EP3801920A4 - Centrifuge system for separating cells in suspension - Google Patents

Centrifuge system for separating cells in suspension Download PDF

Info

Publication number
EP3801920A4
EP3801920A4 EP19815510.3A EP19815510A EP3801920A4 EP 3801920 A4 EP3801920 A4 EP 3801920A4 EP 19815510 A EP19815510 A EP 19815510A EP 3801920 A4 EP3801920 A4 EP 3801920A4
Authority
EP
European Patent Office
Prior art keywords
suspension
cells
separation
centrifuge system
centrifuge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19815510.3A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3801920A1 (en
Inventor
S Kessler
T Marro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pneumatic Scale Corp
Original Assignee
Pneumatic Scale Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pneumatic Scale Corp filed Critical Pneumatic Scale Corp
Publication of EP3801920A1 publication Critical patent/EP3801920A1/en
Publication of EP3801920A4 publication Critical patent/EP3801920A4/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/04—Periodical feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/02—Continuous feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B04B11/082—Skimmers for discharging liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Program control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/08—Rotary bowls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Centrifugal Separators (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP19815510.3A 2018-06-08 2019-06-06 Centrifuge system for separating cells in suspension Pending EP3801920A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862682376P 2018-06-08 2018-06-08
PCT/US2019/035855 WO2019236895A1 (en) 2018-06-08 2019-06-06 Centrifuge system for separating cells in suspension

Publications (2)

Publication Number Publication Date
EP3801920A1 EP3801920A1 (en) 2021-04-14
EP3801920A4 true EP3801920A4 (en) 2022-07-13

Family

ID=68770662

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19815510.3A Pending EP3801920A4 (en) 2018-06-08 2019-06-06 Centrifuge system for separating cells in suspension

Country Status (8)

Country Link
EP (1) EP3801920A4 (https=)
JP (1) JP7336467B2 (https=)
KR (2) KR102568313B1 (https=)
CN (2) CN115254458A (https=)
AU (2) AU2019280856B2 (https=)
CA (1) CA3102600C (https=)
MX (2) MX2020011898A (https=)
WO (1) WO2019236895A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12350686B2 (en) * 2011-11-21 2025-07-08 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11878312B2 (en) * 2011-11-21 2024-01-23 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11065629B2 (en) * 2011-11-21 2021-07-20 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11957998B2 (en) * 2019-06-06 2024-04-16 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US20230356111A1 (en) * 2020-08-22 2023-11-09 Sunil Mehta An automated centrifugation device and methods to continuously separate components from different mixtures
CN112798393A (zh) * 2021-02-01 2021-05-14 中博瑞康（北京）生物技术有限公司 一种大体积生物细胞液浓缩洗涤系统及其方法
CN114682397B (zh) * 2022-03-28 2024-03-15 浙江大学 锥形液液轴向离心分离器及分离监控装置
WO2023196391A1 (en) * 2022-04-07 2023-10-12 Mirror Biologics, Inc. Artificial lymph node bioreator

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB675648A (en) * 1950-01-19 1952-07-16 Separator Ab Improved centrifugal separator for the continuous separation and discharge of solid matter from a liquid mixture
US5387174A (en) * 1993-01-29 1995-02-07 Elp Rochat Centrifugal separator with disposable bowl assembly
US5637217A (en) * 1995-01-25 1997-06-10 Fleetguard, Inc. Self-driven, cone-stack type centrifuge
JPH09192215A (ja) * 1996-01-17 1997-07-29 Takaharu Nakane 遠心ボウル
EP0992256A2 (en) * 1998-10-05 2000-04-12 Terumo Kabushiki Kaisha Blood component collection apparatus
EP1011868A1 (de) * 1997-04-16 2000-06-28 FILTERWERK MANN + HUMMEL GmbH Rotor, insbesondere zum einbau in das gehäuse einer freistrahlzentrifuge
US20130089917A1 (en) * 2008-04-22 2013-04-11 Pneumatic Scale Corporation Single Use Centrifuge System for Highly Concentrated and/or Turbid Feeds
US20140045672A1 (en) * 2011-04-08 2014-02-13 Sorin Group Italia S.R.L. Disposable device for centrifugal blood separation
US20170333915A1 (en) * 2014-12-10 2017-11-23 Gea Mechanical Equipment Gmbh Separator

