EP3777642A1 - Flexibler schlauch für ein endoskop, endoskopische medizinische vorrichtung und harzzusammensetzung zur abdeckung des basismaterials des flexiblen schlauches für ein endoskop - Google Patents
Flexibler schlauch für ein endoskop, endoskopische medizinische vorrichtung und harzzusammensetzung zur abdeckung des basismaterials des flexiblen schlauches für ein endoskop Download PDFInfo
- Publication number
- EP3777642A1 EP3777642A1 EP19777274.2A EP19777274A EP3777642A1 EP 3777642 A1 EP3777642 A1 EP 3777642A1 EP 19777274 A EP19777274 A EP 19777274A EP 3777642 A1 EP3777642 A1 EP 3777642A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- flexible tube
- resin
- groups
- polyamide
- endoscope
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000011342 resin composition Substances 0.000 title claims abstract description 14
- 239000000463 material Substances 0.000 title description 3
- -1 amine compound Chemical class 0.000 claims abstract description 234
- 229920005989 resin Polymers 0.000 claims abstract description 69
- 239000011347 resin Substances 0.000 claims abstract description 69
- 239000000758 substrate Substances 0.000 claims abstract description 37
- 229920005992 thermoplastic resin Polymers 0.000 claims abstract description 31
- 229920000178 Acrylic resin Polymers 0.000 claims abstract description 21
- 239000004925 Acrylic resin Substances 0.000 claims abstract description 21
- 239000004645 polyester resin Substances 0.000 claims abstract description 19
- 229920001225 polyester resin Polymers 0.000 claims abstract description 19
- 229920005749 polyurethane resin Polymers 0.000 claims abstract description 17
- 229920006122 polyamide resin Polymers 0.000 claims abstract description 16
- 229920005990 polystyrene resin Polymers 0.000 claims abstract description 15
- 125000004432 carbon atom Chemical group C* 0.000 claims description 89
- 229920001971 elastomer Polymers 0.000 claims description 29
- 239000003963 antioxidant agent Substances 0.000 claims description 28
- 239000000806 elastomer Substances 0.000 claims description 28
- 239000004952 Polyamide Substances 0.000 claims description 20
- 230000003078 antioxidant effect Effects 0.000 claims description 20
- 229920002647 polyamide Polymers 0.000 claims description 20
- 229920000571 Nylon 11 Polymers 0.000 claims description 13
- 229920000299 Nylon 12 Polymers 0.000 claims description 10
- 125000005396 acrylic acid ester group Chemical group 0.000 claims description 8
- 229920006020 amorphous polyamide Polymers 0.000 claims description 8
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims description 8
- 150000003568 thioethers Chemical class 0.000 claims description 7
- 229920006152 PA1010 Polymers 0.000 claims description 6
- 229920006396 polyamide 1012 Polymers 0.000 claims description 6
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 239000010410 layer Substances 0.000 description 47
- 238000012360 testing method Methods 0.000 description 41
- 150000001875 compounds Chemical class 0.000 description 36
- 125000000217 alkyl group Chemical group 0.000 description 35
- 125000001424 substituent group Chemical group 0.000 description 34
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- 230000001954 sterilising effect Effects 0.000 description 24
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 23
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 22
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 18
- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 16
- 238000009864 tensile test Methods 0.000 description 15
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- 125000003118 aryl group Chemical group 0.000 description 13
- 238000003780 insertion Methods 0.000 description 13
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- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 12
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- 125000003545 alkoxy group Chemical group 0.000 description 11
- 229920002292 Nylon 6 Polymers 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 10
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 10
- 229920002302 Nylon 6,6 Polymers 0.000 description 9
- 125000004104 aryloxy group Chemical group 0.000 description 9
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- 150000002009 diols Chemical class 0.000 description 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 8
- 125000000623 heterocyclic group Chemical group 0.000 description 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 8
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 8
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 7
- 125000005647 linker group Chemical group 0.000 description 7
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 229920006111 poly(hexamethylene terephthalamide) Polymers 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 6
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 6
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 6
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 6
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 6
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 6
- 229920002614 Polyether block amide Polymers 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 5
- 125000003277 amino group Chemical group 0.000 description 5
- 125000004122 cyclic group Chemical group 0.000 description 5
- 239000004611 light stabiliser Substances 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 229920002223 polystyrene Polymers 0.000 description 5
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 5
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 4
- 229920003646 Vestamid® Terra Polymers 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 4
- 150000008378 aryl ethers Chemical class 0.000 description 4
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 4
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 description 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
- 229920006123 polyhexamethylene isophthalamide Polymers 0.000 description 4
- 229920006324 polyoxymethylene Polymers 0.000 description 4
- 150000003440 styrenes Chemical class 0.000 description 4
- JCUZDQXWVYNXHD-UHFFFAOYSA-N 2,2,4-trimethylhexane-1,6-diamine Chemical compound NCCC(C)CC(C)(C)CN JCUZDQXWVYNXHD-UHFFFAOYSA-N 0.000 description 3
- DPQHRXRAZHNGRU-UHFFFAOYSA-N 2,4,4-trimethylhexane-1,6-diamine Chemical compound NCC(C)CC(C)(C)CCN DPQHRXRAZHNGRU-UHFFFAOYSA-N 0.000 description 3
- OWXXKGVQBCBSFJ-UHFFFAOYSA-N 6-n-[3-[[4,6-bis[butyl-(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]-[2-[[4,6-bis[butyl-(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]-[3-[[4,6-bis[butyl-(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]-1,3,5-triazin-2-yl]ami Chemical compound N=1C(NCCCN(CCN(CCCNC=2N=C(N=C(N=2)N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)C=2N=C(N=C(N=2)N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)C=2N=C(N=C(N=2)N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)=NC(N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)=NC=1N(CCCC)C1CC(C)(C)N(C)C(C)(C)C1 OWXXKGVQBCBSFJ-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 229920000305 Nylon 6,10 Polymers 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 229930182556 Polyacetal Natural products 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004959 Rilsan Substances 0.000 description 3
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 description 3
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 description 3
- 125000004414 alkyl thio group Chemical group 0.000 description 3
- 125000000304 alkynyl group Chemical group 0.000 description 3
- 125000006598 aminocarbonylamino group Chemical group 0.000 description 3
- 125000001204 arachidyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 125000005162 aryl oxy carbonyl amino group Chemical group 0.000 description 3
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 3
- 125000005200 aryloxy carbonyloxy group Chemical group 0.000 description 3
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 125000000392 cycloalkenyl group Chemical group 0.000 description 3
- 125000000753 cycloalkyl group Chemical group 0.000 description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 125000005442 diisocyanate group Chemical group 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 description 3
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 3
- 125000005328 phosphinyl group Chemical group [PH2](=O)* 0.000 description 3
- 125000004437 phosphorous atom Chemical group 0.000 description 3
- 125000003386 piperidinyl group Chemical group 0.000 description 3
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- 230000002829 reductive effect Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
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- 239000000126 substance Substances 0.000 description 3
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 2
- JLZIIHMTTRXXIN-UHFFFAOYSA-N 2-(2-hydroxy-4-methoxybenzoyl)benzoic acid Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1C(O)=O JLZIIHMTTRXXIN-UHFFFAOYSA-N 0.000 description 2
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 2
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 description 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 2
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 description 2
- SWZOQAGVRGQLDV-UHFFFAOYSA-N 4-[2-(4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)ethoxy]-4-oxobutanoic acid Chemical compound CC1(C)CC(O)CC(C)(C)N1CCOC(=O)CCC(O)=O SWZOQAGVRGQLDV-UHFFFAOYSA-N 0.000 description 2
