EP3784206A1 - Antitranspirantwirksame zubereitung umfassend erdalkalimetallsalze - Google Patents
Antitranspirantwirksame zubereitung umfassend erdalkalimetallsalzeInfo
- Publication number
- EP3784206A1 EP3784206A1 EP19705502.3A EP19705502A EP3784206A1 EP 3784206 A1 EP3784206 A1 EP 3784206A1 EP 19705502 A EP19705502 A EP 19705502A EP 3784206 A1 EP3784206 A1 EP 3784206A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- preparation
- acid
- earth metal
- metal salts
- alkaline earth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000003213 antiperspirant Substances 0.000 title claims abstract description 76
- -1 alkaline-earth metal salts Chemical class 0.000 title claims abstract description 49
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- 238000002360 preparation method Methods 0.000 title claims description 69
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- 239000001205 polyphosphate Substances 0.000 claims abstract description 6
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- 239000003795 chemical substances by application Substances 0.000 claims description 13
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- 150000003839 salts Chemical class 0.000 claims description 12
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical class [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 10
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- 229940070765 laurate Drugs 0.000 description 1
- 229940100556 laureth-23 Drugs 0.000 description 1
- 229940061515 laureth-4 Drugs 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940049292 n-(3-(dimethylamino)propyl)octadecanamide Drugs 0.000 description 1
- WWVIUVHFPSALDO-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCCN(C)C WWVIUVHFPSALDO-UHFFFAOYSA-N 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical class CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940099570 oleth-2 Drugs 0.000 description 1
- 229940095127 oleth-20 Drugs 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229940037624 palmitamidopropyltrimonium chloride Drugs 0.000 description 1
- 229940014662 pantothenate Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940032066 peg-4 dilaurate Drugs 0.000 description 1
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 1
- 229940032052 peg-8 dioleate Drugs 0.000 description 1
- 229940032041 peg-8 laurate Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229940057874 phenyl trimethicone Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 235000017807 phytochemicals Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229940093424 polyaminopropyl biguanide Drugs 0.000 description 1
- 229920000059 polyethylene glycol stearate Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229940113171 polysorbate 85 Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229940078491 ppg-15 stearyl ether Drugs 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- 229940071139 pyrrolidone carboxylate Drugs 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229940074091 schisandra chinensis fruit extract Drugs 0.000 description 1
- 229930192961 schisandrol Natural products 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229940071575 silver citrate Drugs 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 244000005714 skin microbiome Species 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical class [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940075554 sorbate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229950004959 sorbitan oleate Drugs 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229940098760 steareth-2 Drugs 0.000 description 1
- 229940100459 steareth-20 Drugs 0.000 description 1
- 229940100458 steareth-21 Drugs 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 108060007951 sulfatase Proteins 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 208000013460 sweaty Diseases 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000759 toxicological effect Toxicity 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 102000042565 transient receptor (TC 1.A.4) family Human genes 0.000 description 1
- 108091053409 transient receptor (TC 1.A.4) family Proteins 0.000 description 1
- 230000005068 transpiration Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- GAWWVVGZMLGEIW-GNNYBVKZSA-L zinc ricinoleate Chemical compound [Zn+2].CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O.CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O GAWWVVGZMLGEIW-GNNYBVKZSA-L 0.000 description 1
- 229940100530 zinc ricinoleate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
Definitions
- An antiperspirant active preparation comprising alkaline earth metal salts
- the invention is a combination of one or more alkaline earth metal salts and one or more substances synergistic with the alkaline earth metal salts
- secreted aqueous secretion There are three types of sweat glands in the skin, namely, apocrine, eccrine, and apoekrine sweat glands (Int J Cosmet Sei. 2007 Jun;
- the eccrine sweat glands in humans are distributed practically throughout the body and can produce significant amounts of a clear, odorless secretion that is over 99% water.
- the apocrine sweat glands occur only in the hairy body areas of the armpit and genital region and on the nipples. They produce small amounts of a milky secretion that contains proteins and lipids and is chemically neutral.
- Sweating also known as transpiration, is an effective mechanism to release excess heat and thereby regulate body temperature.
- the volume-rich aqueous secretion of the eccrine glands which can produce up to 2-4 liters per hour or 10-14 liters a day in adults, is used for this purpose.
