CN115254458A - 用于分离悬浊液中的细胞的离心机系统 - Google Patents

用于分离悬浊液中的细胞的离心机系统 Download PDF

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Publication number
CN115254458A
CN115254458A CN202210885991.0A CN202210885991A CN115254458A CN 115254458 A CN115254458 A CN 115254458A CN 202210885991 A CN202210885991 A CN 202210885991A CN 115254458 A CN115254458 A CN 115254458A
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CN
China
Prior art keywords
concentrate
pump
centrifuge
chamber
centrate
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Pending
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CN202210885991.0A
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English (en)
Chinese (zh)
Inventor
S·凯斯勒
T·马罗
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New Medix
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New Medix
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Publication of CN115254458A publication Critical patent/CN115254458A/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/04—Periodical feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/30—Control equipment
    • B01D21/32—Density control of clear liquid or sediment, e.g. optical control ; Control of physical properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/02—Continuous feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/08—Skimmers or scrapers for discharging ; Regulating thereof
    • B04B11/082—Skimmers for discharging liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B13/00—Control arrangements specially designed for centrifuges; Program control of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/08—Rotary bowls
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Centrifugal Separators (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN202210885991.0A 2018-06-08 2019-06-06 用于分离悬浊液中的细胞的离心机系统 Pending CN115254458A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862682376P 2018-06-08 2018-06-08
US62/682,376 2018-06-08
PCT/US2019/035855 WO2019236895A1 (en) 2018-06-08 2019-06-06 Centrifuge system for separating cells in suspension
CN201980038216.8A CN112236236A (zh) 2018-06-08 2019-06-06 用于分离悬浊液中的细胞的离心机系统

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201980038216.8A Division CN112236236A (zh) 2018-06-08 2019-06-06 用于分离悬浊液中的细胞的离心机系统

Publications (1)

Publication Number Publication Date
CN115254458A true CN115254458A (zh) 2022-11-01

Family

ID=68770662

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202210885991.0A Pending CN115254458A (zh) 2018-06-08 2019-06-06 用于分离悬浊液中的细胞的离心机系统
CN201980038216.8A Pending CN112236236A (zh) 2018-06-08 2019-06-06 用于分离悬浊液中的细胞的离心机系统

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201980038216.8A Pending CN112236236A (zh) 2018-06-08 2019-06-06 用于分离悬浊液中的细胞的离心机系统

Country Status (8)

Country Link
EP (1) EP3801920A4 (https=)
JP (1) JP7336467B2 (https=)
KR (2) KR102568313B1 (https=)
CN (2) CN115254458A (https=)
AU (2) AU2019280856B2 (https=)
CA (1) CA3102600C (https=)
MX (2) MX2020011898A (https=)
WO (1) WO2019236895A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12350686B2 (en) * 2011-11-21 2025-07-08 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11878312B2 (en) * 2011-11-21 2024-01-23 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11065629B2 (en) * 2011-11-21 2021-07-20 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US11957998B2 (en) * 2019-06-06 2024-04-16 Pneumatic Scale Corporation Centrifuge system for separating cells in suspension
US20230356111A1 (en) * 2020-08-22 2023-11-09 Sunil Mehta An automated centrifugation device and methods to continuously separate components from different mixtures
CN112798393A (zh) * 2021-02-01 2021-05-14 中博瑞康（北京）生物技术有限公司 一种大体积生物细胞液浓缩洗涤系统及其方法
CN114682397B (zh) * 2022-03-28 2024-03-15 浙江大学 锥形液液轴向离心分离器及分离监控装置
WO2023196391A1 (en) * 2022-04-07 2023-10-12 Mirror Biologics, Inc. Artificial lymph node bioreator

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09192215A (ja) * 1996-01-17 1997-07-29 Takaharu Nakane 遠心ボウル
US5882289A (en) * 1996-04-03 1999-03-16 Haemonetics Corporation Centrifuge bowl with improved core structure
WO2000043096A1 (en) * 1999-01-26 2000-07-27 Fluid Equipment Development Co., L.L.C. Rotating process chamber with integral pump and energy recovery turbine
CN102387867A (zh) * 2008-12-29 2012-03-21 瓦格纳发展公司 具有一次性接触元件的固体排放离心式分离器
US20130089917A1 (en) * 2008-04-22 2013-04-11 Pneumatic Scale Corporation Single Use Centrifuge System for Highly Concentrated and/or Turbid Feeds
US20140045672A1 (en) * 2011-04-08 2014-02-13 Sorin Group Italia S.R.L. Disposable device for centrifugal blood separation
US20170333915A1 (en) * 2014-12-10 2017-11-23 Gea Mechanical Equipment Gmbh Separator