- DSUFPYCILZXJFF-UHFFFAOYSA-N 4-[[4-[[4-(pentoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamoyloxy]butyl n-[4-[[4-(butoxycarbonylamino)cyclohexyl]methyl]cyclohexyl]carbamate Chemical compound C1CC(NC(=O)OCCCCC)CCC1CC1CCC(NC(=O)OCCCCOC(=O)NC2CCC(CC3CCC(CC3)NC(=O)OCCCC)CC2)CC1 DSUFPYCILZXJFF-UHFFFAOYSA-N 0.000 description 2
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 2
- YXHRTMJUSBVGMX-UHFFFAOYSA-N 4-n-butyl-2-n,4-n-bis(2,2,6,6-tetramethylpiperidin-4-yl)-2-n-[6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]hexyl]-1,3,5-triazine-2,4-diamine Chemical compound N=1C=NC(N(CCCCCCNC2CC(C)(C)NC(C)(C)C2)C2CC(C)(C)NC(C)(C)C2)=NC=1N(CCCC)C1CC(C)(C)NC(C)(C)C1 YXHRTMJUSBVGMX-UHFFFAOYSA-N 0.000 description 2
- GVNWZKBFMFUVNX-UHFFFAOYSA-N Adipamide Chemical compound NC(=O)CCCCC(N)=O GVNWZKBFMFUVNX-UHFFFAOYSA-N 0.000 description 2
- 239000004953 Aliphatic polyamide Substances 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
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- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
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- 125000002252 acyl group Chemical group 0.000 description 2
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- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 description 2
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- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 description 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 description 2
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- 239000004760 aramid Substances 0.000 description 2
- 229920003235 aromatic polyamide Polymers 0.000 description 2
- 125000005135 aryl sulfinyl group Chemical group 0.000 description 2
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 description 2
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- 125000005110 aryl thio group Chemical group 0.000 description 2
- 125000000751 azo group Chemical group [*]N=N[*] 0.000 description 2
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- QMKYBPDZANOJGF-UHFFFAOYSA-N benzene-1,3,5-tricarboxylic acid Chemical compound OC(=O)C1=CC(C(O)=O)=CC(C(O)=O)=C1 QMKYBPDZANOJGF-UHFFFAOYSA-N 0.000 description 2
- 150000001602 bicycloalkyls Chemical group 0.000 description 2
- XITRBUPOXXBIJN-UHFFFAOYSA-N bis(2,2,6,6-tetramethylpiperidin-4-yl) decanedioate Chemical compound C1C(C)(C)NC(C)(C)CC1OC(=O)CCCCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1 XITRBUPOXXBIJN-UHFFFAOYSA-N 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
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- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/50—Properties of the layers or laminate having particular mechanical properties
- B32B2307/546—Flexural strength; Flexion stiffness
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/702—Amorphous
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/70—Other properties
- B32B2307/714—Inert, i.e. inert to chemical degradation, corrosion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2535/00—Medical equipment, e.g. bandage, prostheses, catheter
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/40—Polyamides containing oxygen in the form of ether groups
Definitions
- the present invention relates to flexible tubes for endoscopes, endoscopic medical devices, and resin compositions for covering flexible tube substrates for endoscopes.
- Endoscopes are medical devices for examination of a patient's body cavity. Since an endoscope is inserted and used in a body cavity, an endoscope that does not damage an organ or cause pain and/or discomfort to a patient is desirable.
- a spiral tube formed by spirally winding a flexible metal strip is used as a flexible tube that forms the insertion section of an endoscope.
- the periphery of the spiral tube is covered with a flexible resin so that the spiral tube does not cause stimulation or damage to the surface of a body cavity such as the esophagus or intestine.
- JP2015-16261A discloses that a resin layer covering a flexible tube substrate contains a polyester elastomer and a hindered phenol compound or hindered amine compound to improve the durability to disinfection with peracetic acid and aqueous hydrogen peroxide.
- an object of the present invention is to provide a flexible tube for an endoscope with the desired bending hardness, superior bending durability, and high sterilization durability, an endoscopic medical device including such a flexible tube for an endoscope, and a resin composition with good molding stability that is suitable for forming a resin layer of such a flexible tube for an endoscope.
- the inventors After conducting intensive research in view of the foregoing problems, the inventors have found that the foregoing problems can be solved by the use of a particular thermoplastic resin having a tensile strength at 10% elongation of 10 MPa or more and a hindered amine compound having a particular molecular weight or more as constituent materials for a resin layer of a flexible tube for an endoscope, thus completing the present invention.
- substituents or the like there are a plurality of substituents, linking groups, or the like (hereinafter referred to as "substituents or the like") represented by a particular symbol, or if a plurality of substituents or the like are specified simultaneously or alternatively, it is meant that the individual substituents or the like may be the same or different.
- substituents or the like are adjacent to each other, it is meant that they may be linked or fused to each other to form a ring, even if not specified as such.
- acrylic refers to a wide range of structures having an acryloyl group, including those having a substituent (e.g., an alkyl group (preferably, a methyl group)) at the ⁇ position.
- substituent e.g., an alkyl group (preferably, a methyl group)
- the flexible tube for an endoscope according to the present invention can achieve the desired bending hardness, superior bending durability, and high sterilization durability.
- the endoscopic medical device according to the present invention includes the flexible tube for an endoscope with the above superior properties.
- the resin composition for covering a flexible tube substrate for an endoscope according to the present invention is suitable for use as a constituent material for the resin layer of the flexible tube for an endoscope with the above properties.
- an electronic endoscope will now be described as an example of an endoscopic medical device according to a preferred embodiment of the present invention.
- Electronic endoscopes incorporate a flexible tube for an endoscope (a flexible tube for an endoscope may be hereinafter simply referred to as "flexible tube”) and are widely used as medical devices.
- a flexible tube for an endoscope may be hereinafter simply referred to as "flexible tube”
- an electronic endoscope 2 includes an insertion section 3 for insertion into a body cavity, a main-body operating section 5 connected to the proximal end portion of the insertion section 3, and a universal cord 6 for connection to a processor device and a light source device.
- the insertion section 3 is composed of a flexible tube 3a connected to the main-body operating section 5, an angle portion 3b connected to the flexible tube 3a, and a tip portion 3c connected to the distal end of the angle portion 3b and having an imaging device (not shown) built thereinto for imaging a body cavity.
- the flexible tube 3a which accounts for most of the length of the insertion section 3, is flexible substantially over the entire length thereof. In particular, the portion to be inserted into a site such as a body cavity has a more flexible structure.
- the flexible tube 3a (flexible tube for an endoscope) has a flexible tube substrate 14 and a resin layer 15 (resin layer (A)) covering the outer peripheral surface of the flexible tube substrate 14.
- the flexible tube substrate 14 includes a spiral tube 11 disposed on the innermost side and formed by spirally winding a metal strip 11a, a tubular net 12 covering the spiral tube 11 and formed by weaving metal wires, and caps 13 fitted to both ends.
- the spiral tube 11 is shown as a single layer, it may be composed of two layers coaxially stacked on top of each other.
- the resin layer 15 is shown as being thick relative to the diameter of the flexible tube substrate 14.
- the resin layer 15 is formed with substantially uniform thickness in the longitudinal direction (axial direction) of the flexible tube substrate 14.
- the resin layer 15 has a thickness of, for example, 0.1 to 0.6 mm.
- the flexible tube 3a has an outer diameter D of, for example, 2.0 to 10.0 mm, preferably 3.0 to 8.0 mm.
- the flexible tube substrate 14 has an outer diameter of, for example, 1.6 to 9.6 mm, preferably 2.2 to 7.8 mm.
- the flexible tube for an endoscope according to the present invention can be manufactured as usual except for the configuration of the resin layer (A).
- the flexible tube for an endoscope according to the present invention can be manufactured by referring to JP2014-188217A , JP2015-16261A , and JP2016-209649A .
- the flexible tube according to the present invention has a flexible tube substrate that is flexible and tubular and a resin layer (A) covering the flexible tube substrate.
- the resin layer (A) includes a thermoplastic resin (a) (resin component, component (a)) having a tensile strength at 10% elongation of 10 MPa or more and a hindered amine compound (b) (component (b)) having a molecular weight of 500 or more.
