EP3580597A4 - Optics, device, and system for assaying - Google Patents

Optics, device, and system for assaying Download PDF

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Publication number
EP3580597A4
EP3580597A4 EP18751754.5A EP18751754A EP3580597A4 EP 3580597 A4 EP3580597 A4 EP 3580597A4 EP 18751754 A EP18751754 A EP 18751754A EP 3580597 A4 EP3580597 A4 EP 3580597A4
Authority
EP
European Patent Office
Prior art keywords
assaying
optics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18751754.5A
Other languages
German (de)
French (fr)
Other versions
EP3580597A2 (en
Inventor
Stephen Y. Chou
Wei Ding
Ji QI
Jun Tian
Yufan ZHANG
Wei Dong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Essenlix Corp
Original Assignee
Essenlix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Essenlix Corp filed Critical Essenlix Corp
Publication of EP3580597A2 publication Critical patent/EP3580597A2/en
Publication of EP3580597A4 publication Critical patent/EP3580597A4/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/0008—Microscopes having a simple construction, e.g. portable microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/12—Condensers affording bright-field illumination
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
    • G02B7/02—Mountings, adjusting means, or light-tight connections, for optical elements for lenses
    • G02B7/023—Mountings, adjusting means, or light-tight connections, for optical elements for lenses permitting adjustment
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/51—Housings
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/50—Constructional details
    • H04N23/55—Optical parts specially adapted for electronic image sensors; Mounting thereof
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/56—Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/57—Mechanical or electrical details of cameras or camera modules specially adapted for being embedded in other devices
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/60—Control of cameras or camera modules
    • H04N23/67—Focus control based on electronic image sensor signals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
EP18751754.5A 2017-02-08 2018-02-08 Optics, device, and system for assaying Pending EP3580597A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762456590P 2017-02-08 2017-02-08
US201762456504P 2017-02-08 2017-02-08
US201762456598P 2017-02-08 2017-02-08
US201762457133P 2017-02-09 2017-02-09
US201762456904P 2017-02-09 2017-02-09
US201762459554P 2017-02-15 2017-02-15
US201762460075P 2017-02-16 2017-02-16
US201762460062P 2017-02-16 2017-02-16
PCT/US2018/017504 WO2018148471A2 (en) 2017-02-08 2018-02-08 Optics, device, and system for assaying

Publications (2)

Publication Number Publication Date
EP3580597A2 EP3580597A2 (en) 2019-12-18
EP3580597A4 true EP3580597A4 (en) 2021-05-05

Family

ID=63107057

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18751754.5A Pending EP3580597A4 (en) 2017-02-08 2018-02-08 Optics, device, and system for assaying

Country Status (5)

Country Link
EP (1) EP3580597A4 (en)
JP (1) JP7177073B2 (en)
CN (2) CN116794819A (en)
CA (1) CA3053009A1 (en)
WO (1) WO2018148471A2 (en)