- the sweat - especially the secretion of apocrine sweat glands - is also signaled by the sense of smell. In humans, the apocrine sweat plays in particular in connection with the emotional or stress related
- Cosmetic antiperspirants or deodorants / deodorants are used to eliminate body odor or to reduce their formation.
- Body odor arises when the per se odorless fresh sweat by microorganisms such. Staphylococci and
- Antiperspirants are antiperspirants which, in contrast to the deodorants which generally prevent microbial decomposition of already formed perspiration, are said to prevent the secretion of sweat at all.
- AT preparations may additionally contain substances which inhibit the microbial degradation of the perspiration, such as, for example, Triclosan.
- Triclosan has an effect against gram-positive and gram-negative bacteria as well as against fungi and yeasts, which results in a deodorizing, but no antiperspirant effect, as no influence on the sweat secretion can be deduced from the influence on the bacterial skin flora.
- Odor neutralization (masking), influencing of bacterial metabolisms, the pure perfuming as well as the use of precursors of certain perfume components, which are converted by enzymatic reactions to fragrant substances.
- Antiperspirant active agents, etc. achieved by a "blockage of the sweat gland". They work by blocking sweat gland excretions by precipitating them together with the skin's own proteins, leading to so-called plugs.
- Corneocytes in the sweat duct (Shelley WB and Hurley HJ, Acta, Derm. Venereol. (1975) 55: 241-60), or by the formation of an ACH / AZG gel (Reller HH and Luedders WL, in: Advances in Modern Hemisphere Publishing Company, Washington and London (1977) Vol. 4: 1-5), which is formed by neutralization in the sweat gland duct, remains open. The thus obtained and known constipation is effective only in the short term. strong
- Antiperspirant drugs are (Reller, Lüdders, Pharmacologic and Toxicological Effects of Topically Applied Agents on the eccrine sweat glands, Vol 4, p 18, 1975).
- WO 2013013999 A2 describes the antiperspirant activity (sweat reduction) of alkaline earth metal salts.
- Compounds of polyvalent cations such as beryllium, magnesium, calcium, strontium, barium, titanium, manganese, zinc, hafnium and aluminum, with anions from the group of the halides and carboxylic acids are listed as being AT-active and only the salts acetate, propionate , Pyrrolidonecarboxylate,
- tannins with protein can form stable, reticular compounds. On the skin, this then acts contracting
- tannins are described as astringents. However, these could not be classified as antiperspirant in studies.
- astringent does not necessarily mean reducing sweat.
- tannins are known as astringents, which in turn no antiperspirant
- arylsulfatase-inhibiting substance selected from plant extracts, flavonoids, isoflavonoids, polyphenols and 6,7-disubstituted 2,2-dialkylchromans or -chromenenen in a cosmetic deodorant or antiperspirant composition for reducing by described the hydrolytic decomposition of steroid esters caused body odor.
- the invention is a cosmetic or dermatological preparation comprising one or more alkaline earth metal salts and one or more substances which exhibit a synergistic sweat reduction with the alkaline earth metal salts.
- the substances are selected from the group of saccharides, polyols, carboxylic acids, polyphosphates, polyamino acids and / or astringent substances.
- Preferred preparations according to the invention have an antiperspirant activity without further antiperspirant substances, in particular aluminum salts, being present.
- antiperspirant preparations according to the invention and as antiperspirants is also part of the present invention.
- the preparations according to the invention are used for reducing sweat primarily in the armpit.
- the formulations can also be used to reduce the sweat flow on other body areas where consumers sweat undesirable. This may be, but is not limited to, the feet, the forehead, the palms or the back. Due to the advantageous freedom of aluminum, the
- the formulations are applied in a form that is acceptable to the consumer, which can be advantageous, for example, pump sprays, sprays with aerosols, ball applicators, pens, tubes, soft-touch applicators, capsules.
- antiperspirant act are to be selected from the group of saccharides, polyols,
- Carboxylic acids, polyphosphates, polyamino acids and / or astringent substances are in particular to be selected from the groups listed below:
- Agar The gelling agent derived from red algae is dominated by a galactose polymer with few sulfate groups. Agar is used as a consistency and binder.
- Alginic acid (alginate) is derived from brown algae.