- the thermoplastic resin (a) includes at least one of a polyamide resin, a polyurethane resin, a polyester resin, a polystyrene resin, or an acrylic resin.
- the resin layer (A) may be composed of a single layer or a plurality of layers with different compositions.
- the flexible tube according to the present invention may have, outside the resin layer (A), for example, a topcoat layer described in JP2015-16261A .
- the flexible tube according to the present invention has both flexibility and certain rigidity required of an endoscope insertion section and can also achieve a higher adhesiveness to the flexible tube substrate (bending durability) and the desired sufficient chemical resistance.
- the mechanism is not fully understood, one possible explanation is as follows. Because the resin layer (A) contains, as a matrix, a thermoplastic resin having a tensile strength at 10% elongation of 10 MPa or more and having a particular bond or benzene ring and further contains a hindered amine compound (b) having a particular molecular weight or more, a certain stress is induced in the resin layer (A) at the interface with the flexible tube substrate upon bending.
- the certain stress induced in the resin layer (A) allows it to return to its original form (unbent state) while highly maintaining its adhesiveness to the flexible tube substrate. Furthermore, because the resin layer (A) has superior shape stability, the migration of the hindered amine compound (b) from the resin layer (A) is highly inhibited.
- the thermoplastic resin (a) may be any thermoplastic resin that includes at least one of a polyamide resin, a polyurethane resin, a polyester resin, a polystyrene resin, or an acrylic resin and that has a tensile strength at 10% elongation of 10 MPa or more.
- the tensile strength at 10% elongation of the thermoplastic resin (a) is calculated by the method described in the Examples section later.
- the total amount of the polyamide resin, the polyurethane resin, the polyester resin, the polystyrene resin, and the acrylic resin present in the thermoplastic resin (a) is preferably 70% by mass or more, more preferably 90% by mass or more, and may be 100% by mass.
- thermoplastic resins other than polyamide resins, polyurethane resins, polyester resins, polystyrene resins, and acrylic resins that can be present in the thermoplastic resin (a) include polycarbonate resins, polyacetal resins, and polyphenylene ether resins.
- the total amount of the thermoplastic resin (a) in the resin component forming the resin layer (A) is preferably 70% by mass or more, more preferably 90% by mass or more, even more preferably 96% by mass or more, and may be 100% by mass.
- resins and polymers other than the thermoplastic resin (a) that can be present in the resin layer (A) include polyvinyl chloride resins.
- the tensile strength at 10% elongation is preferably 10 MPa to 50 Mpa, more preferably 15 MPa to 45 Mpa, particularly preferably 20 MPa to 40 Mpa. If the tensile strength at 10% elongation falls within the above range, the stress induced at the interface between the resin layer (A) and the flexible tube substrate decreases, thus inhibiting peeling at the interface and further improving the bending durability.
- the thermoplastic resin (a) preferably has a surface hardness of 45D to 85D, more preferably 50D to 80D, particularly preferably 60D to 75D.
- the surface hardness is calculated by the method described in the Examples section later.
- polyamide resins examples include crystalline polyamides, amorphous polyamides, and polyamide elastomers having tensile strengths at 10% elongation of 10 MPa or more.
- crystalline polyamides examples include aliphatic polyamides and aromatic polyamides.
- aliphatic polyamides examples include poly- ⁇ -capramide (polyamide 6), polytetramethylene adipamide (polyamide 46), polyhexamethylene adipamide (polyamide 66), polycapramide/polyhexamethylene adipamide copolymer (polyamide 6/66), polyundecamide (polyamide 11), polycapramide/polyundecamide copolymer (polyamide 6/11), polydodecamide (polyamide 12), polycapramide/polydodecamide copolymer (polyamide 6/12), polyhexamethylene sebacamide (polyamide 610), polydecamethylene sebacamide (polyamide 1010), polyhexamethylene dodecamide (polyamide 612), polydecamethylene dodecamide (polyamide 1012), polyundecamethylene adipamide (polyamide 116), and mixtures and copolymers thereof.
- aromatic polyamides examples include polyhexamethylene isophthalamide (polyamide 61), polyhexamethylene terephthalamide (polyamide 6T), polyhexamethylene terephthalamide/polyhexamethylene isophthalamide copolymer (polyamide 6T/6I), polycapramide/polyhexamethylene terephthalamide copolymer (polyamide 6/6T), polycapramide/polyhexamethylene isophthalamide copolymer (polyamide 6/61), polyhexamethylene adipamide/polyhexamethylene terephthalamide copolymer (polyamide 66/6T), polyhexamethylene adipamide/polyhexamethylene isophthalamide copolymer (polyamide 66/61), polytrimethylhexamethylene terephthalamide (polyamide TMDT), polybis(4-aminocyclohexyl)methane dodecamide (polyamide PACM 12), polybis(3-methyl-4-a
- amorphous polyamides include isophthalic acid/terephthalic acid/1,6-hexanediamine/bis(3-methyl-4-aminocyclohexyl)methane polycondensate, terephthalic acid/2,2,4-trimethyl-1,6-hexanediamine/2,4,4-trimethyl-1,6-hexanediamine polycondensate, isophthalic acid/bis(3-methyl-4-aminocyclohexyl)methane/ ⁇ -laurolactam polycondensate, isophthalic acid/terephthalic acid/1,6-hexanediamine polycondensate, isophthalic acid/2,2,4-trimethyl-1,6-hexanediamine/2,4,4-trimethyl-1,6-hexanediamine polycondensate, isophthalic acid/terephthalic acid/2,2,4-trimethyl-1,6-hexanediamine/2,4,4-trimethyl-1,6-hexanediamine polyconden
- polyamide elastomers include multiblock copolymers containing polyamide hard segments and polyether or polyester soft segments.
- hard segments include polyamide 6, polyamide 66, polyamide 610, polyamide 11, and polyamide 12.
- polyethers for soft segments include polyethylene glycol, diol poly(oxytetramethylene) glycol, and poly(oxypropylene) glycol.
- polyesters include poly(ethylene adipate) glycol and poly(butylene-1,4-adipate) glycol.
- Preferred polyamides for use in the present invention include polyamide 1010, polyamide 1012, polyamide 11, polyamide 12, polyamide elastomers, and amorphous polyamides. To further improve the bending hardness, the bending durability, and the sterilization durability, polyamide 11, polyamide 12, and polyamide elastomers are preferred.
- polyamide resins for use in the present invention examples include polyamide 11 (the trade name “Rilsan BMN O” available from Arkema Inc.), polyamide 12 (the trade name “Vestamid L1940" available from Daicel-Evonik Ltd.), polyamide 1010 (the trade name "Vestamid Terra DS16” available from Daicel-Evonik Ltd.), polyamide 1012 (the trade name "Vestamid Terra DD16” available from Evonik), amorphous polyamides (the trade name "Trogamid CX7323" available from Daicel-Evonik Ltd.), and polyamide elastomers (the trade name "Pebax 7233" and “Pebax Rnew 80R53” available from Arkema Inc.).
- polyurethane resins examples include carbonate-based, ether-based, and ester-based polyurethane resins having tensile strengths at 10% elongation of 10 MPa or more.
- Polyurethane elastomers are also preferred. Suitable polyurethane elastomers can be selected depending on the purpose. Examples of polyurethane elastomers include elastomers including structural units of hard segments formed from a low-molecular-weight glycol and a diisocyanate and soft segments formed from a polymeric (long-chain) diol and a diisocyanate.
- Diisocyanates may be either aliphatic diisocyanates or aromatic diisocyanates.
- aliphatic diisocyanates include hexamethylene diisocyanate and dicyclohexylmethane 4,4'-diisocyanate.
- aromatic diisocyanates include m-xylylene diisocyanate and 4,4'-diphenylmethane diisocyanate.
- polymeric (long-chain) diols examples include polyalkylene glycols, poly(1,4-butylene adipate), poly(ethylene/1,4-butylene adipate), polycaprolactone, poly(1,6-hexylene carbonate), and poly(1,6-hexylene/neopentylene adipate).
