EP3675840A4 - USE OF INHALED NITRIC OXIDE FOR IMPROVEMENT OF RIGHT AND / OR LEFT VENTRICULAR FUNCTION - Google Patents

USE OF INHALED NITRIC OXIDE FOR IMPROVEMENT OF RIGHT AND / OR LEFT VENTRICULAR FUNCTION Download PDF

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Publication number
EP3675840A4
EP3675840A4 EP18851496.2A EP18851496A EP3675840A4 EP 3675840 A4 EP3675840 A4 EP 3675840A4 EP 18851496 A EP18851496 A EP 18851496A EP 3675840 A4 EP3675840 A4 EP 3675840A4
Authority
EP
European Patent Office
Prior art keywords
improvement
nitric oxide
left ventricular
ventricular function
inhaled nitric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18851496.2A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3675840A1 (en
Inventor
Deborah Quinn
Parag Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bellerophon Pulse Technologies LLC
Original Assignee
Bellerophon Pulse Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bellerophon Pulse Technologies LLC filed Critical Bellerophon Pulse Technologies LLC
Publication of EP3675840A1 publication Critical patent/EP3675840A1/en
Publication of EP3675840A4 publication Critical patent/EP3675840A4/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1025—Respiratory system
    • A61M2210/1039—Lungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A61M2210/125—Heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/30—Blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EP18851496.2A 2017-08-30 2018-08-29 USE OF INHALED NITRIC OXIDE FOR IMPROVEMENT OF RIGHT AND / OR LEFT VENTRICULAR FUNCTION Withdrawn EP3675840A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762552022P 2017-08-30 2017-08-30
US201762611325P 2017-12-28 2017-12-28
PCT/US2018/048524 WO2019046413A1 (en) 2017-08-30 2018-08-29 USE OF INHALED NITRIC OXIDE FOR ENHANCED RIGHT AND / OR LEFT VENTRICULAR FUNCTION

Publications (2)

Publication Number Publication Date
EP3675840A1 EP3675840A1 (en) 2020-07-08
EP3675840A4 true EP3675840A4 (en) 2021-05-12

Family

ID=65526008

Family Applications (2)

Application Number Title Priority Date Filing Date
EP18852330.2A Withdrawn EP3675719A4 (en) 2017-08-30 2018-08-29 USE OF INHALED NITRIC OXIDE FOR THE TREATMENT OF PULMONARY HYPERTENSION ASSOCIATED WITH PULMONARY DISORDER
EP18851496.2A Withdrawn EP3675840A4 (en) 2017-08-30 2018-08-29 USE OF INHALED NITRIC OXIDE FOR IMPROVEMENT OF RIGHT AND / OR LEFT VENTRICULAR FUNCTION

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP18852330.2A Withdrawn EP3675719A4 (en) 2017-08-30 2018-08-29 USE OF INHALED NITRIC OXIDE FOR THE TREATMENT OF PULMONARY HYPERTENSION ASSOCIATED WITH PULMONARY DISORDER

Country Status (14)

Country Link
US (2) US20200360647A1 (es)
EP (2) EP3675719A4 (es)
JP (3) JP2020532521A (es)
KR (1) KR20200083443A (es)
CN (2) CN111372577A (es)
AU (2) AU2018323547A1 (es)
BR (1) BR112020004205A2 (es)
CA (2) CA3073948A1 (es)
IL (2) IL272314A (es)
MX (1) MX2020002194A (es)
PH (1) PH12020500197A1 (es)
SG (1) SG11202000893QA (es)
TW (3) TW202416939A (es)
WO (2) WO2019046415A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
EP4163253A1 (en) 2017-02-27 2023-04-12 Third Pole, Inc. Systems and methods for generating nitric oxide
EP3585727B1 (en) 2017-02-27 2022-03-16 Third Pole, Inc. Systems and methods for ambulatory generation of nitric oxide
AU2020209661A1 (en) * 2019-01-14 2021-08-19 Bellerophon Therapeutics Combination drug therapies of PDE-5 inhibitors and inhaled nitric oxide
EP3969416A4 (en) 2019-05-15 2023-11-01 Third Pole, Inc. SYSTEMS AND METHODS FOR GENERATING NITRIC OXIDE
CN114269685A (zh) 2019-05-15 2022-04-01 第三极股份有限公司 用于一氧化氮生成的电极
US11691879B2 (en) 2020-01-11 2023-07-04 Third Pole, Inc. Systems and methods for nitric oxide generation with humidity control
US20210345952A1 (en) * 2020-05-06 2021-11-11 Janssen Pharmaceuticals, Inc. Controlling operation of drug administration devices using surgical hubs
WO2021243227A1 (en) * 2020-05-29 2021-12-02 Bellerophon Therapeutics Method for pulsatile delivery of a gaseous drug
WO2021258025A1 (en) 2020-06-18 2021-12-23 Third Pole, Inc. Systems and methods for preventing and treating infections with nitric oxide
US11975139B2 (en) 2021-09-23 2024-05-07 Third Pole, Inc. Systems and methods for delivering nitric oxide