- the polysaccharide consists of
- Changing ratios of the sugar acids (uronic acids) and mannuronic acid guluronic acid is characterized by molecular weights of up to about 200,000 daltons.
- Alginic acid serves as a consistency agent, forms a moisture-binding surface film on the skin and can bind heavy metal ions that are involved in oxidative processes and radical formation.
- Carrageenan (carrageenan): These polysaccharides of different composition are produced, among others, from red algae. An important building block is galactose, which is partially esterified with sulfuric acid and can therefore form sodium, potassium and calcium salts. The salts are z. B. used as a gelling agent in toothpastes. To the carrageenans also the structure-like Furcelleran (from the red alga Furcellaria fastigiata) is counted, whose
- Carrageenan is a particularly preferred combination partner with the alkaline earth metal salts, especially the magnesium and calcium chlorides.
- Chitin is composed of a continuous acetyl-D-glucosamine chain. Deacetylation produces chitosan, which forms water-soluble salts with acids, which can be used to condition hair (shampoos, hair gels) and in toothpaste and mouthwashes as antibacterial components and as cationic film-forming agents in care preparations.
- CM-glucan Glucans are generally called biopolymers of glucose.
- the alpha glucans include z.
- CM-Glucan has skin-protecting and firming properties. It is well suited for sensitive skin as it provides some protection against UVA radiation. Fields of application are the care after exfoliation, laser treatments and shaving as well as in addition to body lotions.
- CMC is the abbreviation for carboxymethylcellulose.
- CMC is prepared analogously to the CM glucan by chemical modification of cellulose. It forms water-soluble sodium salts that have thickening properties and are more effective in detergents and detergents
- Dirt carriers are used. Dextrins are made from starches under heat and acidity. The resulting fragments are in contrast to the starting material water-soluble and have depending on the production of different lengths chains.
- cyclodextrins are of interest, which are formed by enzymatic degradation of starch. Cyclodextrins have a cylinder-like cavity structure and may include organic compounds whose water solubility is thereby increased. They adsorb odors, but on the other hand can also store fragrances and release them slowly. Because of these properties, they are also used as a drug carrier.
- Cyclodextrins are particularly preferred combination partners with the alkaline earth metal salts, especially the magnesium and calcium chlorides.
- Glycogen is a highly branched polysaccharide with a molecular weight of 1-10 megadaltons, which consists of only a small proportion of protein only of glucose and the body's own
- Substructures correspond to the branched amylopectin.
- Guar gum from guar bean is a constituent of surfactant-containing preparations, especially shampoos. It creates an antistatic effect and a good grip of the hair.
- the main constituent of guar gum is the polysaccharide guaran, in which mannose and galactose are present in a ratio of 2: 1. Similar
- locust bean gum (Ceratonia siliqua).
- Gum arabic from the Arabian gum tree (Accacia senegal) consists of intricately structured, branched polysaccharide chains containing various monosaccharides such as galactose and arabinose as well as the glucuronic acid resulting from glucose.
- the polysaccharide comes from the juice of various African acacia species and is used in the form of its alkali and alkaline earth salts as a thickener.
- HSP Hydroxypropyl Starch Phosphate
- Hydroxypropyl starch prepared with phosphoric acid. Both substances are present as thickeners and emulsion stabilizers in foods and cosmetics
- Hyaluronic acid is an endogenous polysaccharide consisting of alternating D-glucuronic acid and N-acetyl-D-glucosamine units. Today it is produced biotechnologically and binds a lot of water. In addition, because it adheres very well to the keratin of the skin, in contrast to many other polysaccharides, a very flexible film is formed on the skin surface, which has a cushioning and wrinkle-smoothing effect. Low molecular weight hyaluronic acid fragments are also released as signaling agents in inflammation. Hyaluronic acid or its salts are particularly preferred combination partners with the alkaline earth metal salts, in particular the magnesium and calcium chlorides.
- HEC Hydroxyethyl cellulose
- Ethylene oxide (EO) produced. It is together with hydroxypropylcellulose (HPC),
- HPMC Hydroxypropylmethylcellulose
- Methylcellulose is formed by etherification of free hydroxyl groups of the cellulose.