- Polymeric (long-chain) diols preferably have a number average molecular weight of 500 to 10,000.
- low-molecular-weight glycols examples include short-chain diols such as ethylene glycol, propylene glycol, 1,4-butanediol, and bisphenol A. Short-chain diols preferably have a number average molecular weight of 48 to 500.
- the polyurethane used in the present invention preferably has an aliphatic diisocyanate-derived component in its repeating units.
- the polyurethane used in the present invention preferably has repeating units having a polyalkylene glycol-derived component.
- the alkylene in the polyalkylene glycol-derived component preferably contains 2 or more carbon atoms, more preferably 4 or more carbon atoms, particularly preferably 6 or more carbon atoms.
- the upper limit is preferably 12 or less carbon atoms, more preferably 10 or less carbon atoms.
- polyurethane resins for use in the present invention include aliphatic ether-based polyurethanes (the trade name “Tecoflex EG-72D” available from Lubrizol Corporation), aliphatic carbonate-based polyurethanes (the trade name “Carbothane PC-3572D” available from Lubrizol Corporation), aromatic ether-based polyurethanes (the trade name "Miractran E574PNAT” available from Nippon Polyurethane Industry Co., Ltd.), and aromatic ether-based polyurethanes (the trade name "Isoplast 2510" available from Lubrizol Corporation).
- aliphatic ether-based polyurethanes the trade name "Tecoflex EG-72D” available from Lubrizol Corporation
- aliphatic carbonate-based polyurethanes the trade name "Carbothane PC-3572D” available from Lubrizol Corporation
- aromatic ether-based polyurethanes the trade name "Miractran E574PNAT” available from Nippon Poly
- polyester resins include polyester resins composed of a dicarboxylic acid component and a diol component and having tensile strengths at 10% elongation of 10 MPa or more and polyester resins composed of a hydroxycarboxylic acid component and having tensile strengths at 10% elongation of 10 MPa or more.
- dicarboxylic acid components include terephthalic acid, isophthalic acid, phthalic acid, 2,6-naphthalenedicarboxylic acid, 5-sodiosulfoisophthalic acid, oxalic acid, succinic acid, adipic acid, sebacic acid, azelaic acid, dodecanedioic acid, dimer acids, maleic anhydride, maleic acid, fumaric acid, itaconic acid, citraconic acid, mesaconic acid, and cyclohexanedicarboxylic acid.
- diol components include ethylene glycol, diethylene glycol, 1,3-propanediol, 1,4-butanediol, neopentyl glycol, 1,6-hexanediol, cyclohexanedimethanol, triethylene glycol, polyethylene glycol, polypropylene glycol, polytetramethylene glycol, and ethylene oxide adducts of bisphenol A and bisphenol S.
- hydroxycarboxylic acid components include ⁇ -caprolactone, lactic acid, and 4-hydroxybenzoic acid.
- the polyester resin may be a homopolymer of any of the above components or a copolymer thereof and may contain a small amount of a trifunctional compound component such as trimellitic acid, trimesic acid, pyromellitic acid, trimethylolpropane, glycerol, or pentaerythritol.
- a trifunctional compound component such as trimellitic acid, trimesic acid, pyromellitic acid, trimethylolpropane, glycerol, or pentaerythritol.
- polyester resin two or more of such homopolymers and copolymers of the above components may be used in combination.
- the polyester resin be a polyester elastomer.
- block copolymers composed of high-melting-point polyester segments (hard segments) and low-melting-point polymer segments (soft segments) having a molecular weight of 400 to 6,000 can be used, for example, as described in JP1999-92636A ( JP-H11-92636A ).
- the polyester resin used in the present invention preferably has a polybutylene naphthalate-derived structure.
- polyester resins for use in the present invention include polyester elastomers (the trade name “Hytrel 5557” and “Hytrel 7247” available from DuPont-Toray Co., Ltd.) and polyester elastomers (the trade name "TQB-KET 30" available from Teijin Limited).
- the polystyrene resin refers to a resin including 50% by mass or more of a styrene component and having a tensile strength at 10% elongation of 10 MPa or more.
- the styrene component is a structural unit derived from a monomer having a styrene skeleton in its structure.
- polystyrene resins include homopolymers of styrene compounds and copolymers of two or more styrene compounds.
- styrene compound refers to a compound having a styrene skeleton in its structure and is meant to include styrene and compounds derived from styrene by introducing a substituent into a site other than the ethylenically unsaturated bond.
- styrene compounds include styrene; alkylstyrenes such as ⁇ -methylstyrene, o-methylstyrene, m-methylstyrene, p-methylstyrene, 1,3-dimethylstyrene, 2,4-dimethylstyrene, o-ethylstyrene, p-ethylstyrene, and tertbutylstyrene; and substituted styrenes derived from styrene by introducing a substituent such as a hydroxy group, an alkoxy group, a carboxyl group, or a halogen into the benzene core, including hydroxystyrene, tert-butoxystyrene, vinylbenzoic acid, o-chlorostyrene, and p-chlorostyrene.
- alkylstyrenes such as ⁇ -methylst
- the polystyrene may include any constituent component other than the styrene component.
- the polystyrene resin may be a styrene-diene copolymer or a styrene-polymerizable unsaturated carboxylic acid ester copolymer. Mixtures of polystyrene with synthetic rubbers (e.g., polybutadiene and polyisoprene) can also be used. So-called styrene-based elastomers are also suitable for use.
- the polystyrene resin may be hydrogenated (may be a hydrogenated polystyrene).
- Preferred hydrogenated polystyrenes include, but not limited to, hydrogenated styrene-diene-based copolymers such as hydrogenated styrene-butadiene-styrene block copolymer (SEBS) and hydrogenated styrene-isoprene-styrene block copolymer (SEPS), which are resins obtained by hydrogenation of SBS and SIS, respectively.
- SEBS hydrogenated styrene-butadiene-styrene block copolymer
- SEPS hydrogenated styrene-isoprene-styrene block copolymer
- styrene resins for use in the present invention include styrene-based elastomers (the trade name "Septon 2104" available from Kuraray Co., Ltd.).
- acrylic resins include polymers and elastomers obtained by polymerization of a starting monomer containing an acrylic acid ester as a main component and having tensile strengths at 10% elongation of 10 MPa or more.
- acrylic acid esters include methyl methacrylate, methyl acrylate, ethyl methacrylate, ethyl acrylate, butyl acrylate, methoxyethyl acrylate, and ethoxyethyl acrylate.
- Acrylic resins obtained using a starting material such as glycidyl methacrylate or allyl glycidyl ether as a crosslink monomer can also be used.
- these acrylic resins may optionally be copolymerized with, for example, acrylic acid or methacrylic acid.
- acrylic resins may be copolymerized with, for example, acrylonitrile.
- acrylonitrile-butyl acrylate copolymer acrylonitrile-butyl acrylate-ethyl acrylate copolymer
- acrylonitrile-butyl acrylate-glycidyl methacrylate copolymer examples include acrylonitrile-butyl acrylate copolymer, acrylonitrile-butyl acrylate-ethyl acrylate copolymer, and acrylonitrile-butyl acrylate-glycidyl methacrylate copolymer.
- the acrylic resin used in the present invention is preferably a copolymer having two or more acrylic acid ester components, each acrylic acid ester component forming a block structure.
- Preferred examples include acrylic resins having a methyl methacrylate block-methyl acrylate block-methyl methacrylate block structure and acrylic resins having a methyl acrylate block-methyl methacrylate block structure.
- acrylic resins for use in the present invention include acrylic-based elastomers (the trade name "Kurarity LM730H” available from Kuraray Co., Ltd.).
- the hindered amine compound (b) used in the present invention is a normal hindered amine light stabilizer (HALS) having a molecular weight of 500 or more.
- HALS normal hindered amine light stabilizer
- the hindered amine compound (b) is preferably a compound having a structural moiety represented by general formula (3) below.
