d'imatinib, fabrication et utilisations de celles-ci |
JP2024502990A (ja) * | 2021-01-06 | 2024-01-24 | インカーダ セラピューティクス, インコーポレイテッド | 吸入可能なイマチニブ製剤 |
KR102634754B1 (ko) * | 2021-07-07 | 2024-02-08 | 애니머스큐어 주식회사 | 이마티닙을 포함하는 근육 질환의 예방 또는 치료용 조성물 |
WO2023147868A1 (fr) * | 2022-02-04 | 2023-08-10 | Justus-Liebig-Universität Giessen | Imatinib inhalé pour le traitement de l'hypertension pulmonaire |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1988089A1 (fr) * | 2006-10-26 | 2008-11-05 | Sicor, Inc. | Base d'imatinib, et mesylate d'imatinib et son procédé de préparation |
EP2582689A1 (fr) * | 2010-06-18 | 2013-04-24 | KRKA, D.D., Novo Mesto | Nouvelle forme polymorphique d'imatinib base et préparation de ses sels |
Family Cites Families (60)
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US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
WO1996025918A1 (fr) * | 1995-02-24 | 1996-08-29 | Nanosystems L.L.C. | Aerosols contenant des dispersions de nanoparticules |
GB0009468D0 (en) | 2000-04-17 | 2000-06-07 | Vectura Ltd | Improvements in or relating to formulations for use in inhaler devices |
US20060094674A1 (en) * | 2002-07-05 | 2006-05-04 | Neel Benjamin G | Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms |
GB2398565A (en) | 2003-02-18 | 2004-08-25 | Cipla Ltd | Imatinib preparation and salts |
US20040204439A1 (en) | 2003-04-14 | 2004-10-14 | Staniforth John Nicholas | Composition, device, and method for treating sexual dysfunction via inhalation |
GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
EP2260849A1 (fr) | 2004-01-21 | 2010-12-15 | Emory University | Compositions et procédés à utiliser pour les inhibiteurs de tyrosine kinase pour traiter les infections pathogènes |
EP1833815B1 (fr) | 2004-12-30 | 2010-09-15 | Instytut Farmaceutyczny | Procede de preparation d'une base d'imatinibe |
US7507821B2 (en) | 2004-12-30 | 2009-03-24 | Chemagis Ltd. | Process for preparing Imatinib |
EP1695728A1 (fr) | 2005-02-23 | 2006-08-30 | Activaero GmbH | Composant pour un dispositif d'inhalation, le dispositif d'inhalation avec ce composant et une méthode de contrôle pour un tel composant |
EP1700614B1 (fr) | 2005-03-08 | 2013-05-08 | Activaero GmbH | Dispositif d'inhalation |
JP2008542397A (ja) * | 2005-06-03 | 2008-11-27 | エラン ファーマ インターナショナル リミテッド | ナノ粒子メシル酸イマチニブ製剤 |
ES2290827T3 (es) | 2005-07-06 | 2008-02-16 | Activaero Gmbh | Valvula regulable y dispositivo para inhalar. |
EP2111863B1 (fr) | 2005-10-26 | 2012-03-28 | Asahi Kasei Pharma Corporation | Combinaison du fasudil et bosentan pour le traitement de l'hypertension artérielle pulmonaire |
MXPA06007070A (es) | 2006-03-24 | 2007-09-24 | Univ Kyushu | Compuestos organicos. |
US20060223817A1 (en) | 2006-05-15 | 2006-10-05 | Chemagis Ltd. | Crystalline imatinib base and production process therefor |
US20080181958A1 (en) | 2006-06-19 | 2008-07-31 | Rothrock Ginger D | Nanoparticle fabrication methods, systems, and materials |
EP2076507A2 (fr) | 2006-10-26 | 2009-07-08 | Sicor, Inc. | Imatinib base et mésylate d'imatinib et procédés pour la préparation de ceux-ci |
US20130177598A1 (en) * | 2007-02-27 | 2013-07-11 | The University Of North Carolina At Chapel Hill | Discrete size and shape specific pharmaceutical organic nanoparticles |
WO2008136010A1 (fr) | 2007-05-07 | 2008-11-13 | Natco Pharma Limited | Procédé de préparation de l'imatinib base hautement pure |
ES2526211T3 (es) | 2007-07-13 | 2015-01-08 | Nestec S.A. | Selección de fármacos para la terapia del cáncer de pulmón utilizando matrices basadas en anticuerpos |
