EP3724166A1 - Procédé de fabrication d'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase de type 1 - Google Patents

Procédé de fabrication d'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase de type 1

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Publication number
EP3724166A1
EP3724166A1 EP18829243.7A EP18829243A EP3724166A1 EP 3724166 A1 EP3724166 A1 EP 3724166A1 EP 18829243 A EP18829243 A EP 18829243A EP 3724166 A1 EP3724166 A1 EP 3724166A1
Authority
EP
European Patent Office
Prior art keywords
compound
formula
range
organic solvent
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18829243.7A
Other languages
German (de)
English (en)
Inventor
Piero GEOTTI-BIANCHINI
Katalin GYERGYÓI
Marc-Matthias HEIDL
András Szabó
Stefánia SZÜCSNÉ CSERÉPI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
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Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of EP3724166A1 publication Critical patent/EP3724166A1/fr
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé de fabrication d'un composé de formule (I) dans laquelle Y est CHR7, CR7R8 ou O, n vaut 0, 1 ou 2, R1 et R2 sont indépendamment l'un de l'autre choisis dans le groupe constitué par H, F, Cl, méthyle et éthyle, et R3, R4, R5, R6, R7 et R8 sont indépendamment l'un de l'autre choisis parmi H ou un alkyle en C1-C6. Les composés de formule (I) sont des inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase de type 1 et peuvent être utilisés pour réduire les taux de cortisol dans les kératinocytes et pour améliorer la teneur en collagène dermique dans la peau humaine après exposition à la cortisone et aux UV.
EP18829243.7A 2017-12-12 2018-12-11 Procédé de fabrication d'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase de type 1 Withdrawn EP3724166A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17206574 2017-12-12
EP18171625 2018-05-09
PCT/EP2018/084367 WO2019115531A1 (fr) 2017-12-12 2018-12-11 Procédé de fabrication d'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase de type 1

Publications (1)

Publication Number Publication Date
EP3724166A1 true EP3724166A1 (fr) 2020-10-21

Family

ID=64901992

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18829243.7A Withdrawn EP3724166A1 (fr) 2017-12-12 2018-12-11 Procédé de fabrication d'inhibiteurs de 11-bêta-hydroxystéroïde déshydrogénase de type 1

Country Status (3)

Country Link
EP (1) EP3724166A1 (fr)
CN (1) CN111433189A (fr)
WO (1) WO2019115531A1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6874250B2 (ja) 2015-07-23 2021-05-19 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 新規な選択的１１−ベータ−ヒドロキシステロイド脱水素酵素１型

Also Published As

Publication number Publication date
WO2019115531A1 (fr) 2019-06-20
CN111433189A (zh) 2020-07-17

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