- R 6 to R 9 represent a hydrogen atom or an alkyl group having 1 to 12 carbon atoms (preferably 1 to 8 carbon atoms, more preferably 1 to 5 carbon atoms).
- alkyl groups represented by R 6 to R 9 include methyl, ethyl, n-butyl, isopropyl, s-butyl, t-butyl, t-pentyl, t-hexyl, and t-octyl.
- R 6 to R 9 are primary (linear) alkyl groups. More preferably, all of R 6 to R 9 are primary (linear) alkyl groups (particularly preferably methyl groups).
- R 10 represents a hydrogen atom, an alkyl group having 1 to 18 carbon atoms (preferably 1 to 10 carbon atoms, more preferably 1 to 5 carbon atoms, even more preferably 1 to 3 carbon atoms, further preferably 1 or 2 carbon atoms), or -OR 11 , where R 11 represents a hydrogen atom or a linear, branched, or cyclic alkyl group having 1 to 20 carbon atoms (preferably 1 to 12 carbon atoms).
- R 10 is preferably an alkyl group or an alkoxy group, which results in a higher sterilization durability
- R 10 in general formula (3) may be a simple direct bond (-) or a divalent linking group. If R 10 is a divalent linking group, an alkylene group (preferably having 1 to 12 carbon atoms, more preferably 1 to 8 carbon atoms, even more preferably 1 to 5 carbon atoms) is preferred.
- the component (b) has a molecular weight of 500 or more, preferably 650 or more, more preferably 800 or more, even more preferably 1,000 or more. Although there is no particular upper limit, the component (b) preferably has a molecular weight of 10,000 or less, more preferably 5,000 or less. The desorption of the component (b) from the surface of the resin layer (A) can be reduced, and the degradation of the resin component due to sterilization treatment can be more effectively reduced, thus further improving the sterilization durability.
- the above molecular weight refers to the number average molecular weight.
- the number average molecular weight is calculated by the following measurement method.
- An HLC-8220 (trade name, available from Tosoh Corporation) GPC apparatus is used.
- the eluant used is tetrahydrofuran.
- the columns used are G3000HXL and G2000HXL (both of which are trade names, available from Tosoh Corporation).
- the temperature is 23°C.
- the flow rate is 1 mL/min.
- An RI detector can be used for detection.
- the component (b) may be an N-H type hindered amine compound, an N-R type hindered amine compound, or an N-OR type hindered amine compound.
- N-H type hindered amine compounds have a hydrogen atom attached to a nitrogen atom in a piperidine skeleton.
- Specific examples of N-H type hindered amine light stabilizers include Tinuvin 770 DF, Chimassorb 2020 FDL, and Chimassorb 944 FDL (all of which are trade names, available from BASF); ADK STAB LA-68 and ADK STAB LA-57 (both of which are trade names, available from Adeka Corporation); and Cyasorb UV-3346 and Cyasorb UV-3853 (both of which are trade names, available from Sun Chemical Company Ltd.).
- N-R type hindered amine compounds have an organic group R (R is an alkyl group represented by R 10 above) attached to a nitrogen atom in a piperidine skeleton.
- R is an alkyl group represented by R 10 above
- Specific examples of N-R type hindered amine compounds include Tinuvin 622 SF, Tinuvin 765, Tinuvin PA 144, Chimassorb 119, and Tinuvin 111 (all of which are trade names, available from BASF); Sabostab UV 119 (trade name, available from Sabo S.p.A.); and ADK STAB LA-63P and ADK STAB LA-52 (both of which are trade names, available from Adeka Corporation).
- N-OR type hindered amine compounds have -OR (R is an alkyl group represented by R 11 above) attached to a nitrogen atom in a piperidine skeleton.
- R is an alkyl group represented by R 11 above
- Specific examples of N-OR type hindered amine compounds include Tinuvin 123, Tinuvin 5100, Tinuvin NOR 371 FF, and Flamestab NOR 116 FF (all of which are trade names, available from BASF).
- the amount of the component (b) is preferably 0.2% to 8% by mass, more preferably 0.2% to 4% by mass, based on 100% by mass of all components forming the resin layer (A). If the amount of the component (b) is not less than the above lower limit, the sterilization durability can be further improved. On the other hand, if the amount of the component (b) is not more than the above upper limit, the bending hardness and the bending durability can be further improved.
- the resin layer (A) preferably includes an antioxidant (c) to further improve the bending durability.
- an antioxidant c
- Various antioxidants can be used as the component (c), including phenol-based antioxidants, amine-based antioxidants, phosphorus-based (phosphite-based) antioxidants, sulfur-based (thioether-based) antioxidants, hydrazine-based antioxidants, and amide-based antioxidants.
- a phosphite-based antioxidant or a thioether-based antioxidant is preferably used as the component (c) to further improve the bending durability.
- the phosphite-based antioxidant is preferably a compound having a structure represented by general formula (1):
- R 1 and R 2 represent an alkyl group, an aryl group, an alkoxy group, an aryloxy group, or a halogen atom
- R 3 represents an alkyl group or an aryl group
- at least two of R 1 , R 2 , or R 3 may be linked to each other via a divalent or higher-valent group or a single bond.
- compounds having a structure represented by general formula (1) include, in addition to compounds represented by general formula (1), compounds (i) and (ii) below.
- compounds having a structure represented by general formula (1) are meant to include compounds represented by general formula (1) and compounds having a structure in which a plurality of structures represented by general formula (1) are present in one molecule.
- the alkyl groups represented by R 1 , R 2 , and R 3 in general formula (1) above are linear, branched, or cyclic substituted or unsubstituted alkyl groups.
- the alkyl groups Preferably, the alkyl groups have 1 to 50 carbon atoms, more preferably 1 to 30 carbon atoms, particularly preferably 1 to 20 carbon atoms.
- Preferred examples include methyl, ethyl, n-propyl, isopropyl, cyclopropyl, butyl, isobutyl, t-butyl, s-butyl, pentyl, isopentyl, neopentyl, t-pentyl, hexyl, cyclohexyl, heptyl, cyclopentyl, octyl, 2-ethylhexyl, nonyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, eicosyl, docosyl, and triacontyl.
- the alkyl groups represented by R 1 , R 2 , and R 3 may further have a substituent.
- substituents include halogen atoms, alkyl groups (including cycloalkyl groups), alkenyl groups (including cycloalkenyl groups and bicycloalkenyl groups), alkynyl groups, aryl groups, cyano groups, hydroxy groups, nitro groups, carboxy groups, alkoxy groups, aryloxy groups, acyloxy groups, carbamoyloxy groups, alkoxycarbonyloxy groups, aryloxycarbonyloxy groups, amino groups (including anilino groups), acylamino groups, aminocarbonylamino groups, alkoxycarbonylamino groups, aryloxycarbonylamino groups, acyl groups, aryloxycarbonyl groups, alkoxycarbonyl groups, and carbamoyl groups.
