EP3728107A4 - MICROFLUIDIC CHIP DEVICE FOR OPTICAL FORCE MEASUREMENTS AND CELL IMAGING USING MICROFLUIDIC CHIP CONFIGURATION AND DYNAMICS - Google Patents

MICROFLUIDIC CHIP DEVICE FOR OPTICAL FORCE MEASUREMENTS AND CELL IMAGING USING MICROFLUIDIC CHIP CONFIGURATION AND DYNAMICS Download PDF

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Publication number
EP3728107A4
EP3728107A4 EP17935210.9A EP17935210A EP3728107A4 EP 3728107 A4 EP3728107 A4 EP 3728107A4 EP 17935210 A EP17935210 A EP 17935210A EP 3728107 A4 EP3728107 A4 EP 3728107A4
Authority
EP
European Patent Office
Prior art keywords
microfluidic chip
dynamics
cell imaging
force measurements
optical force
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17935210.9A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3728107A1 (en
Inventor
Sean Hart
Colin HEBERT
Christopher Field
Shweta KRISHNAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumacyte LLC
Original Assignee
Lumacyte LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumacyte LLC filed Critical Lumacyte LLC
Publication of EP3728107A1 publication Critical patent/EP3728107A1/en
Publication of EP3728107A4 publication Critical patent/EP3728107A4/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP17935210.9A 2017-12-23 2017-12-23 MICROFLUIDIC CHIP DEVICE FOR OPTICAL FORCE MEASUREMENTS AND CELL IMAGING USING MICROFLUIDIC CHIP CONFIGURATION AND DYNAMICS Pending EP3728107A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2017/068373 WO2019125502A1 (en) 2017-12-23 2017-12-23 Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics

Publications (2)

Publication Number Publication Date
EP3728107A1 EP3728107A1 (en) 2020-10-28
EP3728107A4 true EP3728107A4 (en) 2021-08-04

Family

ID=66995019

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17935210.9A Pending EP3728107A4 (en) 2017-12-23 2017-12-23 MICROFLUIDIC CHIP DEVICE FOR OPTICAL FORCE MEASUREMENTS AND CELL IMAGING USING MICROFLUIDIC CHIP CONFIGURATION AND DYNAMICS

Country Status (12)

Country Link
EP (1) EP3728107A4 (pt)
JP (2) JP7390305B2 (pt)
KR (2) KR20230157541A (pt)
CN (1) CN111819153B (pt)
AU (2) AU2017443695B2 (pt)
BR (1) BR112020012748A2 (pt)
CA (1) CA3086498A1 (pt)
GB (1) GB2584218A (pt)
MX (1) MX2020007182A (pt)
RU (1) RU2764676C1 (pt)
SG (1) SG11202005872XA (pt)
WO (1) WO2019125502A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102656008B1 (ko) * 2020-09-08 2024-04-11 경북대학교 산학협력단 질병 진단용 키트, 질병 진단용 키트를 이용한 질병 진단 방법 및 질병 진단용 키트의 제조 방법
CN112986063B (zh) * 2021-01-18 2022-04-15 西北大学 高通量染色体和细胞骨架应变流式分析仪及实施方法
CN114088588B (zh) * 2021-10-27 2024-04-09 西安理工大学 一种基于无透镜成像的红细胞三维尺寸测量方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US20050002025A1 (en) * 2003-05-15 2005-01-06 Toshiba Ceramics Co., Ltd. Channel structure and process for production thereof
US20090032449A1 (en) * 2002-07-31 2009-02-05 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US20160369337A1 (en) * 2007-02-05 2016-12-22 Intelligent Biosystems, Inc. Detection device and methods of use