- Mucopolysaccharides contain amino sugar units, for example N-acetyl-D-glucosamine, which alternate with various monosaccharides or their relatives. They are important components of the connective tissue, as they are able to bind water so tightly that the tissue withstands external pressure. Hyaluronic acid, heparin and chondroitin belong to this group of substances. They are characterized by diverse biological functions.
- Pectin consists of galacturonic acid chains. It comes in fruits such. For example, apples. Its composition varies depending on the crop. Pectins are gelling agents, they increase the
- T ragant This rubbery plant sap from the T ragant plant consists of the polysaccharides tragacanthin and bassorin. While tragacanthin like pectin one
- Galacturonic acid main chain with branches consisting of the mono sugars xylose, fucose and galactose, is an elongated elongated molecule of arabinose,
- Xanthan gum is a biotechnologically produced polysaccharide consisting of a main chain of glucose units, which usually carries on every second glucose molecule a side chain of mannose, glucuronic acid and ketalized pyruvic acid. Acetic acid may also be bound ester-like.
- Xanthan Gum has a thickening effect and increases the lubricity of gels. Similar to hyaluronic acid, xanthan gives a pleasant skin smoothing effect - combined with a moisture binding effect.
- Sugar surfactants include synthetic alkylpolyglycosides (APG), whose chains consist of glucose molecules that are etherified with fatty alcohols at the ends. APG Especially in shampoos, they have a good skin feel and can be used in microemulsions. Coco glucoside (INCI) is z. As a sugar with Ce-16-alkyl groups.
- Fucoidan is a polysaccharide found in brown algae, consisting mainly of sulfated L-fucose in 1, 2alpha glycoside compound. In addition, even smaller amounts of the monomers xylose, galactose and uronic acid may be present.
- Gellan gum is a polysaccharide produced by fermentation, it is a linear molecule consisting of a basic unit of rhamnose, two glucoses and glucuronic acid, and is esterified to varying degrees by acetic acid or glyceric acid. The glucouronic acid is present as a salt. Gellan gum is widely used in food chemistry and is known as E418.
- Tamarindus Indica Seed Polysaccharide is available on the market as Xilogel®.
- Tamarindus indica seed polysaccharide is a particularly preferred combination partner with the alkaline earth metal salts, especially the magnesium and calcium chlorides.
- Saccharides preferred according to the invention are sulfated polysaccharides such as carragenan, algae extracts such as Luminact brite, cyclic oligosaccharides, in particular cyclodextrins, polysaccharides such as xilogel, a tamaride extract, locust bean gum (galactomannans) and / or phytic acid (hexaphosphoric acid ester).
- sulfated polysaccharides such as carragenan, algae extracts such as Luminact brite, cyclic oligosaccharides, in particular cyclodextrins, polysaccharides such as xilogel, a tamaride extract, locust bean gum (galactomannans) and / or phytic acid (hexaphosphoric acid ester).
- Very particularly preferred polysaccharides and preferred oligosaccharides or derivatives thereof are carrageenans, dextrins, glycosaminoglycan and fucoidan.
- Another preferred group of antiperspirant combination partners are:
- astringent refers above all to the term “contraction”.
- Tannins are chemically polyhydroxyphenols. They are soluble in water, ethanol and acetone and contain sufficient ortho-phenolic hydroxyl groups to
- crosslinks between macromolecules such as proteins, cellulose and pectin.
- Such crosslinks can inhibit the activity of plant enzymes and organelles and provide durability and protection against microorganisms (tanning) in leather manufacture.
- the vegetable tannins vary significantly in their chemical structure and biological activity. Tannins with strong absorption properties are generally found in the vacuoles, separated from the protoplasm of the plants. The physiological activity results from the selective binding ability of tannins to proteins, especially to large and proline-rich open-conformation molecules.
- Tannins are divided into two groups because of their chemical properties
- condensed tannins (catechin tannins); also known as condensed
- the former can be hydrolyzed to glucose, other polyhydric alcohols, gallic acid or ellagic acid.
- An example of a hydrolyzable tannin is the corilagin.
- Condensed tannin consists of co-polymerized flavonoid phenols such as catechins, epicatechin, anthocyanins, etc. They are corresponding polymers whose monomeric units consist of phenolic flavanes, mostly catechin (flavan-3-ol).
- Tannic acid is a specific form of tannin, a type of polyphenol. Its weak acid (pKa around 10) is due to the numerous phenolic groups in the structure.