- substituents include halogen atoms (e.g., chlorine, bromine, and iodine atoms); alkyl groups (which represent linear, branched, or cyclic substituted or unsubstituted alkyl groups, including alkyl groups (preferably alkyl groups having 1 to 30 carbon atoms, e.g., methyl, ethyl, n-propyl, isopropyl, t-butyl, n-octyl, eicosyl, 2-chloroethyl, 2-cyanoethyl, and 2-ethylhexyl), cycloalkyl groups (preferably substituted or unsubstituted cycloalkyl groups having 3 to 30 carbon atoms, e.g., cyclohexyl, cyclopentyl, and 4-n-dodecylcyclohexyl), bicycloalkyl groups (preferably substituted or unsubstituted
- alkynyl groups preferably substituted or unsubstituted alkynyl groups having 2 to 30 carbon atoms, e.g., ethynyl, propargyl, and trimethylsilylethynyl
- aryl groups preferably substituted or unsubstituted aryl groups having 6 to 30 carbon atoms, e.g., phenyl, p-tolyl, naphthyl, m-chlorophenyl, and o-hexadecanoylaminophenyl
- heterocyclic groups preferably monovalent groups derived by removing one hydrogen atom from 5- or 6-membered substituted or unsubstituted aromatic or nonaromatic heterocyclic compounds, more preferably 5- or 6-membered aromatic heterocyclic groups having 3 to 30 carbon atoms, e.g., 2-furanyl, 2-thienyl, 2-pyrimidinyl, and 2-benzothiazolinyl
- cyano groups
- amino groups preferably amino groups, substituted or unsubstituted alkylamino groups having 1 to 30 carbon atoms, and substituted or unsubstituted anilino groups having 6 to 30 carbon atoms, e.g., amino, methylamino, dimethylamino, anilino, N-methyl-anilino, and diphenylamino
- acylamino groups preferably formylamino groups, substituted or unsubstituted alkylcarbonylamino groups having 1 to 30 carbon atoms, and substituted or unsubstituted arylcarbonylamino groups having 6 to 30 carbon atoms, e.g., formylamino, acetylamino, pivaloylamino, lauroylamino, benzoylamino, and 3,4,5-tri-n-octyloxyphenylcarbonylamino); aminocarbonylamino groups (preferably substituted or unsubstituted aminocarbony
- alkylthio groups preferably substituted or unsubstituted alkylthio groups having 1 to 30 carbon atoms, e.g., methylthio, ethylthio, and n-hexadecylthio
- arylthio groups preferably substituted or unsubstituted arylthio groups having 6 to 30 carbon atoms, e.g., phenylthio, p-chlorophenylthio, and m-methoxyphenylthio
- heterocyclic thio groups preferably substituted or unsubstituted heterocyclic thio groups having 2 to 30 carbon atoms, e.g., 2-benzothiazolylthio and 1-phenyltetrazol-5-ylthio
- sulfamoyl groups preferably substituted or unsubstituted sulfamoyl groups having 0 to 30 carbon atoms, e.g., N-
- alkylsulfonyl and arylsulfonyl groups preferably substituted or unsubstituted alkylsulfonyl groups having 1 to 30 carbon atoms and substituted or unsubstituted arylsulfonyl groups having 6 to 30 carbon atoms, e.g., methylsulfonyl, ethylsulfonyl, phenylsulfonyl, and p-methylphenylsulfonyl
- acyl groups preferably formyl groups, substituted or unsubstituted alkylcarbonyl groups having 2 to 30 carbon atoms, substituted or unsubstituted arylcarbonyl groups having 7 to 30 carbon atoms, and substituted or unsubstituted heterocyclic carbonyl groups having 4 to 30 carbon atoms in which any of the carbon atoms is attached to the carbonyl group), e.g., acetyl, pivaloyl,
- carbamoyl groups (preferably substituted or unsubstituted carbamoyl groups having 1 to 30 carbon atoms, e.g., carbamoyl, N-methylcarbamoyl, N,N-dimethylcarbamoyl, N,N-di-n-octylcarbamoyl, and N-(methylsulfonyl)carbamoyl); arylazo and heterocyclic azo groups (preferably substituted or unsubstituted arylazo groups having 6 to 30 carbon atoms and substituted or unsubstituted heterocyclic azo groups having 3 to 30 carbon atoms, e.g., phenylazo, p-chlorophenylazo, and 5-ethylthio-1,3,4-thiadiazol-2-ylazo); imide groups (preferably N-succinimide and N-phthalimide); phosphino groups (preferably substituted or unsubstituted phosphino
- substituents those having hydrogen atoms may have their hydrogen atoms replaced by the above substituents.
- substituents include alkylcarbonylaminosulfonyl groups, arylcarbonylaminosulfonyl groups, alkylsulfonylaminocarbonyl groups, arylsulfonylaminocarbonyl groups, methylsulfonylaminocarbonyl groups, p-methylphenylsulfonylaminocarbonyl groups, acetylaminosulfonyl groups, and benzoylaminosulfonyl groups.
- the aryl groups represented by R 1 , R 2 , and R 3 represent substituted or unsubstituted aryl groups.
- the aryl groups have 6 to 50 carbon atoms, more preferably 6 to 30 carbon atoms, particularly preferably 6 to 20 carbon atoms.
- Preferred examples include phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-ethylphenyl, 4-ethylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 2,4,6-trimethylphenyl, 1-naphthyl, 2-naphthyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 2-benzylphenyl, 4-benzylphenyl, 2-methylcarbonylphenyl, and 4-methylcarbonylphenyl.
- the aryl groups represented by R 1 , R 2 , and R 3 are phenyl, 2-methylphenyl, 4-methylphenyl, 2-ethylphenyl, 4-ethylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 2,4,6-trimethylphenyl, 1-naphthyl, 2-naphthyl, 2-chlorophenyl, 4-chlorophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 2-benzylphenyl, or 4-benzylphenyl, particularly preferably phenyl.
- the above aryl groups represented by R 1 , R 2 , and R 3 may further have a substituent.
- substituents include the substituents listed above that the alkyl groups represented by R 1 , R 2 , and R 3 may have.
- the alkoxy groups represented by R 1 and R 2 represent linear, branched, or cyclic substituted or unsubstituted alkoxy groups.
- the alkoxy groups have 1 to 50 carbon atoms, more preferably 1 to 30 carbon atoms, particularly preferably 1 to 20 carbon atoms.
- Preferred examples include methoxy, ethoxy, n-propoxy, isopropoxy, cyclopropoxy, butoxy, isobutoxy, t-butoxy, s-butoxy, pentyloxy, isopentyloxy, neopentyloxy, t-pentyloxy, hexyloxy, cyclohexyloxy, heptyloxy, cyclopentyloxy, octyloxy, 2-ethylhexyloxy, nonyloxy, decyloxy, dodecyloxy, tetradecyloxy, hexadecyloxy, octadecyloxy, eicosyloxy, docosyloxy, and triacontyloxy, more preferably methoxy, ethoxy, n-propoxy, isopropoxy, butoxy, isobutoxy, t-butoxy, s-butoxy, pentyloxy, isopentyl
- the above alkoxy groups represented by R 1 and R 2 may further have a substituent.
- substituents include the substituents listed above that the alkyl groups represented by R 1 , R 2 , and R 3 may have.
- the aryloxy groups represented by R 1 and R 2 represent substituted or unsubstituted aryloxy groups.
- the aryloxy groups have 6 to 50 carbon atoms, more preferably 6 to 30 carbon atoms, particularly preferably 6 to 20 carbon atoms.
- Preferred examples include phenoxy, 2-methylphenoxy, 3-methylphenoxy, 4-methylphenoxy, 2-ethylphenoxy, 4-ethylphenoxy, 2,4-dimethylphenoxy, 2,4-di-t-butylphenoxy, 2,6-di-t-butylphenoxy, 2,6-dimethylphenoxy, 2,6-di-t-butyl-4-methylphenoxy, 2,4,6-trimethylphenoxy, 2,4,6-tri-t-butylphenoxy, 1-naphthyloxy, 2-naphthyloxy, 2-chlorophenoxy, 3-chlorophenoxy, 4-chlorophenoxy, 2-methoxyphenoxy, 3-methoxyphenoxy, 4-methoxyphenoxy, 2-benzylphenoxy, 4-benzylphenoxy, 2-methylcarbonylphenoxy, and 4-methylcarbonylphenoxy.
- More preferred examples include phenyl, 2,4-di-t-butylphenoxy, and 2,4,6-tri-t-butylphenoxy.
- the above aryloxy groups represented by R 1 and R 2 may further have a substituent.
- substituents include the substituents listed above that the alkyl groups represented by R 1 , R 2 , and R 3 may have.
- R 1 and R 2 be alkoxy groups or aryloxy groups
- R 3 be an alkyl group or an aryl group.
- divalent or higher-valent groups that serve as a linking group in the compound having a structure represented by general formula (1) include divalent or higher-valent groups derived by removing one or more hydrogen atoms from the substituents listed above for the alkyl groups represented by R 1 , R 2 , and R 3 (divalent groups if one hydrogen atom is removed from the substituents, or trivalent groups if two hydrogen atoms are removed from the substituents) and combinations thereof.