ES2398921T3 (es) | 2007-08-02 | 2013-03-22 | Activaero Gmbh | Dispositivo y sistema para dirigir partículas aerosolizadas a un área específica de los pulmones |
EP2033674A1 (fr) | 2007-09-06 | 2009-03-11 | Activaero GmbH | Appareil d'inhalation |
RU2011109078A (ru) | 2008-08-13 | 2012-09-20 | Новартис АГ (CH) | Лечение легочной артериальной гипертензии |
US8834848B2 (en) | 2009-02-04 | 2014-09-16 | Activaero Gmbh Research & Development | Flow and volume regulated inhalation for treatment of severe oral corticosteroid-dependent asthma |
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CZ2009570A3 (cs) | 2009-08-26 | 2011-03-09 | Zentiva, K. S. | Príprava, stabilizace a využití polymorfu imatinib mesylátu pro vývoj lékových forem |
WO2011039782A1 (fr) | 2009-09-29 | 2011-04-07 | Ind-Swift Laboratories Limited | Procédés de préparation d'imatinib et de ses sels pharmaceutiquement acceptables |
WO2011038901A1 (fr) | 2009-09-29 | 2011-04-07 | Activaero Gmbh | Procédé amélioré pour le traitement de patients atteints de la mucoviscidose |
EP2509973A1 (fr) | 2009-12-10 | 2012-10-17 | Arch Pharmalabs Limited | Procédé de préparation d'imatinib et de ses sels |
WO2011095835A1 (fr) | 2010-02-02 | 2011-08-11 | Actavis Group Ptc Ehf | Imatinib de grande pureté ou un sel pharmaceutiquement acceptable de celui-ci |
WO2011100282A2 (fr) | 2010-02-09 | 2011-08-18 | Dr. Reddy's Laboratories Ltd. | Polymorphes de mésylate d'imatinib |
EP2547671A1 (fr) | 2010-03-15 | 2013-01-23 | Natco Pharma Limited | Procédé de préparation d'une base imatinib cristalline très pure |
TR201007005A2 (tr) | 2010-08-23 | 2011-09-21 | Mustafa Nevzat İlaç Sanayi̇i̇ A.Ş. | İmatinib baz üretim yöntemi |
WO2012090221A1 (fr) | 2010-12-29 | 2012-07-05 | Cadila Healthcare Limited | Nouveaux sels d'imatinib |
DK2670242T3 (da) | 2011-01-31 | 2022-05-02 | Avalyn Pharma Inc | Aerosolpirfenidon- og pyridonanalogforbindelser og anvendelser deraf |
US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
EP2965748A1 (fr) | 2011-04-26 | 2016-01-13 | Vectura GmbH | Administration d'iloprost en tant que bolus aérosol |
KR101903028B1 (ko) | 2012-03-09 | 2018-10-02 | 벡투라 게엠베하 | 흡입 장치용 혼합 채널 및 흡입 장치 |
CN103570676B (zh) * | 2012-08-04 | 2016-03-16 | 正大天晴药业集团股份有限公司 | 甲磺酸伊马替尼α结晶的制备及其药物组合物 |
JP2015529683A (ja) * | 2012-09-17 | 2015-10-08 | バインド セラピューティックス インコーポレイテッド | 治療剤を含む治療用ナノ粒子とその製造方法および使用方法 |
DK2724741T3 (en) | 2012-10-26 | 2017-09-18 | Vectura Gmbh | Inhalation device for use in aerosol treatment |
EP2914244B1 (fr) | 2012-10-31 | 2024-01-03 | Vectura GmbH | Administration d'iloprost en aérosol |
CA2897651C (fr) | 2013-01-10 | 2021-09-21 | Pulmokine, Inc. | Inhibiteurs de kinase non selectifs |
AU2014205481A1 (en) * | 2013-01-10 | 2015-08-27 | Gilead Sciences, Inc. | Therapeutic indications of kinase inhibitors |
CA3172586A1 (fr) * | 2013-07-31 | 2015-02-05 | Avalyn Pharma Inc. | Composes d'imatinib en aerosol et utilisations connexes |
TR201808138T4 (tr) | 2013-08-16 | 2018-07-23 | Vectura Gmbh | Bir inhalasyon cihazı için dozlama sistemi. |
CA2926793C (fr) | 2013-10-11 | 2022-11-22 | Lawrence S. ZISMAN | Formulations a sechage par pulverisation pour le traitement de l'hypertension arterielle pulmonaire |
EP3091976A4 (fr) | 2014-01-10 | 2017-10-11 | Genoa Pharmaceuticals Inc. | Composés analogues de pyridone et de pirfénidone en aérosol, et leurs utilisations |
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WO2015188243A1 (fr) * | 2014-06-10 | 2015-12-17 | Cristália Produtos Químicos Farmacêuticos Ltda | Procédé de préparation d'imatinib et de mésylate d'imatinib sous forme α2 non aciculaire |