- the chemical formula for commercial tannic acid is often given as C76H52046, which agrees with decagalloylglucose, but in fact it is a mixture of polygalloylglucoses or polygalloylquinic esters with the number of galloyl residues per molecule in the range of 2 to 12 the vegetable source used to produce the To extract tannic acid.
- tannic acid is usually extracted from one of the following parts of plants: tara pods (Caesalpinia spinosa), rhus semialata or Quercus infectoria or Sicilian sicacic leaves (Rhus coriaria).
- Another antiperspirant group is formed by extracts containing catechols, such as schisandrol (Schisandra chinensis fruit extract), gingko or acmella oleracea extract.
- catechols such as schisandrol (Schisandra chinensis fruit extract), gingko or acmella oleracea extract.
- the latter includes spilanthol as an active substance of biological relevance in the
- Sweat inhibition shows, since it can affect the TRP channels.
- Polyphenols are aromatic compounds which contain two or more hydroxy groups directly attached to an aromatic ring and which are considered to be secondary phytochemicals. Natural polyphenols are found in plants as bioactive substances such as colors, flavors and tannins.
- Alkaline earth metal salts are included.
- a preparation may be applied to the skin, which comprises, for example, the carragenan.
- a preparation is applied, which comprises the alkaline earth metal salt, such as MgCl 2.
- the described AT effect occurs due to, for example, a pore narrowing.
- Sweat inhibition characterized by the application of a preparation according to the invention to the skin.
- a method according to the invention also comprises the sequence of
- a preferred non-therapeutic antiperspirant process which is characterized by the application of a preparation to the skin.
- Preferred methods are non-therapeutic methods, cosmetic methods that lead to cosmetic sweat reduction or inhibition.
- the methods are preferred in which are selected as alkaline earth metal salts of magnesium or calcium chlorides.
- the preparations according to the invention can be prepared, for example, as follows.
- the water phase and fat phase are heated and combined with stirring. Subsequently, the emulsion is cooled down with stirring and the active substance phase, the soluble
- Alkaline earth metal salts such as magnesium chloride
- alkaline earth metal salts are preferably the halides, sulfates, carbonates,
- Hydrogen phosphates Oxylene phosphates, oxides, lactates, aminoates, sorbates, carboxylates and / or nitrates.
- alkaline earth salts are preferably used magnesium, calcium and
- Strontium halides in particular magnesium chloride and its hydrates, in particular hydrates to MgCl 2 * 6H 2 0, in particular MgCl 2 * 6H 2 0, and / or calcium chloride, and
- the proportion of one or more alkaline earth salts is preferably selected in the range from 2 to 20% by weight, in particular in the range from 7 to 10% by weight, based on the total mass of the preparation.
- Aluminiumchlorohydrate added to the preparations of the invention.
- Preparations according to the invention are preferably O / W emulsions, W / O emulsions, aqueous-alcoholic preparations, alcoholic (ethanolic) solutions, PIT emulsions or hydrodispersions.
- the preparations according to the invention comprise one or more lipids.
- Preferably used lipids are selected from the group of Capric / Caprylic
- Octyldodecanol Paraffinum Liquidum, Isododecane, Isopropyl Palmitate, Persea Gratissima, Caprylyl Carbonate, Helianthus Annuus, Ethylhexyl Cocoate, C12-15 Alkyl Benzoate,
- Cyclomethicones and / or dimethicones phenyltrimethicone, sunflower oil, rapeseed oil,
- Capric / Caprylic triglyceride isopropyl myristate, isopropyl palmitate, isopropyl stearate, cetearyl ethylhexanoate, hydrogenated polydecenes, glycine soya (soybean) oil, olive oil also Guerbet alcohols such as hexyldecanol, octyldodecanol and 2-ethylhexyl alcohol, Guerbetalkoholester, and mixtures of Guerbet alcohols and
- Guerbet alcohol esters e.g. Hexyldecanol and hexyldecyl laurate.