- These divalent or higher-valent groups are preferably divalent to hexavalent, more preferably divalent to tetravalent.
- the above divalent or higher-valent groups are preferably organic groups.
- the above divalent or higher-valent groups may further have a substituent.
- substituents include the substituents listed above that the alkyl groups represented by R 1 , R 2 , and R 3 may have.
- the above divalent or higher-valent groups preferably have a molecular weight of 10 to 1,000.
- Preferred of the above divalent or higher-valent groups and single bonds are single bonds and divalent or higher-valent groups derived by removing one or more hydrogen atoms from amino groups, alkyl groups, aryl groups, bis-aryl groups (arylaryl groups), arylalkylaryl groups, aryloxyaryl groups, alkoxyalkyl groups, alkoxyaryl groups, and alkylaryl groups.
- the compound having a structure represented by general formula (1) is a compound in which a plurality of structures represented by general formula (1) are present in one molecule, the compound preferably has, in one molecule, 2 to 20 phosphorus atoms, more preferably 2 to 10 phosphorus atoms, even more preferably 2 to 5 phosphorus atoms.
- the thioether-based antioxidant is preferably a compound having a structure represented by general formula (2): R 4 -S-R 5 general formula (2)
- R 4 and R 5 represent an alkyl group and may be linked to each other via a divalent or higher-valent group or a single bond.
- compounds having a structure represented by general formula (2) includes, in addition to compounds represented by general formula (2), compounds (iii) and (iv) below.
- compounds having a structure represented by general formula (2) are meant to include compounds represented by general formula (2) and compounds having a structure in which a plurality of structures represented by general formula (2) are present in one molecule.
- the alkyl groups represented by R 4 and R 5 represent linear, branched, or cyclic substituted or unsubstituted alkyl groups.
- the alkyl groups have 1 to 50 carbon atoms, more preferably 2 to 30 carbon atoms, particularly preferably 2 to 20 carbon atoms.
- Preferred examples include methyl, ethyl, n-propyl, isopropyl, cyclopropyl, butyl, isobutyl, t-butyl, s-butyl, pentyl, isopentyl, neopentyl, t-pentyl, hexyl, cyclohexyl, heptyl, cyclopentyl, octyl, 2-ethylhexyl, nonyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, eicosyl, docosyl, and triacontyl.
- substituents for the substituted alkyl groups represented by R 4 and R 5 include the substituents listed above that the alkyl groups represented by R 1 , R 2 , and R 3 in general formula (1) may have.
- alkoxycarbonylalkyl groups are preferred.
- the alkoxycarbonyl groups of the alkoxycarbonylalkyl groups preferably have 2 to 50 carbon atoms, more preferably 5 to 30 carbon atoms, particularly preferably 9 to 20 carbon atoms.
- the divalent or higher-valent group serving as a linking group in the compound having a structure represented by general formula (2) is similar to the divalent or higher-valent group described as a linking group in general formula (1) above, and a preferred range is also similar.
- the amount of the component (c) is preferably 0.15% to 4% by mass, more preferably 0.25% to 4% by mass, based on 100% by mass of all components forming the resin layer (A). If the amount of the component (c) is not less than the above lower limit, the bending durability can be further improved. On the other hand, if the amount of the component (c) is not more than the above upper limit, the bending hardness can be further improved.
- the resin layer (A) may include components other than the components (a) to (c) as long as they do not interfere with the advantages of the present invention.
- examples of such components include plasticizers, light stabilizers, lubricants, antistatic agents, release agents, and colorants (e.g., pigments and dyes).
- the flexible tube according to the present invention is preferably produced using a resin composition for covering a flexible tube substrate for an endoscope according to the present invention.
- the resin composition for covering a flexible tube substrate for an endoscope according to the present invention includes a thermoplastic resin (a) including at least one of a polyamide, a polyurethane, a polyester, a polystyrene, or an acrylic resin and having a tensile strength at 10% elongation of 10 MPa or more and a hindered amine compound (b) having a molecular weight of 500 or more.
- the resin composition for covering a flexible tube substrate for an endoscope according to the present invention can be prepared as usual.
- the amounts of the individual components (solid components) in the resin composition for covering a flexible tube substrate for an endoscope according to the present invention are the same as those in the flexible tube according to the present invention.
- an electronic endoscope for observation of an image of the condition of a subject captured using an imaging device has been described by way of example in the foregoing embodiment, the present invention is not limited thereto, but may also be applied to an endoscope for observation of the condition of a subject using an optical image guide.
- the flexible tube for an endoscope according to the present invention is not limited to endoscope applications, but can also be applied to a wide variety of endoscopic medical devices.
- the flexible tube according to the present invention can be applied to an endoscope equipped with a clip or wire at the distal end thereof or to a device equipped with a basket or brush and provides its superior effect.
- Endoscopic medical devices are meant to include a wide variety of flexible medical and diagnostic devices for introduction and use in a body, including medical devices having an endoscope as a basic structure, as described above, and remotely operated medical devices.
- Resin compositions were prepared by mixing together a thermoplastic resin (a), a hindered amine compound (b), and an antioxidant (c) in the amounts (in parts by mass) shown in Table 1 below.
- Each of the resin compositions was introduced into a twin-screw kneader (the trade name KZW15-30MG available from Technovel Corporation) in which the barrel temperature and the die temperature were set to a temperature 20°C above the melting point of the thermoplastic resin (a) and was kneaded at a screw rotational speed of 100 rpm.
- a molten resin strand ejected from the twin-screw kneader was cooled in a water bath and was then cut with a pelletizer to form a pelletized sample.
- This sample was compression-molded (at a pressure of 50 MPa) at a temperature 5°C above the melting point of the thermoplastic resin (a) to form a resin sheet having a length of 100 mm, a width of 100 mm, and a thickness of 2 mm.
- a pelletized sample prepared from the thermoplastic resin (a) alone in the same manner as above was compression-molded at a temperature 5°C above the melting point to obtain a resin sheet of the thermoplastic resin (a) having a length of 100 mm, a width of 100 mm, and a thickness of 2 mm.
- a No. 1 dumbbell-shaped specimen was cut out and was subjected to a tensile test in accordance with JIS K 6251:2017 to determine the strength at an elongation of 10% (the strength at which the length of the specimen was 44 mm when the specimen was stretched in the machine direction at a chuck-to-chuck distance of 40 mm).
- thermoplastic resin (a) Four resin sheets (thickness: 8 mm) of the thermoplastic resin (a) were stacked together, and the surface hardness was determined with a rubber hardness tester in accordance with JIS K 6253-3:2012.
- each of the pelletized samples prepared as described above and containing the components (a) to (c) was introduced into a single-screw extruder (the trade name Labo Plastomill model M available from Toyo Seiki Seisaku-sho, Ltd.) in which the barrel temperature and the die temperature were set to a temperature 20°C above the melting point of the thermoplastic resin (a).
- the ejection speed was set to 1 kg/hr, and the sample was ejected in a molten state from the die. The masses of the sample ejected during the period from 5 to 6 minutes and the period from 60 to 61 minutes upon starting of ejection were measured.
- Ejected mass fraction % mass g of sample ejected during period from 60 to 61 minutes upon starting of ejection / mass g of sample ejected during period from 5 to 6 minutes upon starting of ejection ⁇ 100
- Each of the pelletized samples prepared as described above and containing the components (a) to (c) was compression-molded at a temperature 5°C above the melting point to obtain a resin sheet having a length of 100 mm, a width of 100 mm, and a thickness of 4 mm.
- the resin sheet was then cut to obtain a test specimen having a length of 80 mm, a width of 10 mm, and a thickness of 4 mm.
- This test specimen was subjected to a bending test at a room temperature of 23°C and a test speed of 2 mm/min in accordance with JIS K 7171-1:2016 (Method A) to determine the flexural modulus of elasticity.
