GB202011401D0 - Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics - Google Patents

Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics

Info

Publication number
GB202011401D0
GB202011401D0 GBGB2011401.3A GB202011401A GB202011401D0 GB 202011401 D0 GB202011401 D0 GB 202011401D0 GB 202011401 A GB202011401 A GB 202011401A GB 202011401 D0 GB202011401 D0 GB 202011401D0
Authority
GB
United Kingdom
Prior art keywords
microfluidic chip
dynamics
cell imaging
force measurements
optical force
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GBGB2011401.3A
Other versions
GB2584218A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumacyte LLC
Original Assignee
Lumacyte LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumacyte LLC filed Critical Lumacyte LLC
Publication of GB202011401D0 publication Critical patent/GB202011401D0/en
Publication of GB2584218A publication Critical patent/GB2584218A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Computer Hardware Design (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
GB2011401.3A 2017-12-23 2017-12-23 Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics Withdrawn GB2584218A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2017/068373 WO2019125502A1 (en) 2017-12-23 2017-12-23 Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics

Publications (2)

Publication Number Publication Date
GB202011401D0 true GB202011401D0 (en) 2020-09-09
GB2584218A GB2584218A (en) 2020-11-25

Family

ID=66995019

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2011401.3A Withdrawn GB2584218A (en) 2017-12-23 2017-12-23 Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics

Country Status (12)

Country Link
EP (1) EP3728107A4 (en)
JP (2) JP7390305B2 (en)
KR (2) KR20230157541A (en)
CN (1) CN111819153B (en)
AU (2) AU2017443695B2 (en)
BR (1) BR112020012748A2 (en)
CA (1) CA3086498A1 (en)
GB (1) GB2584218A (en)
MX (1) MX2020007182A (en)
RU (1) RU2764676C1 (en)
SG (1) SG11202005872XA (en)
WO (1) WO2019125502A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102656008B1 (en) * 2020-09-08 2024-04-11 경북대학교 산학협력단 Disease diagnosis kit, disease diagnosis method using the disease diagnosis kit and method for manufacturing the disease diagnosis kit
CN112986063B (en) * 2021-01-18 2022-04-15 西北大学 High-throughput chromosome and cytoskeleton strain flow analyzer and implementation method
CN114088588B (en) * 2021-10-27 2024-04-09 西安理工大学 Three-dimensional red blood cell size measuring method based on lens-free imaging

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5768545U (en) * 1980-10-15 1982-04-24
JPS63241337A (en) * 1986-11-07 1988-10-06 Hitachi Ltd Flow cell for photometer
US5214593A (en) * 1990-11-07 1993-05-25 Rainin Instrument Co., Inc. Method and apparatus for extending the linear dynamic range of absorbance detectors including multi-lightpath flow cells
US5184192A (en) * 1991-07-17 1993-02-02 Millipore Corporation Photometric apparatus with a flow cell coated with an amorphous fluoropolymer
US6167910B1 (en) * 1998-01-20 2001-01-02 Caliper Technologies Corp. Multi-layer microfluidic devices
US6778724B2 (en) * 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US7699767B2 (en) * 2002-07-31 2010-04-20 Arryx, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
JP3910118B2 (en) * 2002-08-05 2007-04-25 株式会社プラントテクノス Liquid particle image analyzer
JP4119217B2 (en) 2002-10-10 2008-07-16 財団法人川村理化学研究所 Microfluidic device, fluid processing device, and fluid processing method
CN2662247Y (en) 2003-04-25 2004-12-08 谭玉山 Optical fibre array biochip based on transformation rule of white light reflection interference frequency spectrum
US20050002025A1 (en) * 2003-05-15 2005-01-06 Toshiba Ceramics Co., Ltd. Channel structure and process for production thereof
FR2882939B1 (en) * 2005-03-11 2007-06-08 Centre Nat Rech Scient FLUIDIC SEPARATION DEVICE
EP1889034A1 (en) 2005-05-24 2008-02-20 Agilent Technologies, Inc. Multi-path flow cell correction
WO2007021809A2 (en) * 2005-08-11 2007-02-22 Eksigent Technologies, Llc Microfluidic systems, devices and methods for reducing background autofluorescence and the effects thereof
JP2007148981A (en) * 2005-11-30 2007-06-14 Univ Waseda Particle sorting microsystem and particle sorting method
GB2458855B (en) * 2007-02-05 2011-06-08 Intelligent Bio Systems Inc A system for imaging treated bio-molecules in a flow-cell using a non-lasing light source
JP2008191119A (en) * 2007-02-08 2008-08-21 Citizen Holdings Co Ltd Flow cell for fluid sample
JP4064445B1 (en) 2007-10-26 2008-03-19 リオン株式会社 Particle measuring device
US9594071B2 (en) 2007-12-21 2017-03-14 Colin G. Hebert Device and method for laser analysis and separation (LAS) of particles
US10281385B2 (en) * 2007-12-21 2019-05-07 The United States Of America, As Represented By The Secretary Of The Navy Device for laser analysis and separation (LAS) of particles
RU2380418C1 (en) * 2008-10-01 2010-01-27 Учреждение Российской академии наук Институт молекулярной биологии им. В.А. Энгельгардта РАН Replaceable microfluid module for automated recovery and purification of nucleic acids from biological samples and method for recovery and purification nucleic acids with using thereof
JP5901121B2 (en) 2011-02-16 2016-04-06 キヤノン株式会社 Flow path device and liquid transfer method using the flow path device
KR20130113207A (en) * 2012-04-05 2013-10-15 삼성전자주식회사 Filter for capturing target material
AU2013284286A1 (en) * 2012-06-29 2015-02-05 University Of South Australia Fluid connection ports
RU2510509C1 (en) * 2012-07-16 2014-03-27 Федеральное государственное бюджетное учреждение науки Институт цитологии и генетики Сибирского отделения Российской академии наук Microfluid system for immunoassay
US20140193892A1 (en) * 2012-07-25 2014-07-10 Theranos, Inc. Image analysis and measurement of biological samples
JP2014032098A (en) 2012-08-03 2014-02-20 Hitachi High-Technologies Corp Liquid chromatographic analysis device
US9529203B2 (en) * 2012-09-17 2016-12-27 Cytonome/St, Llc Focal plane shifting system
US9731293B2 (en) 2012-10-03 2017-08-15 The United States Of America, As Represented By The Secretary Of The Navy Paired laser and electrokinetic separation, manipulation, and analysis device
US20150306598A1 (en) * 2014-04-25 2015-10-29 Berkeley Lights, Inc. DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus
CN103926190A (en) * 2014-05-08 2014-07-16 齐鲁工业大学 Automatic single cell analysis method based on microfluidic system
JP6332098B2 (en) 2015-03-25 2018-05-30 株式会社島津製作所 Flow cell
JP6713730B2 (en) * 2015-05-20 2020-06-24 シスメックス株式会社 Cell detection device and cell detection method
CN105738331B (en) * 2016-01-29 2019-07-23 山东师范大学 A kind of bidifly light induced fluorescence polychrome detector for Single-cell electrophoresis chip