- the preparations according to the invention are advantageously one or more
- Emulsifiers from the group of nonionic emulsifiers such as, for example, propylene glycol isostearate (HLB 2.5), glycol stearate (HLB 2.9), glyceryl isostearate (HLB 3.5),
- Sorbitan sesquioleate (HLB 3.7), glyceryl stearate (HLB 3.8), lecithin (HLB 4), sorbitan oleate (HLB 4.3), sorbitan monostearate NF (HLB 4.7), sorbitan stearate (HLB 4.7), sorbitan
- Hydrogenated Castor Oil (HLB 10.8), Stearamide MEA (HLB 11), Glyceryl Stearate (and) PEG-100 Stearate (HLB 11), Polysorbate 85 (HLB 11), PEG-7 Olivate (HLB 11), Cetearyl Glucoside (HLB 11 ), PEG-8 oleate (HLB 11.6), polyglyceryl-3-methylglucose distearate (HLB 12), PG-10 Stearates (HLB 12), oleth-10 (HLB 12.4), oleth-10 / polyoxyl 10 oleyl ether NF (HLB 12.4), ceteth-10 (HLB 12.9), PEG-8 laurate (HLB 13), ceteareth-12 (HLB 13.5), Cocamide MEA (HLB 13.5), Polysorbate 60 NF (HLB 14.9), Polysorbate 60 (HLB 14.9), PEG-40 Hydrogenated Castor Oil (HLB 15), Polysorbate 80 (HLB 15), isosteareth-20
- the emulsions of the invention may also contain anionic or cationic emulsifiers.
- Preferred suitable cationic emulsifiers are selected from the group Cetrimonium Chloride, Palmitamidopropyltrimonium Chloride, Quaternium-87, Behentrimonium Chloride, Distearoylethyl Dimonium Chloride, Distearyldimonium Chloride, Stearamidopropyl Dimethylamine and / or Behentrimonium Methosulfate.
- aqueous phase of the preparations according to the invention may advantageously contain customary cosmetic auxiliaries, for example alcohols, in particular those of low C number, such as isopropanol, diols or polyols of low C number and also their ethers, preferably
- Propylene glycol 2-methylpropane-1,3-diol, pentane-1,2-diol, hexane-1,2-diol, octane-1,2-diol, decane-1,2-diol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, foam stabilizers, electrolytes, etc.
- the preparation according to the invention is characterized in that the preparation is propylene glycol, butylene glycol, 2-methylpropane-1, 3-diol, 1, 2-pentanediol, 1, 2-hexanediol, 1, 2-octanediol and / or 1, 2-decanediol contains.
- Suitable acids may include citric acid, lactic acid, maleic acid, malonic acid, succinic acid,
- Hydroxysuccinic acid (malic acid), fumaric acid, salicylic acid, etidronic acid, phosphoric acid, hydrochloric acid and sulfuric acid.
- Suitable alkalizing agents for creating a buffer system for example, sodium hydroxide, potassium hydroxide, ammonia, mono-, di- and trialkylamines and the Hydroxyalkylamines, aminomethylpropanol (2-amino-2-methylpropan-1-ol), ethanolamine (2-aminoethanol), triethanolamine (2,2 ', 2 "-nitrilotriethanol) and tetrahydroxypropylethylenediamine (1, T, 1", 1') Ethylenedinitrilotetrapropan-2-ol).
- the study participants do not use a leave-on at least three days before the start of the study
- Products e.g., hand creams
- detergents on the test area forearm as well as during the course of the study.
- the forearms Before application of the test substances and controls, the forearms are washed with a surfactant-containing solution. Subsequently, the test areas are recorded with the help of a template on the forearm (inside) for the recovery in the multiple application.
- the application amount of preparation to be tested is adapted to the corresponding test area based on the usual amount of 500 mg.
- the preparation, active ingredient solution or formulation is distributed evenly on the test area after application.
- semi-occlusive patches are pasted over the test areas 5 min after application. After another 2 or 4 hours, the patches are removed again.
- the sweat-reducing effect of the preparation, drug solution or formulation on the weight gain of a liquid-absorbent matrix compared to a matrix applied over an untreated control area is determined gravimetrically before introduction into a suitable sample carrier.
- the subsequent uptake of water / sweat allows a direct inference to the antiperspirant efficacy of the applied sample.
- the antiperspirant efficacy of the formulations / drug solutions is calculated by normalization to untreated control sites.
- the preconditioning / behavior during the study corresponds to that of the AUT test.