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FI3901281T3 (en) 2015-04-10 2023-01-31 Spatially distinguished, multiplex nucleic acid analysis of biological specimens
WO2020047177A1 (en) * 2018-08-28 2020-03-05 Essenlix Corporation Assay accuracy improvement
USD898221S1 (en) 2018-11-15 2020-10-06 Essenlix Corporation Assay plate
USD897555S1 (en) 2018-11-15 2020-09-29 Essenlix Corporation Assay card
USD898224S1 (en) 2018-11-15 2020-10-06 Essenlix Corporation Assay plate with sample landing mark
USD898939S1 (en) 2018-11-20 2020-10-13 Essenlix Corporation Assay plate with sample landing mark
USD910202S1 (en) 2018-11-21 2021-02-09 Essenlix Corporation Assay plate with sample landing mark
USD893469S1 (en) 2018-11-21 2020-08-18 Essenlix Corporation Phone holder
USD910203S1 (en) 2018-11-27 2021-02-09 Essenlix Corporation Assay plate with sample landing mark
USD893470S1 (en) 2018-11-28 2020-08-18 Essenlix Corporation Phone holder
USD912842S1 (en) 2018-11-29 2021-03-09 Essenlix Corporation Assay plate
EP3894587A1 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Resolving spatial arrays by proximity-based deconvolution
USD898222S1 (en) 2019-01-18 2020-10-06 Essenlix Corporation Assay card
CN110297322A (en) * 2019-01-21 2019-10-01 福鼎市一雄光学仪器有限公司 The mobile phone high definition close-shot enlarging lens device of built-in fiber illumination
CN111289443A (en) * 2019-07-03 2020-06-16 无锡市人民医院 Drainage liquid colorimetric card convenient for recycling and colorimetric method thereof
WO2021003518A1 (en) * 2019-07-11 2021-01-14 Sensibility Pty Ltd Machine learning based phone imaging system and analysis method
US20220276235A1 (en) * 2019-07-18 2022-09-01 Essenlix Corporation Imaging based homogeneous assay
EP3798614A1 (en) * 2019-09-30 2021-03-31 IAssay, Inc. Modular multiplex analysis devices and platforms
GB201918948D0 (en) 2019-12-20 2020-02-05 Oxford Immune Algorithmics Ltd Portable device for imaging biological sample
CN113155555B (en) * 2020-01-23 2023-04-11 天津市政工程设计研究总院有限公司 Manufacturing method of magnesium alloy model for simulating concrete pipe gallery
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
EP4414459A3 (en) 2020-05-22 2024-09-18 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
AU2021288090A1 (en) * 2020-06-10 2023-01-19 10X Genomics, Inc. Fluid delivery methods
US20220020481A1 (en) 2020-07-20 2022-01-20 Abbott Laboratories Digital pass verification systems and methods
WO2022043998A1 (en) * 2020-08-23 2022-03-03 My-Or Diagnostics Ltd. Apparatus and method for determining hemoglobin levels
EP4213993A2 (en) * 2020-09-18 2023-07-26 10X Genomics, Inc. Sample handling apparatus and fluid delivery methods
CN112276370B (en) * 2020-11-27 2021-10-08 华中科技大学 Three-dimensional code laser marking method and system based on spatial light modulator
WO2022119459A1 (en) * 2020-12-03 2022-06-09 Pictor Limited Device and method of analyte detection
AU2021409136A1 (en) 2020-12-21 2023-06-29 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
EP4275087A1 (en) * 2021-01-06 2023-11-15 Scopgenx Private Limited A compact portable multimodal microscopy
US20240151737A1 (en) * 2021-02-18 2024-05-09 Peek Technologies, Inc. Configurable diagnostic platform systems and methods for performing chemical test assays
WO2022178267A2 (en) 2021-02-19 2022-08-25 10X Genomics, Inc. Modular assay support devices
EP4347879A1 (en) 2021-06-03 2024-04-10 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
CN113984759B (en) * 2021-09-24 2023-12-12 暨南大学 Optical instant detection system and body fluid slide crystallization and detection method
WO2024092682A1 (en) * 2022-11-04 2024-05-10 深圳华大智造科技股份有限公司 Optical system and detection method

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US20130300919A1 (en) * 2008-01-02 2013-11-14 The Regents Of The University Of California Cellscope apparatus and methods for imaging
US20120157160A1 (en) * 2010-12-21 2012-06-21 The Regents Of The University Of California Compact wide-field fluorescent imaging on a mobile device
US20160004057A1 (en) * 2014-07-07 2016-01-07 Aidmics Biotechnology Co., Ltd. Portable microscope device
US20170032206A1 (en) * 2015-07-30 2017-02-02 Fuji Xerox Co., Ltd. Unit for photographing and photographing system

Also Published As

Publication number Publication date
WO2018148471A3 (en) 2018-10-04
WO2018148471A2 (en) 2018-08-16
JP2020509403A (en) 2020-03-26
CN111465882A (en) 2020-07-28
CN111465882B (en) 2023-05-26
CA3053009A1 (en) 2018-08-16
JP7177073B2 (en) 2022-11-22
CN116794819A (en) 2023-09-22
EP3580597A2 (en) 2019-12-18

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