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CA894304A (en) * 1972-02-29 Fujisawa Mitsumaro Embossing film with compressed air on recessed drum and applying second film
DE941267C (de) * 1950-01-19 1956-04-05 Separator Ab Schleudermaschine fuer die kontinuierliche Trennung und Austragung fester Bestandteile aus einem Fluessigkeitsgemisch
CA1057254A (en) * 1976-05-14 1979-06-26 Baxter Travenol Laboratories Disposable centrifugal blood processing system
DE3231070A1 (de) * 1982-08-19 1984-08-23 Herwig 1000 Berlin Michel-Kim Vorrichtung zur austragung von in silos gelagerten stoffen
EP0257755B1 (en) * 1986-07-22 1991-07-03 Haemonetics Corporation Centrifuge bowl or rotor for plasmapheresis
US5318500A (en) * 1992-10-15 1994-06-07 Eli Lilly And Company Method for controlling intermittently discharged centrifuges
CH687505A5 (fr) * 1993-01-29 1996-12-31 Elp Rochat Séparateur centrifuge pour fluides.
US5637217A (en) * 1995-01-25 1997-06-10 Fleetguard, Inc. Self-driven, cone-stack type centrifuge
EP0868215B1 (en) * 1995-12-01 2002-01-30 Baker Hughes Incorporated Method and apparatus for controlling and monitoring continuous feed centrifuge
DE19715661A1 (de) * 1997-04-16 1998-10-22 Mann & Hummel Filter Zentrifugenrotor
JP3817079B2 (ja) * 1998-10-05 2006-08-30 テルモ株式会社 血液成分採取装置
US6629919B2 (en) * 1999-06-03 2003-10-07 Haemonetics Corporation Core for blood processing apparatus
EP1688183A1 (fr) * 2005-02-03 2006-08-09 Jean-Denis Rochat Procede et dispositif jetable pour la separation par centrifugation d'un liquide physiologique
US7628749B2 (en) * 2005-09-01 2009-12-08 Wagner Development Inc. Solids recovery using cross-flow microfilter and automatic piston discharge centrifuge
CN201094937Y (zh) * 2007-09-18 2008-08-06 江苏牡丹离心机制造有限公司 一种吊袋式离心机中的挤袋装置
SI3199511T1 (sl) * 2009-06-04 2020-07-31 Genomatica, Inc. Proces separacije komponent fermentacijske brozge
WO2015186057A1 (en) * 2014-06-04 2015-12-10 Biosafe S.A. System for multi-processing and separation of biological fluids
US9833557B2 (en) * 2014-12-19 2017-12-05 Fenwal, Inc. Systems and methods for determining free plasma hemoglobin
DE102015105988B3 (de) * 2015-04-20 2016-05-25 Hiller Gmbh Vorrichtung zum kontinuierlichen Trennen fließfähiger Stoffe unterschiedlicher Dichte in einer Zentrifuge
WO2017011527A1 (en) * 2015-07-13 2017-01-19 Haemonetics Corporation System and method for removing fat from salvaged blood
EP3347134A4 (en) * 2015-09-07 2019-04-17 Mann+Hummel GmbH CLADDING WITH SEAL FOR ROTOR OF A CENTRIFUGAL SEPARATOR
CN106238229B (zh) * 2016-08-31 2018-07-24 苏州盛天力离心机制造有限公司 抽滤离心机转鼓组件

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09192215A (ja) * 1996-01-17 1997-07-29 Takaharu Nakane 遠心ボウル
US5882289A (en) * 1996-04-03 1999-03-16 Haemonetics Corporation Centrifuge bowl with improved core structure
WO2000043096A1 (en) * 1999-01-26 2000-07-27 Fluid Equipment Development Co., L.L.C. Rotating process chamber with integral pump and energy recovery turbine
US20130089917A1 (en) * 2008-04-22 2013-04-11 Pneumatic Scale Corporation Single Use Centrifuge System for Highly Concentrated and/or Turbid Feeds
CN102387867A (zh) * 2008-12-29 2012-03-21 瓦格纳发展公司 具有一次性接触元件的固体排放离心式分离器
US20140045672A1 (en) * 2011-04-08 2014-02-13 Sorin Group Italia S.R.L. Disposable device for centrifugal blood separation
US20170333915A1 (en) * 2014-12-10 2017-11-23 Gea Mechanical Equipment Gmbh Separator

Also Published As

Publication number Publication date
JP2021526957A (ja) 2021-10-11
AU2019280856A1 (en) 2020-12-17
CN112236236A (zh) 2021-01-15
KR20210018796A (ko) 2021-02-18
KR102568313B1 (ko) 2023-08-18
BR112020025083A2 (pt) 2021-03-23
AU2022204733B2 (en) 2024-07-04
MX2022003223A (es) 2022-04-12
AU2022204733A1 (en) 2022-07-21
EP3801920A4 (en) 2022-07-13
CA3102600A1 (en) 2019-12-12
MX2020011898A (es) 2021-01-15
AU2019280856B2 (en) 2022-06-30
WO2019236895A1 (en) 2019-12-12
EP3801920A1 (en) 2021-04-14
KR20220039841A (ko) 2022-03-29
JP7336467B2 (ja) 2023-08-31
KR102568314B1 (ko) 2023-08-18
CA3102600C (en) 2024-06-11

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