- test areas are marked on the back and the test areas
- Formulations / drug solutions and controls based on the common amount of 500mg randomized and allied applied. This is followed by a 5 minute drying time. Subsequently, the areas are covered with an occlusive, non-absorbent foil, which is removed after 2 hours. The application and Oclussion of the test substances is repeated several times (about 2-5 times) at intervals of about 24 h. To the corresponding
- Test time (4 - 96 h) is the sweat-reducing effect of the drug solution or
- Formulation on the weight gain of a water-absorbing matrix compared to an untreated control area is determined gravimetrically before being placed in a suitable sample carrier before it is glued occlusive to the back.
- the test areas on the back are first wiped with a cloth, then applied the weighed pads.
- the measuring phase takes place horizontally in the sauna at 80 ° C for approx. 15 min.
- the pads are immediately weighed under standard conditions.
- the amount of sweat is determined by calculating the difference of the pad before and after the sweat phase.
- the calculated uptake of water / sweat compared to an untreated control allows a direct inference to the antiperspirant efficacy of the applied sample and thus of the drug solution / formulation.
- Overall, at least 20 subjects per drug solution / formulation were evaluated. The test was performed both 24h and 48h after the last application.
- liquid-absorbent matrix pads, conventional cotton cosmetic pads or dressing materials such as Fixomull® can be used.
- the test was carried out both 4h, after 24h and after 48h after the last application.
- a sweat reduction after 4h of 40% or more can be considered significant.
- a sweat reduction after 8h of 20% or more can be considered significant.
- Sweat reduction after more than 10% after 24 hours is also considered significant.
- FIGS 1 and 2 show the sweat reduction of the individual substances, which are all below 20% and 40%, respectively.
- Figures 3 and 4 show the significantly increased and synergistic sweat reduction of the combinations which are exemplary of the combinations according to the invention.
- Preferred substances according to the invention which are to be selected in combination with alkaline earth metal salts are carrageenan, cyclodextrins, hyaluronic acid, Tamarindus indica seed Polysaccharide, Luminact brite, Maritech Bright, Xilogel, Gellan gum, locust bean gum, phytic acid, glycosaminoglycan, fucoidan, tannic acid, castalagin, extracts containing
- Catechols succinic acid, salicylic acid, mandelic acid, citric acid, poly-L-lysine hydrochloride and / or polyglyceryl-2-caprate.
- one or more deodorizing agents are advantageously added to the preparations according to the invention.
- deodorizing agents may preferably be selected from cationic polymers, in particular Polyquaternium-16, Polyquaternium-7, Polyquaternium-6, Polyquaternium-11 and Polyquaternium 37, polyaminopropyl biguanide and epsilon-polylysine.
- deodorizing agents may also be advantageous octenidine hydrochloride
- Alexidine dihydrochloride benzyl alcohol, benzalkonium chloride, cetyltrimethylammonium chloride, silver citrate, triclosan, ethylhexylglycerol, triethyl citrate, 2-butyloctanoic acid, methylphenylbutanol, phenoxyethanol, zinc ricinoleate, and other drugs that reduce the number of bacteria on the skin.
- the preparations according to the invention therefore preferably also comprise one or more polyquaternium polymers.
- polyquaternium polymers are selected from the group of polyquaternium-16 polymers and polyquaternium-6 polymers. These are present in preparations according to the invention in a proportion of 0.1 to 10% by weight, in particular in a proportion of 0.15 to 5% by weight, based on the total mass of the preparation.
- polyquaternium-16 polymers (3-methyl-1-vinylimidazolium chloride-1-vinyl-2-pyrrolidinone chlorides) are selected. According to the invention, the polyquaternium polymers used, and in particular PQ-16 polymers, have an additional antimicrobial activity.
- Polyquaternium polymers containing one or more other deodorant substances are used.
- the cosmetic or dermatological preparations according to the invention may further contain cosmetic adjuvants and active ingredients, such as are usually present in such
- Preparations are used, for. As agents, preservatives, preservatives, bactericides, lipids, substances for preventing foaming, dyes and
- Color pigments, thickeners, moisturizing and / or moisturizing substances or other customary constituents of a cosmetic or dermatological formulation such as polyols, polymers, foam stabilizers, organic solvents or silicone derivatives, provided that Addition, the required properties in terms of stability, pH values and AT effect are not impaired or excluded.