- the resulting flexural modulus of elasticity (MPa) was evaluated for bending hardness on the following evaluation scale, where "C" or higher is satisfactory in this test.
- the resulting flexible tube for an endoscope was repeatedly bent back and forth in the center in the longitudinal direction so as to be U-shaped with a radius of curvature of 5 cm.
- the number of bending cycles to peeling between the flexible tube substrate and the resin layer was evaluated on the following evaluation scale, where "C" or higher is satisfactory.
- test Example 3 Flexible tubes for endoscopes shown in FIG. 2 were produced as in Test Example 3.
- the resin layer was stripped from each of the flexible tube substrates, and a test specimen with a size of 1 cm ⁇ 10 cm was cut from the resin layer.
- This test specimen was subjected to lowtemperature plasma sterilization treatment on the advanced course of an STERRAD (registered trademark) NX (trade name, available from Johnson & Johnson). This sterilization treatment was performed 100 times for each test specimen. After testing (after hydrogen peroxide plasma treatment), the test specimen was dried at 23°C and 50% RH (relative humidity) for 24 hours and was then subjected to a tensile test with a TENSILON RTF-1210 universal material testing machine (trade name, available from A&D Company, Limited). The test specimen was evaluated on the following evaluation scale (an elongation of 100% means stretching to twice the original length), where "C" or higher is satisfactory in this test.
- test Example 4 Flexible tubes for endoscopes were produced as in Test Example 4.
- the resin layer was stripped from each of the flexible tube substrates, and a test specimen with a size of 1 cm ⁇ 10 cm was cut from the resin layer.
- This test specimen was subjected to hydrogen peroxide gas sterilization treatment with a V-PRO (registered trademark) 60 (trade name, available from Steris Inc.). This sterilization treatment was performed 100 times for each test specimen.
- the test specimen was dried at 23°C and 50% RH (relative humidity) for 24 hours and was then subjected to a tensile test with a TENSILON RTF-1210 universal material testing machine (trade name, available from A&D Company, Limited).
- the test specimen was evaluated on the following evaluation scale (an elongation of 100% means stretching to twice the original length), where "C" or higher is satisfactory in this test.
- Comparative Examples 1 to 6 which did not meet the requirements of the present invention, were unsatisfactory in terms of bending hardness, bending durability, or sterilization durability.
- the flexible tube for an endoscope that had a covering layer containing a polyolefin as a resin component was unsatisfactory in terms of bending durability even though it had a tensile strength at 10% elongation of 10 MPa or more.
- Examples 1 to 41 which met the requirements of the present invention, were satisfactory in all of the bending hardness, bending durability, and sterilization durability tests.
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018063153 | 2018-03-28 | ||
| PCT/JP2019/012609 WO2019189035A1 (ja) | 2018-03-28 | 2019-03-25 | 内視鏡用可撓管、内視鏡型医療機器及び内視鏡用可撓管基材被覆用樹脂組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3777642A1 true EP3777642A1 (de) | 2021-02-17 |
| EP3777642A4 EP3777642A4 (de) | 2021-05-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19777274.2A Pending EP3777642A4 (de) | 2018-03-28 | 2019-03-25 | Flexibler schlauch für ein endoskop, endoskopische medizinische vorrichtung und harzzusammensetzung zur abdeckung des basismaterials des flexiblen schlauches für ein endoskop |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11993697B2 (de) |
| EP (1) | EP3777642A4 (de) |
| JP (1) | JP6846571B2 (de) |
| CN (1) | CN111867440A (de) |
| WO (1) | WO2019189035A1 (de) |
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| CN115697175A (zh) | 2020-06-29 | 2023-02-03 | 富士胶片株式会社 | 内窥镜用挠性管、内窥镜型医疗器材、构成内窥镜用挠性管的被覆材料的制造方法及内窥镜用挠性管的制造方法 |
| CN115942896A (zh) * | 2020-06-29 | 2023-04-07 | 富士胶片株式会社 | 内窥镜用挠性管、内窥镜型医疗器械、及它们的制造方法 |
| JPWO2022004658A1 (de) * | 2020-06-29 | 2022-01-06 | ||
| WO2022004659A1 (ja) * | 2020-06-29 | 2022-01-06 | 富士フイルム株式会社 | 内視鏡用可撓管、内視鏡型医療機器、及び内視鏡用可撓管基材被覆用材料 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7930782B2 (en) * | 1994-04-19 | 2011-04-26 | Applied Elastomerics, Inc. | Gels, gel composites, and gel articles |
| JP3947943B2 (ja) | 1997-09-22 | 2007-07-25 | 東洋紡績株式会社 | 熱可塑性ポリエステルエラストマー樹脂組成物及びその製造法 |
| WO2010003809A2 (en) | 2008-07-11 | 2010-01-14 | Basf Se | Liquid oxyalkylene bridged bis- and tris-phosphite ester mixtures |
| US20110028621A1 (en) * | 2009-07-30 | 2011-02-03 | E. I. Du Pont De Nemours And Company | Heat aging resistant polyamide compositions including polyhydroxy polymers |
| JP6047440B2 (ja) | 2013-03-27 | 2016-12-21 | 富士フイルム株式会社 | 内視鏡用可撓管およびその製造方法 |
| JP5991951B2 (ja) | 2013-07-12 | 2016-09-14 | 富士フイルム株式会社 | 内視鏡用可撓管および内視鏡型医療機器 |
| EP2980466B1 (de) * | 2013-03-27 | 2019-01-09 | FUJIFILM Corporation | Schlauch für endoskope und verfahren zur herstellung davon |
| EP2896635B1 (de) * | 2014-01-17 | 2018-05-23 | Fujifilm Corporation | Beweglicher Schlauch, medizinische Endoskopvorrichtung und Harzzusammensetzung für Deckschicht |
| JP6329804B2 (ja) * | 2014-04-07 | 2018-05-23 | 富士フイルム株式会社 | 可撓管、これを用いた内視鏡型医療機器、その接着剤、可撓管および内視鏡型医療機器の製造方法 |
| JP6110827B2 (ja) * | 2014-09-29 | 2017-04-05 | 富士フイルム株式会社 | 内視鏡用可撓管、内視鏡用接着剤、内視鏡型医療機器、ならびに内視鏡用可撓管および内視鏡型医療機器の製造方法 |
| JP6226494B2 (ja) | 2016-08-16 | 2017-11-08 | 富士フイルム株式会社 | 内視鏡用可撓管および内視鏡型医療機器 |
| JP6811579B2 (ja) | 2016-10-18 | 2021-01-13 | 株式会社岩黒製作所 | 押圧装置、スリット形成装置及び刻印装置 |
| CN110709000B (zh) * | 2017-06-30 | 2021-11-12 | 富士胶片株式会社 | 内窥镜型医疗器械、内窥镜用挠性管及其基材包覆用树脂组合物及该包覆用树脂组合物的组 |
| CN110769735B (zh) | 2017-06-30 | 2022-01-11 | 富士胶片株式会社 | 挠性管、医疗器械、挠性管基材包覆用树脂组合物及其组 |
-
2019
- 2019-03-25 WO PCT/JP2019/012609 patent/WO2019189035A1/ja unknown
- 2019-03-25 EP EP19777274.2A patent/EP3777642A4/de active Pending
- 2019-03-25 CN CN201980019439.XA patent/CN111867440A/zh active Pending
- 2019-03-25 JP JP2020510829A patent/JP6846571B2/ja active Active
-
2020
- 2020-09-16 US US17/022,662 patent/US11993697B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200405918A1 (en) | 2020-12-31 |
| JPWO2019189035A1 (ja) | 2020-12-03 |
| US11993697B2 (en) | 2024-05-28 |
| CN111867440A (zh) | 2020-10-30 |
| WO2019189035A1 (ja) | 2019-10-03 |
| EP3777642A4 (de) | 2021-05-26 |
| JP6846571B2 (ja) | 2021-03-24 |
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