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA894304A (en) * 1972-02-29 Fujisawa Mitsumaro Embossing film with compressed air on recessed drum and applying second film
CA1057254A (en) * 1976-05-14 1979-06-26 Baxter Travenol Laboratories Disposable centrifugal blood processing system
DE3231070A1 (de) * 1982-08-19 1984-08-23 Herwig 1000 Berlin Michel-Kim Vorrichtung zur austragung von in silos gelagerten stoffen
EP0257755B1 (en) * 1986-07-22 1991-07-03 Haemonetics Corporation Centrifuge bowl or rotor for plasmapheresis
US5318500A (en) * 1992-10-15 1994-06-07 Eli Lilly And Company Method for controlling intermittently discharged centrifuges
EP0868215B1 (en) * 1995-12-01 2002-01-30 Baker Hughes Incorporated Method and apparatus for controlling and monitoring continuous feed centrifuge
JP3313572B2 (ja) * 1996-04-03 2002-08-12 ヘモネティクス・コーポレーション 血液処理用遠心分離器ボウル
AU2625000A (en) * 1999-01-26 2000-08-07 Fluid Equipment Development Company, Llc Rotating process chamber with integral pump and energy recovery turbine
US6629919B2 (en) * 1999-06-03 2003-10-07 Haemonetics Corporation Core for blood processing apparatus
EP1688183A1 (fr) * 2005-02-03 2006-08-09 Jean-Denis Rochat Procede et dispositif jetable pour la separation par centrifugation d'un liquide physiologique
US7628749B2 (en) * 2005-09-01 2009-12-08 Wagner Development Inc. Solids recovery using cross-flow microfilter and automatic piston discharge centrifuge
CN201094937Y (zh) * 2007-09-18 2008-08-06 江苏牡丹离心机制造有限公司 一种吊袋式离心机中的挤袋装置
AU2009334385B2 (en) * 2008-12-29 2015-10-08 Wagner Development, Inc. Solids discharge centrifugal separator with disposable contact elements
SI3199511T1 (sl) * 2009-06-04 2020-07-31 Genomatica, Inc. Proces separacije komponent fermentacijske brozge
WO2015186057A1 (en) * 2014-06-04 2015-12-10 Biosafe S.A. System for multi-processing and separation of biological fluids
US9833557B2 (en) * 2014-12-19 2017-12-05 Fenwal, Inc. Systems and methods for determining free plasma hemoglobin
DE102015105988B3 (de) * 2015-04-20 2016-05-25 Hiller Gmbh Vorrichtung zum kontinuierlichen Trennen fließfähiger Stoffe unterschiedlicher Dichte in einer Zentrifuge
WO2017011527A1 (en) * 2015-07-13 2017-01-19 Haemonetics Corporation System and method for removing fat from salvaged blood
EP3347134A4 (en) * 2015-09-07 2019-04-17 Mann+Hummel GmbH CLADDING WITH SEAL FOR ROTOR OF A CENTRIFUGAL SEPARATOR
CN106238229B (zh) * 2016-08-31 2018-07-24 苏州盛天力离心机制造有限公司 抽滤离心机转鼓组件

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB675648A (en) * 1950-01-19 1952-07-16 Separator Ab Improved centrifugal separator for the continuous separation and discharge of solid matter from a liquid mixture
US5387174A (en) * 1993-01-29 1995-02-07 Elp Rochat Centrifugal separator with disposable bowl assembly
US5637217A (en) * 1995-01-25 1997-06-10 Fleetguard, Inc. Self-driven, cone-stack type centrifuge
JPH09192215A (ja) * 1996-01-17 1997-07-29 Takaharu Nakane 遠心ボウル
EP1011868A1 (de) * 1997-04-16 2000-06-28 FILTERWERK MANN + HUMMEL GmbH Rotor, insbesondere zum einbau in das gehäuse einer freistrahlzentrifuge
EP1011868B1 (de) * 1997-04-16 2002-03-27 FILTERWERK MANN + HUMMEL GmbH Rotor, insbesondere zum einbau in das gehäuse einer freistrahlzentrifuge
EP0992256A2 (en) * 1998-10-05 2000-04-12 Terumo Kabushiki Kaisha Blood component collection apparatus
US20130089917A1 (en) * 2008-04-22 2013-04-11 Pneumatic Scale Corporation Single Use Centrifuge System for Highly Concentrated and/or Turbid Feeds
US20140045672A1 (en) * 2011-04-08 2014-02-13 Sorin Group Italia S.R.L. Disposable device for centrifugal blood separation
US20170333915A1 (en) * 2014-12-10 2017-11-23 Gea Mechanical Equipment Gmbh Separator