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Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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DE102018206621.3A DE102018206621A1 (de) | 2018-04-27 | 2018-04-27 | Antitranspirantwirksame Zubereitung umfassend Erdalkalimetallsalze |
PCT/EP2019/053759 WO2019206489A1 (de) | 2018-04-27 | 2019-02-15 | Antitranspirantwirksame zubereitung umfassend erdalkalimetallsalze |
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EP3784206A1 true EP3784206A1 (de) | 2021-03-03 |
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EP19705502.3A Pending EP3784206A1 (de) | 2018-04-27 | 2019-02-15 | Antitranspirantwirksame zubereitung umfassend erdalkalimetallsalze |
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EP (1) | EP3784206A1 (de) |
AU (1) | AU2019259322A1 (de) |
BR (1) | BR112020018419A2 (de) |
DE (1) | DE102018206621A1 (de) |
WO (1) | WO2019206489A1 (de) |
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DE102019216547A1 (de) * | 2019-10-28 | 2021-04-29 | Beiersdorf Ag | Kosmetische Zubereitung umfassend Erdalkalimetallsalze, Carbonsäuren und Emulgatoren mit verzweigter hydrophober Kette |
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DE10028207A1 (de) * | 2000-06-09 | 2002-01-03 | Henkel Kgaa | Nanopartikel enthaltende deodorierende Seifenstifte |
DE10260954A1 (de) | 2002-12-20 | 2004-07-01 | Henkel Kgaa | Arylsulfatase-Inhibitoren in Deodorantien und Antitranspirantien |
US6923952B2 (en) * | 2003-08-14 | 2005-08-02 | The Gillette Company | Enhanced efficacy antiperspirant compositions containing strontium or calcium |
DE102004020646A1 (de) * | 2004-04-22 | 2005-11-24 | Coty B.V. | Schweißabsorbierender Komplex für kosmetische Produkte |
DE102005060788A1 (de) | 2005-12-16 | 2007-06-28 | Beiersdorf Ag | Verbesserte Langzeitwirkung von Antitranspirantien |
EP2001435A1 (de) * | 2006-03-22 | 2008-12-17 | Takasago International Corporation | Desodorierende zusammensetzung |
DE102007032642B4 (de) * | 2007-07-11 | 2011-12-01 | Beiersdorf Ag | Verwendung von kurzkettigen Glykolen als antitranspirantwirksame Mittel |
DE102007035741A1 (de) * | 2007-07-24 | 2009-02-05 | Beiersdorf Ag | Stabilisierung kosmetischer oder dermatologischer Formulierung enthaltend Mandelsäure |
FR2978035B1 (fr) * | 2011-07-22 | 2015-03-20 | Oreal | Utilisation comme antitranspirant d'un sel de cation multivalent sans antitranspirant halogene d'aluminium ni de compose susceptible de reagir avec ledit sel pour produire un effet antitranspirant |
CN105722556B (zh) * | 2013-10-09 | 2019-01-11 | 里曼贸易有限责任公司 | 改进的止汗组合物 |
DE102015213344A1 (de) * | 2015-07-16 | 2017-01-19 | Henkel Ag & Co. Kgaa | Verfahren zur Reduzierung des Schweißes und/oder Körpergeruchs unter Verwendung von Phosphatverbindungen |
DE102015011694A1 (de) * | 2015-09-14 | 2017-03-16 | Forschungszentrum Jülich GmbH | Reinigungsmittel auf Mikroemulsionsbasis |
CH711849A2 (fr) * | 2015-12-01 | 2017-06-15 | Bernhard Denis | Crème cosmétique de sudation. |
-
2018
- 2018-04-27 DE DE102018206621.3A patent/DE102018206621A1/de not_active Withdrawn
-
2019
- 2019-02-15 WO PCT/EP2019/053759 patent/WO2019206489A1/de active Application Filing
- 2019-02-15 EP EP19705502.3A patent/EP3784206A1/de active Pending
- 2019-02-15 BR BR112020018419-5A patent/BR112020018419A2/pt not_active Application Discontinuation
- 2019-02-15 AU AU2019259322A patent/AU2019259322A1/en not_active Abandoned
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AU2019259322A1 (en) | 2020-12-17 |
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DE102018206621A1 (de) | 2019-10-31 |
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