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5768545U (pt) * 1980-10-15 1982-04-24
JPS63241337A (ja) * 1986-11-07 1988-10-06 Hitachi Ltd 光度計用フローセル
US5214593A (en) * 1990-11-07 1993-05-25 Rainin Instrument Co., Inc. Method and apparatus for extending the linear dynamic range of absorbance detectors including multi-lightpath flow cells
US5184192A (en) * 1991-07-17 1993-02-02 Millipore Corporation Photometric apparatus with a flow cell coated with an amorphous fluoropolymer
US6778724B2 (en) * 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
JP3910118B2 (ja) * 2002-08-05 2007-04-25 株式会社プラントテクノス 液中粒子の画像解析装置
JP4119217B2 (ja) 2002-10-10 2008-07-16 財団法人川村理化学研究所 マイクロ流体素子、流体処理デバイス、および流体処理方法
CN2662247Y (zh) 2003-04-25 2004-12-08 谭玉山 基于白光反射干涉频谱变化规律的光纤阵列生物芯片
FR2882939B1 (fr) * 2005-03-11 2007-06-08 Centre Nat Rech Scient Dispositif de separation fluidique
EP1889034A1 (en) 2005-05-24 2008-02-20 Agilent Technologies, Inc. Multi-path flow cell correction
WO2007021809A2 (en) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic systems, devices and methods for reducing background autofluorescence and the effects thereof
JP2007148981A (ja) * 2005-11-30 2007-06-14 Univ Waseda 微粒子分別マイクロシステムおよび微粒子分別方法
JP2008191119A (ja) * 2007-02-08 2008-08-21 Citizen Holdings Co Ltd 流体試料用フローセル
JP4064445B1 (ja) 2007-10-26 2008-03-19 リオン株式会社 粒子測定装置
US9594071B2 (en) 2007-12-21 2017-03-14 Colin G. Hebert Device and method for laser analysis and separation (LAS) of particles
US10281385B2 (en) * 2007-12-21 2019-05-07 The United States Of America, As Represented By The Secretary Of The Navy Device for laser analysis and separation (LAS) of particles
RU2380418C1 (ru) * 2008-10-01 2010-01-27 Учреждение Российской академии наук Институт молекулярной биологии им. В.А. Энгельгардта РАН Сменный микрофлюидный модуль для автоматизированного выделения и очистки нуклеиновых кислот из биологических образцов и способ выделения и очистки нуклеиновых кислот с его использованием
JP5901121B2 (ja) 2011-02-16 2016-04-06 キヤノン株式会社 流路デバイス、及び該流路デバイスを用いた液体の搬送方法
KR20130113207A (ko) * 2012-04-05 2013-10-15 삼성전자주식회사 타겟 물질 포획용 필터
AU2013284286A1 (en) * 2012-06-29 2015-02-05 University Of South Australia Fluid connection ports
RU2510509C1 (ru) * 2012-07-16 2014-03-27 Федеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук Микрофлюидная система для проведения иммуноанализа
US20140193892A1 (en) * 2012-07-25 2014-07-10 Theranos, Inc. Image analysis and measurement of biological samples
JP2014032098A (ja) 2012-08-03 2014-02-20 Hitachi High-Technologies Corp 液体クロマトグラフ分析装置
US9529203B2 (en) * 2012-09-17 2016-12-27 Cytonome/St, Llc Focal plane shifting system
US9731293B2 (en) 2012-10-03 2017-08-15 The United States Of America, As Represented By The Secretary Of The Navy Paired laser and electrokinetic separation, manipulation, and analysis device
US20150306598A1 (en) * 2014-04-25 2015-10-29 Berkeley Lights, Inc. DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus
CN103926190A (zh) * 2014-05-08 2014-07-16 齐鲁工业大学 基于微流控系统的单细胞自动分析方法
JP6332098B2 (ja) 2015-03-25 2018-05-30 株式会社島津製作所 フローセル
JP6713730B2 (ja) * 2015-05-20 2020-06-24 シスメックス株式会社 細胞検出装置および細胞検出方法
CN105738331B (zh) * 2016-01-29 2019-07-23 山东师范大学 一种用于单细胞电泳芯片的双激光诱导荧光多色检测器

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US20090032449A1 (en) * 2002-07-31 2009-02-05 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
US20050002025A1 (en) * 2003-05-15 2005-01-06 Toshiba Ceramics Co., Ltd. Channel structure and process for production thereof
US20160369337A1 (en) * 2007-02-05 2016-12-22 Intelligent Biosystems, Inc. Detection device and methods of use

Also Published As

Publication number Publication date
JP2021515239A (ja) 2021-06-17
AU2017443695B2 (en) 2023-09-28
GB202011401D0 (en) 2020-09-09
RU2764676C1 (ru) 2022-01-19
GB2584218A (en) 2020-11-25
AU2023286012A1 (en) 2024-01-25
CN111819153A (zh) 2020-10-23
KR102602599B1 (ko) 2023-11-16
CA3086498A1 (en) 2019-06-27
KR20200104354A (ko) 2020-09-03
JP2024020465A (ja) 2024-02-14
JP7390305B2 (ja) 2023-12-01
SG11202005872XA (en) 2020-07-29
CN111819153B (zh) 2024-08-30
MX2020007182A (es) 2020-08-24
KR20230157541A (ko) 2023-11-16
EP3728107A1 (en) 2020-10-28
WO2019125502A1 (en) 2019-06-27
BR112020012748A2 (pt) 2020-12-01
AU2017443695A1 (en) 2020-07-09

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