KR20170093120A (ko) | 2014-10-10 | 2017-08-14 | 아블린쓰 엔.브이. | Rsv 감염의 치료 방법 |
WO2017042341A1 (fr) | 2015-09-09 | 2017-03-16 | Vectura Limited | Procédé de broyage à jet |
WO2017042696A1 (fr) | 2015-09-09 | 2017-03-16 | Novartis Ag | Administration ciblée de formulations séchées par pulvérisation aux poumons |
CN110730819A (zh) | 2016-10-26 | 2020-01-24 | 索尼克马斯特有限公司 | 肌肉谱系细胞的改善产生及其治疗用途 |
RU2766163C2 (ru) | 2017-09-19 | 2022-02-08 | Эвапко, Инк. | Теплообменное устройство воздушного охлаждения с интегрированной и механизированной системой предварительного охлаждения воздуха |
AU2019324188A1 (en) | 2018-08-22 | 2021-04-01 | Avalyn Pharma Inc. | Specially formulated compositions of inhaled nintedanib and nintedanib salts |
US11464776B2 (en) | 2019-05-16 | 2022-10-11 | Aerovate Therapeutics, Inc. | Inhalable imatinib formulations, manufacture, and uses thereof |
CN114514016A (zh) * | 2019-05-16 | 2022-05-17 | 埃渃维特治疗学公司 | 伊马替尼调配物、制造和其用途 |
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2020
- 2020-05-14 CN CN202080051359.5A patent/CN114514016A/zh active Pending
- 2020-05-14 SG SG11202112719XA patent/SG11202112719XA/en unknown
- 2020-05-14 US US16/874,143 patent/US20200360277A1/en active Pending
- 2020-05-14 EP EP20806383.4A patent/EP3968963A4/fr active Pending
- 2020-05-14 US US16/874,168 patent/US20200360279A1/en active Pending
- 2020-05-14 KR KR1020217041312A patent/KR20220050839A/ko unknown
- 2020-05-14 AU AU2020274521A patent/AU2020274521A1/en active Pending
- 2020-05-14 WO PCT/US2020/032874 patent/WO2020232238A1/fr active Application Filing
- 2020-05-14 BR BR112021023014A patent/BR112021023014A2/pt unknown
- 2020-05-14 JO JOP/2021/0305A patent/JOP20210305A1/ar unknown
- 2020-05-14 EP EP20806763.7A patent/EP3969111A4/fr active Pending
- 2020-05-14 MX MX2021014029A patent/MX2021014029A/es unknown
- 2020-05-14 US US16/874,111 patent/US11229650B2/en active Active
- 2020-05-14 US US16/874,122 patent/US11413289B2/en active Active
- 2020-05-14 CA CA3140641A patent/CA3140641A1/fr active Pending
- 2020-05-14 JP JP2021568694A patent/JP2022532431A/ja active Pending
- 2020-05-14 US US16/874,118 patent/US11298355B2/en active Active
- 2020-05-14 US US16/874,128 patent/US20200360276A1/en active Pending
- 2020-05-14 WO PCT/US2020/032872 patent/WO2020232236A1/fr active Application Filing
- 2020-05-14 US US16/874,190 patent/US20200360477A1/en active Pending
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2021
- 2021-11-14 IL IL288111A patent/IL288111A/en unknown
- 2021-11-15 ZA ZA2021/09070A patent/ZA202109070B/en unknown
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2022
- 2022-01-24 US US17/582,599 patent/US11806349B2/en active Active
- 2022-03-03 US US17/685,704 patent/US20220184080A1/en active Pending
- 2022-08-15 US US17/887,866 patent/US11813263B2/en active Active
- 2022-10-11 US US17/963,607 patent/US20230056721A1/en active Pending
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2023
- 2023-10-06 US US18/377,561 patent/US20240108622A1/en active Pending
- 2023-10-11 US US18/378,949 patent/US20240041879A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1988089A1 (fr) * | 2006-10-26 | 2008-11-05 | Sicor, Inc. | Base d'imatinib, et mesylate d'imatinib et son procédé de préparation |
EP2582689A1 (fr) * | 2010-06-18 | 2013-04-24 | KRKA, D.D., Novo Mesto | Nouvelle forme polymorphique d'imatinib base et préparation de ses sels |
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