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019236895A1 *

Also Published As

Publication number Publication date
JP2021526957A (ja) 2021-10-11
AU2019280856A1 (en) 2020-12-17
CN112236236A (zh) 2021-01-15
KR20210018796A (ko) 2021-02-18
KR102568313B1 (ko) 2023-08-18
BR112020025083A2 (pt) 2021-03-23
AU2022204733B2 (en) 2024-07-04
MX2022003223A (es) 2022-04-12
AU2022204733A1 (en) 2022-07-21
CA3102600A1 (en) 2019-12-12
MX2020011898A (es) 2021-01-15
AU2019280856B2 (en) 2022-06-30
WO2019236895A1 (en) 2019-12-12
CN115254458A (zh) 2022-11-01
EP3801920A1 (en) 2021-04-14
KR20220039841A (ko) 2022-03-29
JP7336467B2 (ja) 2023-08-31
KR102568314B1 (ko) 2023-08-18
CA3102600C (en) 2024-06-11

Similar Documents

Publication Publication Date Title
EP3801920A4 (en) Centrifuge system for separating cells in suspension
HUE042277T2 (hu) Eljárások fehérjék begyûjtésére emlõssejttenyészetekbõl
EP3532075A4 (en) VIRAL METHODS OF MANUFACTURING GENETICALLY MODIFIED CELLS
PL3708668T3 (pl) Sztuczne cząsteczki kwasu nukleinowego dla poprawy ekspresji białka
EP4282977C0 (en) ANALYSIS OF MULTIPLE SPATIALLY DIFFERENTIATED NUCLEIC ACIDS FROM ORGANIC SPECIMENS
EP3674396C0 (en) SYSTEMS AND METHODS FOR TREATMENT OF TISSUES AND PREPARATION OF CELLULAR SUSPENSION THEREFROM
EP3540067A4 (en) METHOD OF INTRODUCING EXOGENOUS MITOCHONDRIA INTO CELLS
EP3359665C0 (en) EARLY POST-TRANSFECTION ISOLATION OF CELLS TO PREPARE BIOLOGICAL PRODUCTS
EP3541936C0 (en) SYSTEMS AND METHODS FOR IDENTIFYING AND EXPRESSING GENE GROUPS
DK3319704T3 (da) Separationssystem til simultan fjernelse af både faststofpartikler og flydende smådråber opslæmmet i en anden væske
DE102016123729A8 (de) System zur Angleichung von Batterieladung
PL3443636T3 (pl) Sposób i układ balansowania ogniw
EP3427806A4 (en) SOLID LIQUID SEPARATOR AND SOLID FLUID SEPARATION SYSTEM
EP3683579C0 (en) METHODS FOR THE DETECTION OF HOST CELL PROTEINS
IL250969B (en) Microfluidic methods and cartridges for cell separation
EP3551767C0 (en) IMAGE-DIFFERENTIATED MULTIPLEX ASSAYS FOR MULTIPLEX DETECTION OF DNA MUTATIONS
EP3362784C0 (en) SYSTEM AND METHOD FOR REGULATING THE PRODUCTION OF BIOLOGICAL COMPOUNDS BASED ON CELL CULTURE
EP3410120A4 (en) CELL SEPARATION SCHIP AND SYSTEM
EP3288983C0 (en) METHODS FOR SEPARING PROTEINS AND OTHER IMPURITIES FROM MICROBIAL CAPSULAR POLYSACCHARIDES
EP3116645A4 (en) Separation matrices for purification of biological particles
EP3475412A4 (en) CELL CULTURE CONTAINER
EP3160611A4 (en) Methods and reagents for purification of proteins
EP3530727A4 (en) SOMATIC CELL PRODUCTION SYSTEM
EP3440193A4 (en) METHOD FOR ISOLATING NUCLEATED CELLS AND NUCLEATED CELL POPULATIONS AND USES THEREOF
EP3092055A4 (en) Simultaneous extraction and separation of rna and dna from single cells using electrophoretic techniques

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210104

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: B01D 21/32 20060101ALI20220220BHEP

Ipc: B04B 11/02 20060101ALI20220220BHEP

Ipc: B04B 5/00 20060101ALI20220220BHEP

Ipc: B01D 21/26 20060101ALI20220220BHEP

Ipc: B04B 5/04 20060101AFI20220220BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20220610

RIC1 Information provided on ipc code assigned before grant

Ipc: C12M 1/00 20060101ALI20220603BHEP

Ipc: B04B 7/08 20060101ALI20220603BHEP

Ipc: B01D 21/32 20060101ALI20220603BHEP

Ipc: B04B 11/02 20060101ALI20220603BHEP

Ipc: B04B 5/00 20060101ALI20220603BHEP

Ipc: B01D 21/26 20060101ALI20220603BHEP

Ipc: B04B 5/04 20060101AFI20220603BHEP

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230417

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20240313