Also Published As

Publication number Publication date
JP2021515239A (en) 2021-06-17
AU2017443695B2 (en) 2023-09-28
RU2764676C1 (en) 2022-01-19
GB2584218A (en) 2020-11-25
AU2023286012A1 (en) 2024-01-25
CN111819153A (en) 2020-10-23
KR102602599B1 (en) 2023-11-16
CA3086498A1 (en) 2019-06-27
KR20200104354A (en) 2020-09-03
JP2024020465A (en) 2024-02-14
JP7390305B2 (en) 2023-12-01
SG11202005872XA (en) 2020-07-29
CN111819153B (en) 2024-08-30
MX2020007182A (en) 2020-08-24
KR20230157541A (en) 2023-11-16
EP3728107A1 (en) 2020-10-28
WO2019125502A1 (en) 2019-06-27
BR112020012748A2 (en) 2020-12-01
EP3728107A4 (en) 2021-08-04
AU2017443695A1 (en) 2020-07-09

Similar Documents

Publication Publication Date Title
EP3439039A4 (en) Imaging element and imaging device
EP3439289A4 (en) Imaging element and imaging device
EP3400062A4 (en) Device and system for personal uv exposure measurements
HK1257848A1 (en) Blood-sugar-level measurement reagent, blood-sugar-level measurement chip, and blood-sugar-level measurement device set
EP3255473A4 (en) Imaging lens and imaging device
PL3392931T3 (en) Separator for electrochemical device and electrochemical device including the same
IL268481B1 (en) Size measurement device and size measurement system
SG11201707285TA (en) Semiconductor device and image sensor module
EP3591454A4 (en) Optical module and distance measurement device
EP3565468A4 (en) Force measurement device
EP3693453C0 (en) Cell capturing device
EP3252514A4 (en) Imaging lens, imaging device using same, and distance measuring system
EP3092788A4 (en) Imaging module and imaging device
HUE040364T2 (en) Holding device for an optical measurement device
EP3203243A4 (en) Component measurement device and measurement chip
GB202011401D0 (en) Microfluidic chip device for optical force measurements and cell imaging using microfluidic chip configuration and dynamics
HK1254981A1 (en) Transfer and weighing device
GB201407922D0 (en) Lens array and imaging device
FR3045851B1 (en) DEVICE FOR HOLDING AND RELEASING APPENDICES
EP3875575C0 (en) Micro-fluid chip and micro-fluid device
IL265705A (en) Optical imaging device and cap
EP3435658A4 (en) Imaging element and imaging device
EP3708531A4 (en) Microfluidic chip and microfluidic device
IL254613A0 (en) Optical imaging device and cap
EP3484146A4 (en) Imaging element and imaging device

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)