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2012075420A1 (en) * 2010-12-03 2012-06-07 Geno Llc Nitric oxide treatments
WO2017139113A1 (en) * 2016-02-12 2017-08-17 Mallinckrodt Hospital Products IP Limited Use and monitoring of inhaled nitric oxide with left ventricular assist devices

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HUE025355T2 (en) * 2006-12-12 2016-02-29 Gilead Sciences Inc Composition for treating pulmonary hypertension
WO2009048521A1 (en) * 2007-10-11 2009-04-16 Duke University Potentiating the effect of compound comprising nitric oxide
DK2247297T3 (en) * 2008-01-31 2019-03-11 Univ Vanderbilt THERAPEUTIC TREATMENT OF LUNG CONDITIONS
JP2011010865A (ja) * 2009-06-30 2011-01-20 Ikaria Holdings Inc 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法
US20120093948A1 (en) * 2009-11-20 2012-04-19 Fine David H Nitric Oxide Treatments
WO2013181322A1 (en) * 2012-05-31 2013-12-05 Ino Therapeutics Llc Methods of administering nitric oxide to arterial or arterialized blood
US9795756B2 (en) * 2012-12-04 2017-10-24 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
KR102357044B1 (ko) * 2012-12-04 2022-02-08 말린크로트 파마슈티칼스 아일랜드 리미티드 일산화질소 전달 동안 투약량의 희석을 최소화하기 위한 캐뉼라
JP2017503801A (ja) * 2014-01-10 2017-02-02 イノ セラピューティックス エルエルシー 小児における急性呼吸促迫症候群の治療のための吸入一酸化窒素ガスを使用する方法
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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2012075420A1 (en) * 2010-12-03 2012-06-07 Geno Llc Nitric oxide treatments
WO2017139113A1 (en) * 2016-02-12 2017-08-17 Mallinckrodt Hospital Products IP Limited Use and monitoring of inhaled nitric oxide with left ventricular assist devices

Non-Patent Citations (6)

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Title
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 2012, MARTYNYUK T V ET AL: "Inhaled nitric oxide: Clinical effects and influence on the profile of inflammatory markers in patients with idiopathic pulmonary hypertension", XP002802502, Database accession no. EMB-2013079330 *
MARTYNYUK T V ET AL: "Inhaled nitric oxide: Clinical effects and influence on the profile of inflammatory markers in patients with idiopathic pulmonary hypertension", RATIONAL PHARMACOTHERAPY IN CARDIOLOGY 2012 STOLICHNAYA IZDATELSKAYA KOMPANIYA RUS, vol. 8, no. 4, 2012, pages 500 - 508, XP055789906, ISSN: 1819-6446 *
REA RHONDA S ET AL: "Role of Inhaled Nitric Oxide in Adult Heart or Lung Transplant Recipients", ANNALS OF PHARMACOTHERAPY, vol. 39, no. 5, May 2005 (2005-05-01), US, pages 913 - 917, XP055789717, ISSN: 1060-0280, DOI: 10.1345/aph.1E228 *
ROBYN J. BARST ET AL: "Clinical Perspectives with Long-Term Pulsed Inhaled Nitric Oxide for the Treatment of Pulmonary Arterial Hypertension", PULMONARY CIRCULATION, vol. 2, no. 2, April 2012 (2012-04-01), US, pages 139 - 147, XP055572871, ISSN: 2045-8932, DOI: 10.4103/2045-8932.97589 *
See also references of WO2019046413A1 *
VONBANK K ET AL: "Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD", THORAX, vol. 58, no. 4, April 2003 (2003-04-01), GB, pages 289 - 293, XP055789636, ISSN: 0040-6376, DOI: 10.1136/thorax.58.4.289 *

Also Published As

Publication number Publication date
TW202416939A (zh) 2024-05-01
WO2019046415A1 (en) 2019-03-07
PH12020500197A1 (en) 2020-10-19
EP3675719A4 (en) 2021-07-14
US20200188319A1 (en) 2020-06-18
AU2018324004A1 (en) 2020-02-13
CA3073949A1 (en) 2019-03-07
AU2018323547A1 (en) 2020-02-13
JP2020532521A (ja) 2020-11-12
SG11202000893QA (en) 2020-02-27
WO2019046413A1 (en) 2019-03-07
JP2020532531A (ja) 2020-11-12
TW201919590A (zh) 2019-06-01
IL272308A (en) 2020-03-31
TW201912151A (zh) 2019-04-01
IL272314A (en) 2020-03-31
EP3675719A1 (en) 2020-07-08
US20200360647A1 (en) 2020-11-19
MX2020002194A (es) 2020-11-24
BR112020004205A2 (pt) 2020-09-01
EP3675840A1 (en) 2020-07-08
KR20200083443A (ko) 2020-07-08
CN111315283A (zh) 2020-06-19
CA3073948A1 (en) 2019-03-07
CN111372577A (zh) 2020-07-03
JP2023100985A (ja) 2023-07-19

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